Wei-Chen Chang

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 34

Top Topics

Iron Deficiency

Structural Basis

Hydrogen Peroxide

Top Venues

Journal of the American Chemical Society

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Paul G Young, Paul W R Harris, Muhammad S H Naqvi, Martin J Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N Baker, Christopher J Squire
Poly-γ-glutamylation of biomolecules. Nature communications 15 (1) (2024)
Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Paul G Young, Paul W R Harris, Muhammad S H Naqvi, Martin J Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N Baker, Christopher J Squire
Poly-γ-glutamylation of biomolecules. Nature communications 15 (1) (2024)
Ghader Bashiri, Esther M M Bulloch, William R Bramley, Madison Davidson, Stephanie M Stuteley, Paul G Young, Paul W R Harris, Muhammad S H Naqvi, Martin J Middleditch, Michael Schmitz, Wei-Chen Chang, Edward N Baker, Christopher J Squire
Poly-γ-glutamylation of biomolecules. Nature communications 15 (1) (2024)
Jared C Paris, Yuk Hei Cheung, Tao Zhang, Wei-Chen Chang, Pinghua Liu, Yisong Guo
New Frontiers in Nonheme Enzymatic Oxyferryl Species. Chembiochem : a European journal of chemical biology (2024)
Eliott S Wenger, Ryan J Martinie, Richiro Ushimaru, Christopher J Pollock, Debangsu Sil, Aaron Li, Nhi Hoang, Gavin M Palowitch, Brandt P Graham, Irene Schaperdoth, Evan J Burke, Ailiena O Maggiolo, Wei-Chen Chang, Benjamin D Allen, Carsten Krebs, Alexey Silakov, Amie K Boal, J Martin Bollinger
Optimized Substrate Positioning Enables Switches in the C-H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase. Journal of the American Chemical Society (2024)
Lide Cha, Jared C Paris, Brady Zanella, Martha Spletzer, Angela Yao, Yisong Guo, Wei-Chen Chang
Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes. Journal of the American Chemical Society 145 (11) (2023)
Richiro Ushimaru, Lide Cha, Shotaro Shimo, Xiaojun Li, Jared C Paris, Takahiro Mori, Kazunori Miyamoto, Lindsay Coffer, Masanobu Uchiyama, Yisong Guo, Wei-Chen Chang, Leonard Kaysser
Mechanistic Analysis of Stereodivergent Nitroalkane Cyclopropanation Catalyzed by Nonheme Iron Enzymes. Journal of the American Chemical Society (2023)
Han N Phan, Olivia M Manley, Sydney S Skirboll, Lide Cha, Dalton Hilovsky, Wei-Chen Chang, Peter M Thompson, Xiaojing Liu, Thomas M Makris
Excision of a Protein-Derived Amine for p -Aminobenzoate Assembly by the Self-Sacrificial Heterobimetallic Protein CADD. Biochemistry (2023)
Hannah E Gering, Xiaojun Li, Haoyu Tang, Paul D Swartz, Wei-Chen Chang, Thomas M Makris
A Ferric-Superoxide Intermediate Initiates P450-Catalyzed Cyclic Dipeptide Dimerization. Journal of the American Chemical Society (2023)
Lide Cha, Jared C Paris, Brady Zanella, Martha Spletzer, Angela Yao, Yisong Guo, Wei-Chen Chang
Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes. Journal of the American Chemical Society (2023)
Lide Cha, Jared C Paris, Brady Zanella, Martha Spletzer, Angela Yao, Yisong Guo, Wei-Chen Chang
Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes. Journal of the American Chemical Society 145 (11) (2023)
Wantae Kim, Tzu-Yu Chen, Lide Cha, Grace Zhou, Kristi Xing, Nicholas Koenig Canty, Yan Jessie Zhang, Wei-Chen Chang
Elucidation of divergent desaturation pathways in the formation of vinyl isonitrile and isocyanoacrylate. Nature communications 13 (1) (2022)
Xiaojun Li, Shan Xue, Yisong Guo, Wei-Chen Chang
Mechanism of Methyldehydrofosmidomycin Maturation: Use Olefination to Enable Chain Elongation. Journal of the American Chemical Society 144 (18) (2022)
Tzu-Yu Chen, Ziyang Zheng, Xuan Zhang, Jinfeng Chen, Lide Cha, Yijie Tang, Yisong Guo, Jiahai Zhou, Binju Wang, Hung-Wen Liu, Wei-Chen Chang
Deciphering the Reaction Pathway of Mononuclear Iron Enzyme-Catalyzed N≡C Triple Bond Formation in Isocyanide Lipopeptide and Polyketide Biosynthesis. ACS catalysis 12 (4) (2022)
Olivia M Manley, Han N Phan, Allison K Stewart, Dontae A Mosley, Shan Xue, Lide Cha, Hongxia Bai, Veda C Lightfoot, Pierson A Rucker, Leonard Collins, Taufika Islam Williams, Wei-Chen Chang, Yisong Guo, Thomas M Makris
Self-sacrificial tyrosine cleavage by an Fe:Mn oxygenase for the biosynthesis of para -aminobenzoate in Chlamydia trachomatis . Proceedings of the National Academy of Sciences of the United States of America 119 (39) (2022)
Hao-Yu Tang, Min-Hao Wu, Hsiao-Yu Lin, Meng-Ru Han, Yueh-Hua Tu, Zhi-Jie Yang, Tun-Cheng Chien, Nei-Li Chan, Wei-Chen Chang
Mechanistic analysis of carbon-carbon bond formation by deoxypodophyllotoxin synthase. Proceedings of the National Academy of Sciences of the United States of America 119 (1) (2022)
Xiaojun Li, Ryo Shimaya, Tohru Dairi, Wei-Chen Chang, Yasushi Ogasawara
Identification of Cyclopropane Formation in the Biosyntheses of Hormaomycins and Belactosins: Sequential Nitration and Cyclopropanation by Metalloenzymes. Angewandte Chemie (International ed. in English) 61 (7) (2021)
Olivia M Manley, Haoyu Tang, Shan Xue, Yisong Guo, Wei-Chen Chang, Thomas M Makris
BesC Initiates C-C Cleavage through a Substrate-Triggered and Reactive Diferric-Peroxo Intermediate. Journal of the American Chemical Society 143 (50) (2021)
Tzu-Yu Chen, Wei-Chen Chang
A postreplicative C5-cytosine hypermodification triggered by bacteriophage methyltransferase and hydroxylase. Proceedings of the National Academy of Sciences of the United States of America 118 (28) (2021)
Tzu-Yu Chen, Jinfeng Chen, Yijie Tang, Jiahai Zhou, Yisong Guo, Wei-Chen Chang
Pathway from N-Alkylglycine to Alkylisonitrile Catalyzed by Iron(II) and 2-Oxoglutarate-Dependent Oxygenases. Angewandte Chemie (International ed. in English) 59 (19) (2020)
Jikun Li, Hsuan-Jen Liao, Yijie Tang, Jhih-Liang Huang, Lide Cha, Te-Sheng Lin, Justin L Lee, Igor V Kurnikov, Maria G Kurnikova, Wei-Chen Chang, Nei-Li Chan, Yisong Guo
Epoxidation Catalyzed by the Nonheme Iron(II)- and 2-Oxoglutarate-Dependent Oxygenase, AsqJ: Mechanistic Elucidation of Oxygen Atom Transfer by a Ferryl Intermediate. Journal of the American Chemical Society 142 (13) (2020)
Lide Cha, Sergey Milikisiyants, Madison Davidson, Shan Xue, Tatyana Smirnova, Alex I Smirnov, Yisong Guo, Wei-Chen Chang
Alternative Reactivity of Leucine 5-Hydroxylase Using an Olefin-Containing Substrate to Construct a Substituted Piperidine Ring. Biochemistry 59 (21) (2020)
Madison Davidson, Meredith McNamee, Ruixi Fan, Yisong Guo, Wei-Chen Chang
Repurposing Nonheme Iron Hydroxylases To Enable Catalytic Nitrile Installation through an Azido Group Assistance. Journal of the American Chemical Society 141 (8) (2019)
Lauren J Rajakovich, Maria-Eirini Pandelia, Andrew J Mitchell, Wei-Chen Chang, Bo Zhang, Amie K Boal, Carsten Krebs, J Martin Bollinger
A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases. Biochemistry 58 (12) (2019)
Richiro Ushimaru, Mark W Ruszczycky, Wei-Chen Chang, Feng Yan, Yung-Nan Liu, Hung-Wen Liu
Substrate Conformation Correlates with the Outcome of Hyoscyamine 6β-Hydroxylase Catalyzed Oxidation Reactions. Journal of the American Chemical Society 140 (24) (2018)
Hannah R Rose, Manas K Ghosh, Ailiena O Maggiolo, Christopher J Pollock, Elizabeth J Blaesi, Viviane Hajj, Yifeng Wei, Lauren J Rajakovich, Wei-Chen Chang, Yilin Han, Mariana Hajj, Carsten Krebs, Alexey Silakov, Maria-Eirini Pandelia, J Martin Bollinger, Amie K Boal
Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor. Biochemistry 57 (18) (2018)
Wei-Chen Chang, Zhi-Jie Yang, Yueh-Hua Tu, Tun-Cheng Chien
Reaction Mechanism of a Nonheme Iron Enzyme Catalyzed Oxidative Cyclization via C-C Bond Formation. Organic letters 21 (1) (2018)
Jhih-Liang Huang, Yijie Tang, Cheng-Ping Yu, Dev Sanyal, Xinglin Jia, Xinyu Liu, Yisong Guo, Wei-Chen Chang
Mechanistic Investigation of Oxidative Decarboxylation Catalyzed by Two Iron(II)- and 2-Oxoglutarate-Dependent Enzymes. Biochemistry 57 (12) (2018)
Cheng-Ping Yu, Yijie Tang, Lide Cha, Sergey Milikisiyants, Tatyana I Smirnova, Alex I Smirnov, Yisong Guo, Wei-Chen Chang
Elucidating the Reaction Pathway of Decarboxylation-Assisted Olefination Catalyzed by a Mononuclear Non-Heme Iron Enzyme. Journal of the American Chemical Society 140 (45) (2018)
Juan Pan, Minakshi Bhardwaj, Bo Zhang, Wei-Chen Chang, Christopher L Schardl, Carsten Krebs, Robert B Grossman, J Martin Bollinger
Installation of the Ether Bridge of Lolines by the Iron- and 2-Oxoglutarate-Dependent Oxygenase, LolO: Regio- and Stereochemistry of Sequential Hydroxylation and Oxacyclization Reactions. Biochemistry 57 (14) (2018)
Noah P Dunham, Wei-Chen Chang, Andrew J Mitchell, Ryan J Martinie, Bo Zhang, Jonathan A Bergman, Lauren J Rajakovich, Bo Wang, Alexey Silakov, Carsten Krebs, Amie K Boal, J Martin Bollinger
Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance. Journal of the American Chemical Society 140 (23) (2018)
Hsuan-Jen Liao, Jikun Li, Jhih-Liang Huang, Madison Davidson, Igor Kurnikov, Te-Sheng Lin, Justin L Lee, Maria Kurnikova, Yisong Guo, Nei-Li Chan, Wei-Chen Chang
Insights into the Desaturation of Cyclopeptin and its C3 Epimer Catalyzed by a non-Heme Iron Enzyme: Structural Characterization and Mechanism Elucidation. Angewandte Chemie (International ed. in English) 57 (7) (2018)
Andrew J Mitchell, Noah P Dunham, Ryan J Martinie, Jonathan A Bergman, Christopher J Pollock, Kai Hu, Benjamin D Allen, Wei-Chen Chang, Alexey Silakov, J Martin Bollinger, Carsten Krebs, Amie K Boal
Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase. Journal of the American Chemical Society 139 (39) (2017)
Wei-Chen Chang, Dev Sanyal, Jhih-Liang Huang, Kuljira Ittiamornkul, Qin Zhu, Xinyu Liu
In Vitro Stepwise Reconstitution of Amino Acid Derived Vinyl Isocyanide Biosynthesis: Detection of an Elusive Intermediate. Organic letters 19 (5) (2017)