David E Root (D E Root, David Root)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 58

Top Topics

Estrogen Receptor

Top Venues

Nature communications

Cancer discovery

Cancer research

This page only lists publications with an associated author ORCID identifier.

Publications

Alissandra L Hillis, Timothy D Martin, Haley E Manchester, Jenny Högström, Na Zhang, Emmalyn Lecky, Nina Kozlova, Jonah Lee, Nicole S Persky, David E Root, Myles A Brown, Karen Cichowski, Stephen J Elledge, Taru Muranen, David A Fruman, Simon T Barry, John Gerard Clohessy, Ralitsa R Madsen, Alex Toker
Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer. Cancer research (2024)
Foteini Tsiami, Chiara Lago, Noemi Pozza, Frederica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E Root, Luca Tiberi, Marcel Kool, Cornelia Brendle, Pratiti Bandopadhayay, Rosalind A Segal, Ghazaleh Tabatabai, Daniel J Merk
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma. Acta neuropathologica communications 12 (1) (2024)
Tikvah K Hayes, Elisa Aquilanti, Nicole S Persky, Xiaoping Yang, Erica E Kim, Lisa Brenan, Amy B Goodale, Douglas Alan, Ted Sharpe, Robert E Shue, Lindsay Westlake, Lior Golomb, Brianna R Silverman, Myshal D Morris, Ty Running Fisher, Eden Beyene, Yvonne Y Li, Andrew D Cherniak, Frederica Piccioni, J Kevin Hicks, Andrew S Chi, Daniel P Cahill, Jorg Dietrich, Tracy T Batchelor, David E Root, Cory M Johannessen, Matthew L Meyerson
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature communications 15 (1) (2024)
Karuna Mittal, Garrett W Cooper, Benjamin P Lee, Yongdong Su, Katie T Skinner, Jenny Shim, Hunter C Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D Kynnap, Amanda L Christie, Xiaoping Yang, Glenn S Cowley, Brittaney A Leeper, Christopher L Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M Clinton, Manoj K Bhasin, Brian D Crompton, Yuen-Yi Tseng, Jesse S Boehm, Keith L Ligon, David E Root, Andrew Jackson Murphy, David M Weinstock, Prafulla C Gokhale, Jennifer M Spangle, Miguel N Rivera, Elizabeth A Mullen, Kimberly Stegmaier, Kelly C Goldsmith, William C Hahn, Andrew L Hong
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin. Communications biology 7 (1) (2024)
Karuna Mittal, Garrett W Cooper, Benjamin P Lee, Yongdong Su, Katie T Skinner, Jenny Shim, Hunter C Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D Kynnap, Amanda L Christie, Xiaoping Yang, Glenn S Cowley, Brittaney A Leeper, Christopher L Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M Clinton, Manoj K Bhasin, Brian D Crompton, Yuen-Yi Tseng, Jesse S Boehm, Keith L Ligon, David E Root, Andrew Jackson Murphy, David M Weinstock, Prafulla C Gokhale, Jennifer M Spangle, Miguel N Rivera, Elizabeth A Mullen, Kimberly Stegmaier, Kelly C Goldsmith, William C Hahn, Andrew L Hong
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin. Communications biology 7 (1) (2024)
Tikvah K Hayes, Elisa Aquilanti, Nicole S Persky, Xiaoping Yang, Erica E Kim, Lisa Brenan, Amy B Goodale, Douglas Alan, Ted Sharpe, Robert E Shue, Lindsay Westlake, Lior Golomb, Brianna R Silverman, Myshal D Morris, Ty Running Fisher, Eden Beyene, Yvonne Y Li, Andrew D Cherniak, Frederica Piccioni, J Kevin Hicks, Andrew S Chi, Daniel P Cahill, Jorg Dietrich, Tracy T Batchelor, David E Root, Cory M Johannessen, Matthew L Meyerson
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods 21 (6) (2024)
Daniel J Merk, Linda Paul, Foteini Tsiami, Helen Hohenthanner, Ghazal Mohseni Kouchesfahani, Lara A Haeusser, Bianca Walter, Adam Brown, Nicole S Persky, David E Root, Ghazaleh Tabatabai
CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines. Genome medicine 16 (1) (2024)
Foteini Tsiami, Chiara Lago, Noemi Pozza, Frederica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E Root, Luca Tiberi, Marcel Kool, Cornelia Brendle, Pratiti Bandopadhayay, Rosalind A Segal, Ghazaleh Tabatabai, Daniel J Merk
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma. Acta neuropathologica communications 12 (1) (2024)
Tikvah K Hayes, Elisa Aquilanti, Nicole S Persky, Xiaoping Yang, Erica E Kim, Lisa Brenan, Amy B Goodale, Douglas Alan, Ted Sharpe, Robert E Shue, Lindsay Westlake, Lior Golomb, Brianna R Silverman, Myshal D Morris, Ty Running Fisher, Eden Beyene, Yvonne Y Li, Andrew D Cherniak, Frederica Piccioni, J Kevin Hicks, Andrew S Chi, Daniel P Cahill, Jorg Dietrich, Tracy T Batchelor, David E Root, Cory M Johannessen, Matthew L Meyerson
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods (2024)
Foteini Tsiami, Chiara Lago, Noemi Pozza, Frederica Piccioni, Xuesong Zhao, Fabienne Lülsberg, David E Root, Luca Tiberi, Marcel Kool, Cornelia Brendle, Pratiti Bandopadhayay, Rosalind A Segal, Ghazaleh Tabatabai, Daniel J Merk
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma. Acta neuropathologica communications 12 (1) (2024)
Tikvah K Hayes, Elisa Aquilanti, Nicole S Persky, Xiaoping Yang, Erica E Kim, Lisa Brenan, Amy B Goodale, Douglas Alan, Ted Sharpe, Robert E Shue, Lindsay Westlake, Lior Golomb, Brianna R Silverman, Myshal D Morris, Ty Running Fisher, Eden Beyene, Yvonne Y Li, Andrew D Cherniak, Frederica Piccioni, J Kevin Hicks, Andrew S Chi, Daniel P Cahill, Jorg Dietrich, Tracy T Batchelor, David E Root, Cory M Johannessen, Matthew L Meyerson
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature communications 15 (1) (2024)
Tikvah K Hayes, Elisa Aquilanti, Nicole S Persky, Xiaoping Yang, Erica E Kim, Lisa Brenan, Amy B Goodale, Douglas Alan, Ted Sharpe, Robert E Shue, Lindsay Westlake, Lior Golomb, Brianna R Silverman, Myshal D Morris, Ty Running Fisher, Eden Beyene, Yvonne Y Li, Andrew D Cherniak, Frederica Piccioni, J Kevin Hicks, Andrew S Chi, Daniel P Cahill, Jorg Dietrich, Tracy T Batchelor, David E Root, Cory M Johannessen, Matthew L Meyerson
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature communications 15 (1) (2024)
Tikvah K Hayes, Elisa Aquilanti, Nicole S Persky, Xiaoping Yang, Erica E Kim, Lisa Brenan, Amy B Goodale, Douglas Alan, Ted Sharpe, Robert E Shue, Lindsay Westlake, Lior Golomb, Brianna R Silverman, Myshal D Morris, Ty Running Fisher, Eden Beyene, Yvonne Y Li, Andrew D Cherniak, Frederica Piccioni, J Kevin Hicks, Andrew S Chi, Daniel P Cahill, Jorg Dietrich, Tracy T Batchelor, David E Root, Cory M Johannessen, Matthew L Meyerson
Author Correction: Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods 21 (6) (2024)
Sean A Misek, Aaron Fultineer, Jérémie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua M Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G Doench, David E Root, James M McFarland, Rameen Beroukhim, Jesse S Boehm
Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries. Nature communications 15 (1) (2024)
Tikvah K Hayes, Elisa Aquilanti, Nicole S Persky, Xiaoping Yang, Erica E Kim, Lisa Brenan, Amy B Goodale, Douglas Alan, Ted Sharpe, Robert E Shue, Lindsay Westlake, Lior Golomb, Brianna R Silverman, Myshal D Morris, Ty Running Fisher, Eden Beyene, Yvonne Y Li, Andrew D Cherniak, Frederica Piccioni, J Kevin Hicks, Andrew S Chi, Daniel P Cahill, Jorg Dietrich, Tracy T Batchelor, David E Root, Cory M Johannessen, Matthew L Meyerson
Author Correction: Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods 21 (6) (2024)
Sean A Misek, Aaron Fultineer, Jérémie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua M Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G Doench, David E Root, James M McFarland, Rameen Beroukhim, Jesse S Boehm
Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries. Nature communications 15 (1) (2024)
Karuna Mittal, Garrett W Cooper, Benjamin P Lee, Yongdong Su, Katie T Skinner, Jenny Shim, Hunter C Jonus, Won Jun Kim, Mihir Doshi, Diego Almanza, Bryan D Kynnap, Amanda L Christie, Xiaoping Yang, Glenn S Cowley, Brittaney A Leeper, Christopher L Morton, Bhakti Dwivedi, Taylor Lawrence, Manali Rupji, Paula Keskula, Stephanie Meyer, Catherine M Clinton, Manoj K Bhasin, Brian D Crompton, Yuen-Yi Tseng, Jesse S Boehm, Keith L Ligon, David E Root, Andrew Jackson Murphy, David M Weinstock, Prafulla C Gokhale, Jennifer M Spangle, Miguel N Rivera, Elizabeth A Mullen, Kimberly Stegmaier, Kelly C Goldsmith, William C Hahn, Andrew L Hong
Targeting TRIP13 in favorable histology Wilms tumor with nuclear export inhibitors synergizes with doxorubicin. Communications biology 7 (1) (2024)
Daniel J Merk, Linda Paul, Foteini Tsiami, Helen Hohenthanner, Ghazal Mohseni Kouchesfahani, Lara A Haeusser, Bianca Walter, Adam Brown, Nicole S Persky, David E Root, Ghazaleh Tabatabai
CRISPR-Cas9 screens reveal common essential miRNAs in human cancer cell lines. Genome medicine 16 (1) (2024)
Tikvah K Hayes, Elisa Aquilanti, Nicole S Persky, Xiaoping Yang, Erica E Kim, Lisa Brenan, Amy B Goodale, Douglas Alan, Ted Sharpe, Robert E Shue, Lindsay Westlake, Lior Golomb, Brianna R Silverman, Myshal D Morris, Ty Running Fisher, Eden Beyene, Yvonne Y Li, Andrew D Cherniak, Frederica Piccioni, J Kevin Hicks, Andrew S Chi, Daniel P Cahill, Jorg Dietrich, Tracy T Batchelor, David E Root, Cory M Johannessen, Matthew L Meyerson
Comprehensive mutational scanning of EGFR reveals TKI sensitivities of extracellular domain mutants. Nature communications 15 (1) (2024)
Sean A Misek, Aaron Fultineer, Jérémie Kalfon, Javad Noorbakhsh, Isabella Boyle, Priyanka Roy, Joshua M Dempster, Lia Petronio, Katherine Huang, Alham Saadat, Thomas Green, Adam Brown, John G Doench, David E Root, James M McFarland, Rameen Beroukhim, Jesse S Boehm
Germline variation contributes to false negatives in CRISPR-based experiments with varying burden across ancestries. Nature communications 15 (1) (2024)
Srinivas Niranj Chandrasekaran, Beth A Cimini, Amy Goodale, Lisa Miller, Maria Kost-Alimova, Nasim Jamali, John G Doench, Briana Fritchman, Adam Skepner, Michelle Melanson, Alexandr A Kalinin, John Arevalo, Marzieh Haghighi, Juan C Caicedo, Daniel Kuhn, Desiree Hernandez, James Berstler, Hamdah Shafqat-Abbasi, David E Root, Susanne E Swalley, Sakshi Garg, Shantanu Singh, Anne E Carpenter
Three million images and morphological profiles of cells treated with matched chemical and genetic perturbations. Nature methods 21 (6) (2024)
Lisa D Cervia, Tsukasa Shibue, Ashir A Borah, Benjamin Gaeta, Linh He, Lisa Leung, Naomi Li, Sydney M Moyer, Brian H Shim, Nancy Dumont, Alfredo E Gonzalez, Nolan R Bick, Mariya Kazachkova, Joshua M Dempster, John Michael Krill-Burger, Frederica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas. Cancer discovery 13 (3) (2023)
Yeying Huang, R Taylor Durall, Nhi M Luong, Hans J Hertzler, Julianna Huang, Prafulla C Gokhale, Brittaney A Leeper, Nicole S Persky, David E Root, Praju Vikas Anekal, Paula Montero Llopis, Clement N David, Jeffery L Kutok, Alejandra Raimondi, Karan Saluja, Jia Luo, Cynthia A Zahnow, Biniam Adane, Kimberly Stegmaier, Catherine E Hawkins, Christopher Ponne, Quan Le, Geoffrey I Shapiro, Madeleine E Lemieux, Kyle P Eagen, Christopher A French
EZH2 synergizes with BRD4-NUT to drive NUT carcinoma growth through silencing of key tumor suppressor genes. Cancer research (2023)
Damon A Hofman, Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R Clauser, Alexandra-Larisa Condurat, Jip T van Dinter, Sem A G Engels, Amy Goodale, Jasper van der Lugt, Tanaz Abid, Li Wang, Kevin N Zhou, Jayne Vogelzang, Keith L Ligon, Timothy N Phoenix, Jennifer A Roth, David E Root, Norbert Hübner, Todd R Golub, Pratiti Bandopadhayay, Sebastiaan van Heesch, John R Prensner
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma. bioRxiv : the preprint server for biology (2023)
Lisa D Cervia, Tsukasa Shibue, Ashir A Borah, Benjamin Gaeta, Linh He, Lisa Leung, Naomi Li, Sydney M Moyer, Brian H Shim, Nancy Dumont, Alfredo E Gonzalez, Nolan R Bick, Mariya Kazachkova, Joshua M Dempster, John Michael Krill-Burger, Frederica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas. Cancer discovery 13 (3) (2023)
Lisa D Cervia, Tsukasa Shibue, Ashir A Borah, Benjamin Gaeta, Linh He, Lisa Leung, Naomi Li, Sydney M Moyer, Brian H Shim, Nancy Dumont, Alfredo E Gonzalez, Nolan R Bick, Mariya Kazachkova, Joshua M Dempster, John Michael Krill-Burger, Frederica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
A Ubiquitination Cascade Regulating the Integrated Stress Response and Survival in Carcinomas. Cancer discovery 13 (3) (2023)
Adrian Mariño-Enriquez, Jan Philipp Novotny, Doga C Gulhan, Isabella Klooster, Antuan V Tran, Macy Kasbo, Meijun Z Lundberg, Wen-Bin Ou, Derrick L Tao, Daniel F Pilco-Janeta, Victor Y Mao, Frank T Zenke, Brittaney A Leeper, Prafulla C Gokhale, Glenn S Cowley, Laurence H Baker, Karla V Ballman, David E Root, Joachim Albers, Peter J Park, Suzanne George, Jonathan A Fletcher
Hyper-Dependence on NHEJ Enables Synergy Between DNA-PK Inhibitors and Low-Dose Doxorubicin in Leiomyosarcoma. Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Damon A Hofman, Jorge Ruiz-Orera, Ian Yannuzzi, Rakesh Murugesan, Adam Brown, Karl R Clauser, Alexandra-Larisa Condurat, Jip T van Dinter, Sem A G Engels, Amy Goodale, Jasper van der Lugt, Tanaz Abid, Li Wang, Kevin N Zhou, Jayne Vogelzang, Keith L Ligon, Timothy N Phoenix, Jennifer A Roth, David E Root, Norbert Hübner, Todd R Golub, Pratiti Bandopadhayay, Sebastiaan van Heesch, John R Prensner
Translation of non-canonical open reading frames as a cancer cell survival mechanism in childhood medulloblastoma. bioRxiv : the preprint server for biology (2023)
Tanaz Abid, Amy B Goodale, Zohra Kalani, Meghan Wyatt, Elizabeth M Gonzalez, Kevin Ning Zhou, Kenin Qian, Dana Novikov, Alexandra-Larisa Condurat, Pratiti Bandopadhayay, Frederica Piccioni, Nicole S Persky, David E Root
Genome-wide pooled CRISPR screening in neurospheres. Nature protocols (2023)
Tanaz Sharifnia, Mathias J Wawer, Amy Goodale, Yenarae Lee, Mariya Kazachkova, Joshua M Dempster, Sandrine Muller, Joan Levy, Daniel M Freed, Josh Sommer, Jérémie Kalfon, Francisca Vazquez, William C Hahn, David E Root, Paul A Clemons, Stuart L Schreiber
Mapping the landscape of genetic dependencies in chordoma. Nature communications 14 (1) (2023)
Prasidda Khadka, Zachary J Reitman, Sophie Lu, Graham Buchan, Gabrielle Gionet, Frank Dubois, Diana M Carvalho, Juliann Shih, Shu Zhang, Noah F Greenwald, Travis Zack, Ofer Shapira, Kristine Pelton, Rachel Hartley, Heather Bear, Yohanna Georgis, Spandana Jarmale, Randy Melanson, Kevin Bonanno, Kathleen Schoolcraft, Peter G Miller, Alexandra L Condurat, Elizabeth M Gonzalez, Kenin Qian, Eric Morin, Jaldeep Langhnoja, Leslie E Lupien, Veronica Rendo, Jeromy Digiacomo, Dayle K Wang, Kevin Ning Zhou, Rushil Kumbhani, Maria E Guerra Garcia, Claire E Sinai, Sarah Becker, Rachel Schneider, Jayne Vogelzang, Karsten Krug, Amy Goodale, Tanaz Abid, Zohra Kalani, Frederica Piccioni, Rameen Beroukhim, Nicole S Persky, David E Root, Angel Montero Carcaboso, Benjamin L Ebert, Christine Fuller, Ozgun Babur, Mark W Kieran, Chris Jones, Hasmik Keshishian, Keith L Ligon, Steven A Carr, Timothy N Phoenix, Pratiti Bandopadhayay
PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation. Nature communications 13 (1) (2022)
Lisa D Cervia, Tsukasa Shibue, Ashir A Borah, Benjamin Gaeta, Linh He, Lisa Leung, Naomi Li, Sydney M Moyer, Brian H Shim, Nancy Dumont, Alfredo E Gonzalez, Nolan R Bick, Mariya Kazachkova, Joshua M Dempster, John Michael Krill-Burger, Frederica Piccioni, Namrata D Udeshi, Meagan E Olive, Steven A Carr, David E Root, James M McFarland, Francisca Vazquez, William C Hahn
A ubiquitination cascade regulating the integrated stress response and survival in carcinomas. Cancer discovery (2022)
Juan Dubrot, Peter P Du, Sarah Kate Lane-Reticker, Emily A Kessler, Audrey J Muscato, Arnav Mehta, Samuel S Freeman, Peter M Allen, Kira E Olander, Kyle M Ockerman, Clara H Wolfe, Fabius Wiesmann, Nelson H Knudsen, Hsiao-Wei Tsao, Arvin Iracheta-Vellve, Emily M Schneider, Andrea N Rivera-Rosario, Ian C Kohnle, Hans W Pope, Austin Ayer, Gargi Mishra, Margaret D Zimmer, Sarah Y Kim, Animesh Mahapatra, Hakimeh Ebrahimi-Nik, Dennie T Frederick, Genevieve M Boland, W Nicholas Haining, David E Root, John G Doench, Nir Hacohen, Kathleen B Yates, Robert T Manguso
In vivo CRISPR screens reveal the landscape of immune evasion pathways across cancer. Nature immunology 23 (10) (2022)
Eshini Panditharatna, Joana G Marques, Tingjian Wang, Maria C Trissal, Ilon Liu, Li Jiang, Alexander Beck, Andrew Groves, Neekesh V Dharia, Deyao Li, Samantha E Hoffman, Guillaume Kugener, McKenzie L Shaw, Hafsa M Mire, Olivia A Hack, Joshua M Dempster, Caleb A Lareau, Lingling Dai, Logan H Sigua, Michael A Quezada, Ann-Catherine J Stanton, Meghan Wyatt, Zohra Kalani, Amy Goodale, Francisca Vazquez, Frederica Piccioni, John G Doench, David E Root, Jamie N Anastas, Kristen L Jones, Amy Saur Conway, Sylwia A Stopka, Michael S Regan, Yu Liang, Hyuk-Soo Seo, Kijun Song, Puspalata Bashyal, William P Jerome, Nathan D Mathewson, Sirano Dhe-Paganon, Mario L Suvà, Angel Montero Carcaboso, Cinzia Lavarino, Jaume Catala-Mora, Quang-De Nguyen, Keith L Ligon, Yang Shi, Sameer Agnihotri, Nathalie Y R Agar, Kimberly Stegmaier, Charles D Stiles, Michelle Monje, Todd R Golub, Jun Qi, Mariella G Filbin
BAF Complex Maintains Glioma Stem Cells in Pediatric H3K27M Glioma. Cancer discovery 12 (12) (2022)
Matthew G Rees, Lisa Brenan, Mariana do Carmo, Patrick Duggan, Besnik Bajrami, Michael Arciprete, Andrew S Boghossian, Emma Vaimberg, Steven J Ferrara, Timothy A Lewis, Danny Rosenberg, Tenzin Sangpo, Jennifer A Roth, Virendar K Kaushik, Federica Piccioni, John G Doench, David E Root, Cory M Johannessen
Systematic identification of biomarker-driven drug combinations to overcome resistance. Nature chemical biology 18 (6) (2022)
Peter G Miller, Murugappan Sathappa, Jamie A Moroco, Wei Jiang, Yue Qian, Sumaiya Iqbal, Qi Guo, Andrew O Giacomelli, Subrata Shaw, Camille Vernier, Besnik Bajrami, Xiaoping Yang, Cerise Raffier, Adam S Sperling, Christopher J Gibson, Josephine Kahn, Cyrus Jin, Matthew J Ranaghan, Alisha Caliman, Merissa Brousseau, Eric S Fischer, Robert Lintner, Federica Piccioni, Arthur J Campbell, David E Root, Colin W Garvie, Benjamin L Ebert
Allosteric inhibition of PPM1D serine/threonine phosphatase via an altered conformational state. Nature communications 13 (1) (2022)
Jason J Kwon, Behnoush Hajian, Xiang-Qun Sean Xie, Lucy C Young, Alvaro J Amor, James R Fuller, Cara V Fraley, Abbey M Sykes, Jonathan So, Joshua Pan, Laura Baker, Sun Joo Lee, Douglas B Wheeler, David L Mayhew, Nicole S Persky, Xiaoping Yang, David E Root, Anthony M Barsotti, Andrew W Stamford, Charles K Perry, Alex Burgin, Frank McCormick, Christopher T Lemke, William C Hahn, Andrew J Aguirre
Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature 609 (7926) (2022)
Daniel P Bondeson, Brenton R Paolella, Adhana Asfaw, Michael V Rothberg, Thomas A Skipper, Carly Langan, Gabriel Mesa, Alfredo Gonzalez, Lauren E Surface, Kentaro Ito, Mariya Kazachkova, William N Colgan, Allison Warren, Joshua M Dempster, John Michael Krill-Burger, Maria Ericsson, Andrew A Tang, Iris Fung, Emily S Chambers, Mai Abdusamad, Nancy Dumont, John G Doench, Federica Piccioni, David E Root, Jesse S Boehm, William C Hahn, Michael Mannstadt, James M McFarland, Francisca Vazquez, Todd R Golub
Phosphate dysregulation via the XPR1-KIDINS220 protein complex is a therapeutic vulnerability in ovarian cancer. Nature cancer 3 (6) (2022)
Ursula S A Stalmann, Fabio Ticconi, Inge A M Snoeren, Ronghui Li, Hélène F E Gleitz, Glenn S Cowley, Marie E McConkey, Aaron Benson Wong, Stephani Schmitz, Stijn N R Fuchs, Shubhankar Sood, Nils Bastian Leimkühler, Sergio Martinez-Høyer, Bella Banjanin, David E Root, Tim Henrik Brümmendorf, Juliette E Pearce, Andreas Schuppert, Eric M J Bindels, Marieke A Essers, Dirk Heckl, Thomas Stiehl, Ivan G Costa, Benjamin L Ebert, Rebekka K Schneider
Genetic barcoding systematically compares genes in del(5q) MDS and reveals a central role for CSNK1A1 in clonal expansion. Blood advances 6 (6) (2022)
Christian Marinaccio, Praveen Suraneni, Hamza Celik, Andrew Volk, Qiang Jeremy Wen, Te Ling, Marinka Bulic, Terra Lasho, Richard P Koche, Christopher A Famulare, Noushin Farnoud, Brady Stein, Michael Schieber, Sandeep Gurbuxani, David E Root, Scott T Younger, Ronald Hoffman, Naseema Gangat, Panagiotis Ntziachristos, Navdeep S Chandel, Ross L Levine, Raajit K Rampal, Grant A Challen, Ayalew Tefferi, John D Crispino
LKB1/STK11 Is a Tumor Suppressor in the Progression of Myeloproliferative Neoplasms. Cancer discovery 11 (6) (2021)
Clare F Malone, Neekesh V Dharia, Guillaume Kugener, Alexandra B Forman, Michael V Rothberg, Mai Abdusamad, Alfredo Gonzalez, Miljan Kuljanin, Amanda L Robichaud, Amy Saur Conway, Joshua M Dempster, Brenton R Paolella, Nancy Dumont, Volker Hovestadt, Joseph D Mancias, Scott T Younger, David E Root, Todd R Golub, Francisca Vazquez, Kimberly Stegmaier
Selective Modulation of a Pan-Essential Protein as a Therapeutic Strategy in Cancer. Cancer discovery 11 (9) (2021)
Takahiro Ito, Michael J Young, Ruitong Li, Sidharth S Jain, Andreas Wernitznig, John Michael Krill-Burger, Christopher T Lemke, Davide Monducci, Diego J Rodriguez, Liang Chang, Sanjukta Dutta, Debjani Pal, Brenton R Paolella, Michael V Rothberg, David E Root, Cory M Johannessen, Laxmi Parida, Gad A Getz, Francisca Vazquez, John G Doench, Mahdi Zamanighomi, William R Sellers
Paralog knockout profiling identifies DUSP4 and DUSP6 as a digenic dependence in MAPK pathway-driven cancers. Nature genetics 53 (12) (2021)
John R Prensner, Oana M Enache, Victor Luria, Karsten Krug, Karl R Clauser, Joshua M Dempster, Amir Karger, Li Wang, Karolina Stumbraite, Vickie M Wang, Ginevra Botta, Nicholas J Lyons, Amy Goodale, Zohra Kalani, Briana Fritchman, Adam Brown, Douglas Alan, Thomas Green, Xiaoping Yang, Jacob D Jaffe, Jennifer A Roth, Federica Piccioni, Marc W Kirschner, Zhe Ji, David E Root, Todd R Golub
Noncanonical open reading frames encode functional proteins essential for cancer cell survival. Nature biotechnology 39 (6) (2021)
N S Persky, D Hernandez, M Do Carmo, L Brenan, O Cohen, S Kitajima, U Nayar, A Walker, S Pantel, Y Lee, J Cordova, M Sathappa, C Zhu, T K Hayes, P Ram, P Pancholi, T S Mikkelsen, D A Barbie, X Yang, Rizwan Haq, Frederica Piccioni, David E Root, Cory M Johannessen
Defining the landscape of ATP-competitive inhibitor resistance residues in protein kinases. Nature structural & molecular biology 27 (1) (2020)
Pingping Mao, Ofir Cohen, Kailey J Kowalski, Justin G Kusiel, Jorge E Buendia-Buendia, Michael S Cuoco, Pedro Exman, Seth A Wander, Adrienne G Waks, Utthara Nayar, Jon H Chung, Samuel S Freeman, Orit Rozenblatt-Rosen, Vincent A Miller, Frederica Piccioni, David E Root, Aviv Regev, Eric P Winer, Nancy U Lin, Nikhil Wagle
Acquired FGFR and FGF Alterations Confer Resistance to Estrogen Receptor (ER) Targeted Therapy in ER+ Metastatic Breast Cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 26 (22) (2020)
Steffen Boettcher, Peter Grant Miller, Rohan Sharma, Marie McConkey, Matthew Joseph Leventhal, Andrei V Krivtsov, Andrew O Giacomelli, Waihay J Wong, Jesi Kim, Sherry Chao, Kari J Kurppa, Xiaoping Yang, Kirsten Milenkowic, Frederica Piccioni, David E Root, Frank G Rücker, Yael Flamand, Donna S Neuberg, R Coleman Lindsley, Pasi A Jänne, William C Hahn, Tyler Jacks, Hartmut Döhner, Scott A Armstrong, Benjamin L Ebert
A dominant-negative effect drives selection of TP53 missense mutations in myeloid malignancies. Science (New York, N.Y.) 365 (6453) (2020)
Charlotte K Milton, Annette J Self, Paul Andrew Clarke, Udai Banerji, Federica Piccioni, David E Root, Steven R Whittaker
A Genome-scale CRISPR Screen Identifies the ERBB and mTOR Signaling Networks as Key Determinants of Response to PI3K Inhibition in Pancreatic Cancer. Molecular cancer therapeutics 19 (7) (2020)
Carla Eller, Laura Heydmann, Che C Colpitts, Houssein El Saghire, Frederica Piccioni, Frank Jühling, Karim Majzoub, Caroline Pons, Charlotte Bach, Julie Lucifora, Joachim Lupberger, Michael Nassal, Glenn S Cowley, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, Emanuele Felli, Patrick Pessaux, Camille Sureau, Catherine Schuster, David E Root, Thomas F Baumert, Thomas F Baumert
A genome-wide gain-of-function screen identifies CDKN2C as a HBV host factor. Nature communications 11 (1) (2020)
Haoxin Li, Shaoyang Ning, Mahmoud Ghandi, Gregory V Kryukov, Shuba Gopal, Amy Deik, Amanda Souza, Kerry Pierce, Paula Keskula, Desiree Hernandez, Julie Ann, Dojna Shkoza, Verena Apfel, Yilong Zou, Francisca Vazquez, Jordi Barretina, Raymond A Pagliarini, Giorgio G Galli, David E Root, William C Hahn, Aviad Tsherniak, Marios Giannakis, Stuart L Schreiber, Andrew T Chan, Levi A Garraway, William R Sellers
The landscape of cancer cell line metabolism. Nature medicine 25 (5) (2019)
Pratiti Bandopadhayay, Frederica Piccioni, Ryan O'Rourke, Patricia Ho, Elizabeth M Gonzalez, Graham Buchan, Kenin Qian, Gabrielle Gionet, Emily Girard, Margo Coxon, Matthew G Rees, Lisa Brenan, Frank Dubois, Ofer Shapira, Noah F Greenwald, Melanie Pages, Amanda Balboni Iniguez, Brenton R Paolella, Alice Meng, Claire Sinai, Giovanni Roti, Neekesh V Dharia, Amanda Creech, Benjamin Tanenbaum, Prasidda Khadka, Adam Tracy, Hong L Tiv, Andrew L Hong, Shannon Coy, Rumana Rashid, Jia-Ren Lin, Glenn S Cowley, Fred C Lam, Amy Goodale, Yenarae Lee, Kathleen Schoolcraft, Francisca Vazquez, William C Hahn, Aviad Tsherniak, James E Bradner, Michael B Yaffe, Till Milde, Stefan M Pfister, Jun Qi, Monica Schenone, Steven A Carr, Keith L Ligon, Mark W Kieran, Sandro Santagata, James M Olson, Prafulla C Gokhale, Jacob D Jaffe, David E Root, Kimberly Stegmaier, Cory M Johannessen, Rameen Beroukhim
Neuronal differentiation and cell-cycle programs mediate response to BET-bromodomain inhibition in MYC-driven medulloblastoma. Nature communications 10 (1) (2019)
Tikvah K Hayes, Flora Luo, Ofir Cohen, Amy B Goodale, Yenarae Lee, Sasha Pantel, Mukta Bagul, Federica Piccioni, David E Root, Levi A Garraway, Matthew Meyerson, Cory M Johannessen
A Functional Landscape of Resistance to MEK1/2 and CDK4/6 Inhibition in NRAS-Mutant Melanoma. Cancer research 79 (9) (2019)
Joshua M Dempster, Clare Pacini, Sasha Pantel, Fiona M Behan, Thomas Green, John Michael Krill-Burger, Charlotte M Beaver, Scott T Younger, Victor Zhivich, Hanna Najgebauer, Felicity Allen, Emanuel Gonçalves, Rebecca Shepherd, John G Doench, Kosuke Yusa, Francisca Vazquez, Leopold Parts, Jesse S Boehm, Todd R Golub, William C Hahn, David E Root, Mathew J Garnett, Aviad Tsherniak, Francesco Iorio
Agreement between two large pan-cancer CRISPR-Cas9 gene dependency data sets. Nature communications 10 (1) (2019)
Gil Redelman-Sidi, Anna Binyamin, Isabella Gaeta, Wilhelm Palm, Craig B Thompson, Paul B Romesser, Scott W Lowe, Mukta Bagul, John G Doench, David E Root, Michael S Glickman
The Canonical Wnt Pathway Drives Macropinocytosis in Cancer. Cancer research 78 (16) (2018)
Matthew G Oser, Raquel Fonseca, Abhishek A Chakraborty, Rachel Brough, Alexander Spektor, Rebecca B Jennings, Abdallah Flaifel, Jesse S Novak, Aditi Gulati, Elizabeth Buss, Scott T Younger, Samuel K McBrayer, Glenn S Cowley, Dennis M Bonal, Quang-De Nguyen, Laura Brulle-Soumare, Paula Taylor, Stefano Cairo, Colm J Ryan, Elizabeth J Pease, Kim Maratea, Jon Travers, David E Root, Sabina Signoretti, David Pellman, Susan Ashton, Christopher J Lord, Simon T Barry, William G Kaelin
Cells Lacking the RB1 Tumor Suppressor Gene Are Hyperdependent on Aurora B Kinase for Survival. Cancer discovery 9 (2) (2018)