Takashi Umehara

ResearcherID Researcher Name Resolver ID ORCID

Publication Activity (10 Years)

Years Active: 2018-2023
Publications (10 Years): 24

Top Venues

Nature communications

Epigenomes

Journal of medicinal chemistry

ChemMedChem

RIKEN

The University of Tokyo (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

RIKEN

Japan

Team Leader

RIKEN

Japan

Unit Leader

RIKEN

Japan

Senior Scientist

RIKEN

Japan

Research Scientist

RIKEN

Japan

Research Associate

Japan Science and Technology Agency

Japan

Research Manager

Japan Science and Technology Agency

Japan

Research Fellow

Education History

The University of Tokyo

Japan

PHD :: Graduate School of Pharmaceutical Sciences

Publications

Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nature communications 14 (1) (2023)
Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Ko Kikuzato, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Takeshi Sonoda, Noriaki Hashimoto, Ryosuke Namie, Teruki Honma, Takashi Umehara, Mikako Shirouzu, Hiroo Koyama, Minoru Yoshida, Akihiro Ito, Fumiyuki Shirai
Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents. Journal of medicinal chemistry 66 (6) (2023)
Nando Dulal Das, Hideaki Niwa, Takashi Umehara
Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery. Epigenomes 7 (1) (2023)
Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nature communications 14 (1) (2023)
Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nature communications 14 (1) (2023)
Shohei Takase, Takashi Hiroyama, Fumiyuki Shirai, Yuki Maemoto, Akiko Nakata, Mayumi Arata, Seiji Matsuoka, Takeshi Sonoda, Hideaki Niwa, Shin Sato, Takashi Umehara, Mikako Shirouzu, Yosuke Nishigaya, Tatsunobu Sumiya, Noriaki Hashimoto, Ryosuke Namie, Masaya Usui, Tomokazu Ohishi, Shun-Ichi Ohba, Manabu Kawada, Yoshihiro Hayashi, Hironori Harada, Tokio Yamaguchi, Yoichi Shinkai, Yukio Nakamura, Minoru Yoshida, Akihiro Ito
A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression. Nature communications 14 (1) (2023)
Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Ko Kikuzato, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Takeshi Sonoda, Noriaki Hashimoto, Ryosuke Namie, Teruki Honma, Takashi Umehara, Mikako Shirouzu, Hiroo Koyama, Minoru Yoshida, Akihiro Ito, Fumiyuki Shirai
Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents. Journal of medicinal chemistry 66 (6) (2023)
Nando Dulal Das, Hideaki Niwa, Takashi Umehara
Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery. Epigenomes 7 (1) (2023)
Masaki Kikuchi, Shohei Takase, Tsuyoshi Konuma, Kota Noritsugu, Saaya Sekine, Takahisa Ikegami, Akihiro Ito, Takashi Umehara
GAS41 promotes H2A.Z deposition through recognition of the N terminus of histone H3 by the YEATS domain. Proceedings of the National Academy of Sciences of the United States of America 120 (43) (2023)
Nando Dulal Das, Hideaki Niwa, Takashi Umehara
Chemical Inhibitors Targeting the Histone Lysine Demethylase Families with Potential for Drug Discovery. Epigenomes 7 (1) (2023)
Masaki Kikuchi, Satoshi Morita, Masatoshi Wakamori, Shin Sato, Tomomi Uchikubo-Kamo, Takehiro Suzuki, Naoshi Dohmae, Mikako Shirouzu, Takashi Umehara
Epigenetic mechanisms to propagate histone acetylation by p300/CBP. Nature communications 14 (1) (2023)
Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Ko Kikuzato, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Takeshi Sonoda, Noriaki Hashimoto, Ryosuke Namie, Teruki Honma, Takashi Umehara, Mikako Shirouzu, Hiroo Koyama, Minoru Yoshida, Akihiro Ito, Fumiyuki Shirai
Discovery of Novel Substrate-Competitive Lysine Methyltransferase G9a Inhibitors as Anticancer Agents. Journal of medicinal chemistry (2023)
Shinsuke Ito, Nando Dulal Das, Takashi Umehara, Haruhiko Koseki
Factors and Mechanisms That Influence Chromatin-Mediated Enhancer-Promoter Interactions and Transcriptional Regulation. Cancers 14 (21) (2022)
Yasuko Koda, Shin Sato, Hirofumi Yamamoto, Hideaki Niwa, Hisami Watanabe, Chiduru Watanabe, Tomohiro Sato, Kana Nakamura, Akiko Tanaka, Mikako Shirouzu, Teruki Honma, Takehiro Fukami, Hiroo Koyama, Takashi Umehara
Design and Synthesis of Tranylcypromine-Derived LSD1 Inhibitors with Improved hERG and Microsomal Stability Profiles. ACS medicinal chemistry letters 13 (5) (2022)
Takashi Umehara
Epidrugs: Toward Understanding and Treating Diverse Diseases. Epigenomes 6 (3) (2022)
Hideaki Niwa, Chiduru Watanabe, Shin Sato, Toshiyuki Harada, Hisami Watanabe, Ryo Tabusa, Shunsuke Fukasawa, Ayane Shiobara, Tomoko Hashimoto, Osamu Ohno, Kana Nakamura, Keiko Tsuganezawa, Akiko Tanaka, Mikako Shirouzu, Teruki Honma, Kenji Matsuno, Takashi Umehara
Structure-Activity Relationship and In Silico Evaluation of cis - and trans -PCPA-Derived Inhibitors of LSD1 and LSD2. ACS medicinal chemistry letters 13 (9) (2022)
Hiroki Kitagawa, Masaki Kikuchi, Shin Sato, Hisami Watanabe, Naoki Umezawa, Maiko Kato, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi
Structure-Based Identification of Potent Lysine-Specific Demethylase 1 Inhibitor Peptides and Temporary Cyclization to Enhance Proteolytic Stability and Cell Growth-Inhibitory Activity. Journal of medicinal chemistry 64 (7) (2021)
Erna Davydova, Tadahiro Shimazu, Maren Kirstin Schuhmacher, Magnus E Jakobsson, Hanneke L D M Willemen, Tongri Liu, Anders Moen, Angela Y Y Ho, Jędrzej M Małecki, Lisa Schroer, Rita Pinto, Takehiro Suzuki, Ida A Grønsberg, Yoshihiro Sohtome, Mai Akakabe, Sara Weirich, Masaki Kikuchi, Jesper Velgaard Olsen, Naoshi Dohmae, Takashi Umehara, Mikiko Sodeoka, Valentina Siino, Michael A McDonough, Niels Eijkelkamp, Christopher J Schofield, Albert Jeltsch, Yoichi Shinkai, Pål Ø Falnes
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature communications 12 (1) (2021)
Hideaki Niwa, Shin Sato, Noriko Handa, Toru Sengoku, Takashi Umehara, Shigeyuki Yokoyama
Development and Structural Evaluation of N-Alkylated trans-2-Phenylcyclopropylamine-Based LSD1 Inhibitors. ChemMedChem 15 (9) (2020)
Helen D Wu, Masaki Kikuchi, Onur Dagliyan, Adam K Aragaki, Hideki Nakamura, Nikolay V Dokholyan, Takashi Umehara, Takanari Inoue
Rational design and implementation of a chemically inducible heterotrimerization system. Nature methods 17 (9) (2020)
Hideaki Niwa, Shin Sato, Tomoko Hashimoto, Kenji Matsuno, Takashi Umehara
Crystal Structure of LSD1 in Complex with 4-[5-(Piperidin-4-ylmethoxy)-2-(p-tolyl)pyridin-3-yl]benzonitrile. Molecules (Basel, Switzerland) 23 (7) (2018)
Naoki Umezawa, Kasumi Tsuji, Shin Sato, Masaki Kikuchi, Hisami Watanabe, Yuhei Horai, Masashi Yamaguchi, Yosuke Hisamatsu, Takashi Umehara, Tsunehiko Higuchi
Inhibition of FAD-dependent lysine-specific demethylases by chiral polyamine analogues. RSC advances 8 (64) (2018)
Lusy Handoko, Bogumil Kaczkowski, Chung-Chau Hon, Marina Lizio, Masatoshi Wakamori, Takayoshi Matsuda, Takuhiro Ito, Prashanti Jeyamohan, Yuko Sato, Kensaku Sakamoto, Shigeyuki Yokoyama, Hitoshi Kurumizaka, Aki Minoda, Takashi Umehara
JQ1 affects BRD2-dependent and independent transcription regulation without disrupting H4-hyperacetylated chromatin states. Epigenetics 13 (4) (2018)
Tomoya Hirano, Takashi Fujiwara, Hideaki Niwa, Michitake Hirano, Kasumi Ohira, Yusuke Okazaki, Shin Sato, Takashi Umehara, Yuki Maemoto, Akihiro Ito, Minoru Yoshida, Hiroyuki Kagechika
Development of Novel Inhibitors for Histone Methyltransferase SET7/9 based on Cyproheptadine. ChemMedChem 13 (15) (2018)

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Publication Activity (10 Years)

Top Topics

Top Venues

Takashi Umehara