Michael A McDonough

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 21

Top Topics

Structural Basis

Endothelial Cells

Arabidopsis Thaliana

Top Venues

Communications chemistry

Nature communications

Nature chemistry

Angewandte Chemie (Weinheim an der Bergstrasse, Germany)

This page only lists publications with an associated author ORCID identifier.

Publications

William D Figg, Giorgia Fiorini, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2. Proteins (2023)
Takashi Miura, Tika R Malla, C David Owen, Anthony Tumber, Lennart Brewitz, Michael A McDonough, Eidarus Salah, Naohiro Terasaka, Takayuki Katoh, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek, Martin Austin Walsh, Akane Kawamura, Christopher J Schofield, Hiroaki Suga
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ 2,4 -amino acids targeting the SARS-CoV-2 main protease. Nature chemistry (2023)
Simranjeet Kaur, Nok Yin Tam, Michael A McDonough, Christopher J Schofield, Wei Shen Aik
Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic acids research 50 (7) (2022)
Ysobel R Baker, Cameron Thorpe, Jinfeng Chen, Laura M Poller, Lina Cox, Pawan Kumar, Wooi Fang Lim, Lillian Lie, Graham McClorey, Sven Epple, Daniel Singleton, Michael A McDonough, Jack S Hardwick, Kirsten E Christensen, Matthew John Andrew Wood, James P Hall, Afaf Helmy El-Sagheer, Tom Brown
An LNA-amide modification that enhances the cell uptake and activity of phosphorothioate exon-skipping oligonucleotides. Nature communications 13 (1) (2022)
Amelia Brasnett, Inga Pfeffer, Lennart Brewitz, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (26) (2021)
Shifali Shishodia, Marina Demetriades, Dong Zhang, Nok Yin Tam, Pratheesh Maheswaran, Caitlin Clunie-O'Connor, Anthony Tumber, Ivanhoe K H Leung, Yi Min Ng, Thomas M Leissing, Afaf Helmy El-Sagheer, Eidarus Salah, Tom Brown, Wei Shen Aik, Michael A McDonough, Christopher J Schofield
Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors. Journal of medicinal chemistry 64 (22) (2021)
Amelia Brasnett, Inga Pfeffer, Lennart Brewitz, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Human Oxygenase Variants Employing a Single Protein FeII Ligand Are Catalytically Active. Angewandte Chemie (International ed. in English) 60 (26) (2021)
Jürgen Brem, Tharindi D Panduwawala, Jon Ulf Hansen, Joanne Hewitt, Edgars Liepins, Pawel Donets, Laura Espina, Alistair J M Farley, Kirill Shubin, Gonzalo Gomez Campillos, Paula S Kiuru, Shifali Shishodia, Daniel Krahn, Robert K Leśniak, Juliane Schmidt Adrian, Karina Calvopiña, María-Carmen Turrientes, Madeline E Kavanagh, Dmitrijs Lubriks, Philip Hinchliffe, Gareth W Langley, Ali F Aboklaish, Anders Eneroth, Maria Backlund, Andrei G Baran, Elisabet I Nielsen, Michael Speake, Janis Kuka, John Robinson, Solveiga Grinberga, Lindsay Robinson, Michael A McDonough, Anna M Rydzik, Thomas M Leissing, Juan Carlos Jimenez-Castellanos, Matthew B Avison, Solange Da Silva Pinto, Andrew D Pannifer, Marina Martjuga, Emma Widlake, Martins Priede, Iva Hopkins Navratilova, Marek Gniadkowski, Anna Karin Belfrage, Peter Brandt, Jari T Yli-Kauhaluoma, Eric Bacque, Malcolm G P Page, Fredrik Björkling, Jonathan M Tyrrell, James Spencer, Pauline A Lang, Pawel Baranczewski, Rafael Cantón, Stuart P McElroy, Philip S Jones, Fernando Baquero, Edgars Suna, Angus Morrison, Timothy R Walsh, Christopher J Schofield
Imitation of β-lactam binding enables broad-spectrum metallo-β-lactamase inhibitors. Nature chemistry 14 (1) (2021)
Erna Davydova, Tadahiro Shimazu, Maren Kirstin Schuhmacher, Magnus E Jakobsson, Hanneke L D M Willemen, Tongri Liu, Anders Moen, Angela Y Y Ho, Jędrzej M Małecki, Lisa Schroer, Rita Pinto, Takehiro Suzuki, Ida A Grønsberg, Yoshihiro Sohtome, Mai Akakabe, Sara Weirich, Masaki Kikuchi, Jesper Velgaard Olsen, Naoshi Dohmae, Takashi Umehara, Mikiko Sodeoka, Valentina Siino, Michael A McDonough, Niels Eijkelkamp, Christopher J Schofield, Albert Jeltsch, Yoichi Shinkai, Pål Ø Falnes
The methyltransferase METTL9 mediates pervasive 1-methylhistidine modification in mammalian proteomes. Nature communications 12 (1) (2021)
Amelia Brasnett, Inga Pfeffer, Lennart Brewitz, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (26) (2021)
William D Figg, Michael A McDonough, Rasheduzzaman Chowdhury, Yu Nakashima, Zhihong Zhang, James P Holt-Martyn, Alen Krajnc, Christopher J Schofield
Structural Basis of Prolyl Hydroxylase Domain Inhibition by Molidustat. ChemMedChem 16 (13) (2021)
Hwanho Choi, Adam P Hardy, Thomas M Leissing, Rasheduzzaman Chowdhury, Yu Nakashima, Wei Ge, Marios Markoulides, John S Scotti, Philip A Gerken, Helen Thorbjornsrud, Dahye Kang, Sungwoo Hong, Joongoo Lee, Michael A McDonough, Hwangseo Park, Christopher J Schofield
A human protein hydroxylase that accepts D-residues. Communications chemistry 3 (1) (2020)
Hwanho Choi, Adam P Hardy, Thomas M Leissing, Rasheduzzaman Chowdhury, Yu Nakashima, Wei Ge, Marios Markoulides, John S Scotti, Philip A Gerken, Helen Thorbjornsrud, Dahye Kang, Sungwoo Hong, Joongoo Lee, Michael A McDonough, Hwangseo Park, Christopher J Schofield
A human protein hydroxylase that accepts D-residues. Communications chemistry 3 (1) (2020)
Hwanho Choi, Adam P Hardy, Thomas M Leissing, Rasheduzzaman Chowdhury, Yu Nakashima, Wei Ge, Marios Markoulides, John S Scotti, Philip A Gerken, Helen Thorbjornsrud, Dahye Kang, Sungwoo Hong, Joongoo Lee, Michael A McDonough, Hwangseo Park, Christopher J Schofield
A human protein hydroxylase that accepts D-residues. Communications chemistry 3 (1) (2020)
Mark D White, Laura Dalle Carbonare, Mikel Lavilla Puerta, Sergio Iacopino, Martin Edwards, Kate Dunne, Elisabete Pires, Colin Levy, Michael A McDonough, Francesco Licausi, Emily Flashman
Structures of Arabidopsis thaliana oxygen-sensing plant cysteine oxidases 4 and 5 enable targeted manipulation of their activity. Proceedings of the National Academy of Sciences of the United States of America 117 (37) (2020)
James P Holt-Martyn, Anthony Tumber, Mohammed Z Rahman, Kerstin Lippl, William D Figg, Michael A McDonough, Rasheduzzaman Chowdhury, Christopher J Schofield
Studies on spiro[4.5]decanone prolyl hydroxylase domain inhibitors. MedChemComm 10 (4) (2019)
Inga Pfeffer, Lennart Brewitz, Tobias Krojer, Sacha A Jensen, Grazyna T Kochan, Nadia J Kershaw, Kirsty S Hewitson, Luke A McNeill, Holger Kramer, Martin Münzel, Richard J Hopkinson, Udo Oppermann, Penny A Handford, Michael A McDonough, Christopher J Schofield
Aspartate/asparagine-β-hydroxylase crystal structures reveal an unexpected epidermal growth factor-like domain substrate disulfide pattern. Nature communications 10 (1) (2019)
Md Saiful Islam, Michael A McDonough, Rasheduzzaman Chowdhury, Joseph Gault, Amjad Khan, Elisabete Pires, Christopher J Schofield
Biochemical and structural investigations clarify the substrate selectivity of the 2-oxoglutarate oxygenase JMJD6. The Journal of biological chemistry 294 (30) (2019)
Christopher T Lohans, David Y Wang, Christian Jorgensen, Samuel T Cahill, Ian J Clifton, Michael A McDonough, Henry P Oswin, James Spencer, Carmen Domene, Timothy D W Claridge, Jürgen Brem, Christopher J Schofield
13C-Carbamylation as a mechanistic probe for the inhibition of class D β-lactamases by avibactam and halide ions. Organic & biomolecular chemistry 15 (28) (2018)
Ilaria Pettinati, Pawel Grzechnik, Claudia Ribeiro de Almeida, Jurgen Brem, Michael A McDonough, Somdutta Dhir, Nick J Proudfoot, Christopher J Schofield
Biosynthesis of histone messenger RNA employs a specific 3' end endonuclease. eLife 7 (2018)
Guo-Bo Li, Martine I Abboud, Jürgen Brem, Hidenori Someya, Christopher T Lohans, Sheng-Yong Yang, James Spencer, David W Wareham, Michael A McDonough, Christopher J Schofield
NMR-filtered virtual screening leads to non-metal chelating metallo-β-lactamase inhibitors. Chemical science 8 (2) (2016)