A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas.

Lisa D Cervia Tsukasa Shibue Ashir A Borah Benjamin Gaeta Linh He Lisa Leung Naomi Li Sydney M Moyer Brian H Shim Nancy Dumont Alfredo E Gonzalez Nolan R Bick Mariya Kazachkova Joshua M Dempster John Michael Krill-Burger Frederica Piccioni Namrata D Udeshi Meagan E Olive Steven A Carr David E Root James M McFarland Francisca Vazquez William C Hahn

Published in: Cancer discovery (2023)

We describe the identification of a heretofore unrecognized ubiquitin ligase complex that prevents the aberrant activation of the ISR in a subset of cancer cells. This provides a novel insight on the regulation of ISR and exposes a therapeutic opportunity to selectively eliminate these cancer cells. See related commentary Leli and Koumenis, p. 535. This article is highlighted in the In This Issue feature, p. 517.

Keyphrases

machine learning
deep learning
high grade
free survival
bioinformatics analysis
drug induced