Youcef Mehellou

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 23

Top Topics

Top Venues

Chembiochem : a European journal of chemical biology

Journal of medicinal chemistry

RSC medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Qin Xu, Maria Sharif, Edward James, Jack O Dismorr, James H R Tucker, Benjamin E Willcox, Youcef Mehellou
Phosphonodiamidate prodrugs of phosphoantigens (ProPAgens) exhibit potent Vγ9/Vδ2 T cell activation and eradication of cancer cells. RSC medicinal chemistry 15 (7) (2024)
Qin Xu, Maria Sharif, Edward James, Jack O Dismorr, James H R Tucker, Benjamin E Willcox, Youcef Mehellou
Phosphonodiamidate prodrugs of phosphoantigens (ProPAgens) exhibit potent Vγ9/Vδ2 T cell activation and eradication of cancer cells. RSC medicinal chemistry 15 (7) (2024)
Youcef Mehellou
Parkinson's Disease: Are PINK1 Activators Inching Closer to the Clinic? ACS medicinal chemistry letters 14 (7) (2023)
Olivia A Lambourne, Shane Bell, Léa P Wilhelm, Erika B Yarbrough, Gabriel G Holly, Oliver M Russell, Arwa M Alghamdi, Azeza M Fdel, Carmine Varricchio, Emma L Lane, Ian G Ganley, Arwyn T Jones, Matthew S Goldberg, Youcef Mehellou
PINK1-Dependent Mitophagy Inhibits Elevated Ubiquitin Phosphorylation Caused by Mitochondrial Damage. Journal of medicinal chemistry (2023)
Ashwag S Alanazi, Ageo Miccoli, Youcef Mehellou
Aryloxy Pivaloyloxymethyl Prodrugs as Nucleoside Monophosphate Prodrugs. Journal of medicinal chemistry 64 (22) (2021)
Qin Xu, Taher E Taher, Elizabeth Ashby, Maria Sharif, Benjamin E Willcox, Youcef Mehellou
Generation of Stable Isopentenyl Monophosphate Aryloxy Triester Phosphoramidates as Activators of Vγ9Vδ2 T Cells. ChemMedChem 16 (15) (2021)
Karen T Elvers, Magdalena Lipka-Lloyd, Rebecca C Trueman, Benjamin D Bax, Youcef Mehellou
Structures of the Human SPAK and OSR1 Conserved C-Terminal (CCT) Domains*. Chembiochem : a European journal of chemical biology (2021)
Ageo Miccoli, Binar A Dhiani, Peter J Thornton, Olivia A Lambourne, Edward James, Hachemi Kadri, Youcef Mehellou
Aryloxy Triester Phosphoramidates as Phosphoserine Prodrugs: A Proof of Concept Study. ChemMedChem 15 (8) (2020)
Hachemi Kadri, Taher E Taher, Qin Xu, Maria Sharif, Elizabeth Ashby, Richard T Bryan, Benjamin E Willcox, Youcef Mehellou
Aryloxy Diester Phosphonamidate Prodrugs of Phosphoantigens (ProPAgens) as Potent Activators of Vγ9/Vδ2 T-Cell Immune Responses. Journal of medicinal chemistry 63 (19) (2020)
Binar A Dhiani, Youcef Mehellou
The Cul4-DDB1-WDR3/WDR6 Complex Binds SPAK and OSR1 Kinases in a Phosphorylation-Dependent Manner. Chembiochem : a European journal of chemical biology 21 (5) (2019)
Mubarak A AlAmri, Hachemi Kadri, Luke J Alderwick, Mark Jeeves, Youcef Mehellou
The Photosensitising Clinical Agent Verteporfin Is an Inhibitor of SPAK and OSR1 Kinases. Chembiochem : a European journal of chemical biology 19 (19) (2018)
Hachemi Kadri, Olivia A Lambourne, Youcef Mehellou
Niclosamide, a Drug with Many (Re)purposes. ChemMedChem 13 (11) (2018)
Erica Barini, Ageo Miccoli, Federico Tinarelli, Katie Mulholland, Hachemi Kadri, Farhat Khanim, Laste Stojanovski, Kevin D Read, Kerry Burness, Julian J Blow, Youcef Mehellou, Miratul M K Muqit
The Anthelmintic Drug Niclosamide and Its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1. Chembiochem : a European journal of chemical biology 19 (5) (2018)
Martin S Davey, Roshni Malde, Rory C Mykura, Alfie T Baker, Taher E Taher, Cécile S Le Duff, Benjamin E Willcox, Youcef Mehellou
Synthesis and Biological Evaluation of ( E)-4-Hydroxy-3-methylbut-2-enyl Phosphate (HMBP) Aryloxy Triester Phosphoramidate Prodrugs as Activators of Vγ9/Vδ2 T-Cell Immune Responses. Journal of medicinal chemistry 61 (5) (2018)
Olivia A Lambourne, Youcef Mehellou
Chemical Strategies for Activating PINK1, a Protein Kinase Mutated in Parkinson's Disease. Chembiochem : a European journal of chemical biology 19 (23) (2018)
Ageo Miccoli, Binar A Dhiani, Youcef Mehellou
Phosphotyrosine prodrugs: design, synthesis and anti-STAT3 activity of ISS-610 aryloxy triester phosphoramidate prodrugs. MedChemComm 10 (2) (2018)
Hachemi Kadri, Mubarak A Alamri, Iva H Navratilova, Luke J Alderwick, Nigel S Simpkins, Youcef Mehellou
Towards the Development of Small-Molecule MO25 Binders as Potential Indirect SPAK/OSR1 Kinase Inhibitors. Chembiochem : a European journal of chemical biology 18 (5) (2017)
Mubarak A AlAmri, Hachemi Kadri, Binar A Dhiani, Shumail Mahmood, Abdulrahman Elzwawi, Youcef Mehellou
WNK Signaling Inhibitors as Potential Antihypertensive Drugs. ChemMedChem 12 (20) (2017)
Laura Osgerby, Yu-Chiang Lai, Peter J Thornton, Joseph Amalfitano, Cécile S Le Duff, Iqra Jabeen, Hachemi Kadri, Ageo Miccoli, James H R Tucker, Miratul M K Muqit, Youcef Mehellou
Kinetin Riboside and Its ProTides Activate the Parkinson's Disease Associated PTEN-Induced Putative Kinase 1 (PINK1) Independent of Mitochondrial Depolarization. Journal of medicinal chemistry 60 (8) (2017)
Mubarak A AlAmri, Hachemi Kadri, Luke J Alderwick, Nigel S Simpkins, Youcef Mehellou
Rafoxanide and Closantel Inhibit SPAK and OSR1 Kinases by Binding to a Highly Conserved Allosteric Site on Their C-terminal Domains. ChemMedChem 12 (9) (2017)
Youcef Mehellou, Hardeep S Rattan, Jan Balzarini
The ProTide Prodrug Technology: From the Concept to the Clinic. Journal of medicinal chemistry 61 (6) (2017)
Mahboob Salim, Timothy J Knowles, Alfie T Baker, Martin S Davey, Mark Jeeves, Pooja Sridhar, John Wilkie, Carrie R Willcox, Hachemi Kadri, Taher E Taher, Pierre Vantourout, Adrian Hayday, Youcef Mehellou, Fiyaz Mohammed, Benjamin E Willcox
BTN3A1 Discriminates γδ T Cell Phosphoantigens from Nonantigenic Small Molecules via a Conformational Sensor in Its B30.2 Domain. ACS chemical biology 12 (10) (2017)
Youcef Mehellou
The ProTides Boom. ChemMedChem 11 (11) (2016)