Vern L Schramm

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 36

Top Topics

Molecular Docking

Trypanosoma Cruzi

Helicobacter Pylori

Top Venues

ACS infectious diseases

ACS chemical biology

Journal of the American Chemical Society

This page only lists publications with an associated author ORCID identifier.

Publications

Ashleigh S Paparella, Isabella Brew, Huynh A Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C Tyler, Vern L Schramm
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile -Induced Mortality. ACS infectious diseases 10 (3) (2024)
Ashleigh S Paparella, Isabella Brew, Huynh A Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C Tyler, Vern L Schramm
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile -Induced Mortality. ACS infectious diseases 10 (3) (2024)
Ashleigh S Paparella, Isabella Brew, Huynh A Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C Tyler, Vern L Schramm
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile -Induced Mortality. ACS infectious diseases (2024)
Ashleigh S Paparella, Isabella Brew, Huynh A Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C Tyler, Vern L Schramm
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile -Induced Mortality. ACS infectious diseases (2024)
Ashleigh S Paparella, Isabella Brew, Huynh A Hong, William Ferriera, Simon Cutting, Farah Lamiable-Oulaidi, Michael Popadynec, Peter C Tyler, Vern L Schramm
Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile -Induced Mortality. ACS infectious diseases 10 (3) (2024)
Morais Brown, Vern L Schramm
Decreased Transition-State Analogue Affinity in Isotopically Heavy MTAN with Increased Catalysis. Biochemistry (2023)
Morais Brown, Peter C Tyler, Vern L Schramm
Residence Times for Femtomolar and Picomolar Inhibitors of MTANs. Biochemistry (2023)
Niusha Mahmoodi, Yacoba V T Minnow, Rajesh K Harijan, Gabriel T Bedard, Vern L Schramm
Cell-Effective Transition-State Analogue of Phenylethanolamine N -Methyltransferase. Biochemistry (2023)
Mu Feng, Hilda Namanja-Magliano, Saranathan Rajagopalan, Tanmay Mishra, Rodrigo Gay Ducati, Brett M Hirsch, Libusha Kelly, Wendy Szymczak, Jorge Eduardo Fajardo, Simone Sidoli, Andras Fiser, William R Jacobs, Vern L Schramm
MAT Gain of Activity Mutation in Helicobacter pylori Is Associated with Resistance to MTAN Transition State Analogues. ACS infectious diseases (2023)
Yacoba V T Minnow, Vern L Schramm, Steven C Almo, Agnidipta Ghosh
Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity. Biochemistry (2023)
Farah Lamiable-Oulaidi, Rajesh K Harijan, Karl J Shaffer, Douglas R Crump, Yan Sun, Quan Du, Shivali A Gulab, Ashna A Khan, Andreas Luxenburger, Anthony D Woolhouse, Simone Sidoli, Peter C Tyler, Vern L Schramm
Synthesis and Characterization of Transition-State Analogue Inhibitors against Human DNA Methyltransferase 1. Journal of medicinal chemistry 65 (7) (2022)
Kayla Glockzin, Demetrios Kostomiris, Yacoba V T Minnow, Kajitha Suthagar, Keith Clinch, Sinan Gai, Joshua N Buckler, Vern L Schramm, Peter C Tyler, Thomas D Meek, Ardala Katzfuss
Kinetic Characterization and Inhibition of Trypanosoma cruzi Hypoxanthine-Guanine Phosphoribosyltransferases. Biochemistry 61 (19) (2022)
Ashleigh S Paparella, Sean M Cahill, Briana L Aboulache, Vern L Schramm
Clostridioides difficile TcdB Toxin Glucosylates Rho GTPase by an S N i Mechanism and Ion Pair Transition State. ACS chemical biology 17 (9) (2022)
Yacoba V T Minnow, Kajitha Suthagar, Keith Clinch, Rodrigo Gay Ducati, Agnidipta Ghosh, Joshua N Buckler, Rajesh K Harijan, Sean M Cahill, Peter C Tyler, Vern L Schramm
Inhibition and Mechanism of Plasmodium falciparum Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase. ACS chemical biology (2022)
Ashleigh S Paparella, Briana L Aboulache, Rajesh K Harijan, Kathryn S Potts, Peter C Tyler, Vern L Schramm
Inhibition of Clostridium difficile TcdA and TcdB toxins with transition state analogues. Nature communications 12 (1) (2021)
Mu Feng, Rajesh K Harijan, Lawrence D Harris, Peter C Tyler, Richard F G Fröhlich, Morais Brown, Vern L Schramm
Aminofutalosine Deaminase in the Menaquinone Pathway of Helicobacter pylori. Biochemistry 60 (24) (2021)
Ananda K Ghosh, Vern L Schramm
Protein Mass-Modulated Effects in Alkaline Phosphatase. Biochemistry 60 (2) (2021)
Agnidipta Ghosh, Courtney N Niland, Sean M Cahill, Nishant M Karadkhelkar, Vern L Schramm
Mechanism of Triphosphate Hydrolysis by Human MAT2A at 1.07 Å Resolution. Journal of the American Chemical Society 143 (43) (2021)
Courtney N Niland, Agnidipta Ghosh, Sean M Cahill, Vern L Schramm
Mechanism and Inhibition of Human Methionine Adenosyltransferase 2A. Biochemistry 60 (10) (2021)
Di Zhang, Brandon E Burdette, Zhengyu Wang, Kumari Karn, Hong-Yu Li, Vern L Schramm, Peter C Tyler, Gary B Evans, Shanzhi Wang
Transition State Analogues Enhanced by Fragment-Based Structural Analysis: Bacterial Methylthioadenosine Nucleosidases. Biochemistry 59 (7) (2020)
Xiao-Ping Li, Rajesh K Harijan, Jennifer N Kahn, Vern L Schramm, Nilgun E Tumer
Small Molecule Inhibitors Targeting the Interaction of Ricin Toxin A Subunit with Ribosomes. ACS infectious diseases 6 (7) (2020)
Niusha Mahmoodi, Rajesh K Harijan, Vern L Schramm
Transition-State Analogues of Phenylethanolamine N-Methyltransferase. Journal of the American Chemical Society 142 (33) (2020)
Vern L Schramm, Thomas D Meek
Enhanced Antibiotic Discovery by PROSPECTing. Biochemistry 58 (33) (2019)
Rajesh K Harijan, Oskar Hoff, Rodrigo Gay Ducati, Ross S Firestone, Brett M Hirsch, Gary B Evans, Vern L Schramm, Peter C Tyler
Selective Inhibitors of Helicobacter pylori Methylthioadenosine Nucleosidase and Human Methylthioadenosine Phosphorylase. Journal of medicinal chemistry 62 (7) (2019)
Gary B Evans, Vern L Schramm, Peter C Tyler
The transition to magic bullets - transition state analogue drug design. MedChemComm 9 (12) (2018)
Vern L Schramm, Steven D Schwartz
Promoting Vibrations and the Function of Enzymes. Emerging Theoretical and Experimental Convergence. Biochemistry 57 (24) (2018)
Rodrigo Gay Ducati, Rajesh K Harijan, Scott A Cameron, Peter C Tyler, Gary B Evans, Vern L Schramm
Transition-State Analogues of Campylobacter jejuni 5'-Methylthioadenosine Nucleosidase. ACS chemical biology 13 (11) (2018)
Vern L Schramm
Enzymatic Transition States and Drug Design. Chemical reviews 118 (22) (2018)
Rodrigo Gay Ducati, Ross S Firestone, Vern L Schramm
Kinetic Isotope Effects and Transition State Structure for Hypoxanthine-Guanine-Xanthine Phosphoribosyltransferase from Plasmodium falciparum. Biochemistry 56 (48) (2017)
Hilda A Namanja-Magliano, Gary B Evans, Rajesh K Harijan, Peter C Tyler, Vern L Schramm
Transition State Analogue Inhibitors of 5'-Deoxyadenosine/5'-Methylthioadenosine Nucleosidase from Mycobacterium tuberculosis. Biochemistry 56 (38) (2017)
Gary B Evans, Peter C Tyler, Vern L Schramm
Immucillins in Infectious Diseases. ACS infectious diseases 4 (2) (2017)
Gert-Jan Moggré, Myles B Poulin, Peter C Tyler, Vern L Schramm, Emily J Parker
Transition State Analysis of Adenosine Triphosphate Phosphoribosyltransferase. ACS chemical biology 12 (10) (2017)
Lawrence D Harris, Rajesh K Harijan, Rodrigo Gay Ducati, Gary B Evans, Brett M Hirsch, Vern L Schramm
Synthesis of bis-Phosphate Iminoaltritol Enantiomers and Structural Characterization with Adenine Phosphoribosyltransferase. ACS chemical biology 13 (1) (2017)
Ross S Firestone, Vern L Schramm
The Transition-State Structure for Human MAT2A from Isotope Effects. Journal of the American Chemical Society 139 (39) (2017)
Ross S Firestone, Scott A Cameron, Jerome M Karp, Vickery L Arcus, Vern L Schramm
Heat Capacity Changes for Transition-State Analogue Binding and Catalysis with Human 5'-Methylthioadenosine Phosphorylase. ACS chemical biology 12 (2) (2016)
Christopher F Stratton, Myles B Poulin, Quan Du, Vern L Schramm
Kinetic Isotope Effects and Transition State Structure for Human Phenylethanolamine N-Methyltransferase. ACS chemical biology 12 (2) (2016)