Timothy A Springer (Anindya Roy, Timothy Springer)

ORCID

Publication Activity (10 Years)

Years Active: 2014-2024
Publications (10 Years): 38

Top Venues

Nature communications

bioRxiv : the preprint server for biology

eLife

Blood

Children's Hospital Boston

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Children's Hospital Boston

United States

PI :: PCMM

Publications

Xinru Wang, Jordi Guillem-Marti, Saurav Kumar, David S Lee, Daniel Cabrerizo-Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela-Velasco, Analisa N Murray, Cole A DeForest, Timothy A Springer, Hannele Ruohola-Baker, Jonathan A Cooper, Melody G Campbell, Jose Maria Manero, Maria-Pau Ginebra, Jose Maria Manero, Maria-Pau Ginebra, Julien S Baker
De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine. bioRxiv : the preprint server for biology (2024)
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A Springer
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits. bioRxiv : the preprint server for biology (2024)
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A Springer
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits. mAbs 16 (1) (2024)
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A Springer
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits. bioRxiv : the preprint server for biology (2024)
Xinru Wang, Jordi Guillem-Marti, Saurav Kumar, David S Lee, Daniel Cabrerizo-Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela-Velasco, Analisa Murray, Stacey Gerben, Analisa N Murray, Cole A DeForest, Timothy A Springer, Hannele Ruohola-Baker, Jonathan A Cooper, Melody G Campbell, Jose Maria Manero, Maria-Pau Ginebra, Julien S Baker
De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine. bioRxiv : the preprint server for biology (2024)
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A Springer
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits. mAbs 16 (1) (2024)
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A Springer
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits. mAbs 16 (1) (2024)
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A Springer
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits. bioRxiv : the preprint server for biology (2024)
Yuxin Hao, Jiabin Yan, Courtney Fraser, Aiping Jiang, Murali Anuganti, Roushu Zhang, Kenneth Lloyd, Joseph Jardine, Jessica Coppola, Rob Meijers, Jing Li, Timothy A Springer
Synthetic integrin antibodies discovered by yeast display reveal αV subunit pairing preferences with β subunits. mAbs 16 (1) (2024)
Xinru Wang, Jordi Guillem-Marti, Saurav Kumar, David S Lee, Daniel Cabrerizo-Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela-Velasco, Analisa Murray, Stacey Gerben, Analisa N Murray, Cole A DeForest, Timothy A Springer, Hannele Ruohola-Baker, Jonathan A Cooper, Melody G Campbell, Jose Maria Manero, Maria-Pau Ginebra, Julien S Baker
De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine. bioRxiv : the preprint server for biology (2024)
Xinru Wang, Jordi Guillem-Marti, Saurav Kumar, David S Lee, Daniel Cabrerizo-Aguado, Rachel Werther, Kevin Alexander Estrada Alamo, Yan Ting Zhao, Adam Nguyen, Irina Kopyeva, Buwei Huang, Jing Li, Yuxin Hao, Xinting Li, Aritza Brizuela-Velasco, Analisa Murray, Stacey Gerben, Analisa N Murray, Cole A DeForest, Timothy A Springer, Hannele Ruohola-Baker, Jonathan A Cooper, Melody G Campbell, Jose Maria Manero, Maria-Pau Ginebra, Julien S Baker
De Novo Design of Integrin α5β1 Modulating Proteins for Regenerative Medicine. bioRxiv : the preprint server for biology (2024)
Su Zhang, Fangfang Wang, Dujuan Zhang, Dongsheng Liu, Wei Ding, Timothy A Springer, Gaojie Song
Structural insights into MIC2 recognition by MIC2-associated protein in Toxoplasma gondii. Communications biology 6 (1) (2023)
Anindya Roy, Lei Shi, Ashley Chang, Xianchi Dong, Andres N Fernandez, John C Kraft, Jing Li, Viet Q Le, Rebecca Viazzo Winegar, Gerald Maxwell Cherf, Dean Slocum, Peter Daniel Poulson, Garrett E Casper, Mary L Vallecillo-Zúniga, Jonard Corpuz Valdoz, Marcos C Miranda, Hua Bai, Yakov Kipnis, Audrey Olshefsky, Tanu Priya, Lauren Carter, Rashmi Ravichandran, Cameron M Chow, Max R Johnson, Suna Cheng, McKaela Smith, Catherine Overed-Sayer, Donna K Finch, David Lowe, Asim K Bera, Gustavo Matute-Bello, Timothy P Birkland, Frank DiMaio, Ganesh Raghu, Jennifer R Cochran, Lance J Stewart, Melody G Campbell, Pam M Van Ry, Timothy A Springer, Julien S Baker
De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8. Nature communications 14 (1) (2023)
Friedrich Braumann, Dennis Klug, Jessica Kehrer, Gaojie Song, Juan Feng, Timothy A Springer, Friedrich Frischknecht
Conformational change of Plasmodium TRAP is essential for sporozoite migration and transmission. EMBO reports (2023)
Myung Hyun Jo, Jing Li, Valentin Jaumouillé, Yuxin Hao, Jessica Coppola, Jiabin Yan, Clare M Waterman, Timothy A Springer, Taekjip Ha
Single-molecule characterization of subtype-specific β1 integrin mechanics. Nature communications 13 (1) (2022)
Juan Feng, Xianchi Dong, Yang Su, Chafen Lu, Timothy A Springer
Monomeric prefusion structure of an extremophile gamete fusogen and stepwise formation of the postfusion trimeric state. Nature communications 13 (1) (2022)
Klaus Bonazza, Roxana E Iacob, Nathan E Hudson, Jing Li, Chafen Lu, John R Engen, Timothy A Springer
Von Willebrand factor A1 domain stability and affinity for GPIbα are differentially regulated by its O -glycosylated N- and C-linker. eLife 11 (2022)
Aiping Jiang, Yan Qin, Timothy A Springer
Loss of LRRC33-Dependent TGFβ1 Activation Enhances Antitumor Immunity and Checkpoint Blockade Therapy. Cancer immunology research 10 (4) (2022)
Jacob R Anderson, Jing Li, Timothy A Springer, Alan Brown
Structures of VWF tubules before and after concatemerization reveal a mechanism of disulfide bond exchange. Blood 140 (12) (2022)
Hans T Bergal, Yan Jiang, Darren Yang, Timothy A Springer, Wesley P Wong
Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging. Blood (2022)
Hongxia Fu, Yan Jiang, Wesley P Wong, Timothy A Springer
Single-molecule imaging of von Willebrand factor reveals tension-dependent self-association. Blood 138 (23) (2022)
Jing Li, Jiabin Yan, Timothy A Springer
Low affinity integrin states have faster ligand binding kinetics than the high affinity state. eLife 10 (2021)
Juan Feng, Xianchi Dong, Adam DeCosta, Yang Su, Fiona Angrisano, Katarzyna A Sala, Andrew M Blagborough, Chafen Lu, Timothy A Springer
Structural basis of malaria transmission blockade by a monoclonal antibody to gamete fusogen HAP2. eLife 10 (2021)
Rasmus K Jensen, Goran Bajic, Mehmet Sen, Timothy A Springer, Thomas Vorup-Jensen, Gregers Rom Andersen
Complement Receptor 3 Forms a Compact High-Affinity Complex with iC3b. Journal of immunology (Baltimore, Md. : 1950) (2021)
Chafen Lu, Gaojie Song, Kristin Beale, Jiabin Yan, Emma Garst, Juan Feng, Emily Lund, Flaminia Catteruccia, Timothy A Springer
Design and assessment of TRAP-CSP fusion antigens as effective malaria vaccines. PloS one 15 (1) (2020)
Dennis Klug, Sarah Goellner, Jessica Kehrer, Julia Sattler, Léanne Strauss, Mirko Singer, Chafen Lu, Timothy A Springer, Friedrich Frischknecht
Evolutionarily distant I domains can functionally replace the essential ligand-binding domain of Plasmodium TRAP. eLife 9 (2020)
Jianchuan Wang, Yang Su, Roxana E Iacob, John R Engen, Timothy A Springer
General structural features that regulate integrin affinity revealed by atypical αVβ8. Nature communications 10 (1) (2019)
Xianchi Dong, Nina C Leksa, Ekta Seth Chhabra, Joseph W Arndt, Qi Lu, Kevin E Knockenhauer, Robert T Peters, Timothy A Springer
The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis. Blood 133 (14) (2019)
Viet Q Le, Roxana E Iacob, Yuan Tian, William McConaughy, Justin Jackson, Yang Su, Bo Zhao, John R Engen, Michelle Pirruccello-Straub, Timothy A Springer
Tolloid cleavage activates latent GDF8 by priming the pro-complex for dissociation. The EMBO journal 37 (3) (2018)
Chiara Beilin, Kaushik Choudhuri, Gerben Bouma, Dessislava Malinova, Jaime Llodra, David L Stokes, Motumu Shimaoka, Timothy A Springer, Michael L Dustin, Adrian J Thrasher, Siobhan Oisin Burns
Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse. Wellcome open research 3 (2018)
Chiara Beilin, Kaushik Choudhuri, Gerben Bouma, Dessislava Malinova, Jaime Llodra, David L Stokes, Motumu Shimaoka, Timothy A Springer, Michael L Dustin, Adrian J Thrasher, Siobhan Oisin Burns
Dendritic cell-expressed common gamma-chain recruits IL-15 for trans-presentation at the murine immunological synapse. Wellcome open research (2018)
Kristian E Swearingen, Jimmy K Eng, David Shteynberg, Vladimir Vigdorovich, Timothy A Springer, Luis Mendoza, D Noah Sather, Eric W Deutsch, Stefan H I Kappe, Robert L Moritz
A Tandem Mass Spectrometry Sequence Database Search Method for Identification of O-Fucosylated Proteins by Mass Spectrometry. Journal of proteome research 18 (2) (2018)
Juan Feng, Xianchi Dong, Jennifer Pinello, Jun Zhang, Chafen Lu, Roxana E Iacob, John R Engen, William J Snell, Timothy A Springer
Fusion surface structure, function, and dynamics of gamete fusogen HAP2. eLife 7 (2018)
Jing Li, Yang Su, Wei Xia, Yan Qin, Martin J Humphries, Dietmar Vestweber, Carlos Cabañas, Chafen Lu, Timothy A Springer
Conformational equilibria and intrinsic affinities define integrin activation. The EMBO journal 36 (5) (2017)
Pontus Nordenfelt, Travis I Moore, Shalin B Mehta, Joseph Mathew Kalappurakkal, Vinay Swaminathan, Nobuyasu Koga, Talley J Lambert, David Baker, Jennifer C Waters, Rudolf Oldenbourg, Tomomi Tani, Satyajit Mayor, Clare M Waterman, Timothy A Springer
Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration. Nature communications 8 (1) (2017)
Jing Li, Timothy A Springer
Energy landscape differences among integrins establish the framework for understanding activation. The Journal of cell biology 217 (1) (2017)
Hongxia Fu, Yan Jiang, Darren Yang, Friedrich Scheiflinger, Wesley P Wong, Timothy A Springer
Flow-induced elongation of von Willebrand factor precedes tension-dependent activation. Nature communications 8 (1) (2017)
Pontus Nordenfelt, Hunter L Elliott, Timothy A Springer
Coordinated integrin activation by actin-dependent force during T-cell migration. Nature communications 7 (2016)
Timothy A Springer
von Willebrand factor, Jedi knight of the bloodstream. Blood 124 (9) (2014)

Timothy A Springer.css-eqlu8i{font-size:small;padding-left:4px;} (Anindya Roy, Timothy Springer)

Publication Activity (10 Years)

Top Topics

Top Venues

Timothy A Springer (Anindya Roy, Timothy Springer)