Axel Abelein

Publication Activity (10 Years)

Years Active: 2020-2024
Publications (10 Years): 23

Top Topics

Endoplasmic Reticulum

Quality Control

Cognitive Decline

Top Venues

Nature communications

Protein science : a publication of the Protein Society

Communications biology

Accounts of chemical research

This page only lists publications with an associated author ORCID identifier.

Publications

Rakesh Kumar, Tanguy Le Marchand, Laurène Adam, Raitis Bobrovs, Gefei Chen, Jēkabs Fridmanis, Nina Kronqvist, Henrik Biverstål, Kristaps Jaudzems, Jan Johansson, Guido Pintacuda, Axel Abelein
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain. Nature communications 15 (1) (2024)
Rakesh Kumar, Tanguy Le Marchand, Laurène Adam, Raitis Bobrovs, Gefei Chen, Jēkabs Fridmanis, Nina Kronqvist, Henrik Biverstål, Kristaps Jaudzems, Jan Johansson, Guido Pintacuda, Axel Abelein
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain. Nature communications 15 (1) (2024)
Rakesh Kumar, Tanguy Le Marchand, Laurène Adam, Raitis Bobrovs, Gefei Chen, Jēkabs Fridmanis, Nina Kronqvist, Henrik Biverstål, Kristaps Jaudzems, Jan Johansson, Guido Pintacuda, Axel Abelein
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain. Nature communications 15 (1) (2024)
Laurène Adam, Rakesh Kumar, Luis Enrique Arroyo-Garcia, Willem Hendrik Molenkamp, Jan Stanislaw Nowak, Hannah Klute, Azad Farzadfard, Rami Alkenayeh, Janni Nielsen, Henrik Biverstål, Daniel E Otzen, Jan Johansson, Axel Abelein
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS. Protein science : a publication of the Protein Society 33 (8) (2024)
Laurène Adam, Rakesh Kumar, Luis Enrique Arroyo-Garcia, Willem Hendrik Molenkamp, Jan Stanislaw Nowak, Hannah Klute, Azad Farzadfard, Rami Alkenayeh, Janni Nielsen, Henrik Biverstål, Daniel E Otzen, Jan Johansson, Axel Abelein
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS. Protein science : a publication of the Protein Society 33 (8) (2024)
Rakesh Kumar, Tanguy Le Marchand, Laurène Adam, Raitis Bobrovs, Gefei Chen, Jēkabs Fridmanis, Nina Kronqvist, Henrik Biverstål, Kristaps Jaudzems, Jan Johansson, Guido Pintacuda, Axel Abelein
Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain. Nature communications 15 (1) (2024)
Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Xueying Zhong, Anna Belorusova, Gregg Siegal, Caroline Jegerschöld, Philip J B Koeck, Axel Abelein, Hans Hebert, Stefan D Knight, Jan Johansson
Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain. Protein science : a publication of the Protein Society 33 (7) (2024)
Laurène Adam, Rakesh Kumar, Luis Enrique Arroyo-Garcia, Willem Hendrik Molenkamp, Jan Stanislaw Nowak, Hannah Klute, Azad Farzadfard, Rami Alkenayeh, Janni Nielsen, Henrik Biverstål, Daniel E Otzen, Jan Johansson, Axel Abelein
Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS. Protein science : a publication of the Protein Society 33 (8) (2024)
Gefei Chen, Yu Wang, Zihan Zheng, Wangshu Jiang, Axel Leppert, Xueying Zhong, Anna Belorusova, Gregg Siegal, Caroline Jegerschöld, Philip J B Koeck, Axel Abelein, Hans Hebert, Stefan D Knight, Jan Johansson
Molecular basis for different substrate-binding sites and chaperone functions of the BRICHOS domain. Protein science : a publication of the Protein Society 33 (7) (2024)
Gefei Chen, Axel Leppert, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson
Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation. Communications biology 6 (1) (2023)
Gefei Chen, Axel Leppert, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson
Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation. Communications biology 6 (1) (2023)
Axel Abelein
Metal Binding of Alzheimer's Amyloid-β and Its Effect on Peptide Self-Assembly. Accounts of chemical research (2023)
Rakesh Kumar, Luis Enrique Arroyo-García, Shaffi Manchanda, Laurène Adam, Giusy Pizzirusso, Henrik Biverstål, Per Nilsson, André Fisahn, Jan Johansson, Axel Abelein
Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone. ACS chemical neuroscience (2023)
Gefei Chen, Axel Leppert, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson
Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation. Communications biology 6 (1) (2023)
Axel Abelein, Jan Johansson
Amyloid inhibition by molecular chaperones in vitro can be translated to Alzheimer's pathology in vivo . RSC medicinal chemistry 14 (5) (2023)
Gefei Chen, Axel Leppert, Helen Poska, Harriet E Nilsson, Carlos Piedrafita Alvira, Xueying Zhong, Philip Koeck, Caroline Jegerschöld, Axel Abelein, Hans Hebert, Jan Johansson
Short hydrophobic loop motifs in BRICHOS domains determine chaperone activity against amorphous protein aggregation but not against amyloid formation. Communications biology 6 (1) (2023)
Mirjam Brackhan, Giulio Calza, Kristiina Lundgren, Pablo Bascuñana, Thomas Brüning, Rabah Soliymani, Rakesh Kumar, Axel Abelein, Marc Baumann, Maciej M Lalowski, Jens Pahnke
Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration. EMBO reports 23 (7) (2022)
Xueying Zhong, Rakesh Kumar, Yu Wang, Henrik Biverstål, Caroline Ingeborg Jegerschöld, Philip J B Koeck, Jan Johansson, Axel Abelein, Gefei Chen
Amyloid Fibril Formation of Arctic Amyloid-β 1-42 Peptide is Efficiently Inhibited by the BRICHOS Domain. ACS chemical biology 17 (8) (2022)
Gefei Chen, Yuniesky Andrade-Talavera, Xueying Zhong, Sameer Hassan, Henrik Biverstål, Helen Poska, Axel Abelein, Axel Leppert, Nina Kronqvist, Anna Rising, Hans Hebert, Philip J B Koeck, André Fisahn, Jan Johansson
Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue. RSC chemical biology 3 (11) (2022)
Axel Abelein, Simone Ciofi-Baffoni, Cecilia Mörman, Rakesh Kumar, Andrea Giachetti, Mario Piccioli, Henrik Biverstål
Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease. JACS Au 2 (11) (2022)
Tina Arndt, Kristaps Jaudzems, Olga Shilkova, Juanita Francis, Mathias Johansson, Peter R Laity, Cagla Sahin, Urmimala Chatterjee, Nina Kronqvist, Edgar Barajas-Ledesma, Rakesh Kumar, Gefei Chen, Roger Strömberg, Axel Abelein, Maud Langton, Michael Landreh, Andreas Barth, Chris Holland, Jan Johansson, Anna Rising
Spidroin N-terminal domain forms amyloid-like fibril based hydrogels and provides a protein immobilization platform. Nature communications 13 (1) (2022)
Axel Leppert, Ann Tiiman, Nina Kronqvist, Michael Landreh, Axel Abelein, Vladana Vukojevic, Jan Johansson
Smallest Secondary Nucleation Competent Aβ Aggregates Probed by an ATP-Independent Molecular Chaperone Domain. Biochemistry 60 (9) (2021)
Gefei Chen, Yuniesky Andrade-Talavera, Simone Tambaro, Axel Leppert, Harriet E Nilsson, Xueying Zhong, Michael Landreh, Per Nilsson, Hans Hebert, Henrik Biverstål, André Fisahn, Axel Abelein, Jan Johansson
Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro. Communications biology 3 (1) (2020)