Christopher J Schofield (Chris J Schofield, C J Schofield)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 187

Top Venues

Journal of medicinal chemistry

Chemical science

Nature communications

ChemMedChem

University of Manchester Institute of Science & Technology (BSC)

This page only lists publications with an associated author ORCID identifier.

Education History

University of Manchester Institute of Science & Technology

United Kingdom

BSC :: Chemistry

Publications

Hannah Lawson, James P Holt-Martyn, Vilma Dembitz, Yuka Kabayama, Lydia M Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon, Jozef Durko, Louie N van de Lagemaat, Azzura L De Pace, Anthony Tumber, Thomas P Corner, Eidarus Salah, Christine Arndt, Lennart Brewitz, Matthew J Bowen, Louis Dubusse, Derek George, Lewis Allen, Amélie Valérie Guitart, Tsz Kan Fung, Chi Wai Eric So, Juerg Schwaller, Paolo Gallipoli, Donal O'Carroll, Christopher J Schofield, Kamil R Kranc
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia. Nature cancer 5 (6) (2024)
null Gayatri, Lennart Brewitz, Lewis Ibbotson, Eidarus Salah, Shyam Basak, Hani Choudhry, Christopher J Schofield
Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation. Chemical science 15 (20) (2024)
Hannah Lawson, James P Holt-Martyn, Vilma Dembitz, Yuka Kabayama, Lydia M Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon, Jozef Durko, Louie N van de Lagemaat, Azzura L De Pace, Anthony Tumber, Thomas P Corner, Eidarus Salah, Christine Arndt, Lennart Brewitz, Matthew J Bowen, Louis Dubusse, Derek George, Lewis Allen, Amélie Valérie Guitart, Tsz Kan Fung, Chi Wai Eric So, Juerg Schwaller, Paolo Gallipoli, Donal O'Carroll, Christopher J Schofield, Kamil R Kranc
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia. Nature cancer 5 (6) (2024)
Midhun George Thomas, Simahudeen Bathir J S Rifayee, Shobhit S Chaturvedi, Koteswara Rao Gorantla, Walter White, Jon Wildey, Christopher J Schofield, Christo Z Christov
The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A. Inorganic chemistry 63 (23) (2024)
Jos J A G Kamps, Dong Zhang, Timothy D W Claridge, Christopher J Schofield
Rhodanine derived enethiols react to give 1,3-dithiolanes and mixed disulfides. RSC medicinal chemistry 15 (7) (2024)
Mariska de Munnik, Pauline A Lang, Karina Calvopiña, Patrick Rabe, Jürgen Brem, Christopher J Schofield
Biochemical and crystallographic studies of L,D-transpeptidase 2 from Mycobacterium tuberculosis with its natural monomer substrate. Communications biology 7 (1) (2024)
Lonnie P Swift, B Christoffer Lagerholm, Lucy R Henderson, Malitha Ratnaweera, Hannah T Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D Ulrich, Joseph A Newman, Christopher J Schofield, Peter J McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Nature communications 15 (1) (2024)
null Gayatri, Lennart Brewitz, Lewis Ibbotson, Eidarus Salah, Shyam Basak, Hani Choudhry, Christopher J Schofield
Thiophene-fused γ-lactams inhibit the SARS-CoV-2 main protease via reversible covalent acylation. Chemical science 15 (20) (2024)
Hannah Lawson, James P Holt-Martyn, Vilma Dembitz, Yuka Kabayama, Lydia M Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon, Jozef Durko, Louie N van de Lagemaat, Azzura L De Pace, Anthony Tumber, Thomas P Corner, Eidarus Salah, Christine Arndt, Lennart Brewitz, Matthew J Bowen, Louis Dubusse, Derek George, Lewis Allen, Amélie Valérie Guitart, Tsz Kan Fung, Chi Wai Eric So, Juerg Schwaller, Paolo Gallipoli, Donal O'Carroll, Christopher J Schofield, Kamil R Kranc
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia. Nature cancer 5 (6) (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Midhun George Thomas, Simahudeen Bathir J S Rifayee, Shobhit S Chaturvedi, Koteswara Rao Gorantla, Walter White, Jon Wildey, Christopher J Schofield, Christo Z Christov
The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A. Inorganic chemistry 63 (23) (2024)
Lonnie P Swift, B Christoffer Lagerholm, Lucy R Henderson, Malitha Ratnaweera, Hannah T Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D Ulrich, Joseph A Newman, Christopher J Schofield, Peter J McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Nature communications 15 (1) (2024)
Hannah Lawson, James P Holt-Martyn, Vilma Dembitz, Yuka Kabayama, Lydia M Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon, Jozef Durko, Louie N van de Lagemaat, Azzura L De Pace, Anthony Tumber, Thomas P Corner, Eidarus Salah, Christine Arndt, Lennart Brewitz, Matthew J Bowen, Louis Dubusse, Derek George, Lewis Allen, Amélie Valérie Guitart, Tsz Kan Fung, Chi Wai Eric So, Juerg Schwaller, Paolo Gallipoli, Donal O'Carroll, Christopher J Schofield, Kamil R Kranc
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia. Nature cancer (2024)
Midhun George Thomas, Simahudeen Bathir J S Rifayee, Shobhit S Chaturvedi, Koteswara Rao Gorantla, Walter White, Jon Wildey, Christopher J Schofield, Christo Z Christov
The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A. Inorganic chemistry 63 (23) (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry 67 (14) (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Tobias John, Nadia Saffoon, John Walsby-Tickle, Svenja S Hester, Felix A Dingler, Christopher L Millington, James S O McCullagh, Ketan J Patel, Richard J Hopkinson, Christopher J Schofield
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism. Chemical science 15 (7) (2024)
Rebecca Roddan, William J Nathan, Joseph A Newman, Afaf Helmy El-Sagheer, David M Wilson, Tom Brown, Christopher J Schofield, Peter J McHugh
Molecular insights into the stimulation of SNM1A nuclease activity by CSB during interstrand crosslink processing. bioRxiv : the preprint server for biology (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry 67 (14) (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry 67 (14) (2024)
Hannah Lawson, James P Holt-Martyn, Vilma Dembitz, Yuka Kabayama, Lydia M Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon, Jozef Durko, Louie N van de Lagemaat, Azzura L De Pace, Anthony Tumber, Thomas P Corner, Eidarus Salah, Christine Arndt, Lennart Brewitz, Matthew J Bowen, Louis Dubusse, Derek George, Lewis Allen, Amélie Valérie Guitart, Tsz Kan Fung, Chi Wai Eric So, Juerg Schwaller, Paolo Gallipoli, Donal O'Carroll, Christopher J Schofield, Kamil R Kranc
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia. Nature cancer 5 (6) (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry (2024)
Midhun George Thomas, Simahudeen Bathir J S Rifayee, Shobhit S Chaturvedi, Koteswara Rao Gorantla, Walter White, Jon Wildey, Christopher J Schofield, Christo Z Christov
The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A. Inorganic chemistry (2024)
Midhun George Thomas, Simahudeen Bathir J S Rifayee, Shobhit S Chaturvedi, Koteswara Rao Gorantla, Walter White, Jon Wildey, Christopher J Schofield, Christo Z Christov
The Unique Role of the Second Coordination Sphere to Unlock and Control Catalysis in Nonheme Fe(II)/2-Oxoglutarate Histone Demethylase KDM2A. Inorganic chemistry 63 (23) (2024)
Lonnie P Swift, B Christoffer Lagerholm, Lucy R Henderson, Malitha Ratnaweera, Hannah T Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D Ulrich, Joseph A Newman, Christopher J Schofield, Peter J McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Nature communications 15 (1) (2024)
Lennart Brewitz, Christopher J Schofield
Fixing the Achilles Heel of Pfizer's Paxlovid for COVID-19 Treatment. Journal of medicinal chemistry 67 (14) (2024)
Lonnie P Swift, B Christoffer Lagerholm, Lucy R Henderson, Malitha Ratnaweera, Hannah T Baddock, Blanka Sengerova, Sook Lee, Abimael Cruz-Migoni, Dominic Waithe, Christian Renz, Helle D Ulrich, Joseph A Newman, Christopher J Schofield, Peter J McHugh
SNM1A is crucial for efficient repair of complex DNA breaks in human cells. Nature communications 15 (1) (2024)
Yue Wu, Yafen Chen, Thomas P Corner, Yu Nakashima, Eidarus Salah, Zhihong Li, Linjian Zhang, Le Yang, Anthony Tumber, Zhuoli Sun, Yukang Wen, Ailin Zhong, Fulai Yang, Xiang Li, Zhihong Zhang, Christopher J Schofield, Xiaojin Zhang
A Small-Molecule Inhibitor of Factor Inhibiting HIF Binding to a Tyrosine-Flip Pocket for the Treatment of Obesity. Angewandte Chemie (International ed. in English) (2024)
Anandhu Krishnan, Sodiq O Waheed, Ann Varghese, Fathima Hameed Cherilakkudy, Christopher J Schofield, Tatyana G Karabencheva-Christova
Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH. Chemical science 15 (10) (2024)
Anandhu Krishnan, Sodiq O Waheed, Sreerag Melayikandy, Ciara LaRouche, Meredith Paik, Christopher J Schofield, Tatyana G Karabencheva-Christova
Effects of Clinical Mutations in the Second Coordination Sphere and Remote Regions on the Catalytic Mechanism of Non-Heme Fe(II)/2-Oxoglutarate-Dependent Aspartyl Hydroxylase AspH. Chemphyschem : a European journal of chemical physics and physical chemistry (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry (2024)
Rongling Wang, Mario Gomez Salazar, Iris Pruñonosa Cervera, Amanda S Coutts, Karen French, Marlene Magalhaes Pinto, Sabrina Gohlke, Rubén García-Martín, Matthias Blüher, Christopher J Schofield, Ioannis Kourtzelis, Roland H Stimson, Cécile Bénézech, Mark Christian, Tim Julius Schulz, Elias Freyr Gudmundsson, Lori L Jennings, Vilmundur G Gudnason, Triantafyllos Chavakis, Nicholas M Morton, Valur Emilsson, Zoi Michailidou
Adipocyte deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutrality. Nature communications 15 (1) (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Tobias John, Nadia Saffoon, John Walsby-Tickle, Svenja S Hester, Felix A Dingler, Christopher L Millington, James S O McCullagh, Ketan J Patel, Richard J Hopkinson, Christopher J Schofield
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism. Chemical science 15 (7) (2024)
Anandhu Krishnan, Sodiq O Waheed, Ann Varghese, Fathima Hameed Cherilakkudy, Christopher J Schofield, Tatyana G Karabencheva-Christova
Unusual catalytic strategy by non-heme Fe(ii)/2-oxoglutarate-dependent aspartyl hydroxylase AspH. Chemical science 15 (10) (2024)
Hannah Lawson, James P Holt-Martyn, Vilma Dembitz, Yuka Kabayama, Lydia M Wang, Aarushi Bellani, Samanpreet Atwal, Nadia Saffoon, Jozef Durko, Louie N van de Lagemaat, Azzura L De Pace, Anthony Tumber, Thomas P Corner, Eidarus Salah, Christine Arndt, Lennart Brewitz, Matthew J Bowen, Louis Dubusse, Derek George, Lewis Allen, Amélie Valérie Guitart, Tsz Kan Fung, Chi Wai Eric So, Juerg Schwaller, Paolo Gallipoli, Donal O'Carroll, Christopher J Schofield, Kamil R Kranc
The selective prolyl hydroxylase inhibitor IOX5 stabilizes HIF-1α and compromises development and progression of acute myeloid leukemia. Nature cancer (2024)
Roman Belle, Hilal Saraç, Eidarus Salah, Bhaskar Bhushan, Aleksandra Szykowska, Grace Roper, Anthony Tumber, Skirmantas Kriaucionis, Nicola Burgess-Brown, Christopher J Schofield, Tom Brown, Akane Kawamura
Focused Screening Identifies Different Sensitivities of Human TET Oxygenases to the Oncometabolite 2-Hydroxyglutarate. Journal of medicinal chemistry 67 (6) (2024)
Marcin Bielinski, Lucy R Henderson, Yuliana Yosaatmadja, Lonnie P Swift, Hannah T Baddock, Matthew J Bowen, Jürgen Brem, Philip S Jones, Stuart P McElroy, Angus Morrison, Michael Speake, Stan van Boeckel, Els van Doornmalen, Jan van Groningen, Helma van den Hurk, Opher Gileadi, Joseph A Newman, Peter J McHugh, Christopher J Schofield
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chemical science 15 (21) (2024)
Tobias John, Nadia Saffoon, John Walsby-Tickle, Svenja S Hester, Felix A Dingler, Christopher L Millington, James S O McCullagh, Ketan J Patel, Richard J Hopkinson, Christopher J Schofield
Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism. Chemical science 15 (7) (2024)
Marcin Bielinski, Lucy R Henderson, Yuliana Yosaatmadja, Lonnie P Swift, Hannah T Baddock, Matthew J Bowen, Jürgen Brem, Philip S Jones, Stuart P McElroy, Angus Morrison, Michael Speake, Stan van Boeckel, Els van Doornmalen, Jan van Groningen, Helma van den Hurk, Opher Gileadi, Joseph A Newman, Peter J McHugh, Christopher J Schofield
Cell-active small molecule inhibitors validate the SNM1A DNA repair nuclease as a cancer target. Chemical science 15 (21) (2024)
Jos J A G Kamps, Dong Zhang, Timothy D W Claridge, Christopher J Schofield
Rhodanine derived enethiols react to give 1,3-dithiolanes and mixed disulfides. RSC medicinal chemistry 15 (7) (2024)
Mariska de Munnik, Pauline A Lang, Francisco De Dios Anton, Mónica Cacho, Robert H Bates, Jürgen Brem, Beatriz Rodríguez Miquel, Christopher J Schofield
High-throughput screen with the l,d-transpeptidase Ldt Mt2 of Mycobacterium tuberculosis reveals novel classes of covalently reacting inhibitors. Chemical science 14 (26) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Tobias John, Elisabete Pires, Svenja S Hester, Eidarus Salah, Richard J Hopkinson, Christopher J Schofield
Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals. Communications chemistry 6 (1) (2023)
H T Henry Chan, Lennart Brewitz, Petra Lukacik, Claire Strain-Damerell, Martin Austin Walsh, Christopher J Schofield, Fernanda Duarte
Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein. RSC chemical biology 5 (2) (2023)
Vildan A Türkmen, Jordi C J Hintzen, Anthony Tumber, Laust Moesgaard, Eidarus Salah, Jacob Kongsted, Christopher J Schofield, Jasmin Mecinovic
Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66. RSC chemical biology 4 (3) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Vildan A Türkmen, Jordi C J Hintzen, Anthony Tumber, Laust Moesgaard, Eidarus Salah, Jacob Kongsted, Christopher J Schofield, Jasmin Mecinovic
Substrate selectivity and inhibition of histidine JmjC hydroxylases MINA53 and NO66. RSC chemical biology 4 (3) (2023)
H T Henry Chan, Ana Sofia F Oliveira, Christopher J Schofield, Adrian J Mulholland, Fernanda Duarte
Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease. JACS Au 3 (6) (2023)
Vijil Chenthamarakshan, Samuel C Hoffman, C David Owen, Petra Lukacik, Claire Strain-Damerell, Daren Fearon, Tika R Malla, Anthony Tumber, Christopher J Schofield, Helen M E Duyvesteyn, Wanwisa Dejnirattisai, Loic Carrique, Thomas S Walter, Gavin R Screaton, Tetiana Matviiuk, Aleksandra Mojsilovic, Jason Crain, Martin Austin Walsh, David I Stuart, Payel Das
Accelerating drug target inhibitor discovery with a deep generative foundation model. Science advances 9 (25) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Tobias John, Elisabete Pires, Svenja S Hester, Eidarus Salah, Richard J Hopkinson, Christopher J Schofield
Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals. Communications chemistry 6 (1) (2023)
Anthony Tumber, Eidarus Salah, Lennart Brewitz, Thomas P Corner, Christopher J Schofield
Kinetic and inhibition studies on human Jumonji-C (JmjC) domain-containing protein 5. RSC chemical biology 4 (6) (2023)
Ryan A Herold, Christopher J Schofield, Fraser A Armstrong
Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer-drug Kinetics. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 135 (42) (2023)
Lennart Brewitz, Yu Nakashima, Sonia K Piasecka, Eidarus Salah, Sally C Fletcher, Anthony Tumber, Thomas P Corner, Tristan J Kennedy, Giorgia Fiorini, Armin Thalhammer, Kirsten E Christensen, Mathew L Coleman, Christopher J Schofield
5-Substituted Pyridine-2,4-dicarboxylate Derivatives Have Potential for Selective Inhibition of Human Jumonji-C Domain-Containing Protein 5. Journal of medicinal chemistry (2023)
Ryan A Herold, Christopher J Schofield, Fraser A Armstrong
Electrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer-drug Kinetics. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 135 (42) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry (2023)
Mariska de Munnik, Jasper Lithgow, Lennart Brewitz, Kirsten E Christensen, Robert H Bates, Beatriz Rodríguez Miquel, Christopher J Schofield
αβ,α'β'-Diepoxyketones are mechanism-based inhibitors of nucleophilic cysteine enzymes. Chemical communications (Cambridge, England) (2023)
William D Figg, Giorgia Fiorini, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Structural basis for binding of the renal carcinoma target hypoxia-inducible factor 2α to prolyl hydroxylase domain 2. Proteins (2023)
Catherine L Tooke, Philip Hinchliffe, Michael Beer, Kirill Zinovjev, Charlotte K Colenso, Christopher J Schofield, Adrian J Mulholland, James Spencer
Tautomer-Specific Deacylation and Ω-Loop Flexibility Explain the Carbapenem-Hydrolyzing Broad-Spectrum Activity of the KPC-2 β-Lactamase. Journal of the American Chemical Society (2023)
H T Henry Chan, Ana Sofia F Oliveira, Christopher J Schofield, Adrian J Mulholland, Fernanda Duarte
Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease. JACS Au 3 (6) (2023)
H T Henry Chan, Lennart Brewitz, Petra Lukacik, Claire Strain-Damerell, Martin Austin Walsh, Christopher J Schofield, Fernanda Duarte
Studies on the selectivity of the SARS-CoV-2 papain-like protease reveal the importance of the P2' proline of the viral polyprotein. RSC chemical biology 5 (2) (2023)
Takashi Miura, Tika R Malla, C David Owen, Anthony Tumber, Lennart Brewitz, Michael A McDonough, Eidarus Salah, Naohiro Terasaka, Takayuki Katoh, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek, Martin Austin Walsh, Akane Kawamura, Christopher J Schofield, Hiroaki Suga
In vitro selection of macrocyclic peptide inhibitors containing cyclic γ 2,4 -amino acids targeting the SARS-CoV-2 main protease. Nature chemistry (2023)
Shuang Liu, Martine I Abboud, Victor Mikhailov, Xiao Liu, Raphael Reinbold, Christopher J Schofield
Differentiating Inhibition Selectivity and Binding Affinity of Isocitrate Dehydrogenase 1 Variant Inhibitors. Journal of medicinal chemistry (2023)
H T Henry Chan, Ana Sofia F Oliveira, Christopher J Schofield, Adrian J Mulholland, Fernanda Duarte
Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease. JACS Au 3 (6) (2023)
Thomas P Corner, Ryan Z R Teo, Yue Wu, Eidarus Salah, Yu Nakashima, Giorgia Fiorini, Anthony Tumber, Amelia Brasnett, James P Holt-Martyn, William D Figg, Xiaojin Zhang, Lennart Brewitz, Christopher J Schofield
Structure-guided optimisation of N -hydroxythiazole-derived inhibitors of factor inhibiting hypoxia-inducible factor-α. Chemical science 14 (43) (2023)
H T Henry Chan, Ana Sofia F Oliveira, Christopher J Schofield, Adrian J Mulholland, Fernanda Duarte
Dynamical Nonequilibrium Molecular Dynamics Simulations Identify Allosteric Sites and Positions Associated with Drug Resistance in the SARS-CoV-2 Main Protease. JACS Au 3 (6) (2023)
Lennart Brewitz, Leo Dumjahn, Yilin Zhao, C David Owen, Stephen M Laidlaw, Tika R Malla, Dung Nguyen, Petra Lukacik, Eidarus Salah, Adam D Crawshaw, Anna J Warren, Jose Trincao, Claire Strain-Damerell, Miles W Carroll, Martin Austin Walsh, Christopher J Schofield
Alkyne Derivatives of SARS-CoV-2 Main Protease Inhibitors Including Nirmatrelvir Inhibit by Reacting Covalently with the Nucleophilic Cysteine. Journal of medicinal chemistry 66 (4) (2023)
Kyoko Morimoto, Daniel Krahn, Farnusch Kaschani, Digby Hopkinson-Woolley, Anna Gee, Pierre Buscaill, Shabaz Mohammad, Stephan A Sieber, Benjamin F Cravatt, Christopher J Schofield, van der Hoorn Renier A L
Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme. The New phytologist 235 (3) (2022)
Haotian Liu, Yong Xie, Xia Wang, Martine I Abboud, Chao Ma, Wei Ge, Christopher J Schofield
Exploring links between 2-oxoglutarate-dependent oxygenases and Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association (2022)
Ryan A Herold, Raphael Reinbold, Christopher J Schofield, Fraser A Armstrong
NADP(H)-dependent biocatalysis without adding NADP(H). Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Arathy Jose, Daniel Guest, Remi LeGay, Graham J Tizzard, Simon J Coles, Mariliza Derveni, Edward Wright, Lester Marrison, Alpha A Lee, Aaron Morris, Matt Robinson, Frank von Delft, Daren Fearon, Lizbé Koekemoer, Tetiana Matviuk, Anthony Aimon, Christopher J Schofield, Tika R Malla, Nir London, Barnaby W Greenland, Mark C Bagley, John Spencer, null The Covid Moonshot Consortium
Expanding the Repertoire of Low-Molecular-Weight Pentafluorosulfanyl-Substituted Scaffolds. ChemMedChem 17 (7) (2022)
Ryan A Herold, Raphael Reinbold, Christopher J Schofield, Fraser A Armstrong
NADP(H)-dependent biocatalysis without adding NADP(H). Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Christopher J Brereton, Liudi Yao, Elizabeth R Davies, Yilu Zhou, Milica Vukmirovic, Joseph A Bell, Siyuan Wang, Robert A Ridley, Lareb S N Dean, Orestis G Andriotis, Franco Conforti, Lennart Brewitz, Soran Mohammed, Timothy Wallis, Ali Tavassoli, Rob M Ewing, Aiman Alzetani, Benjamin G Marshall, Sophie V Fletcher, Philipp J Thurner, Aurelie Fabre, Naftali Kaminski, Luca Richeldi, Atul Bhaskar, Christopher J Schofield, Matthew Loxham, Donna E Davies, Yihua Wang, Mark G Jones
Pseudohypoxic HIF pathway activation dysregulates collagen structure-function in human lung fibrosis. eLife 11 (2022)
Pauline A Lang, Ritu Raj, Anthony Tumber, Christopher T Lohans, Patrick Rabe, Carol V Robinson, Jürgen Brem, Christopher J Schofield
Studies on enmetazobactam clarify mechanisms of widely used β-lactamase inhibitors. Proceedings of the National Academy of Sciences of the United States of America 119 (18) (2022)
Zhihong Li, Yue Wu, Shuai Zhen, Kaijun Su, Linjian Zhang, Fulai Yang, Michael A McDonough, Christopher J Schofield, Xiaojin Zhang
In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (45) (2022)
Raphael Reinbold, Ingvild C Hvinden, Patrick Rabe, Ryan A Herold, Alina Finch, James Wood, Melissa Morgan, Maximillian Staudt, Ian J Clifton, Fraser A Armstrong, James S O McCullagh, Jo Redmond, Chiara Bardella, Martine I Abboud, Christopher J Schofield
Resistance to the isocitrate dehydrogenase 1 mutant inhibitor ivosidenib can be overcome by alternative dimer-interface binding inhibitors. Nature communications 13 (1) (2022)
Roman Belle, Jos J A G Kamps, Jordi Poater, Kiran Kumar, Bas J G E Pieters, Eidarus Salah, Timothy D W Claridge, Robert S Paton, Friedrich Matthias Bickelhaupt, Akane Kawamura, Christopher J Schofield, Jasmin Mecinovic
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins. Communications chemistry 5 (1) (2022)
Roman Belle, Jos J A G Kamps, Jordi Poater, Kiran Kumar, Bas J G E Pieters, Eidarus Salah, Timothy D W Claridge, Robert S Paton, Friedrich Matthias Bickelhaupt, Akane Kawamura, Christopher J Schofield, Jasmin Mecinovic
Reading and erasing of the phosphonium analogue of trimethyllysine by epigenetic proteins. Communications chemistry 5 (1) (2022)
Simranjeet Kaur, Nok Yin Tam, Michael A McDonough, Christopher J Schofield, Wei Shen Aik
Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic acids research 50 (7) (2022)
Ryan A Herold, Raphael Reinbold, Christopher J Schofield, Fraser A Armstrong
NADP(H)-dependent biocatalysis without adding NADP(H). Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Nils Frank, Jeremy Nugent, Bethany R Shire, Helena D Pickford, Patrick Rabe, Alistair J Sterling, Tryfon Zarganes-Tzitzikas, Thomas Grimes, Amber L Thompson, Russell C Smith, Christopher J Schofield, Paul E Brennan, Fernanda Duarte, Edward A Anderson
Synthesis of meta-substituted arene bioisosteres from [3.1.1]propellane. Nature 611 (7937) (2022)
Ryan A Herold, Raphael Reinbold, Christopher J Schofield, Fraser A Armstrong
NADP(H)-dependent biocatalysis without adding NADP(H). Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Zhihong Li, Yue Wu, Shuai Zhen, Kaijun Su, Linjian Zhang, Fulai Yang, Michael A McDonough, Christopher J Schofield, Xiaojin Zhang
In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (45) (2022)
Ryan A Herold, Raphael Reinbold, Christopher J Schofield, Fraser A Armstrong
NADP(H)-dependent biocatalysis without adding NADP(H). Proceedings of the National Academy of Sciences of the United States of America 120 (1) (2022)
Tika R Malla, Lennart Brewitz, Dorian-Gabriel Muntean, Hiba Aslam, C David Owen, Eidarus Salah, Anthony Tumber, Petra Lukacik, Claire Strain-Damerell, Halina Mikolajek, Martin A Walsh, Christopher J Schofield
Penicillin Derivatives Inhibit the SARS-CoV-2 Main Protease by Reaction with Its Nucleophilic Cysteine. Journal of medicinal chemistry 65 (11) (2022)
Matthew E Cockman, Yoichiro Sugimoto, Hamish B Pegg, Norma Masson, Eidarus Salah, Anthony Tumber, Helen R Flynn, Joanna M Kirkpatrick, Christopher J Schofield, Peter J Ratcliffe
Widespread hydroxylation of unstructured lysine-rich protein domains by JMJD6. Proceedings of the National Academy of Sciences of the United States of America 119 (32) (2022)
Shobhit S Chaturvedi, Simahudeen Bathir J S Rifayee, Sodiq O Waheed, Jon Wildey, Cait Warner, Christopher J Schofield, Tatyana G Karabencheva-Christova, Christo Z Christov
Can Second Coordination Sphere and Long-Range Interactions Modulate Hydrogen Atom Transfer in a Non-Heme Fe(II)-Dependent Histone Demethylase? JACS Au 2 (9) (2022)
Lennart Brewitz, Jos J A G Kamps, Petra Lukacik, Claire Strain-Damerell, Yilin Zhao, Anthony Tumber, Tika R Malla, Allen M Orville, Martin A Walsh, Christopher J Schofield
Mass Spectrometric Assays Reveal Discrepancies in Inhibition Profiles for the SARS-CoV-2 Papain-Like Protease. ChemMedChem 17 (9) (2022)
Zhihong Li, Yue Wu, Shuai Zhen, Kaijun Su, Linjian Zhang, Fulai Yang, Michael A McDonough, Christopher J Schofield, Xiaojin Zhang
In Situ Inhibitor Synthesis and Screening by Fluorescence Polarization: An Efficient Approach for Accelerating Drug Discovery. Angewandte Chemie (International ed. in English) 61 (45) (2022)
Anka Lucic, Tika R Malla, Karina Calvopiña, Catherine L Tooke, Jürgen Brem, Michael A McDonough, James Spencer, Christopher J Schofield
Studies on the Reactions of Biapenem with VIM Metallo β-Lactamases and the Serine β-Lactamase KPC-2. Antibiotics (Basel, Switzerland) 11 (3) (2022)
Shuang Liu, Martine I Abboud, Tobias John, Victor Mikhailov, Ingvild C Hvinden, John Walsby-Tickle, Xiao Liu, Ilaria Pettinati, Tom Cadoux-Hudson, James S O McCullagh, Christopher J Schofield
Roles of metal ions in the selective inhibition of oncogenic variants of isocitrate dehydrogenase 1. Communications biology 4 (1) (2021)
Alistair J M Farley, Yuri Ermolovich, Karina Calvopiña, Patrick Rabe, Tharindi Panduwawala, Jürgen Brem, Fredrik Björkling, Christopher J Schofield
Structural Basis of Metallo-β-lactamase Inhibition by N-Sulfamoylpyrrole-2-carboxylates. ACS infectious diseases 7 (6) (2021)
Amelia Brasnett, Inga Pfeffer, Lennart Brewitz, Rasheduzzaman Chowdhury, Yu Nakashima, Anthony Tumber, Michael A McDonough, Christopher J Schofield
Human Oxygenase Variants Employing a Single Protein Fe II Ligand Are Catalytically Active. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (26) (2021)
Yue Wu, Zhihong Li, Michael A McDonough, Christopher J Schofield, Xiaojin Zhang
Inhibition of the Oxygen-Sensing Asparaginyl Hydroxylase Factor Inhibiting Hypoxia-Inducible Factor: A Potential Hypoxia Response Modulating Strategy. Journal of medicinal chemistry 64 (11) (2021)

Christopher J Schofield.css-eqlu8i{font-size:small;padding-left:4px;} (Chris J Schofield, C J Schofield)

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Christopher J Schofield (Chris J Schofield, C J Schofield)