Yu Chen

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 25

Top Topics

Pseudomonas Aeruginosa

Klebsiella Pneumoniae

Crystal Structure

Top Venues

Antibiotics (Basel, Switzerland)

ACS infectious diseases

Antimicrobial agents and chemotherapy

This page only lists publications with an associated author ORCID identifier.

Publications

Michael Dominic Sacco, Lauren R Hammond, Radwan E Noor, Dipanwita Bhattacharya, Lily J McKnight, Jesper J Madsen, Xiujun Zhang, Shane G Butler, M Trent Kemp, Aiden C Jaskolka-Brown, Sebastian J Khan, Ioannis Gelis, Prahathees J Eswara, Yu Chen
Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB. eLife 13 (2024)
Michael Dominic Sacco, Lauren R Hammond, Radwan E Noor, Dipanwita Bhattacharya, Lily J McKnight, Jesper J Madsen, Xiujun Zhang, Shane G Butler, M Trent Kemp, Aiden C Jaskolka-Brown, Sebastian J Khan, Ioannis Gelis, Prahathees J Eswara, Yu Chen
Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB. eLife 13 (2024)
Michael Dominic Sacco, Lauren R Hammond, Radwan E Noor, Dipanwita Bhattacharya, Lily J McKnight, Jesper J Madsen, Xiujun Zhang, Shane G Butler, M Trent Kemp, Aiden C Jaskolka-Brown, Sebastian J Khan, Ioannis Gelis, Prahathees J Eswara, Yu Chen
Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB. eLife 13 (2024)
Lian M C Jacobs, Patrick Consol, Yu Chen
Drug Discovery in the Field of β-Lactams: An Academic Perspective. Antibiotics (Basel, Switzerland) 13 (1) (2024)
Michael D Sacco, Lauren R Hammond, Radwan E Noor, Dipanwita Bhattacharya, Lily J McKnight, Jesper J Madsen, Xiujun Zhang, Shane G Butler, M Trent Kemp, Aiden C Jaskolka-Brown, Sebastian J Khan, Ioannis Gelis, Prahathees J Eswara, Yu Chen
Staphylococcus aureus FtsZ and PBP4 bind to the conformationally dynamic N-terminal domain of GpsB. eLife 13 (2024)
Lian M C Jacobs, Patrick Consol, Yu Chen
Drug Discovery in the Field of β-Lactams: An Academic Perspective. Antibiotics (Basel, Switzerland) 13 (1) (2024)
Lian M C Jacobs, Patrick Consol, Yu Chen
Drug Discovery in the Field of β-Lactams: An Academic Perspective. Antibiotics (Basel, Switzerland) 13 (1) (2024)
Michael D Sacco, Shaohui Wang, Swamy R Adapa, Xiujun Zhang, Eric M Lewandowski, Maura Verenice Gongora, Dimitra Keramisanou, Zachary D Atlas, Julia A Townsend, Jean R Gatdula, Ryan T Morgan, Lauren R Hammond, Michael Thomas Marty, Jun Wang, Prahathees J Eswara, Ioannis Gelis, Rays H Y Jiang, Xingmin Sun, Yu Chen
A unique class of Zn 2+ -binding serine-based PBPs underlies cephalosporin resistance and sporogenesis in Clostridioides difficile. Nature communications 13 (1) (2022)
Lauren R Hammond, Michael D Sacco, Sebastian J Khan, Catherine Spanoudis, Abigail Hough-Neidig, Yu Chen, Prahathees J Eswara
GpsB Coordinates Cell Division and Cell Surface Decoration by Wall Teichoic Acids in Staphylococcus aureus. Microbiology spectrum 10 (3) (2022)
Eric M Lewandowski, Kyle G Kroeck, Lian M C Jacobs, Tyler G Fenske, Robin N Witt, Alyssa M Hintz, Elizabeth R Ramsden, Xiujun Zhang, Francis Peterson, Brian F Volkman, Christopher T Veldkamp, Yu Chen
Structural Insights into Molecular Recognition by Human Chemokine CCL19. Biochemistry 61 (5) (2022)
Michael D Sacco, Kyle Defrees, Xiujun Zhang, William Lawless, Emeka Nwanochie, Amelia Balsizer, Sophie E Darch, Adam R Renslo, Yu Chen
Structure-Based Ligand Design Targeting Pseudomonas aeruginosa LpxA in Lipid A Biosynthesis. ACS infectious diseases 8 (7) (2022)
Jin Ou, Eric Lewandowski, Yanmei Hu, Austin Lipinski, Ryan T Morgan, Lian Jacobs, Xiujun Zhang, Melissa J Bikowitz, Paul Langlais, Haozhou Tan, Jun Wang, Yu Chen, John Choy
A yeast-based system to study SARS-CoV-2 Mpro structure and to identify nirmatrelvir resistant mutations. Research square (2022)
M Trent Kemp, Derek A Nichols, Xiujun Zhang, Kyle Defrees, Insung Na, Adam R Renslo, Yu Chen
Mutation of the conserved Asp-Asp pair impairs the structure, function, and inhibition of CTX-M Class A β-lactamase. FEBS letters (2021)
Brian G O'Flynn, Eric M Lewandowski, Karin Claire Prins, Gabriela Suarez, Angelica N McCaskey, Nasha M Rios-Guzman, Ryan L Anderson, Britney A Shepherd, Ioannis Gelis, James W Leahy, Yu Chen, David J Merkler
Characterization of Arylalkylamine N-Acyltransferase from Tribolium castaneum: An Investigation into a Potential Next-Generation Insecticide Target. ACS chemical biology 15 (2) (2020)
Eric M Lewandowski, Łukasz Szczupak, Aleksandra Kowalczyk, Gracia Mendoza, Manuel Arruebo, Lian M C Jacobs, Paweł Stączek, Yu Chen, Konrad Kowalski
Metallocenyl 7-ACA Conjugates: Antibacterial Activity Studies and Atomic-Resolution X-ray Crystal Structure with CTX-M β-Lactamase. Chembiochem : a European journal of chemical biology 21 (15) (2020)
Michael Dominic Sacco, Chunlong Ma, Panagiotis Lagarias, Ang Gao, Julia Alma Townsend, Xiangzhi Meng, Peter Dube, Xiujun Zhang, Yanmei Hu, Naoya Kitamura, Brett L Hurst, E Bart Tarbet, Michael Thomas Marty, Antonios Kolocouris, Yan Xiang, Yu Chen, Jun Wang
Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against Mpro and cathepsin L. Science advances 6 (50) (2020)
Afroza Akhtar, Orville A Pemberton, Yu Chen
Structural Basis for Substrate Specificity and Carbapenemase Activity of OXA-48 Class D β-Lactamase. ACS infectious diseases 6 (2) (2020)
Orville A Pemberton, Ruslan Tsivkovski, Maxim Totrov, Olga Lomovskaya, Yu Chen
Structural Basis and Binding Kinetics of Vaborbactam in Class A β-Lactamase Inhibition. Antimicrobial agents and chemotherapy 64 (10) (2020)
Scott J Hecker, K Raja Reddy, Olga Lomovskaya, David C Griffith, Debora Rubio-Aparicio, Kirk Nelson, Ruslan Tsivkovski, Dongxu Sun, Mojgan Sabet, Ziad Tarazi, Jonathan Parkinson, Maxim Totrov, Serge H Boyer, Tomasz W Glinka, Orville A Pemberton, Yu Chen, Michael N Dudley
Discovery of Cyclic Boronic Acid QPX7728, an Ultrabroad-Spectrum Inhibitor of Serine and Metallo-β-lactamases. Journal of medicinal chemistry 63 (14) (2020)
Joseph M Pennington, Michael Kemp, Lauren McGarry, Yu Chen, M Elizabeth Stroupe
Siroheme synthase orients substrates for dehydrogenase and chelatase activities in a common active site. Nature communications 11 (1) (2020)
Michael D Sacco, Kyle G Kroeck, M Trent Kemp, Xiujun Zhang, Logan D Andrews, Yu Chen
Influence of the α-Methoxy Group on the Reaction of Temocillin with Pseudomonas aeruginosa PBP3 and CTX-M-14 β-Lactamase. Antimicrobial agents and chemotherapy 64 (1) (2019)
Orville A Pemberton, Priyadarshini Jaishankar, Afroza Akhtar, Jessie L Adams, Lindsey Neil Shaw, Adam R Renslo, Yu Chen
Heteroaryl Phosphonates as Noncovalent Inhibitors of Both Serine- and Metallocarbapenemases. Journal of medicinal chemistry 62 (18) (2019)
Nicholas J Torelli, Afroza Akhtar, Kyle DeFrees, Priyadarshini Jaishankar, Orville A Pemberton, Xiujun Zhang, Cody Johnson, Adam R Renslo, Yu Chen
Active-Site Druggability of Carbapenemases and Broad-Spectrum Inhibitor Discovery. ACS infectious diseases 5 (6) (2019)
Orville A Pemberton, Xiujun Zhang, Derek A Nichols, Kyle DeFrees, Priyadarshini Jaishankar, Richard Bonnet, Jessie Adams, Lindsey Neil Shaw, Adam R Renslo, Yu Chen
Antibacterial Spectrum of a Tetrazole-Based Reversible Inhibitor of Serine β-Lactamases. Antimicrobial agents and chemotherapy 62 (8) (2018)
Orville A Pemberton, Xiujun Zhang, Yu Chen
Molecular Basis of Substrate Recognition and Product Release by the Klebsiella pneumoniae Carbapenemase (KPC-2). Journal of medicinal chemistry 60 (8) (2017)