Ashley C W Pike

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 14

Top Topics

Structural Basis

Obstructive Sleep Apnea

Angiotensin Converting Enzyme

Top Venues

Nature communications

Nature structural & molecular biology

Science advances

Science (New York, N.Y.)

This page only lists publications with an associated author ORCID identifier.

Publications

Huanyu Z Li, Ashley C W Pike, Irina Lotsaris, Gamma Chi, Jesper S Hansen, Sarah C Lee, Karin E J Rödström, Simon R Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A Burgess-Brown, Robert J Vandenberg, Timothy R Dafforn, Elisabeth P Carpenter, David B Sauer
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2. Nature communications 15 (1) (2024)
Huanyu Z Li, Ashley C W Pike, Irina Lotsaris, Gamma Chi, Jesper S Hansen, Sarah C Lee, Karin E J Rödström, Simon R Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A Burgess-Brown, Robert J Vandenberg, Timothy R Dafforn, Elisabeth P Carpenter, David B Sauer
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2. Nature communications 15 (1) (2024)
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nature communications 15 (1) (2024)
Huanyu Z Li, Ashley C W Pike, Irina Lotsaris, Gamma Chi, Jesper S Hansen, Sarah C Lee, Karin E J Rödström, Simon R Bushell, David Speedman, Adam Evans, Dong Wang, Didi He, Leela Shrestha, Chady Nasrallah, Nicola A Burgess-Brown, Robert J Vandenberg, Timothy R Dafforn, Elisabeth P Carpenter, David B Sauer
Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2. Nature communications 15 (1) (2024)
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nature communications 15 (1) (2024)
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nature communications 15 (1) (2024)
Karin E J Rödström, Alexander Cloake, Janina Sörmann, Agnese Baronina, Kathryn H M Smith, Ashley C W Pike, Jackie Ang, Peter Proks, Marcus Schewe, Ingelise Holland-Kaye, Simon R Bushell, Jenna Elliott, Els Pardon, Thomas Baukrowitz, Raymond J Owens, Simon Newstead, Jan Steyaert, Elisabeth P Carpenter, Stephen J Tucker
Extracellular modulation of TREK-2 activity with nanobodies provides insight into the mechanisms of K2P channel regulation. Nature communications 15 (1) (2024)
Gamma Chi, Larissa Dietz, Haiping Tang, Matthew Snee, Andreea Scacioc, Dong Wang, Gavin Mckinley, Shubhashish M M Mukhopadhyay, Ashley C W Pike, Rod Chalk, Nicola A Burgess-Brown, Jean-Pierre Timmermans, Wouter van Putte, Carol V Robinson, Katharina L Dürr
Structural characterization of human urea transporters UT-A and UT-B and their inhibition. Science advances 9 (39) (2023)
Laiyin Nie, Tomas C Pascoa, Ashley C W Pike, Simon R Bushell, Andrew Quigley, Gian Filippo Ruda, Amy Chu, Victoria Cole, David Speedman, Tiago Moreira, Leela Shrestha, Shubhashish M M Mukhopadhyay, Nicola A Burgess-Brown, James D Love, Paul E Brennan, Elisabeth P Carpenter
The structural basis of fatty acid elongation by the ELOVL elongases. Nature structural & molecular biology 28 (6) (2021)
Karin E J Rödström, Aytuğ K Kiper, Wei Zhang, Susanne Rinné, Ashley C W Pike, Matthias Goldstein, Linus J Conrad, Martina Delbeck, Michael G Hahn, Heinrich Meier, Magdalena Platzk, Andrew Quigley, David Speedman, Leela Shrestha, Shubhashish M M Mukhopadhyay, Nicola A Burgess-Brown, Stephen J Tucker, Thomas Müller, Niels Decher, Elisabeth P Carpenter
A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature 582 (7812) (2020)
Marcus Schewe, Han Sun, Ümit Mert, Alexandra Mackenzie, Ashley C W Pike, Friederike Schulz, Cristina Constantin, Kirsty S Vowinkel, Linus J Conrad, Aytuğ K Kiper, Wendy González, Marianne Musinszki, Marie Tegtmeier, David C Pryde, Hassane Belabed, Marc Nazare, Bert L de Groot, Niels Decher, Bernd Fakler, Elisabeth P Carpenter, Stephen J Tucker, Thomas Baukrowitz
A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science (New York, N.Y.) 363 (6429) (2019)
Simon R Bushell, Ashley C W Pike, Maria E Falzone, Nils J G Rorsman, Chau M Ta, Robin A Corey, Thomas D Newport, John C Christianson, Lara F Scofano, Chitra A Shintre, Annamaria Tessitore, Amy Chu, Qinrui Wang, Leela Shrestha, Shubhashish M M Mukhopadhyay, James D Love, Nicola A Burgess-Brown, Rebecca Sitsapesan, Phillip J Stansfeld, Juha T Huiskonen, Paolo Tammaro, Alessio Accardi, Elisabeth P Carpenter
The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nature communications 10 (1) (2019)
Martin Wilkes, Gregor M Madej, Lydia Kreuter, Daniel Rhinow, Veronika Heinz, Silvia De Sanctis, Sabine Ruppel, Rebecca M Richter, Friederike Joos, Marina Grieben, Ashley C W Pike, Juha T Huiskonen, Elisabeth P Carpenter, Werner Kühlbrandt, Ralph Witzgall, Christine Ziegler
Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2. Nature structural & molecular biology 24 (2) (2017)
Mariana Grieben, Ashley C W Pike, Chitra A Shintre, Elisa Venturi, Sam El-Ajouz, Annamaria Tessitore, Leela Shrestha, Shubhashish Mukhopadhyay, Pravin Mahajan, Rod Chalk, Nicola A Burgess-Brown, Rebecca Sitsapesan, Juha T Huiskonen, Elisabeth P Carpenter
Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2). Nature structural & molecular biology 24 (2) (2016)