Anthony G Letai (Anthony Letai)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 44

Top Topics

Acute Myeloid Leukemia

Multiple Myeloma

Top Venues

Blood cancer discovery

Nature communications

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Elyse A Olesinski, Karanpreet Singh Bhatia, Chuqi Wang, Marissa S Pioso, Xiao Xian Lin, Ahmed M Mamdouh, Shu Xuan Ng, Vedant Sandhu, Shaista Shabbir Jasdanwala, Binyam Yilma, Stephan Bohl, Jeremy Adam Ryan, Disha Malani, Marlise R Luskin, Olli Kallioniemi, Kimmo Porkka, Sophia Adamia, Wee-Joo Chng, Motomi Osato, David M Weinstock, Jacqueline S Garcia, Anthony G Letai, Shruti Bhatt
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts. Blood cancer discovery (2024)
Elyse A Olesinski, Karanpreet Singh Bhatia, Chuqi Wang, Marissa S Pioso, Xiao Xian Lin, Ahmed M Mamdouh, Shu Xuan Ng, Vedant Sandhu, Shaista Shabbir Jasdanwala, Binyam Yilma, Stephan Bohl, Jeremy Adam Ryan, Disha Malani, Marlise R Luskin, Olli Kallioniemi, Kimmo Porkka, Sophia Adamia, Wee-Joo Chng, Motomi Osato, David M Weinstock, Jacqueline S Garcia, Anthony G Letai, Shruti Bhatt
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts. Blood cancer discovery 5 (3) (2024)
Elyse A Olesinski, Karanpreet Singh Bhatia, Chuqi Wang, Marissa S Pioso, Xiao Xian Lin, Ahmed M Mamdouh, Shu Xuan Ng, Vedant Sandhu, Shaista Shabbir Jasdanwala, Binyam Yilma, Stephan Bohl, Jeremy Adam Ryan, Disha Malani, Marlise R Luskin, Olli Kallioniemi, Kimmo Porkka, Sophia Adamia, Wee-Joo Chng, Motomi Osato, David M Weinstock, Jacqueline S Garcia, Anthony G Letai, Shruti Bhatt
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts. Blood cancer discovery 5 (3) (2024)
Patrick D Bhola, Anthony G Letai
The Siren Song of Synergy. Blood cancer discovery 5 (2) (2024)
Felix Korell, Michael L Olson, Diego Salas-Benito, Mark B Leick, Rebecca C Larson, Amanda Bouffard, Harrison Silva, Alessandro Gasparetto, Trisha R Berger, Michael C Kann, Markus Mergen, Tamina Kienka, Marc Wehrli, Nicholas J Haradhvala, Stefanie R Bailey, Anthony G Letai, Marcela V Maus
Comparative analysis of Bcl-2 family protein overexpression in CAR T cells alone and in combination with BH3 mimetics. Science translational medicine 16 (750) (2024)
Patrick D Bhola, Anthony G Letai
The Siren Song of Synergy. Blood cancer discovery 5 (2) (2024)
Elyse A Olesinski, Karanpreet Singh Bhatia, Chuqi Wang, Marissa S Pioso, Xiao Xian Lin, Ahmed M Mamdouh, Shu Xuan Ng, Vedant Sandhu, Shaista Shabbir Jasdanwala, Binyam Yilma, Stephan Bohl, Jeremy Adam Ryan, Disha Malani, Marlise R Luskin, Olli Kallioniemi, Kimmo Porkka, Sophia Adamia, Wee-Joo Chng, Motomi Osato, David M Weinstock, Jacqueline S Garcia, Anthony G Letai, Shruti Bhatt
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts. Blood cancer discovery 5 (3) (2024)
Patrick D Bhola, Anthony G Letai
The Siren Song of Synergy. Blood cancer discovery 5 (2) (2024)
Patrick D Bhola, Anthony G Letai
The Siren Song of Synergy. Blood cancer discovery (2024)
Elyse A Olesinski, Karanpreet Singh Bhatia, Chuqi Wang, Marissa S Pioso, Xiao Xian Lin, Ahmed M Mamdouh, Shu Xuan Ng, Vedant Sandhu, Shaista Shabbir Jasdanwala, Binyam Yilma, Stephan Bohl, Jeremy Adam Ryan, Disha Malani, Marlise R Luskin, Olli Kallioniemi, Kimmo Porkka, Sophia Adamia, Wee-Joo Chng, Motomi Osato, David M Weinstock, Jacqueline S Garcia, Anthony G Letai, Shruti Bhatt
Acquired Multidrug Resistance in AML Is Caused by Low Apoptotic Priming in Relapsed Myeloblasts. Blood cancer discovery 5 (3) (2024)
Felix Korell, Michael L Olson, Diego Salas-Benito, Mark B Leick, Rebecca C Larson, Amanda Bouffard, Harrison Silva, Alessandro Gasparetto, Trisha R Berger, Michael C Kann, Markus Mergen, Tamina Kienka, Marc Wehrli, Nicholas J Haradhvala, Stefanie R Bailey, Anthony G Letai, Marcela V Maus
Comparative analysis of Bcl-2 family protein overexpression in CAR T cells alone and in combination with BH3 mimetics. Science translational medicine 16 (750) (2024)
Danielle S Potter, Ruochen Du, Stephan R Bohl, Kin-Hoe Chow, Keith L Ligon, Raphael Bueno, Anthony G Letai
Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma. Nature communications 14 (1) (2023)
Danielle S Potter, Ruochen Du, Stephan R Bohl, Kin-Hoe Chow, Keith L Ligon, Raphael Bueno, Anthony G Letai
Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma. Nature communications 14 (1) (2023)
Danielle S Potter, Ruochen Du, Stephan R Bohl, Kin-Hoe Chow, Keith L Ligon, Raphael Bueno, Anthony G Letai
Dynamic BH3 profiling identifies pro-apoptotic drug combinations for the treatment of malignant pleural mesothelioma. Nature communications 14 (1) (2023)
Emmalyn Lecky, Atreyi Mukherji, Rebecca German, Gabriella Antonellis, Jia-Ren Lin, Michael Yorsz, Kelley E McQueeney, Jeremy Adam Ryan, Kimmie Ng, Ewa Sicinska, Peter Karl Sorger, Anthony G Letai, Patrick D Bhola
Sequential apoptotic and multiplexed proteomic evaluation of single cancer cells. Science advances 9 (25) (2023)
Alexandra L Pourzia, Michael L Olson, Stefanie R Bailey, Angela C Boroughs, Aditi Aryal, Jeremy Adam Ryan, Marcela V Maus, Anthony G Letai
Quantifying requirements for mitochondrial apoptosis in CAR T killing of cancer cells. Cell death & disease 14 (4) (2023)
Anthony G Letai
Functional Precision Medicine: Putting Drugs on Patient Cancer Cells and Seeing What Happens. Cancer discovery 12 (2) (2022)
Anthony G Letai
Apoptosis: Directly Targeted at Last. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 40 (15) (2022)
Kimberly Bodaar, Natsuko Yamagata, Anais Barthe, Jack Landrigan, Triona Ni Chonghaile, Melissa Burns, Kristen E Stevenson, Meenakshi Devidas, Mignon L Loh, Stephen P Hunger, Brent Wood, Lewis B Silverman, David Trent Teachey, Jules P P Meijerink, Anthony G Letai, Alejandro Gutierrez
JAK3 mutations and mitochondrial apoptosis resistance in T-cell acute lymphoblastic leukemia. Leukemia 36 (6) (2022)
Sophia Adamia, Shruti Bhatt, Kenneth Wen, Zuzana Chyra, Geoffrey G Fell, Yu-Tzu Tai, Marisa S Pioso, Ivane Abiatari, Anthony G Letai, David M Dorfman, Teru Hideshima, Kenneth C Anderson
Combination therapy targeting Erk1/2 and CDK4/6i in relapsed refractory multiple myeloma. Leukemia 36 (4) (2022)
Brandon J Aubrey, Jevon A Cutler, Wallace Bourgeois, Katherine A Donovan, Shengqing Gu, Charles Hatton, Sarah Perlee, Florian Perner, Homa Rahnamoun, Alexandra C P Theall, Jill A Henrich, Qian Zhu, Radosław P Nowak, Young Joon Kim, Salma Parvin, Anjali Cremer, Sarah Naomi Olsen, Nicholas A Eleuteri, Yana Pikman, Gerard M McGeehan, Kimberly Stegmaier, Anthony G Letai, Eric S Fischer, X Shirley Liu, Scott A Armstrong
IKAROS and MENIN coordinate therapeutically actionable leukemogenic gene expression in MLL-r acute myeloid leukemia. Nature cancer 3 (5) (2022)
Jing Deng, Aneel Paulus, Douglas D Fang, Alak Manna, Guangfeng Wang, Hengbang Wang, Saijie Zhu, Jianyong Chen, Ping Min, Yan Yin, Navnita Dutta, Nabanita Halder, Gina Ciccio, John A Copland Iii, James L Miller, Bing Han, Longchuan Bai, Liu Liu, Mi Wang, Donna McEachern, Sally Przybranowski, Chao-Yie Yang, Jeanne A Stuckey, De-Pei Wu, Caixia Li, Jeremy Adam Ryan, Anthony G Letai, Sikandar Ailawadhi, Dajun Yang, Shaomeng Wang, Asher A Chanan-Khan, Yifan Zhai
Lisaftoclax (APG-2575) is a Novel BCL-2 Inhibitor with Robust Antitumor Activity in Preclinical Models of Hematologic Malignancy. Clinical cancer research : an official journal of the American Association for Cancer Research (2022)
Qi Zhang, Bridget Riley-Gillis, Lina Han, Yannan Jia, Alessia Lodi, Haijiao Zhang, Saravanan Ganesan, Rongqing Pan, Sergej N Konoplev, Shannon R Sweeney, Jeremy Adam Ryan, Yulia Jitkova, Kenneth Dunner, Shaun E Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Wencai Ma, Stephen Kurtz, Vivian R Ruvolo, Helen Ma, Connie C Weng, Cassandra L Ramage, Natalia Baran, Ce Shi, Tianyu Cai, Richard Eric Davis, Venkata Lokesh Battula, Yingchang Mi, Jing Wang, Courtney D DiNardo, Michael Andreeff, Jeffery W Tyner, Aaron Schimmer, Anthony G Letai, Rose Ann Padua, Carlos E Bueso-Ramos, Stefano Tiziani, Joel Leverson, Relja Popovic, Marina Konopleva
Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia. Signal transduction and targeted therapy 7 (1) (2022)
Matthew L Hemming, Patrick Bhola, Michael A Loycano, Justin A Anderson, Madeleine L Taddei, Leona A Doyle, Elizaveta Lavrova, Jessica L Andersen, Kelly S Klega, Morgan R Benson, Brian D Crompton, Chandrajit P Raut, Suzanne George, Anthony G Letai, George D Demetri, Ewa Sicinska
Preclinical Modeling of Leiomyosarcoma Identifies Susceptibility to Transcriptional CDK Inhibitors through Antagonism of E2F-Driven Oncogenic Gene Expression. Clinical cancer research : an official journal of the American Association for Cancer Research 28 (11) (2022)
Qi Zhang, Bridget Riley-Gillis, Lina Han, Yannan Jia, Alessia Lodi, Haijiao Zhang, Saravanan Ganesan, Rongqing Pan, Sergej N Konoplev, Shannon R Sweeney, Jeremy Adam Ryan, Yulia Jitkova, Kenneth Dunner, Shaun E Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Wencai Ma, Stephen Kurtz, Vivian R Ruvolo, Helen Ma, Connie C Weng, Cassandra L Ramage, Natalia Baran, Ce Shi, Tianyu Cai, Richard Eric Davis, Venkata Lokesh Battula, Yingchang Mi, Jing Wang, Courtney D DiNardo, Michael Andreeff, Jeffery W Tyner, Aaron Schimmer, Anthony G Letai, Rose Ann Padua, Carlos E Bueso-Ramos, Stefano Tiziani, Joel Leverson, Relja Popovic, Marina Konopleva
Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia. Signal transduction and targeted therapy 7 (1) (2022)
Anat Biran, Shanye Yin, Helene Kretzmer, Elisa Ten Hacken, Salma Parvin, Jennifer A Woyach, Mohamed Uduman, Catherine Gutierrez, Nathan Dangle, Leah Billington, Fara Faye Regis, Laura Z Rassenti, Arman Mohammad, Gabriela Brunsting Hoffmann, Kristen Stevenson, Mei Zheng, Elizabeth Witten, Stacey Fernandes, Eugen Tausch, Clare Sun, Stephan Stilgenbauer, Jennifer R Brown, Thomas J Kipps, Jon C Aster, Andreas Gnirke, Donna S Neuberg, Anthony G Letai, Lili Wang, Ruben D Carrasco, Alexander Meissner, Catherine J Wu
Activation of Notch and Myc signaling via B cell-restricted depletion of Dnmt3a generates a consistent murine model of chronic lymphocytic leukemia. Cancer research (2021)
Philippe Pihán, Fernanda Lisbona, Janina Borgonovo, Sandra Edwards-Jorquera, Paula Nunes-Hasler, Karen Castillo, Oliver Kepp, Hery Urra, Suvi Saarnio, Helena Vihinen, Amado Carreras-Sureda, Sabrina Forveille, Allan Sauvat, Daniela De Giorgis, Amaury Pupo, Diego A Rodriguez, Giovanni Quarato, Alfredo I Sagredo, Fernanda Lourido, Anthony G Letai, Ramon Latorre, Guido Kroemer, Nicolas Demaurex, Eija S Jokitalo, Miguel L Concha, Álvaro Glavic, Douglas R Green, Claudio Hetz
Control of lysosomal-mediated cell death by the pH-dependent calcium channel RECS1. Science advances 7 (46) (2021)
Veerle W Daniels, Jason J Zoeller, Nick van Gastel, Kelley E McQueeney, Salma Parvin, Danielle S Potter, Geoffrey G Fell, Vinícius G Ferreira, Binyam Yilma, Rajat Gupta, Johan K E Spetz, Patrick D Bhola, Jennifer E Endress, Isaac S Harris, Emanuel Carrilho, Kristopher A Sarosiek, David T Scadden, Joan S Brugge, Anthony G Letai
Metabolic perturbations sensitize triple-negative breast cancers to apoptosis induced by BH3 mimetics. Science signaling 14 (686) (2021)
Danielle S Potter, Ruochen Du, Patrick Bhola, Raphael Bueno, Anthony G Letai
Dynamic BH3 profiling identifies active BH3 mimetic combinations in non-small cell lung cancer. Cell death & disease 12 (8) (2021)
Jorge Gomez Tejeda Zanudo, Pingping Mao, Clara Alcon, Kailey Kowalski, Gabriela N Johnson, Guotai Xu, Jose Baselga, Maurizio Scaltriti, Anthony G Letai, Joan Montero, Reka Albert, Nikhil Wagle
Cell Line-Specific Network Models of ER+ Breast Cancer Identify Potential PI3Kα Inhibitor Resistance Mechanisms and Drug Combinations. Cancer research 81 (17) (2021)
Francisco J Sánchez Rivera, Jeremy Adam Ryan, Yadira M Soto-Feliciano, Mary Clare Beytagh, Lucius Xuan, David M Feldser, Michael T Hemann, Jesse Zamudio, Nadya Dimitrova, Anthony G Letai, Tyler Jacks
Mitochondrial apoptotic priming is a key determinant of cell fate upon p53 restoration. Proceedings of the National Academy of Sciences of the United States of America 118 (23) (2021)
Shan Lin, Clement Larrue, Nastassja K Scheidegger, Bo Kyung Alex Seong, Neekesh V Dharia, Miljan Kuljanin, Caroline S Wechsler, Guillaume Kugener, Amanda L Robichaud, Amy Saur Conway, Thelma Mashaka, Sarah Mouche, Biniam Adane, Jeremy Adam Ryan, Joseph D Mancias, Scott T Younger, Frederica Piccioni, Lynn H Lee, Mark Wunderlich, Anthony G Letai, Jerome Tamburini, Kimberly Stegmaier
An in vivo CRISPR screening platform for prioritizing therapeutic targets in AML. Cancer discovery (2021)
Catherine Gutierrez, Aziz M Al'Khafaji, Eric Brenner, Kaitlyn E Johnson, Satyen H Gohil, Ziao Lin, Binyamin Asher Knisbacher, Russell E Durrett, Shuqiang Li, Salma Parvin, Anat Biran, Wandi Zhang, Laura Rassenti, Thomas J Kipps, Kenneth J Livak, Donna S Neuberg, Anthony G Letai, Gad A Getz, Catherine J Wu, Amy Brock
Multifunctional barcoding with ClonMapper enables high-resolution study of clonal dynamics during tumor evolution and treatment. Nature cancer 2 (7) (2021)
Eleni Skourti, Anthony G Letai
In Conversation with Tony Letai. The FEBS journal 288 (21) (2021)
Ryan N Rys, Claudia M Wever, Dominique Geoffrion, Christophe Goncalves, Artin Ghassemian, Eugene Brailovski, Jeremy Adam Ryan, Liliana Stoica, Josée Hébert, Tina Petrogiannis-Haliotis, Svetlana Dmitrienko, Saul Frenkiel, Annette M Staiger, German Ott, Christian Steidl, David W Scott, Pierre Sesques, Sonia Del Rincon, Koren K Mann, Anthony G Letai, Nathalie A Johnson
Apoptotic Blocks in Primary Non-Hodgkin B Cell Lymphomas Identified by BH3 Profiling. Cancers 13 (5) (2021)
Catríona M Dowling, Kate E R Hollinshead, Alessandra Di Grande, Justin Pritchard, Hua Zhang, Eugene T Dillon, Kathryn E Haley, Eleni Papadopoulos, Anita K Mehta, Rachel Bleach, Andreas U Lindner, Brian Mooney, Heiko Düssmann, Darran O'Connor, Jochen H M Prehn, Kieran Wynne, Michael T Hemann, James E Bradner, Alec C Kimmelman, Jennifer L Guerriero, Gerard Cagney, Kwok-Kin Wong, Anthony G Letai, Tríona Ní Chonghaile
Multiple screening approaches reveal HDAC6 as a novel regulator of glycolytic metabolism in triple-negative breast cancer. Science advances 7 (3) (2021)
Clara Alcon, Jorge Gómez Tejeda Zañudo, Reka Albert, Nikhil Wagle, Maurizio Scaltriti, Anthony G Letai, Josep Samitier, Joan Montero
ER+ Breast Cancer Strongly Depends on MCL-1 and BCL-xL Anti-Apoptotic Proteins. Cells 10 (7) (2021)
Rumani Singh, Anthony G Letai, Kristopher A Sarosiek
Regulation of apoptosis in health and disease: the balancing act of BCL-2 family proteins. Nature reviews. Molecular cell biology 20 (3) (2020)
Patrick D Bhola, Eman Ahmed, Jennifer L Guerriero, Ewa Sicinska, Emily Su, Elizaveta Lavrova, Jing Ni, Otari Chipashvili, Timothy Hagan, Marissa S Pioso, Kelley McQueeney, Kimmie Ng, Andrew J Aguirre, James M Cleary, David Cocozziello, Alaba Sotayo, Jeremy Adam Ryan, Jean J Zhao, Anthony G Letai
High-throughput dynamic BH3 profiling may quickly and accurately predict effective therapies in solid tumors. Science signaling 13 (636) (2020)
Joan Montero, Cécile Gstalder, Daniel J Kim, Dorota Sadowicz, Wayne Miles, Michael Manos, Justin R Cidado, J Paul Secrist, Adriana E Tron, Keith T Flaherty, F Stephen Hodi, Charles H Yoon, Anthony G Letai, David E Fisher, Rizwan Haq
Destabilization of NOXA mRNA as a common resistance mechanism to targeted therapies. Nature communications 10 (1) (2019)
Marcel A Dammert, Johannes Brägelmann, Rachelle R Olsen, Stefanie Böhm, Niloufar Monhasery, Christopher P Whitney, Milind D Chalishazar, Hannah L Tumbrink, Matthew R Guthrie, Sebastian Klein, Abbie S Ireland, Jeremy Adam Ryan, Anna Schmitt, Annika Marx, Luka Ozretić, Roberta Castiglione, Carina Lorenz, Ron D Jachimowicz, Elmar Wolf, Roman K Thomas, John T Poirier, Reinhard Büttner, Triparna Sen, Lauren A Byers, H Christian Reinhardt, Anthony G Letai, Trudy G Oliver, Martin L Sos
MYC paralog-dependent apoptotic priming orchestrates a spectrum of vulnerabilities in small cell lung cancer. Nature communications 10 (1) (2019)
Marina Konopleva, Anthony G Letai
BCL-2 inhibition in AML: an unexpected bonus? Blood 132 (10) (2018)
Justin Kale, Meryem Ozlem Kutuk, Glauber Costa Brito, Tallulah S Andrews, Brian Leber, Anthony G Letai, David William Andrews
Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance. EMBO reports 19 (9) (2018)
Paula Gutierrez-Martinez, Leah Hogdal, Manavi Nagai, Miriama Kruta, Rumani Singh, Kristopher Sarosiek, Andre Nussenzweig, Isabel Beerman, Anthony G Letai, Derrick J Rossi
Diminished apoptotic priming and ATM signalling confer a survival advantage onto aged haematopoietic stem cells in response to DNA damage. Nature cell biology 20 (4) (2018)