Your account is not claimed yet. You can sign up with ORCID to claim your account.

Chao-Yie Yang

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2023
Publications (10 Years): 27

Top Venues

Journal of medicinal chemistry

ACS pharmacology & translational science

ACS medicinal chemistry letters

The journal of physical chemistry. B

University of Michigan

Case Western Reserve University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Michigan Apr 1o 2019

United States

Adjunct Research Associate Scientist :: Internal Medicine

Education History

Case Western Reserve University Sep 1o 1991 - Aug 31o 1996

United States

PHD :: Chemistry

Publications

Xinrui Yuan, Hua Jiang, Denggang Fu, Jason C Rech, Aaron Robida, Krishani Rajanayake, Hebao Yuan, Miao He, Bo Wen, Duxin Sun, Chen Liu, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Sophie Paczesny, Chao-Yie Yang
Prophylactic Mitigation of Acute Graft versus Host Disease by Novel 2-(Pyrrolidin-1-ylmethyl)pyrrole-Based Stimulation-2 (ST2) Inhibitors. ACS pharmacology & translational science 6 (9) (2023)
Madison N Sluter, Rajib Bhuniya, Xinrui Yuan, Andhavaram Ramaraju, Yu Chen, Ying Yu, Keyur R Parmar, Zaid H Temrikar, Ashish Srivastava, Bernd Meibohm, Jianxiong Jiang, Chao-Yie Yang
Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo . ACS pharmacology & translational science 6 (4) (2023)
Canhui Zheng, Rohan Kalyan Rej, Mi Wang, Liyue Huang, Ester Fernandez-Salas, Chao-Yie Yang, Shaomeng Wang
Discovery of Pyrrolo[2,3- c ]pyridines as Potent and Reversible LSD1 Inhibitors. ACS medicinal chemistry letters 14 (10) (2023)
Madison N Sluter, Rajib Bhuniya, Xinrui Yuan, Andhavaram Ramaraju, Yu Chen, Ying Yu, Keyur R Parmar, Zaid H Temrikar, Ashish Srivastava, Bernd Meibohm, Jianxiong Jiang, Chao-Yie Yang
Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo . ACS pharmacology & translational science 6 (4) (2023)
Madison N Sluter, Rajib Bhuniya, Xinrui Yuan, Andhavaram Ramaraju, Yu Chen, Ying Yu, Keyur R Parmar, Zaid H Temrikar, Ashish Srivastava, Bernd Meibohm, Jianxiong Jiang, Chao-Yie Yang
Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo . ACS pharmacology & translational science 6 (4) (2023)
Madison N Sluter, Rajib Bhuniya, Xinrui Yuan, Andhavaram Ramaraju, Yu Chen, Ying Yu, Keyur R Parmar, Zaid H Temrikar, Ashish Srivastava, Bernd Meibohm, Jianxiong Jiang, Chao-Yie Yang
Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo . ACS pharmacology & translational science 6 (4) (2023)
Xin Han, Lijie Zhao, Weiguo Xiang, Bukeyan Miao, Chong Qin, Mi Wang, Tianfeng Xu, Donna McEachern, Jianfeng Lu, Yu Wang, Hoda Metwally, Chao-Yie Yang, Paul D Kirchhoff, Lu Wang, Aleksas Matvekas, John Takyi-Williams, Bo Wen, Duxin Sun, Mark Ator, Robert Mckean, Shaomeng Wang
Discovery of ARD-2051 as a Potent and Orally Efficacious Proteolysis Targeting Chimera (PROTAC) Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. Journal of medicinal chemistry (2023)
Madison N Sluter, Rajib Bhuniya, Xinrui Yuan, Andhavaram Ramaraju, Yu Chen, Ying Yu, Keyur R Parmar, Zaid H Temrikar, Ashish Srivastava, Bernd Meibohm, Jianxiong Jiang, Chao-Yie Yang
Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo . ACS pharmacology & translational science 6 (4) (2023)
Weiguo Xiang, Lijie Zhao, Xin Han, Tianfeng Xu, Steven Kregel, Mi Wang, Bukeyan Miao, Chong Qin, Mingliang Wang, Donna McEachern, Jianfeng Lu, Longchuan Bai, Chao-Yie Yang, Paul D Kirchhoff, John Takyi-Williams, Lu Wang, Bo Wen, Duxin Sun, Mark Ator, Robert Mckean, Arul M Chinnaiyan, Shaomeng Wang
Discovery of ARD-1676 as a Highly Potent and Orally Efficacious AR PROTAC Degrader with a Broad Activity against AR Mutants for the Treatment of AR + Human Prostate Cancer. Journal of medicinal chemistry (2023)
Xinrui Yuan, Kathryn L Howie, Mona Kazemi Sabzvar, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Chao-Yie Yang
Correction to "Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains". ACS medicinal chemistry letters 14 (5) (2023)
Xinrui Yuan, Kathryn L Howie, Mona Kazemi Sabzvar, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Chao-Yie Yang
Profiling the Binding Activities of Peptides and Inhibitors to the U2 Auxiliary Factor Homology Motif (UHM) Domains. ACS medicinal chemistry letters 14 (4) (2023)
Upendra Mahat, Bhavuk Garg, Chao-Yie Yang, Hrishikesh Mehta, Rabi Hanna, Heesun Joyce Rogers, Aron Flagg, Andrei I Ivanov, Seth J Corey
Lymphocyte cytosolic protein 1 (L-plastin) I232F mutation impairs granulocytic proliferation and causes neutropenia. Blood advances 6 (8) (2022)
Xinrui Yuan, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Chao-Yie Yang
Computational Cosolvent Mapping Analysis Leads to Identify Salicylic Acid Analogs as Weak Inhibitors of ST2 and IL33 Binding. The journal of physical chemistry. B 126 (12) (2022)
Rajib Bhuniya, Xinrui Yuan, Longchuan Bai, Kathryn L Howie, Rui Wang, Wei Li, Frank Park, Chao-Yie Yang
Design, Synthesis, and Biological Evaluation of Apcin-Based CDC20 Inhibitors. ACS medicinal chemistry letters 13 (2) (2022)
Jing Deng, Aneel Paulus, Douglas D Fang, Alak Manna, Guangfeng Wang, Hengbang Wang, Saijie Zhu, Jianyong Chen, Ping Min, Yan Yin, Navnita Dutta, Nabanita Halder, Gina Ciccio, John A Copland, James Miller, Bing Han, Longchuan Bai, Liu Liu, Mi Wang, Donna McEachern, Sally Przybranowski, Chao-Yie Yang, Jeanne A Stuckey, De-Pei Wu, Caixia Li, Jeremy Adam Ryan, Anthony G Letai, Sikander Ailawadhi, Dajun Yang, Shaomeng Wang, Asher A Chanan-Khan, Yifan Zhai
Lisaftoclax (APG-2575) is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Simona Pagliuca, Carmelo Gurnari, Hassan Awada, Ashwin Kishtagari, Sunisa Kongkiatkamon, Laila Terkawi, Misam Zawit, Yihong Guan, Thomas LaFramboise, Babal Kant Jha, Bhumika J Patel, Betty K Hamilton, Navneet S Majhail, Sofie A Lundgren, Mohamed El Missiry, Yogen Saunthararajah, Valeria Visconte, Timothy Chan, Chao-Yie Yang, Tobias Lenz, Jaroslaw P Maciejewski
The Similarity of Class II HLA Genotypes Defines Patterns of Autoreactivity in Idiopathic Bone Marrow Failure Disorders. Blood (2021)
Haibin Zhou, Longchuan Bai, Renqi Xu, Donna McEachern, Krishnapriya Chinnaswamy, Ruiting Li, Bo Wen, Mi Wang, Chao-Yie Yang, Jennifer L Meagher, Duxin Sun, Jeanne A Stuckey, Shaomeng Wang
SD-91 as A Potent and Selective STAT3 Degrader Capable of Achieving Complete and Long-Lasting Tumor Regression. ACS medicinal chemistry letters 12 (6) (2021)
Haibin Zhou, Jianfeng Lu, Krishnapriya Chinnaswamy, Jeanne A Stuckey, Liu Liu, Donna McEachern, Chao-Yie Yang, Denzil Bernard, Hong Shen, Liangyou Rui, Yi Sun, Shaomeng Wang
Selective inhibition of cullin 3 neddylation through covalent targeting DCN1 protects mice from acetaminophen-induced liver toxicity. Nature communications 12 (1) (2021)
Rohan Kalyan Rej, Changwei Wang, Jianfeng Lu, Mi Wang, Elyse Petrunak, Kaitlin P Zawacki, Donna McEachern, Chao-Yie Yang, Lu Wang, Ruiting Li, Krishnapriya Chinnaswamy, Bo Wen, Duxin Sun, Jeanne A Stuckey, Yunlong Zhou, Jianyong Chen, Guozhi Tang, Shaomeng Wang
Discovery of EEDi-5273 as an Exceptionally Potent and Orally Efficacious EED Inhibitor Capable of Achieving Complete and Persistent Tumor Regression. Journal of medicinal chemistry 64 (19) (2021)
Rohan Kalyan Rej, Changwei Wang, Jianfeng Lu, Mi Wang, Elyse Petrunak, Kaitlin P Zawacki, Donna McEachern, Ester Fernandez-Salas, Chao-Yie Yang, Lu Wang, Ruiting Li, Krishnapriya Chinnaswamy, Bo Wen, Duxin Sun, Jeanne Stuckey, Yunlong Zhou, Jianyong Chen, Guozhi Tang, Shaomeng Wang
EEDi-5285: An Exceptionally Potent, Efficacious, and Orally Active Small-Molecule Inhibitor of Embryonic Ectoderm Development. Journal of medicinal chemistry 63 (13) (2020)
Mingliang Wang, Jianfeng Lu, Mi Wang, Chao-Yie Yang, Shaomeng Wang
Discovery of SHP2-D26 as a First, Potent, and Effective PROTAC Degrader of SHP2 Protein. Journal of medicinal chemistry 63 (14) (2020)
Xinrui Yuan, Hong Bu, Jinpei Zhou, Chao-Yie Yang, Huibin Zhang
Recent Advances of SHP2 Inhibitors in Cancer Therapy: Current Development and Clinical Application. Journal of medicinal chemistry 63 (20) (2020)
Jianyong Chen, Yunlong Zhou, Xuyuan Dong, Liu Liu, Longchuan Bai, Donna McEachern, Sally Przybranowski, Chao-Yie Yang, Jeanne Stuckey, Xiaoqin Li, Bo Wen, Ting Zhao, Siwei Sun, Duxin Sun, Lingling Jiao, Yu Jing, Ming Guo, Dajun Yang, Shaomeng Wang
Discovery of CJ-2360 as a Potent and Orally Active Inhibitor of Anaplastic Lymphoma Kinase Capable of Achieving Complete Tumor Regression. Journal of medicinal chemistry 63 (22) (2020)
Jiuling Yang, Yangbing Li, Angelo Aguilar, Zhaomin Liu, Chao-Yie Yang, Shaomeng Wang
Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. Journal of medicinal chemistry 62 (21) (2019)
Haibin Zhou, Longchuan Bai, Renqi Xu, Yujun Zhao, Jianyong Chen, Donna McEachern, Krishnapriya Chinnaswamy, Bo Wen, Lipeng Dai, Praveen Kumar, Chao-Yie Yang, Zhaomin Liu, Mi Wang, Liu Liu, Jennifer L Meagher, Han Yi, Duxin Sun, Jeanne A Stuckey, Shaomeng Wang
Structure-Based Discovery of SD-36 as a Potent, Selective, and Efficacious PROTAC Degrader of STAT3 Protein. Journal of medicinal chemistry 62 (24) (2019)
Chao-Yie Yang, Shaomeng Wang
Allosteric Inactivation of Polycomb Repressive Complex 2 (PRC2) by Inhibiting Its Adapter Protein: Embryonic Ectodomain Development (EED). Journal of medicinal chemistry 60 (6) (2017)
Yujun Zhao, Longchuan Bai, Liu Liu, Donna McEachern, Jeanne A Stuckey, Jennifer L Meagher, Chao-Yie Yang, Xu Ran, Bing Zhou, Yang Hu, Xiaoqin Li, Bo Wen, Ting Zhao, Siwei Li, Duxin Sun, Shaomeng Wang
Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. Journal of medicinal chemistry 60 (9) (2017)

Chao-Yie Yang.css-eqlu8i{font-size:small;padding-left:4px;}

Publication Activity (10 Years)

Top Topics

Top Venues

Chao-Yie Yang