Xiao-Wu Dong (Xiaowu Dong)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 40

Top Topics

Molecular Docking

Tyrosine Kinase

Anti Inflammatory

Top Venues

Journal of medicinal chemistry

Archiv der Pharmazie

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Journal of chemical information and modeling

This page only lists publications with an associated author ORCID identifier.

Publications

Roufen Chen, Yuchen Wang, Zheyuan Shen, Chenyi Ye, Yu Guo, Yan Lu, Jianjun Ding, Xiao-Wu Dong, Donghang Xu, Xiaoli Zheng
Discovery of potent CSK inhibitors through integrated virtual screening and molecular dynamic simulation. Archiv der Pharmazie (2024)
Liu Yang, Xueping Hu, Yang Lu, Ruolan Xu, Yaping Xu, WanLi Ma, Md Shah Alam, Tian-Yu Zhang, Xin Chai, Yixuan Lei, Qing Ye, Xiao-Wu Dong, Yu Kang, Jinxin Che, Ting-Jun Hou, Dan Li
Discovery of N -(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis . Journal of medicinal chemistry 67 (3) (2024)
Liu Yang, Xueping Hu, Yang Lu, Ruolan Xu, Yaping Xu, WanLi Ma, Md Shah Alam, Tian-Yu Zhang, Xin Chai, Yixuan Lei, Qing Ye, Xiao-Wu Dong, Yu Kang, Jinxin Che, Ting-Jun Hou, Dan Li
Discovery of N -(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis . Journal of medicinal chemistry 67 (3) (2024)
Haiting Duan, Jingyu Zhang, Renzhao Gui, Yang Lu, Ao Pang, Beijing Chen, Liteng Shen, Hengyuan Yu, Jia Li, Tengfei Xu, Yu-Wei Wang, Xiao-Jun Yao, Bo Zhang, Nengming Lin, Xiao-Wu Dong, Yubo Zhou, Yong-Zhou Hu
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors. Journal of medicinal chemistry 67 (13) (2024)
Yang Lu, Zexu Shen, Yaping Xu, Haoran Lin, Liteng Shen, Yizhen Jin, Yu Guo, Jialiang Lu, Linjie Li, Yuxin Zhuang, Yuheng Jin, Weihao Zhuang, Wenhai Huang, Xiao-Wu Dong, Haibin Dai, Yong-Zhou Hu
Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers. Journal of medicinal chemistry 67 (14) (2024)
Haiting Duan, Jingyu Zhang, Renzhao Gui, Yang Lu, Ao Pang, Beijing Chen, Liteng Shen, Hengyuan Yu, Jia Li, Tengfei Xu, Yu-Wei Wang, Xiao-Jun Yao, Bo Zhang, Nengming Lin, Xiao-Wu Dong, Yubo Zhou, Yong-Zhou Hu
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors. Journal of medicinal chemistry 67 (13) (2024)
Roufen Chen, Yuchen Wang, Zheyuan Shen, Chenyi Ye, Yu Guo, Yan Lu, Jianjun Ding, Xiao-Wu Dong, Donghang Xu, Xiaoli Zheng
Discovery of potent CSK inhibitors through integrated virtual screening and molecular dynamic simulation. Archiv der Pharmazie 357 (9) (2024)
Yang Lu, Zexu Shen, Yaping Xu, Haoran Lin, Liteng Shen, Yizhen Jin, Yu Guo, Jialiang Lu, Linjie Li, Yuxin Zhuang, Yuheng Jin, Weihao Zhuang, Wenhai Huang, Xiao-Wu Dong, Haibin Dai, Yong-Zhou Hu
Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers. Journal of medicinal chemistry 67 (14) (2024)
Yang Lu, Zexu Shen, Yaping Xu, Haoran Lin, Liteng Shen, Yizhen Jin, Yu Guo, Jialiang Lu, Linjie Li, Yuxin Zhuang, Yuheng Jin, Weihao Zhuang, Wenhai Huang, Xiao-Wu Dong, Haibin Dai, Yong-Zhou Hu
Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers. Journal of medicinal chemistry (2024)
Liu Yang, Xueping Hu, Yang Lu, Ruolan Xu, Yaping Xu, WanLi Ma, Md Shah Alam, Tian-Yu Zhang, Xin Chai, Yixuan Lei, Qing Ye, Xiao-Wu Dong, Yu Kang, Jinxin Che, Ting-Jun Hou, Dan Li
Discovery of N -(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis . Journal of medicinal chemistry 67 (3) (2024)
Mingfei Wu, Yiquan Wu, Yuyuan Jin, Xinfei Mao, Shenxin Zeng, Hengyuan Yu, Jingyu Zhang, Yuheng Jin, Yizhe Wu, Tengfei Xu, Yong Chen, Yu-Wei Wang, Xiaojun Yao, Yong-Zhou Hu, Wenhai Huang, Xiao-Wu Dong
Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy. Journal of medicinal chemistry (2024)
Mingfei Wu, Yiquan Wu, Yuyuan Jin, Xinfei Mao, Shenxin Zeng, Hengyuan Yu, Jingyu Zhang, Yuheng Jin, Yizhe Wu, Tengfei Xu, Yong Chen, Yu-Wei Wang, Xiaojun Yao, Yong-Zhou Hu, Wenhai Huang, Xiao-Wu Dong
Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy. Journal of medicinal chemistry 67 (16) (2024)
Mingfei Wu, Yiquan Wu, Yuyuan Jin, Xinfei Mao, Shenxin Zeng, Hengyuan Yu, Jingyu Zhang, Yuheng Jin, Yizhe Wu, Tengfei Xu, Yong Chen, Yu-Wei Wang, Xiaojun Yao, Yong-Zhou Hu, Wenhai Huang, Xiao-Wu Dong
Discovery of an Exceptionally Orally Bioavailable and Potent HPK1 PROTAC with Enhancement of Antitumor Efficacy of Anti-PD-L1 Therapy. Journal of medicinal chemistry 67 (16) (2024)
Liu Yang, Xueping Hu, Yang Lu, Ruolan Xu, Yaping Xu, WanLi Ma, Md Shah Alam, Tian-Yu Zhang, Xin Chai, Yixuan Lei, Qing Ye, Xiao-Wu Dong, Yu Kang, Jinxin Che, Ting-Jun Hou, Dan Li
Discovery of N -(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis . Journal of medicinal chemistry (2024)
Yu Guo, Zheyuan Shen, Wenbin Zhao, Jialiang Lu, Yi Song, Liteng Shen, Yang Lu, Mingfei Wu, Qiuqiu Shi, Weihao Zhuang, Yueping Qiu, Jianpeng Sheng, Zhan Zhou, Luo Fang, Jinxin Che, Xiao-Wu Dong
Rational Identification of Novel Antibody-Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (13) (2024)
Haiting Duan, Jingyu Zhang, Renzhao Gui, Yang Lu, Ao Pang, Beijing Chen, Liteng Shen, Hengyuan Yu, Jia Li, Tengfei Xu, Yu-Wei Wang, Xiao-Jun Yao, Bo Zhang, Nengming Lin, Xiao-Wu Dong, Yubo Zhou, Yong-Zhou Hu
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors. Journal of medicinal chemistry (2024)
Hao Guo, Zhe-Yuan Shen, Yong-Yi Yuan, Rou-Fen Chen, Jing-Yi Yang, Xing-Chen Liu, Qing Zhang, Qian-Ying Pan, Jian-Jun Ding, Xin-Jun He, Qing-Nan Zhang, Xiao-Wu Dong, Ke-Shu Zhou
Discovery of a Novel and Potent LCK Inhibitor for Leukemia Treatment via Deep Learning and Molecular Docking. Journal of chemical information and modeling 64 (12) (2024)
Yu Guo, Zheyuan Shen, Wenbin Zhao, Jialiang Lu, Yi Song, Liteng Shen, Yang Lu, Mingfei Wu, Qiuqiu Shi, Weihao Zhuang, Yueping Qiu, Jianpeng Sheng, Zhan Zhou, Luo Fang, Jinxin Che, Xiao-Wu Dong
Rational Identification of Novel Antibody-Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 11 (13) (2024)
Yang Lu, Zexu Shen, Yaping Xu, Haoran Lin, Liteng Shen, Yizhen Jin, Yu Guo, Jialiang Lu, Linjie Li, Yuxin Zhuang, Yuheng Jin, Weihao Zhuang, Wenhai Huang, Xiao-Wu Dong, Haibin Dai, Yong-Zhou Hu
Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers. Journal of medicinal chemistry 67 (14) (2024)
Yu Guo, Zheyuan Shen, Wenbin Zhao, Jialiang Lu, Yi Song, Liteng Shen, Yang Lu, Mingfei Wu, Qiuqiu Shi, Weihao Zhuang, Yueping Qiu, Jianpeng Sheng, Zhan Zhou, Luo Fang, Jinxin Che, Xiao-Wu Dong
Rational Identification of Novel Antibody-Drug Conjugate with High Bystander Killing Effect against Heterogeneous Tumors. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024)
Hao Guo, Zhe-Yuan Shen, Yong-Yi Yuan, Rou-Fen Chen, Jing-Yi Yang, Xing-Chen Liu, Qing Zhang, Qian-Ying Pan, Jian-Jun Ding, Xin-Jun He, Qing-Nan Zhang, Xiao-Wu Dong, Ke-Shu Zhou
Discovery of a Novel and Potent LCK Inhibitor for Leukemia Treatment via Deep Learning and Molecular Docking. Journal of chemical information and modeling (2024)
Liu Yang, Xueping Hu, Yang Lu, Ruolan Xu, Yaping Xu, WanLi Ma, Md Shah Alam, Tian-Yu Zhang, Xin Chai, Yixuan Lei, Qing Ye, Xiao-Wu Dong, Yu Kang, Jinxin Che, Ting-Jun Hou, Dan Li
Discovery of N -(1-(6-Oxo-1,6-dihydropyrimidine)-pyrazole) Acetamide Derivatives as Novel Noncovalent DprE1 Inhibitors against Mycobacterium tuberculosis . Journal of medicinal chemistry 67 (3) (2024)
Jinxin Che, Shaowei Bing, Jialiang Lu, Zegao Jin, Jian Gao, Haichao Sheng, Dan Li, Bo Yang, Qiaojun He, Meidan Ying, Xiao-Wu Dong
Discovery of Novel Oxazepine Derivatives as Akt/ROCK Inhibitors for Growth Arrest and Differentiation Induction in Neuroblastoma Treatment. Journal of medicinal chemistry (2023)
Jian Gao, Zheyuan Shen, Yufeng Xie, Jialiang Lu, Yang Lu, Sikang Chen, Qingyu Bian, Yue Guo, Liteng Shen, Jian Wu, Binbin Zhou, Ting-Jun Hou, Qiaojun He, Jinxin Che, Xiao-Wu Dong
TransFoxMol: predicting molecular property with focused attention. Briefings in bioinformatics (2023)
Liteng Shen, Xiuna Sun, Zhen Chen, Yu Guo, Zheyuan Shen, Yi Song, Wenxiu Xin, Haiying Ding, Xinyue Ma, Weiben Xu, Wanying Zhou, Jinxin Che, Lili Tan, Liangsheng Chen, Siqi Chen, Xiao-Wu Dong, Luo Fang, Jian Zhang
ADCdb: the database of antibody-drug conjugates. Nucleic acids research (2023)
Linjie Li, Yu Guo, Yang Lu, Yaping Xu, Yan Lu, Xiuping Zhu, Xiao-Wu Dong, Jinxin Che
An updated patent review of Akt inhibitors (2020-present). Expert opinion on therapeutic patents (2023)
Jingyu Zhang, Jinxin Che, Xiaomin Luo, Mingfei Wu, Weijuan Kan, Yuheng Jin, Hanlin Wang, Ao Pang, Cong Li, Wenhai Huang, Shenxin Zeng, Weihao Zhuang, Yizhe Wu, Yongjin Xu, Yubo Zhou, Jia Li, Xiao-Wu Dong
Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma. Journal of medicinal chemistry 65 (13) (2022)
Lexian Tong, Peipei Wang, Xuemei Li, Xiao-Wu Dong, Xiaobei Hu, Chang Wang, Tao Liu, Jia Li, Yubo Zhou
Identification of 2-Aminopyrimidine Derivatives as FLT3 Kinase Inhibitors with High Selectivity over c-KIT. Journal of medicinal chemistry 65 (4) (2022)
Jinxin Che, Zhilong Wang, Zheyuan Shen, Weihao Zhuang, Huazhou Ying, Yongzhou Hu, Youhong Hu, Xin Xie, Xiao-Wu Dong
Discovery of 1,5-Dihydro-4H-imidazol-4-one Derivatives as Potent, Selective Antagonists of CXC Chemokine Receptor 2. ACS medicinal chemistry letters 12 (5) (2021)
Jinxin Che, Zegao Jin, Fangjie Yan, Jieqiong You, Jiangfeng Xie, Binhui Chen, Gang Cheng, Hong Zhu, Qiaojun He, Yongzhou Hu, Bo Yang, Ji Cao, Xiao-Wu Dong
Discovery of 5,6-Bis(4-methoxy-3-methylphenyl)pyridin-2-amine as a WSB1 Degrader to Inhibit Cancer Cell Metastasis. Journal of medicinal chemistry 64 (12) (2021)
Jinxin Che, Xiaoyang Dai, Jian Gao, Haichao Sheng, Wenhu Zhan, Yang Lu, Dan Li, Zizheng Gao, Zegao Jin, Binhui Chen, Peihua Luo, Bo Yang, Yongzhou Hu, Qiaojun He, Qinjie Weng, Xiao-Wu Dong
Discovery of N-((3S,4S)-4-(3,4-Difluorophenyl)piperidin-3-yl)-2-fluoro-4-(1-methyl-1H-pyrazol-5-yl)benzamide (Hu7691), a Potent and Selective Akt Inhibitor That Enables Decrease of Cutaneous Toxicity. Journal of medicinal chemistry 64 (16) (2021)
Rui-Ying Guo, Han-Min Wang, Xiao-Wu Dong, Yongzhou Hu, Jia Li, Yi Zang, Xin Li
Selectivity Comparison of Tumor-Imaging Probes Designed Based on Various Tumor-Targeting Strategies: A Proof of Concept Study. ACS applied bio materials 4 (3) (2020)
Xiaoyun Chen, Xianmin Wu, Jian Gao, Huazhou Ying, Xiao-Wu Dong, Yong-Zhou Hu, Zhijian Shen
Identification of new IDH2R140Q inhibitors by discriminatory analysis-based molecular docking and biological evaluation. Archiv der Pharmazie 354 (3) (2020)
Xiao-Wu Dong, Wenhu Zhan, Mengting Zhao, Jinxin Che, Xiaoyang Dai, Yizhe Wu, Lei Xu, Yubo Zhou, Yanmei Zhao, Tian Tian, Gang Cheng, Zegao Jin, Jia Li, Yanfei Shao, Qiaojun He, Bo Yang, Qinjie Weng, Yongzhou Hu
Discovery of 3,4,6-Trisubstituted Piperidine Derivatives as Orally Active, Low hERG Blocking Akt Inhibitors via Conformational Restriction and Structure-Based Design. Journal of medicinal chemistry 62 (15) (2019)
Yong Yang, Jinxin Che, Biao Wang, Yizhe Wu, Binhui Chen, Liang Gao, Xiao-Wu Dong, Jinhao Zhao
Visible-light-mediated guest trapping in a photosensitizing porous coordination network: metal-free C-C bond-forming modification of metal-organic frameworks for aqueous-phase herbicide adsorption. Chemical communications (Cambridge, England) 55 (37) (2019)
Qinjie Weng, Jinxin Che, Zhikang Zhang, Jiahuan Zheng, Wenhu Zhan, Sendong Lin, Tian Tian, Jincheng Wang, Renhua Gai, Yongzhou Hu, Bo Yang, Qiaojun He, Xiao-Wu Dong
Phenotypic Screening-Based Identification of 3,4-Disubstituted Piperidine Derivatives as Macrophage M2 Polarization Modulators: An Opportunity for Treating Multiple Sclerosis. Journal of medicinal chemistry 62 (7) (2019)
Yi-Zhe Wu, Hua-Zhou Ying, Lei Xu, Gang Cheng, Jing Chen, Yong-Zhou Hu, Daqiang Li, Xiao-Wu Dong
Design, synthesis, and molecular docking study of 3H-imidazole[4,5-c]pyridine derivatives as CDK2 inhibitors. Archiv der Pharmazie 351 (6) (2018)
Jin-Xin Che, Zhi-Long Wang, Xiao-Wu Dong, You-Hong Hu, Xin Xie, Yong-Zhou Hu
Bicyclo[2.2.1]heptane containing N , N '-diarylsquaramide CXCR2 selective antagonists as anti-cancer metastasis agents. RSC advances 8 (20) (2018)
Chun-Qi Hu, Kang Li, Ting-Ting Yao, Yong-Zhou Hu, Hua-Zhou Ying, Xiao-Wu Dong
Integrating docking scores and key interaction profiles to improve the accuracy of molecular docking: towards novel B-RafV600E inhibitors. MedChemComm 8 (9) (2017)
Can-Liang Ma, Jin-Hao Zhao, Yong Yang, Min-Kui Zhang, Chao Shen, Rong Sheng, Xiao-Wu Dong, Yong-Zhou Hu
A Copper-Catalyzed Tandem Cyclization Reaction of Aminoalkynes with Alkynes for the Construction of Tetrahydropyrrolo[1,2-a]quinolines Scaffold. Scientific reports 7 (1) (2017)