William M Wuest

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 70

Top Venues

ChemMedChem

Organic letters

ACS infectious diseases

Journal of the American Chemical Society

Emory University

University of Pennsylvania (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Emory University Jun 01 2017

United States

GRA Distinguished Investigator and Associate Professor :: Chemistry

Temple University Jul 01 2011 - May 31 2017

United States

Daniel Swern Early Career Development Professor and Assistant Professor :: Chemistry

NovaLyse BioSolutions Jan 01 2016 - Apr 01 2017

United States

Chief Scientific Adviser

Harvard Medical School Jun 01 2008 - Jun 30 2011

United States

NIH NRSA Postdoctoral Fellow :: Biological Chemistry & Molecular Pharmacology

OSI Pharmaceuticals Jun 01 2002 - Aug 01 2003

United States

Research Scientist Intern

Education History

University of Pennsylvania Sep 01 2003 - May 23 2008

United States

PHD :: Chemistry

University of Notre Dame Sep 01 1999 - May 01 2003

United States

BSC :: Chemistry

Publications

Germán G Vargas-Cuebas, Christian A Sanchez, Elise L Bezold, Gabrielle M Walker, Shehreen Siddiqui, Kevin P C Minbiole, William M Wuest
Adaptations to cationic biocide exposure differentially influence virulence factors and pathogenicity in Pseudomonas aeruginosa . Virulence 15 (1) (2024)
Andrew R LeBlanc, William M Wuest
Siderophores: A Case Study in Translational Chemical Biology. Biochemistry 63 (15) (2024)
Amber M Scharnow, Amy E Solinski, Sebastian Rowe, Ines Hübner, Hua Zhang, Elana Shaw, Julia E Page, Hui Wu, Stephan A Sieber, William M Wuest
In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe. Journal of the American Chemical Society 146 (33) (2024)
Andrew R LeBlanc, William M Wuest
Siderophores: A Case Study in Translational Chemical Biology. Biochemistry 63 (15) (2024)
Carter U Brzezinski, Andrew R LeBlanc, Madeline G Clerici, William M Wuest
Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation. Organic letters 26 (26) (2024)
Moneya S Leatherbury, Laura M Thierer, Christian A Sanchez, Germán G Vargas-Cuebas, Ashley A Petersen, Lauren E Amoo, Elise L Bezold, Keshyne C Washington, M Brody Mistrot, Michael J Zdilla, William M Wuest, Kevin P C Minbiole
Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures. ChemMedChem (2024)
Moneya S Leatherbury, Laura M Thierer, Christian A Sanchez, Germán G Vargas-Cuebas, Ashley A Petersen, Lauren E Amoo, Elise L Bezold, Keshyne C Washington, M Brody Mistrot, Michael J Zdilla, William M Wuest, Kevin P C Minbiole
Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures. ChemMedChem 19 (11) (2024)
Germán G Vargas-Cuebas, Christian A Sanchez, Samantha R Brayton, Alexander Nikoloff, Ronald Masters, Kevin P C Minbiole, William M Wuest
Exploring the Correlation of Dynamic Surface Tension with Antimicrobial Activities of Quaternary Ammonium-Based Disinfectants. ChemMedChem (2024)
Amber M Scharnow, Amy E Solinski, Sebastian Rowe, Ines Hübner, Hua Zhang, Elana Shaw, Julia E Page, Hui Wu, Stephan A Sieber, William M Wuest
In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe. Journal of the American Chemical Society 146 (33) (2024)
Amber M Scharnow, Amy E Solinski, Sebastian Rowe, Ines Hübner, Hua Zhang, Elana Shaw, Julia E Page, Hui Wu, Stephan A Sieber, William M Wuest
In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe. Journal of the American Chemical Society 146 (33) (2024)
Andrew R LeBlanc, William M Wuest
Siderophores: A Case Study in Translational Chemical Biology. Biochemistry 63 (15) (2024)
Germán G Vargas-Cuebas, Christian A Sanchez, Samantha R Brayton, Alexander Nikoloff, Ronald Masters, Kevin P C Minbiole, William M Wuest
Exploring the Correlation of Dynamic Surface Tension with Antimicrobial Activities of Quaternary Ammonium-Based Disinfectants. ChemMedChem (2024)
Moneya S Leatherbury, Laura M Thierer, Christian A Sanchez, Germán G Vargas-Cuebas, Ashley A Petersen, Lauren E Amoo, Elise L Bezold, Keshyne C Washington, M Brody Mistrot, Michael J Zdilla, William M Wuest, Kevin P C Minbiole
Chimeric Amphiphilic Disinfectants: Quaternary Ammonium/Quaternary Phosphonium Hybrid Structures. ChemMedChem 19 (11) (2024)
Carter U Brzezinski, Andrew R LeBlanc, Madeline G Clerici, William M Wuest
Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation. Organic letters (2024)
Germán G Vargas-Cuebas, Christian A Sanchez, Samantha R Brayton, Alexander Nikoloff, Ronald Masters, Kevin P C Minbiole, William M Wuest
Exploring the Correlation of Dynamic Surface Tension with Antimicrobial Activities of Quaternary Ammonium-Based Disinfectants. ChemMedChem 19 (16) (2024)
Amber M Scharnow, Amy E Solinski, Sebastian Rowe, Ines Hübner, Hua Zhang, Elana Shaw, Julia E Page, Hui Wu, Stephan A Sieber, William M Wuest
In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe. Journal of the American Chemical Society (2024)
Carter U Brzezinski, Andrew R LeBlanc, Madeline G Clerici, William M Wuest
Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation. Organic letters 26 (26) (2024)
Andrew R LeBlanc, William M Wuest
Siderophores: A Case Study in Translational Chemical Biology. Biochemistry (2024)
Carter U Brzezinski, Andrew R LeBlanc, Madeline G Clerici, William M Wuest
Mild Photochemical Reduction of Alkenes and Heterocycles via Thiol-Mediated Formate Activation. Organic letters 26 (26) (2024)
Amber M Scharnow, Amy E Solinski, Sebastian Rowe, Ines Hübner, Hua Zhang, Elana Shaw, Julia E Page, Hui Wu, Stephan A Sieber, William M Wuest
In Situ Biofilm Affinity-Based Protein Profiling Identifies the Streptococcal Hydrolase GbpB as the Target of a Carolacton-Inspired Chemical Probe. Journal of the American Chemical Society 146 (33) (2024)
Zachary E A Toles, Alice Wu, Christian A Sanchez, Marina E Michaud, Laura M Thierer, William M Wuest, Kevin P C Minbiole
Double BAC and Triple BAC: A Systematic Analysis of the Disinfectant Properties of Multicationic Derivatives of Benzalkonium Chloride (BAC). ChemMedChem (2023)
Learnmore Jeremia, Benjamin E Deprez, Debayan Dey, Graeme L Conn, William M Wuest
Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation. RSC medicinal chemistry 14 (4) (2023)
Justin A Shapiro, Savannah J Post, Gavin C Smith, William M Wuest
Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold. Organic letters 25 (51) (2023)
Justin A Shapiro, Savannah J Post, Gavin C Smith, William M Wuest
Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold. Organic letters 25 (51) (2023)
Logan G Kavanaugh, Andrew R Mahoney, Debayan Dey, William M Wuest, Graeme L Conn
Di-berberine conjugates as chemical probes of Pseudomonas aeruginosa MexXY-OprM efflux function and inhibition. bioRxiv : the preprint server for biology (2023)
Justin A Shapiro, Savannah J Post, Gavin C Smith, William M Wuest
Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold. Organic letters 25 (51) (2023)
Zachary E A Toles, Alice Wu, Christian A Sanchez, Marina E Michaud, Laura M Thierer, William M Wuest, Kevin P C Minbiole
Double BAC and Triple BAC: A Systematic Analysis of the Disinfectant Properties of Multicationic Derivatives of Benzalkonium Chloride (BAC). ChemMedChem (2023)
Justin A Shapiro, Savannah J Post, Gavin C Smith, William M Wuest
Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold. Organic letters 25 (51) (2023)
Learnmore Jeremia, Benjamin E Deprez, Debayan Dey, Graeme L Conn, William M Wuest
Ribosome-targeting antibiotics and resistance via ribosomal RNA methylation. RSC medicinal chemistry 14 (4) (2023)
Justin A Shapiro, Savannah J Post, Gavin C Smith, William M Wuest
Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold. Organic letters 25 (51) (2023)
Andrew R Mahoney, Kelly M Storek, William M Wuest
Structure-Based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance. ACS omega 8 (13) (2023)
Justin A Shapiro, Savannah J Post, Gavin C Smith, William M Wuest
Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold. Organic letters 25 (51) (2023)
Justin A Shapiro, Savannah J Post, Gavin C Smith, William M Wuest
Total Synthesis of the Reported Structure of Cahuitamycin A: Insights into an Elusive Natural Product Scaffold. Organic letters 25 (51) (2023)
Martina M Golden, Savannah J Post, Renata Rivera, William M Wuest
Investigating the Role of Metabolism for Antibiotic Combination Therapies in Pseudomonas aeruginosa . ACS infectious diseases (2023)
Gavin C Smith, Drason H Zhang, Wanli Zhang, Abigail H Soliven, William M Wuest
Visible-Light/Nickel-Catalyzed Carboxylation of C(sp 2 ) Bromides via Formate Activation. The Journal of organic chemistry (2023)
Kyle J Sommers, Marina E Michaud, Cody E Hogue, Amber M Scharnow, Lauren E Amoo, Ashley A Petersen, Robert G Carden, Kevin P C Minbiole, William M Wuest
Quaternary Phosphonium Compounds: An Examination of Non-Nitrogenous Cationic Amphiphiles That Evade Disinfectant Resistance. ACS infectious diseases 8 (2) (2022)
Marina E Michaud, Ryan A Allen, Kelly R Morrison-Lewis, Christian A Sanchez, Kevin P C Minbiole, Savannah J Post, William M Wuest
Quaternary Phosphonium Compound Unveiled as a Potent Disinfectant against Highly Resistant Acinetobacter baumannii Clinical Isolates. ACS infectious diseases 8 (11) (2022)
Savannah J Post, Colleen E Keohane, Lauren M Rossiter, Anna R Kaplan, Jittasak Khowsathit, Katie Matuska, John Karanicolas, William M Wuest
Correction to "Target-Based Design of Promysalin Analogs Identifies a New Putative Binding Cleft in Succinate Dehydrogenase". ACS infectious diseases 8 (7) (2022)
Aaron C Spahr, Marina E Michaud, Lauren E Amoo, Christian A Sanchez, Cody E Hogue, Laura M Thierer, Michael R Gau, William M Wuest, Kevin P C Minbiole
Rigidity-Activity Relationships of bisQPC Scaffolds against Pathogenic Bacteria. ChemMedChem 17 (14) (2022)
Ingrid K Wilt, Adrian R Demeritte, Weiwei Wang, William M Wuest
Total Synthesis and Antibacterial Investigations of 1-Hydroxyboivinianin A. ChemMedChem (2022)
Anna R Kaplan, Cassandra L Schrank, William M Wuest
An Efficient Synthesis of 3-Alkylpyridine Alkaloids Enables Their Biological Evaluation. ChemMedChem 16 (16) (2021)
Cassandra L Schrank, Ingrid K Wilt, Carlos Monteagudo Ortiz, Brittney A Haney, William M Wuest
Using membrane perturbing small molecules to target chronic persistent infections. RSC medicinal chemistry 12 (8) (2021)
Anna R Kaplan, Djamaladdin G Musaev, William M Wuest
Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth in Pseudomonads Demonstrating Siderophore-like Activity. ACS infectious diseases 7 (3) (2021)
Elana Shaw, William M Wuest
Virulence attenuating combination therapy: a potential multi-target synergy approach to treat Pseudomonas aeruginosa infections in cystic fibrosis patients. RSC medicinal chemistry 11 (3) (2020)
Savannah J Post, Colleen E Keohane, Lauren M Rossiter, Anna R Kaplan, Jittasak Khowsathit, Katie Matuska, John Karanicolas, William M Wuest
Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase. ACS infectious diseases 6 (6) (2020)
Michelle A Garrison, Andrew R Mahoney, William M Wuest
Tricepyridinium-inspired QACs yield potent antimicrobials and provide insight into QAC resistance. ChemMedChem 16 (3) (2020)
Saleh Alkhalifa, Megan C Jennings, Daniele Granata, Michael Klein, William M Wuest, Kevin P C Minbiole, Vincenzo Carnevale
Analysis of the Destabilization of Bacterial Membranes by Quaternary Ammonium Compounds: A Combined Experimental and Computational Study. Chembiochem : a European journal of chemical biology 21 (10) (2020)
Kyle J Sommers, Brian S Bentley, Robert G Carden, Savannah J Post, Ryan A Allen, Renee C Kontos, Jacob W Black, William M Wuest, Kevin P C Minbiole
Metallocene QACs: The Incorporation of Ferrocene Moieties into monoQAC and bisQAC Structures. ChemMedChem 16 (3) (2020)
Wanli Zhang, Anna R Kaplan, Emma K Davison, Jared Freeman, Margaret A Brimble, William M Wuest
Building trans-bicyclo[4.4.0]decanes/decenes in complex multifunctional frameworks: the case for antibiotic development. Natural product reports (2020)
Cassandra L Schrank, Kevin P C Minbiole, William M Wuest
Are Quaternary Ammonium Compounds, the Workhorse Disinfectants, Effective against Severe Acute Respiratory Syndrome-Coronavirus-2? ACS infectious diseases 6 (7) (2020)
Ingrid K Wilt, Taylor P A Hari, William M Wuest
Hijacking the Bacterial Circuitry of Biofilm Processes via Chemical "Hot-Wiring": An Under-explored Avenue for Therapeutic Development. ACS infectious diseases 5 (6) (2019)
Amy E Solinski, Amber M Scharnow, Americo J Fraboni, William M Wuest
Synthetic Simplification of Carolacton Enables Chemical Genetic Studies in Streptococcus mutans. ACS infectious diseases 5 (8) (2019)
Savannah J Post, Justin A Shapiro, William M Wuest
Connecting iron acquisition and biofilm formation in the ESKAPE pathogens as a strategy for combatting antibiotic resistance. MedChemComm 10 (4) (2019)
Amber M Scharnow, Amy E Solinski, William M Wuest
Targeting S. mutans biofilms: a perspective on preventing dental caries. MedChemComm 10 (7) (2019)
Ana V Cheng, William M Wuest
Signed, Sealed, Delivered: Conjugate and Prodrug Strategies as Targeted Delivery Vectors for Antibiotics. ACS infectious diseases 5 (6) (2019)
Wooseong Kim, Guijin Zou, Taylor P A Hari, Ingrid K Wilt, Wenpeng Zhu, Nicolas Galle, Hammad A Faizi, Gabriel L Hendricks, Katerina Tori, Wen Pan, Xiaowen Huang, Andrew D Steele, Erika E Csatary, Madeline M Dekarske, Jake L Rosen, Noelly de Queiroz Ribeiro, Kiho Lee, Jenna Port, Beth Burgwyn Fuchs, Petia M Vlahovska, William M Wuest, Huajian Gao, Frederick M Ausubel, Eleftherios Mylonakis
A selective membrane-targeting repurposed antibiotic with activity against persistent methicillin-resistant Staphylococcus aureus. Proceedings of the National Academy of Sciences of the United States of America 116 (33) (2019)
Renee C Kontos, Stephanie A Schallenhammer, Brian S Bentley, Kelly R Morrison, Javier A Feliciano, Julia A Tasca, Anna R Kaplan, Mark W Bezpalko, Wm Scott Kassel, William M Wuest, Kevin P C Minbiole
An Investigation into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics. ChemMedChem 14 (1) (2018)
Justin A Shapiro, Kelly R Morrison, Shreya S Chodisetty, Djamaladdin G Musaev, William M Wuest
Biologically Inspired Total Synthesis of Ulbactin F, an Iron-Binding Natural Product. Organic letters 20 (18) (2018)
Guillaume Ernouf, Ingrid K Wilt, Sara Zahim, William M Wuest
Epoxy Isonitriles, A Unique Class of Antibiotics: Synthesis of Their Metabolites and Biological Investigations. Chembiochem : a European journal of chemical biology 19 (23) (2018)
Justin A Shapiro, John J Varga, Derek Parsonage, William Walton, Matthew R Redinbo, Larry J Ross, E Lucile White, Robert Bostwick, William M Wuest, Al Claiborne, Joanna B Goldberg
Identification of Specific and Nonspecific Inhibitors of Bacillus anthracis Type III Pantothenate Kinase (PanK). ChemMedChem 14 (1) (2018)
Krista M Giglio, Colleen E Keohane, Paul V Stodghill, Andrew D Steele, Christian Fetzer, Stephan A Sieber, Melanie J Filiatrault, William M Wuest
Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440. ACS infectious diseases 4 (8) (2018)
Andrew D Steele, Guillaume Ernouf, Young Eun Lee, William M Wuest
Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action. Organic letters 20 (4) (2018)
Colleen E Keohane, Andrew D Steele, Christian Fetzer, Jittasak Khowsathit, Daria Van Tyne, Lucile Moynié, Michael S Gilmore, John Karanicolas, Stephan A Sieber, William M Wuest
Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase. Journal of the American Chemical Society 140 (5) (2018)
Justin A Shapiro, Anna R Kaplan, William M Wuest
From General to Specific: Can Pseudomonas Primary Metabolism Be Exploited for Narrow-Spectrum Antibiotics? Chembiochem : a European journal of chemical biology 20 (1) (2018)
Amy E Solinski, Alexander B Koval, Richard S Brzozowski, Kelly R Morrison, Americo J Fraboni, Carrie E Carson, Anisa R Eshraghi, Guangfeng Zhou, Robert G Quivey, Vincent A Voelz, Bettina A Buttaro, William M Wuest
Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms. Journal of the American Chemical Society 139 (21) (2017)
Sean E Rossiter, Madison H Fletcher, William M Wuest
Natural Products as Platforms To Overcome Antibiotic Resistance. Chemical reviews 117 (19) (2017)
Amy E Solinski, Cristian Ochoa, Young Eun Lee, Thomas Paniak, Marisa C Kozlowski, William M Wuest
Honokiol-Inspired Analogs as Inhibitors of Oral Bacteria. ACS infectious diseases 4 (2) (2017)
Saleh E Al-Khalifa, Megan C Jennings, William M Wuest, Kevin P C Minbiole
The Development of Next-Generation Pyridinium-Based multiQAC Antiseptics. ChemMedChem 12 (4) (2017)
Sean E Rossiter, William M Wuest
EroS Enzyme from Aliivibrio fischeri Plays Cupid to Choanoflagellates. Chembiochem : a European journal of chemical biology 18 (23) (2017)
Megan E Forman, Megan C Jennings, William M Wuest, Kevin P C Minbiole
Building a Better Quaternary Ammonium Compound (QAC): Branched Tetracationic Antiseptic Amphiphiles. ChemMedChem 11 (13) (2016)

William M Wuest.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

William M Wuest