Mango "Ataulfo" Peel Extract Improves Metabolic Dysregulation in Prediabetic Wistar Rats.

The hypoglycemic effect of functional phytochemicals has been evaluated in diabetic rodents but scarcely in its premorbid condition (prediabetes; PD). This study aimed to evaluate a mango (cv. Ataulfo) peel hydroethanolic (20:80) extract (MPE) for in vivo glycemic/lipidemic-normalizing effect and in vitro enzyme inhibitory (α-amylase/α-glucosidase) activity. The polyphenolic MPE (138 mg EAG.g -1 , mainly gallic acid and mangiferin) with antioxidant capacity (DPPH• 34 mgTE.g -1 ) was fed to PD rats (induction: high-fat diet (60% energy) + single dose streptozotocin (35 mg·kg -1 ), 4 weeks). At the 8th week, fasting glycemia (FG), oral glucose tolerance test, and insulin sensitivity indexes (HOMA-IR, HOMA-β) > blood lipid-normalizing effect were documented as healthy controls > MPE > disease (PD) controls, which was possibly related to the extract's concentration-response in vitro enzyme inhibitory activity (IC 50 ≈ 0.085 mg·mL -1 ). MPE is a rich source of glucose-lowering phytochemicals for the primary prevention of type 2 diabetes.