Christian Siebold

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 26

Top Topics

Low Density Lipoprotein

Mesenchymal Stem Cells

Top Venues

Nature communications

Nature chemical biology

Proceedings of the National Academy of Sciences of the United States of America

This page only lists publications with an associated author ORCID identifier.

Publications

Tomas Malinauskas, Gareth Moore, Amalie F Rudolf, Holly Eggington, Hayley L Belnoue-Davis, Kamel El Omari, Samuel C Griffiths, Rachel E Woolley, Ramona Duman, Armin Wagner, Simon J Leedham, Clair Baldock, Hilary L Ashe, Christian Siebold
Molecular mechanism of BMP signal control by Twisted gastrulation. Nature communications 15 (1) (2024)
Tomas Malinauskas, Gareth Moore, Amalie F Rudolf, Holly Eggington, Hayley L Belnoue-Davis, Kamel El Omari, Samuel C Griffiths, Rachel E Woolley, Ramona Duman, Armin Wagner, Simon J Leedham, Clair Baldock, Hilary L Ashe, Christian Siebold
Molecular mechanism of BMP signal control by Twisted gastrulation. Nature communications 15 (1) (2024)
Tomas Malinauskas, Gareth Moore, Amalie F Rudolf, Holly Eggington, Hayley L Belnoue-Davis, Kamel El Omari, Samuel C Griffiths, Rachel E Woolley, Ramona Duman, Armin Wagner, Simon J Leedham, Clair Baldock, Hilary L Ashe, Christian Siebold
Molecular mechanism of BMP signal control by Twisted gastrulation. Nature communications 15 (1) (2024)
Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling. eLife 13 (2024)
Tomas Malinauskas, Gareth Moore, Amalie F Rudolf, Holly Eggington, Hayley L Belnoue-Davis, Kamel El Omari, Samuel C Griffiths, Rachel E Woolley, Ramona Duman, Armin Wagner, Simon J Leedham, Clair Baldock, Hilary L Ashe, Christian Siebold
Molecular mechanism of BMP signal control by Twisted gastrulation. Nature communications 15 (1) (2024)
Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling. eLife 13 (2024)
Tomas Malinauskas, Gareth Moore, Amalie F Rudolf, Holly Eggington, Hayley L Belnoue-Davis, Kamel El Omari, Samuel C Griffiths, Rachel E Woolley, Ramona Duman, Armin Wagner, Simon J Leedham, Clair Baldock, Hilary L Ashe, Christian Siebold
Molecular mechanism of BMP signal control by Twisted gastrulation. Nature communications 15 (1) (2024)
Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling. eLife 13 (2024)
Samuel C Griffiths, Jia Tan, Armin Wagner, Levi L Blazer, Jarrett J Adams, Srisathya Srinivasan, Shayan Moghisaei, Sachdev S Sidhu, Christian Siebold, Hsin-Yi Henry Ho
Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling. eLife 13 (2024)
Maia Kinnebrew, Rachel E Woolley, Tillson Bertie Ansell, Eamon F X Byrne, Sara Frigui, Giovanni Luchetti, Ria Sircar, Sigrid Nachtergaele, Laurel Mydock-McGrane, Kathiresan Krishnan, Simon Newstead, Mark S P Sansom, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Science advances 8 (22) (2022)
Samuel C Griffiths, Rebekka A Schwab, Kamel El Omari, Benjamin Bishop, Ellen J Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F Covey, Robert C G Gilbert, Rajat Rohatgi, Christian Siebold
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nature communications 12 (1) (2021)
Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D Johnston, Claire E Coupland, Jake L Greenfield, Joshua Newington, Matthew John Fuchter, Anthony I Magee, Christian Siebold, Edward William Tate
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT)*. Angewandte Chemie (International ed. in English) 60 (24) (2021)
Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D Johnston, Claire E Coupland, Jake L Greenfield, Joshua Newington, Matthew John Fuchter, Anthony I Magee, Christian Siebold, Edward William Tate
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT). Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (24) (2021)
Thomas Lanyon-Hogg, Markus Ritzefeld, Leran Zhang, Sebastian A Andrei, Balazs Pogranyi, Milon Mondal, Lea Sefer, Callum D Johnston, Claire E Coupland, Jake L Greenfield, Joshua Newington, Matthew John Fuchter, Anthony I Magee, Christian Siebold, Edward William Tate
Photochemical Probe Identification of a Small-Molecule Inhibitor Binding Site in Hedgehog Acyltransferase (HHAT). Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 133 (24) (2021)
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes. eLife 10 (2021)
Tomas Malinauskas, Tina V Peer, Benjamin Bishop, Thomas D Müller, Christian Siebold
Repulsive guidance molecules lock growth differentiation factor 5 in an inhibitory complex. Proceedings of the National Academy of Sciences of the United States of America 117 (27) (2020)
Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. eLife 9 (2020)
Ian J McGough, Luca Vecchia, Benjamin Bishop, Tomas Malinauskas, Karen Beckett, Dhira Joshi, Nicola O'Reilly, Christian Siebold, Edith Yvonne Jones, Jean-Paul Vincent
Glypicans shield the Wnt lipid moiety to enable signalling at a distance. Nature 585 (7823) (2020)
Arun Radhakrishnan, Rajat Rohatgi, Christian Siebold
Cholesterol access in cellular membranes controls Hedgehog signaling. Nature chemical biology 16 (12) (2020)
Amalie F Rudolf, Maia Kinnebrew, Christiane Kowatsch, T Bertie Ansell, Kamel El Omari, Benjamin Bishop, Els Pardon, Rebekka A Schwab, Tomas Malinauskas, Mingxing Qian, Ramona Duman, Douglas F Covey, Jan Steyaert, Armin Wagner, Mark S P Sansom, Rajat Rohatgi, Christian Siebold
The morphogen Sonic hedgehog inhibits its receptor Patched by a pincer grasp mechanism. Nature chemical biology 15 (10) (2019)
Shuo Chen, Jiale Wu, Shan Zhong, Yuntong Li, Ping Zhang, Jingyi Ma, Jingshan Ren, Yun Tan, Yunhao Wang, Kin Fai Au, Christian Siebold, Gareth L Bond, Zhu Chen, Min Lu, Edith Yvonne Jones, Xin Lu
iASPP mediates p53 selectivity through a modular mechanism fine-tuning DNA recognition. Proceedings of the National Academy of Sciences of the United States of America 116 (35) (2019)
Daniel Rozbeský, Ross A Robinson, Vitul Jain, Max Renner, Tomas Malinauskas, Karl Harlos, Christian Siebold, Edith Yvonne Jones
Diversity of oligomerization in Drosophila semaphorins suggests a mechanism of functional fine-tuning. Nature communications 10 (1) (2019)
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. eLife 8 (2019)
Jennifer H Kong, Christian Siebold, Rajat Rohatgi
Biochemical mechanisms of vertebrate hedgehog signaling. Development (Cambridge, England) 146 (10) (2019)
Caroline M Gorvin, Valerie N Babinsky, Tomas Malinauskas, Peter Henrik Nissen, Anders Jørgen Schou, Aylin C Hanyaloglu, Christian Siebold, Edith Yvonne Jones, Fadil M Hannan, Rajesh V Thakker
A calcium-sensing receptor mutation causing hypocalcemia disrupts a transmembrane salt bridge to activate β-arrestin-biased signaling. Science signaling 11 (518) (2018)
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. eLife 5 (2016)