Rajat Rohatgi (R Rohatgi)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 31

Top Topics

Low Density Lipoprotein

Transcription Factor

Endoplasmic Reticulum

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Nature communications

Communications biology

This page only lists publications with an associated author ORCID identifier.

Publications

S M Niedziółka, S Datta, T Uśpieński, B Baran, W Skarżyńska, E W Humke, Rajat Rohatgi, Paweł Niewiadomski
The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium. Communications biology 7 (1) (2024)
Shimeng Xu, Jared C Smothers, Daphne Rye, Shreya Endapally, Hong Chen, Shili Li, Guosheng Liang, Maia Kinnebrew, Rajat Rohatgi, Bruce A Posner, Arun Radhakrishnan
A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Shimeng Xu, Jared C Smothers, Daphne Rye, Shreya Endapally, Hong Chen, Shili Li, Guosheng Liang, Maia Kinnebrew, Rajat Rohatgi, Bruce A Posner, Arun Radhakrishnan
A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Shimeng Xu, Jared C Smothers, Daphne Rye, Shreya Endapally, Hong Chen, Shili Li, Guosheng Liang, Maia Kinnebrew, Rajat Rohatgi, Bruce A Posner, Arun Radhakrishnan
A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
S M Niedziółka, S Datta, T Uśpieński, B Baran, W Skarżyńska, E W Humke, Rajat Rohatgi, Paweł Niewiadomski
The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium. Communications biology 7 (1) (2024)
S M Niedziółka, S Datta, T Uśpieński, B Baran, W Skarżyńska, E W Humke, Rajat Rohatgi, Paweł Niewiadomski
The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium. Communications biology 7 (1) (2024)
Shimeng Xu, Jared C Smothers, Daphne Rye, Shreya Endapally, Hong Chen, Shili Li, Guosheng Liang, Maia Kinnebrew, Rajat Rohatgi, Bruce A Posner, Arun Radhakrishnan
A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
Shimeng Xu, Jared C Smothers, Daphne Rye, Shreya Endapally, Hong Chen, Shili Li, Guosheng Liang, Maia Kinnebrew, Rajat Rohatgi, Bruce A Posner, Arun Radhakrishnan
A cholesterol-binding bacterial toxin provides a strategy for identifying a specific Scap inhibitor that blocks lipid synthesis in animal cells. Proceedings of the National Academy of Sciences of the United States of America 121 (7) (2024)
S M Niedziółka, S Datta, T Uśpieński, B Baran, W Skarżyńska, E W Humke, Rajat Rohatgi, Paweł Niewiadomski
The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium. Communications biology 7 (1) (2024)
S M Niedziółka, S Datta, T Uśpieński, B Baran, W Skarżyńska, E W Humke, Rajat Rohatgi, Paweł Niewiadomski
The exocyst complex and intracellular vesicles mediate soluble protein trafficking to the primary cilium. Communications biology 7 (1) (2024)
Zachary T Spencer, Victoria H Ng, Hassina Benchabane, Ghalia Saad Siddiqui, Deepesh Duwadi, Ben Maines, Jamal M Bryant, Anna Schwarzkopf, Kai Yuan, Sara N Kassel, Anant Mishra, Ashley Pimentel, Andres M Lebensohn, Rajat Rohatgi, Scott A Gerber, David J Robbins, Ethan Lee, Yashi Ahmed
The USP46 deubiquitylase complex increases Wingless/Wnt signaling strength by stabilizing Arrow/LRP6. Nature communications 14 (1) (2023)
Victoria H Ng, Zachary Spencer, Leif R Neitzel, Anmada Nayak, Matthew A Loberg, Chen Shen, Sara N Kassel, Heather K Kroh, Zhenyi An, Christin C Anthony, Jamal M Bryant, Amanda Lawson, Lily Goldsmith, Hassina Benchabane, Amanda G Hansen, Jingjing Li, Starina D'Souza, Andres M Lebensohn, Rajat Rohatgi, William A Weiss, Vivian Lee Weiss, Charles Williams, Charles C Hong, David J Robbins, Yashi Ahmed, Ethan Lee
The USP46 complex deubiquitylates LRP6 to promote Wnt/β-catenin signaling. Nature communications 14 (1) (2023)
Tillson Bertie Ansell, Robin Adam Corey, Lucrezia Vittoria Viti, Maia Kinnebrew, Rajat Rohatgi, Christian Siebold, Mark S P Sansom
The energetics and ion coupling of cholesterol transport through Patched1. Science advances 9 (34) (2023)
Maia Kinnebrew, Rachel E Woolley, Tillson Bertie Ansell, Eamon F X Byrne, Sara Frigui, Giovanni Luchetti, Ria Sircar, Sigrid Nachtergaele, Laurel Mydock-McGrane, Kathiresan Krishnan, Simon Newstead, Mark S P Sansom, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain. Science advances 8 (22) (2022)
Samuel C Griffiths, Rebekka A Schwab, Kamel El Omari, Benjamin Bishop, Ellen J Iverson, Tomas Malinauskas, Ramin Dubey, Mingxing Qian, Douglas F Covey, Robert C G Gilbert, Rajat Rohatgi, Christian Siebold
Hedgehog-Interacting Protein is a multimodal antagonist of Hedgehog signalling. Nature communications 12 (1) (2021)
David Gokhman, Rachel M Agoglia, Maia Kinnebrew, Wei E Gordon, Danqiong Sun, Vivek K Bajpai, Sahin Naqvi, Coral Chen, Anthony W S Chan, Chider Chen, Dmitri A Petrov, Nadav Ahituv, Honghao Zhang, Yuji Mishina, Joanna Wysocka, Rajat Rohatgi, Hunter B Fraser
Human-chimpanzee fused cells reveal cis-regulatory divergence underlying skeletal evolution. Nature genetics 53 (4) (2021)
Maia Kinnebrew, Giovanni Luchetti, Ria Sircar, Sara Frigui, Lucrezia Vittoria Viti, Tomoki Naito, Francis Beckert, Yasunori Saheki, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi
Patched 1 reduces the accessibility of cholesterol in the outer leaflet of membranes. eLife 10 (2021)
Jennifer H Kong, Cullen B Young, Ganesh V Pusapati, F Hernán Espinoza, Chandni B Patel, Francis Beckert, Sebastian Ho, Bhaven B Patel, George C Gabriel, L Aravind, J Fernando Bazan, Teresa M Gunn, Cecelia W Lo, Rajat Rohatgi
Gene-teratogen interactions influence the penetrance of birth defects by altering Hedgehog signaling strength. Development (Cambridge, England) 148 (19) (2021)
Alexander E Conicella, Gregory L Dignon, Gül H Zerze, Hermann Broder Schmidt, Alexandra M D'Ordine, Young C Kim, Rajat Rohatgi, Yuna M Ayala, Jeetain Mittal, Nicolas L Fawzi
TDP-43 α-helical structure tunes liquid-liquid phase separation and function. Proceedings of the National Academy of Sciences of the United States of America 117 (11) (2020)
Ramin Dubey, Peter van Kerkhof, Ingrid Jordens, Tomas Malinauskas, Ganesh V Pusapati, Joseph K McKenna, Dan Li, Jan E Carette, Mitchell Ho, Christian Siebold, Madelon Maurice, Andres M Lebensohn, Rajat Rohatgi
R-spondins engage heparan sulfate proteoglycans to potentiate WNT signaling. eLife 9 (2020)
Ramin Dubey, Craig E Stivala, Huy Quoc Nguyen, Young-Hwa Goo, Antoni Paul, Jan E Carette, Barry M Trost, Rajat Rohatgi
Lipid droplets can promote drug accumulation and activation. Nature chemical biology 16 (2) (2020)
Arun Radhakrishnan, Rajat Rohatgi, Christian Siebold
Cholesterol access in cellular membranes controls Hedgehog signaling. Nature chemical biology 16 (12) (2020)
Hermann Broder Schmidt, Ariana Barreau, Rajat Rohatgi
Phase separation-deficient TDP43 remains functional in splicing. Nature communications 10 (1) (2019)
Bhaven B Patel, Andres M Lebensohn, Ganesh V Pusapati, Jan E Carette, Julia Salzman, Rajat Rohatgi
Discovery of gene regulatory elements through a new bioinformatics analysis of haploid genetic screens. PloS one 14 (1) (2019)
Maia Kinnebrew, Ellen J Iverson, Bhaven B Patel, Ganesh V Pusapati, Jennifer H Kong, Kristen A Johnson, Giovanni Luchetti, Kaitlyn M Eckert, Jeffrey G McDonald, Douglas F Covey, Christian Siebold, Arun Radhakrishnan, Rajat Rohatgi
Cholesterol accessibility at the ciliary membrane controls hedgehog signaling. eLife 8 (2019)
Jennifer H Kong, Christian Siebold, Rajat Rohatgi
Biochemical mechanisms of vertebrate hedgehog signaling. Development (Cambridge, England) 146 (10) (2019)
Ganesh V Pusapati, Jennifer H Kong, Bhaven B Patel, Mina Gouti, Andreas Sagner, Ria Sircar, Giovanni Luchetti, Philip W Ingham, James Briscoe, Rajat Rohatgi
G protein-coupled receptors control the sensitivity of cells to the morphogen Sonic Hedgehog. Science signaling 11 (516) (2018)
Shi-Rong Hong, Cuei-Ling Wang, Yao-Shen Huang, Yu-Chen Chang, Ya-Chu Chang, Ganesh V Pusapati, Chun-Yu Lin, Ning Hsu, Hsiao-Chi Cheng, Yueh-Chen Chiang, Wei-En Huang, Nathan C Shaner, Rajat Rohatgi, Takanari Inoue, Yu-Chun Lin
Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling. Nature communications 9 (1) (2018)
Andres M Lebensohn, Rajat Rohatgi
R-spondins can potentiate WNT signaling without LGRs. eLife 7 (2018)
Giovanni Luchetti, Ria Sircar, Jennifer H Kong, Sigrid Nachtergaele, Andreas Sagner, Eamon Fx Byrne, Douglas F Covey, Christian Siebold, Rajat Rohatgi
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling. eLife 5 (2016)
Andres M Lebensohn, Ramin Dubey, Leif R Neitzel, Ofelia Tacchelly-Benites, Eungi Yang, Caleb D Marceau, Eric M Davis, Bhaven B Patel, Zahra Bahrami-Nejad, Kyle J Travaglini, Yashi Ahmed, Ethan Lee, Jan E Carette, Rajat Rohatgi
Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. eLife 5 (2016)