Zhenkun Lou

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 39

Top Topics

Oxidative Stress

Small Cell Lung Cancer

Top Venues

Nature communications

Science translational medicine

Signal transduction and targeted therapy

Nature cell biology

This page only lists publications with an associated author ORCID identifier.

Publications

Jiajia Chen, Daniel J Laverty, Surabhi Talele, Ashwin Bale, Brett L Carlson, Kendra A Porath, Katrina K Bakken, Danielle M Burgenske, Paul A Decker, Rachael Ann Vaubel, Jeanette E Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan A C Harley, William F Elmquist, Zachary D Nagel, Shiv K Gupta, Jann N Sarkaria
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Science translational medicine 16 (734) (2024)
Jiajia Chen, Daniel J Laverty, Surabhi Talele, Ashwin Bale, Brett L Carlson, Kendra A Porath, Katrina K Bakken, Danielle M Burgenske, Paul A Decker, Rachael Ann Vaubel, Jeanette E Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan A C Harley, William F Elmquist, Zachary D Nagel, Shiv K Gupta, Jann N Sarkaria
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Science translational medicine 16 (734) (2024)
Jiajia Chen, Daniel J Laverty, Surabhi Talele, Ashwin Bale, Brett L Carlson, Kendra A Porath, Katrina K Bakken, Danielle M Burgenske, Paul A Decker, Rachael Ann Vaubel, Jeanette E Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan A C Harley, William F Elmquist, Zachary D Nagel, Shiv K Gupta, Jann N Sarkaria
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Science translational medicine 16 (734) (2024)
Jiajia Chen, Daniel J Laverty, Surabhi Talele, Ashwin Bale, Brett L Carlson, Kendra A Porath, Katrina K Bakken, Danielle M Burgenske, Paul A Decker, Rachael Ann Vaubel, Jeanette E Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan A C Harley, William F Elmquist, Zachary D Nagel, Shiv K Gupta, Jann N Sarkaria
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Science translational medicine 16 (734) (2024)
Jiajia Chen, Daniel J Laverty, Surabhi Talele, Ashwin Bale, Brett L Carlson, Kendra A Porath, Katrina K Bakken, Danielle M Burgenske, Paul A Decker, Rachael Ann Vaubel, Jeanette E Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan A C Harley, William F Elmquist, Zachary D Nagel, Shiv K Gupta, Jann N Sarkaria
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Science translational medicine 16 (734) (2024)
Jiajia Chen, Daniel J Laverty, Surabhi Talele, Ashwin Bale, Brett L Carlson, Kendra A Porath, Katrina K Bakken, Danielle M Burgenske, Paul A Decker, Rachael Ann Vaubel, Jeanette E Eckel-Passow, Rohit Bhargava, Zhenkun Lou, Petra Hamerlik, Brendan A C Harley, William F Elmquist, Zachary D Nagel, Shiv K Gupta, Jann N Sarkaria
Aberrant ATM signaling and homology-directed DNA repair as a vulnerability of p53-mutant GBM to AZD1390-mediated radiosensitization. Science translational medicine 16 (734) (2024)
Chao Zhang, Qiang Guo, Lifeng Chen, Zheming Wu, Xiao-Jian Yan, Chengyang Zou, Qiuxue Zhang, Jiahong Tan, Tian Fang, Qunxian Rao, Yang Li, Shizhen Shen, Min Deng, Liewei Wang, Huanyao Gao, Jia Yu, Hu Li, Cheng Zhang, Somaira Nowsheen, Jake A Kloeber, Fei Zhao, Ping Yin, Chunbo Teng, Zhongqiu Lin, Kun Song, Shuzhong Yao, Liangqing Yao, Lingying Wu, Yong Zhang, Xiaodong Cheng, Qing-Lei Gao, Jian Yuan, Zhenkun Lou, Jin-San Zhang
A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors. Signal transduction and targeted therapy 8 (1) (2023)
Xiangyu Zeng, Fei Zhao, Jie Jia, Xianxiong Ma, Qi Jiang, Ruizhi Zhang, Cheng-Guo Li, Tao Wang, Weizhen Liu, Yalan Hao, Kaixiong Tao, Zhenkun Lou, Peng Zhang
Targeting BCL6 in gastrointestinal stromal tumor promotes p53-mediated apoptosis to enhance the antitumor activity of imatinib. Cancer research (2023)
Jinhuan Wu, Yuping Chen, Rui Li, Yaping Guan, Mu Chen, Hui Yin, Xiaoning Yang, Mingpeng Jin, Bingsong Huang, Xin Ding, Jie Yang, Zhe Wang, Yiming He, Qianwen Wang, Jian Luo, Ping Wang, Zhiyong Mao, Michael Shing Yan Huen, Zhenkun Lou, Jian Yuan, Fanghua Gong
Synergistic anticancer effect by targeting CDK2 and EGFR-ERK signaling. The Journal of cell biology 223 (1) (2023)
Chao Zhang, Qiang Guo, Lifeng Chen, Zheming Wu, Xiao-Jian Yan, Chengyang Zou, Qiuxue Zhang, Jiahong Tan, Tian Fang, Qunxian Rao, Yang Li, Shizhen Shen, Min Deng, Liewei Wang, Huanyao Gao, Jia Yu, Hu Li, Cheng Zhang, Somaira Nowsheen, Jake A Kloeber, Fei Zhao, Ping Yin, Chunbo Teng, Zhongqiu Lin, Kun Song, Shuzhong Yao, Liangqing Yao, Lingying Wu, Yong Zhang, Xiaodong Cheng, Qing-Lei Gao, Jian Yuan, Zhenkun Lou, Jin-San Zhang
A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors. Signal transduction and targeted therapy 8 (1) (2023)
Qin Zhou, Xinyi Tu, Xiaonan Hou, Jia Yu, Fei Zhao, Jinzhou Huang, Jake Kloeber, Anna Olson, Ming Gao, Kuntian Luo, Shouhai Zhu, Zheming Wu, Yong Zhang, Chenyu Sun, Xiangyu Zeng, Kenneth Schoolmeester, John Weroha, Liewei Wang, Robert Mutter, Zhenkun Lou
Syk-dependent alternative homologous recombination activation promotes cancer resistance to DNA targeted therapy. Research square (2023)
Chao Zhang, Qiang Guo, Lifeng Chen, Zheming Wu, Xiao-Jian Yan, Chengyang Zou, Qiuxue Zhang, Jiahong Tan, Tian Fang, Qunxian Rao, Yang Li, Shizhen Shen, Min Deng, Liewei Wang, Huanyao Gao, Jia Yu, Hu Li, Cheng Zhang, Somaira Nowsheen, Jake A Kloeber, Fei Zhao, Ping Yin, Chunbo Teng, Zhongqiu Lin, Kun Song, Shuzhong Yao, Liangqing Yao, Lingying Wu, Yong Zhang, Xiaodong Cheng, Qing-Lei Gao, Jian Yuan, Zhenkun Lou, Jin-San Zhang
A ribosomal gene panel predicting a novel synthetic lethality in non-BRCAness tumors. Signal transduction and targeted therapy 8 (1) (2023)
Qin Zhou, Jinzhou Huang, Chao Zhang, Fei Zhao, Wootae Kim, Xinyi Tu, Yong Zhang, Somaira Nowsheen, Qian Zhu, Min Deng, Yuping Chen, Bo Qin, Kuntian Luo, Bao-Hua Liu, Zhenkun Lou, Robert W Mutter, Jian Yuan
Author Correction: The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair. Nature communications 13 (1) (2022)
Chenming Wu, Kuntian Luo, Fei Zhao, Ping Yin, Ying Song, Min Deng, Jinzhou Huang, Yuping Chen, Lei Li, SeungBaek Lee, JungJin Kim, Qin Zhou, Xinyi Tu, Somaira Nowsheen, Qifeng Luo, Xiumei Gao, Zhenkun Lou, Zhongmin Liu, Jian Yuan
Correction to: USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization. Cell death and differentiation (2022)
Ming Gao, Zijuan Qi, Min Deng, Hongyang Huang, Zhijie Xu, Guijie Guo, Jiajun Jing, Xiaofeng Huang, Ming Xu, Jake A Kloeber, Sijin Liu, Jinzhou Huang, Zhenkun Lou, Jinxiang Han
The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1. Oncogene 41 (33) (2022)
Bo Qin, Jia Yu, Fei Zhao, Jinzhou Huang, Qin Zhou, Zhenkun Lou
Dynamic recruitment of UFM1-specific peptidase 2 to the DNA double-strand breaks regulated by WIP1. Genome instability & disease 3 (4) (2022)
Xiangyu Zeng, Fei Zhao, Gaofeng Cui, Yong Zhang, Rajashree A Deshpande, Yuping Chen, Min Deng, Jake A Kloeber, Yu Shi, Qin Zhou, Chao Zhang, Jing Hou, Wootae Kim, Xinyi Tu, Yuanliang Yan, Zhijie Xu, Lifeng Chen, Huanyao Gao, Guijie Guo, Jiaqi Liu, Qian Zhu, Yueyu Cao, Jinzhou Huang, Zheming Wu, Shouhai Zhu, Ping Yin, Kuntian Luo, Georges Mer, Tanya T Paull, Jian Yuan, Kaixiong Tao, Zhenkun Lou
METTL16 antagonizes MRE11-mediated DNA end resection and confers synthetic lethality to PARP inhibition in pancreatic ductal adenocarcinoma. Nature cancer 3 (9) (2022)
Lifeng Chen, Jing Hou, Xiangyu Zeng, Qiang Guo, Min Deng, Jake A Kloeber, Xinyi Tu, Fei Zhao, Zheming Wu, Jinzhou Huang, Kuntian Luo, Wootae Kim, Zhenkun Lou
LRRK2 inhibition potentiates PARP inhibitor cytotoxicity through inhibiting homologous recombination-mediated DNA double strand break repair. Clinical and translational medicine 11 (3) (2022)
Guijie Guo, Ming Gao, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Xinyi Tu, Wootae Kim, Fei Zhao, Qin Zhou, Shouhai Zhu, Zheming Wu, Yuanliang Yan, Yong Zhang, Xiangyu Zeng, Qian Zhu, Ping Yin, Kuntian Luo, Jie Sun, Min Deng, Zhenkun Lou
Reciprocal regulation of RIG-I and XRCC4 connects DNA repair with RIG-I immune signaling. Nature communications 12 (1) (2021)
Guijie Guo, Ming Gao, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Kuntian Luo, Yong Zhang, Jie Sun, Min Deng, Zhenkun Lou
SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response. Signal transduction and targeted therapy 6 (1) (2021)
Fei Zhao, Wootae Kim, Huanyao Gao, Chao Liu, Yong Zhang, Yuping Chen, Min Deng, Qin Zhou, Jinzhou Huang, Qi Hu, Shih-Hsun Chen, Somaira Nowsheen, Jake A Kloeber, Bo Qin, Ping Yin, Xinyi Tu, Guijie Guo, Sisi Qin, Chao Zhang, Ming Gao, Kuntian Luo, Yilun Liu, Zhenkun Lou, Jian Yuan
ASTE1 promotes shieldin-complex-mediated DNA repair by attenuating end resection. Nature cell biology 23 (8) (2021)
Chenming Wu, Yiming Chang, Junliang Chen, Yang Su, Lei Li, Yuping Chen, Yunhui Li, Jinhuan Wu, Jinzhou Huang, Fei Zhao, Wenrui Wang, Hui Yin, Shunli Wang, Mingpeng Jin, Zhenkun Lou, Wei-Guo Zhu, Kuntian Luo, Jie Zhang, Jian Yuan
USP37 regulates DNA damage response through stabilizing and deubiquitinating BLM. Nucleic acids research 49 (19) (2021)
Qian Zhu, Jinzhou Huang, Hongyang Huang, Huan Li, Peiqiang Yi, Jake A Kloeber, Jian Yuan, Yuping Chen, Min Deng, Kuntian Luo, Ming Gao, Guijie Guo, Xinyi Tu, Ping Yin, Yong Zhang, Jun Su, Jia-Yi Chen, Zhenkun Lou
RNF19A-mediated ubiquitination of BARD1 prevents BRCA1/BARD1-dependent homologous recombination. Nature communications 12 (1) (2021)
Chen Hu, Mu Zhang, Niko Moses, Cong-Li Hu, Lisa Polin, Wei Chen, Hyejeong Jang, Joshua Heyza, Agnes Malysa, Joseph A Caruso, Shengyan Xiang, Steve M Patrick, Paul Stemmer, Zhenkun Lou, Wenlong Bai, Chuangui Wang, Gerold Bepler, Xiaohong Mary Zhang
The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53. Cell death & disease 11 (5) (2020)
Min Deng, Jing Lin, Somaira Nowsheen, Tongzheng Liu, Yingchun Zhao, Peter W Villalta, Delphine Sicard, Daniel J Tschumperlin, SeungBaek Lee, JungJin Kim, Zhenkun Lou
Extracellular matrix stiffness determines DNA repair efficiency and cellular sensitivity to genotoxic agents. Science advances 6 (37) (2020)
Jia Yu, Bo Qin, Ann M Moyer, Somaira Nowsheen, Xinyi Tu, Haidong Dong, Judy C Boughey, Matthew P Goetz, Richard Weinshilboum, Zhenkun Lou, Liewei Wang
Regulation of sister chromatid cohesion by nuclear PD-L1. Cell research 30 (7) (2020)
Bo Qin, Jia Yu, Somaira Nowsheen, Fei Zhao, Liewei Wang, Zhenkun Lou
STK38 promotes ATM activation by acting as a reader of histone H4 ufmylation. Science advances 6 (23) (2020)
Ming Gao, Guijie Guo, Jinzhou Huang, Jake A Kloeber, Fei Zhao, Min Deng, Xinyi Tu, Wootae Kim, Qin Zhou, Chao Zhang, Ping Yin, Kuntian Luo, Zhenkun Lou
USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP. Nature communications 11 (1) (2020)
Fei Zhao, Wootae Kim, Jake A Kloeber, Zhenkun Lou
DNA end resection and its role in DNA replication and DSB repair choice in mammalian cells. Experimental & molecular medicine 52 (10) (2020)
Qin Zhou, Jinzhou Huang, Chao Zhang, Fei Zhao, Wootae Kim, Xinyi Tu, Yong Zhang, Somaira Nowsheen, Qian Zhu, Min Deng, Yuping Chen, Bo Qin, Kuntian Luo, Bao-Hua Liu, Zhenkun Lou, Robert W Mutter, Jian Yuan
The bromodomain containing protein BRD-9 orchestrates RAD51-RAD54 complex formation and regulates homologous recombination-mediated repair. Nature communications 11 (1) (2020)
Wootae Kim, Fei Zhao, Rentian Wu, Sisi Qin, Somaira Nowsheen, Jinzhou Huang, Qin Zhou, Yuping Chen, Min Deng, Guijie Guo, Kuntian Luo, Zhenkun Lou, Jian Yuan
ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex. Nature communications 10 (1) (2019)
Seung Baek Lee, Jung Jin Kim, Sang-Ah Han, Yingfang Fan, Li-Sha Guo, Khaled Aziz, Somaira Nowsheen, Sung Sun Kim, Seon-Young Park, Qifeng Luo, Jin Ook Chung, Sung Il Choi, Asef Aziz, Ping Yin, Seo-Yun Tong, Fabienne C Fiesel, Wolfdieter Springer, Jin-San Zhang, Zhenkun Lou
The AMPK-Parkin axis negatively regulates necroptosis and tumorigenesis by inhibiting the necrosome. Nature cell biology 21 (8) (2019)
Bo Qin, Jia Yu, Somaira Nowsheen, Minghui Wang, Xinyi Tu, Tongzheng Liu, Honglin Li, Liewei Wang, Zhenkun Lou
UFL1 promotes histone H4 ufmylation and ATM activation. Nature communications 10 (1) (2019)
Zhiwang Song, Xinyi Tu, Qin Zhou, Jinzhou Huang, Yuping Chen, Jiaqi Liu, SeungBaek Lee, Wootae Kim, Somaira Nowsheen, Kuntian Luo, Jian Yuan, Zhenkun Lou
A novel UCHL3 inhibitor, perifosine, enhances PARP inhibitor cytotoxicity through inhibition of homologous recombination-mediated DNA double strand break repair. Cell death & disease 10 (6) (2019)
Somaira Nowsheen, Khaled Aziz, Kuntian Luo, Min Deng, Bo Qin, Jian Yuan, Karthik B Jeganathan, Jia Yu, Henan Zhang, Wei Ding, Jan M van Deursen, Zhenkun Lou
ZNF506-dependent positive feedback loop regulates H2AX signaling after DNA damage. Nature communications 9 (1) (2018)
Lei Li, Tongzheng Liu, Yunhui Li, Chenming Wu, Kuntian Luo, Yujiao Yin, Yuping Chen, Somaira Nowsheen, Jinhuan Wu, Zhenkun Lou, Jian Yuan
The deubiquitinase USP9X promotes tumor cell survival and confers chemoresistance through YAP1 stabilization. Oncogene 37 (18) (2018)
Chenming Wu, Kuntian Luo, Fei Zhao, Ping Yin, Ying Song, Min Deng, Jinzhou Huang, Yuping Chen, Lei Li, SeungBaek Lee, JungJin Kim, Qin Zhou, Xinyi Tu, Somaira Nowsheen, Qifeng Luo, Xiumei Gao, Zhenkun Lou, Zhongmin Liu, Jian Yuan
USP20 positively regulates tumorigenesis and chemoresistance through β-catenin stabilization. Cell death and differentiation 25 (10) (2018)
Somaira Nowsheen, Khaled Aziz, Asef Aziz, Min Deng, Bo Qin, Kuntian Luo, Karthik B Jeganathan, Henan Zhang, Tongzheng Liu, Jia Yu, Yibin Deng, Jian Yuan, Wei Ding, Jan M van Deursen, Zhenkun Lou
L3MBTL2 orchestrates ubiquitin signalling by dictating the sequential recruitment of RNF8 and RNF168 after DNA damage. Nature cell biology 20 (4) (2018)
Kuntian Luo, Yunhui Li, Yujiao Yin, Lei Li, Chenming Wu, Yuping Chen, Somaira Nowsheen, Qi Hu, Lizhi Zhang, Zhenkun Lou, Jian Yuan
USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling. The EMBO journal 36 (10) (2017)