Benjamin F Cravatt (Benjamin Cravatt)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 83

Top Topics

Top Venues

Nature chemical biology

ACS chemical biology

Journal of the American Chemical Society

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Gloria Asantewaa, Emily T Tuttle, Nathan P Ward, Yun Pyo Kang, Yumi Kim, Madeline E Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P Duncan, Zachary R Sechrist, Diana Agostini-Vulaj, Xenia L Schafer, Hayley Chang, Zachary R Smith, Thomas N O'Connor, Sarah Whelan, Laura M Selfors, Jett Crowdis, G Kenneth Gray, Roderick T Bronson, Dirk Brenner, Alessandro Rufini, Robert T Dirksen, Aram F Hezel, Aaron R Huber, Joshua C Munger, Benjamin F Cravatt, Vasilis Vasiliou, Calvin L Cole, Gina M DeNicola, Isaac S Harris
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nature communications 15 (1) (2024)
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Yongfeng Tao, Guoqin Xia, Rachel E Hayward, Minjin Yoo, Tracey Nguyen, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society 146 (15) (2024)
Gloria Asantewaa, Emily T Tuttle, Nathan P Ward, Yun Pyo Kang, Yumi Kim, Madeline E Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P Duncan, Zachary R Sechrist, Diana Agostini-Vulaj, Xenia L Schafer, Hayley Chang, Zachary R Smith, Thomas N O'Connor, Sarah Whelan, Laura M Selfors, Jett Crowdis, G Kenneth Gray, Roderick T Bronson, Dirk Brenner, Alessandro Rufini, Robert T Dirksen, Aram F Hezel, Aaron R Huber, Joshua C Munger, Benjamin F Cravatt, Vasilis Vasiliou, Calvin L Cole, Gina M DeNicola, Isaac S Harris
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nature communications 15 (1) (2024)
Yuanjin Zhang, Zhonglin Liu, Marscha Hirschi, Oleg Brodsky, Eric Johnson, Sang Joon Won, Asako Nagata, Divya Bezwada, Matthew D Petroski, Jaimeen D Majmudar, Sherry Niessen, Todd VanArsdale, Adam M Gilbert, Matthew M Hayward, Al E Stewart, Andrew R Nager, Bruno Melillo, Benjamin F Cravatt
An allosteric cyclin E-CDK2 site mapped by paralog hopping with covalent probes. Nature chemical biology (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology (2024)
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Yongfeng Tao, Guoqin Xia, Rachel E Hayward, Minjin Yoo, Tracey Nguyen, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society 146 (15) (2024)
Evert Njomen, Rachel E Hayward, Kristen E DeMeester, Daisuke Ogasawara, Melissa M Dix, Tracey Nguyen, Paige Ashby, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Multi-tiered chemical proteomic maps of tryptoline acrylamide-protein interactions in cancer cells. Nature chemistry (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Gloria Asantewaa, Emily T Tuttle, Nathan P Ward, Yun Pyo Kang, Yumi Kim, Madeline E Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P Duncan, Zachary R Sechrist, Diana Agostini-Vulaj, Xenia L Schafer, Hayley Chang, Zachary R Smith, Thomas N O'Connor, Sarah Whelan, Laura M Selfors, Jett Crowdis, G Kenneth Gray, Roderick T Bronson, Dirk Brenner, Alessandro Rufini, Robert T Dirksen, Aram F Hezel, Aaron R Huber, Joshua C Munger, Benjamin F Cravatt, Vasilis Vasiliou, Calvin L Cole, Gina M DeNicola, Isaac S Harris
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nature communications 15 (1) (2024)
Gloria Asantewaa, Emily T Tuttle, Nathan P Ward, Yun Pyo Kang, Yumi Kim, Madeline E Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P Duncan, Zachary R Sechrist, Diana Agostini-Vulaj, Xenia L Schafer, Hayley Chang, Zachary R Smith, Thomas N O'Connor, Sarah Whelan, Laura M Selfors, Jett Crowdis, G Kenneth Gray, Roderick T Bronson, Dirk Brenner, Alessandro Rufini, Robert T Dirksen, Aram F Hezel, Aaron R Huber, Joshua C Munger, Benjamin F Cravatt, Vasilis Vasiliou, Calvin L Cole, Gina M DeNicola, Isaac S Harris
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nature communications 15 (1) (2024)
Caroline Stanton, Jie Sun, Kayla Nutsch, Jessica D Rosarda, Thu Nguyen, Chloris Li-Ma, Evert Njomen, Bruno Melillo, Sergei Kutseikin, Enrique Saez, Benjamin F Cravatt, John R Teijaro, R Luke Wiseman, Michael J Bollong
Covalent Targeting As a Common Mechanism for Inhibiting NLRP3 Inflammasome Assembly. ACS chemical biology 19 (2) (2024)
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Yongfeng Tao, Guoqin Xia, Rachel E Hayward, Minjin Yoo, Tracey Nguyen, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society 146 (15) (2024)
Zhonglin Liu, Jarrett R Remsberg, Haoxin Li, Evert Njomen, Kristen E DeMeester, Yongfeng Tao, Guoqin Xia, Rachel E Hayward, Minjin Yoo, Tracey Nguyen, Gabriel M Simon, Stuart L Schreiber, Bruno Melillo, Benjamin F Cravatt
Proteomic Ligandability Maps of Spirocycle Acrylamide Stereoprobes Identify Covalent ERCC3 Degraders. Journal of the American Chemical Society (2024)
Gloria Asantewaa, Emily T Tuttle, Nathan P Ward, Yun Pyo Kang, Yumi Kim, Madeline E Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P Duncan, Zachary R Sechrist, Diana Agostini-Vulaj, Xenia L Schafer, Hayley Chang, Zachary R Smith, Thomas N O'Connor, Sarah Whelan, Laura M Selfors, Jett Crowdis, G Kenneth Gray, Roderick T Bronson, Dirk Brenner, Alessandro Rufini, Robert T Dirksen, Aram F Hezel, Aaron R Huber, Joshua C Munger, Benjamin F Cravatt, Vasilis Vasiliou, Calvin L Cole, Gina M DeNicola, Isaac S Harris
Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nature communications 15 (1) (2024)
Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk-Soo Seo, Ekaterina V Vinogradova, Tomer M Yaron, Evanna L Mills, Haopeng Xiao, Kristine Senkane, Emily M Huntsman, Jared L Johnson, Jianwei Che, Lewis C Cantley, Benjamin F Cravatt, Sirano Dhe-Paganon, Kimberly Stegmaier, Tinghu Zhang, Nathanael S Gray, Edward T Chouchani
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. Nature chemical biology (2023)
Alex Reed, Timothy B Ware, Haoxin Li, J Fernando Bazan, Benjamin F Cravatt
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids. Nature chemical biology 19 (3) (2023)
Narek Darabedian, Wenzhi Ji, Mengyang Fan, Shan Lin, Hyuk-Soo Seo, Ekaterina V Vinogradova, Tomer M Yaron, Evanna L Mills, Haopeng Xiao, Kristine Senkane, Emily M Huntsman, Jared L Johnson, Jianwei Che, Lewis C Cantley, Benjamin F Cravatt, Sirano Dhe-Paganon, Kimberly Stegmaier, Tinghu Zhang, Nathanael S Gray, Edward T Chouchani
Depletion of creatine phosphagen energetics with a covalent creatine kinase inhibitor. Nature chemical biology (2023)
Michael Wichroski, Joseph L Benci, Si-Qi Liu, Louis Chupak, Jie Fang, Carolyn Cao, Cindy Wang, Joelle Onorato, Hongchen Qiu, Yongli Shan, Dana Banas, Ryan Powles, Gregory Locke, Abigail Witt, Caitlyn Stromko, Huilin Qi, Xiaofan Zheng, Scott Martin, Min Ding, Robert Gentles, Nicholas A Meanwell, Upender Velaparthi, Richard Olson, Susan Wee, Daniel J Tenney, Christopher G Parker, Benjamin F Cravatt, Michael Lawrence, Robert Borzilleri, Emma Lees
DGKα/ζ inhibitors combine with PD-1 checkpoint therapy to promote T cell-mediated antitumor immunity. Science translational medicine 15 (719) (2023)
Alex Reed, Timothy B Ware, Haoxin Li, J Fernando Bazan, Benjamin F Cravatt
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids. Nature chemical biology (2023)
Stefan G Kathman, Seong Joo Koo, Garrett L Lindsey, Hsuan-Lin Her, Steven M Blue, Haoxin Li, Steffen Jaensch, Jarrett R Remsberg, Kay Ahn, Gene W Yeo, Brahma Ghosh, Benjamin F Cravatt
Remodeling oncogenic transcriptomes by small molecules targeting NONO. Nature chemical biology (2023)
Yongfeng Tao, David Remillard, Ekaterina V Vinogradova, Minoru Yokoyama, Sofia Banchenko, David Schwefel, Bruno Melillo, Stuart L Schreiber, Xiaoyu Zhang, Benjamin F Cravatt
Correction to "Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1". Journal of the American Chemical Society (2023)
Alex Reed, Timothy B Ware, Haoxin Li, J Fernando Bazan, Benjamin F Cravatt
TMEM164 is an acyltransferase that forms ferroptotic C20:4 ether phospholipids. Nature chemical biology 19 (3) (2023)
Haoxin Li, Tiantai Ma, Jarrett R Remsberg, Sang Joon Won, Kristen E DeMeester, Evert Njomen, Daisuke Ogasawara, Kevin Tianmeng Zhao, Tony P Huang, Bingwen Lu, Gabriel M Simon, Bruno Melillo, Stuart L Schreiber, Jens Lykke-Andersen, David R Liu, Benjamin F Cravatt
Assigning functionality to cysteines by base editing of cancer dependency genes. Nature chemical biology (2023)
Kyoko Morimoto, Daniel Krahn, Farnusch Kaschani, Digby Hopkinson-Woolley, Anna Gee, Pierre Buscaill, Shabaz Mohammad, Stephan A Sieber, Benjamin F Cravatt, Christopher J Schofield, van der Hoorn Renier A L
Broad-range metalloprotease profiling in plants uncovers immunity provided by defence-related metalloenzyme. The New phytologist 235 (3) (2022)
Fu-Long Li, Vivian Fu, Guangbo Liu, Tracy Tang, Andrei W Konradi, Xiao Peng, Esther Kemper, Benjamin F Cravatt, J Matthew Franklin, Zhengming Wu, Joshua Mayfield, Jack E Dixon, William H Gerwick, Kun-Liang Guan
Hippo pathway regulation by phosphatidylinositol transfer protein and phosphoinositides. Nature chemical biology 18 (10) (2022)
Alex Reed, Taka-Aki Ichu, Natalia Milosevich, Bruno Melillo, Michael A Schafroth, Yuka Otsuka, Louis Scampavia, Timothy P Spicer, Benjamin F Cravatt
LPCAT3 Inhibitors Remodel the Polyunsaturated Phospholipid Content of Human Cells and Protect from Ferroptosis. ACS chemical biology 17 (6) (2022)
Madeline E Kavanagh, Benjamin D Horning, Roli Khattri, Nilotpal Roy, Justine P Lu, Landon R Whitby, Elva Ye, Jaclyn C Brannon, Albert Parker, Joel M Chick, Christie L Eissler, Ashley J Wong, Joe L Rodriguez, Socorro Rodiles, Kim Masuda, John R Teijaro, Gabriel M Simon, Matthew P Patricelli, Benjamin F Cravatt
Selective inhibitors of JAK1 targeting an isoform-restricted allosteric cysteine. Nature chemical biology 18 (12) (2022)
Esther K Kemper, Yuanjin Zhang, Melissa M Dix, Benjamin F Cravatt
Global profiling of phosphorylation-dependent changes in cysteine reactivity. Nature methods 19 (3) (2022)
Yongfeng Tao, David Remillard, Ekaterina V Vinogradova, Minoru Yokoyama, Sofia Banchenko, David Schwefel, Bruno Melillo, Stuart L Schreiber, Xiaoyu Zhang, Benjamin F Cravatt
Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1. Journal of the American Chemical Society 144 (40) (2022)
Luís A R Carvalho, Breyan H Ross, Lorenz Fehr, Oguz Bolgi, Svenja Wöhrle, Kenneth M Lum, David Podlesainski, Andreia C Vieira, Reiner Kiefersauer, Rita Félix, Tiago Rodrigues, Susana D Lucas, Olaf Gross, Ruth Geiss-Friedlander, Benjamin F Cravatt, Robert Huber, Markus Kaiser, Rui Moreira
Chemoproteomics-Enabled Identification of 4-Oxo-β-Lactams as Inhibitors of Dipeptidyl Peptidases 8 and 9. Angewandte Chemie (International ed. in English) 61 (47) (2022)
Markus M Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V Dissanayake, Daria Golosova, Michael A Schafroth, Carlos Guijas, Fatih Demir, Johannes Jägers, Megan L Gliozzi, Jingchuan Xue, Martin Höhne, Thomas Benzing, Bernard P Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A Weisz, Benjamin F Cravatt, Marcus Krueger, H Paul Benton, Gary E Siuzdak, Alexander Staruschenko
Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension. Nature communications 13 (1) (2022)
Micah J Niphakis, Benjamin F Cravatt
Ace-ylation in the hole. Nature chemical biology 18 (11) (2022)
Mikail E Abbasov, Madeline E Kavanagh, Taka-Aki Ichu, Michael R Lazear, Yongfeng Tao, Vincent M Crowley, Christopher W Am Ende, Stephan M Hacker, Jordan Ho, Melissa M Dix, Radu Suciu, Matthew M Hayward, Laura L Kiessling, Benjamin F Cravatt
A proteome-wide atlas of lysine-reactive chemistry. Nature chemistry 13 (11) (2021)
Jinjun Gao, Yuan Liu, Fan Yang, Xuemin Chen, Benjamin F Cravatt, Chu Wang
CIMAGE2.0: An Expanded Tool for Quantitative Analysis of Activity-Based Protein Profiling (ABPP) Data. Journal of proteome research 20 (10) (2021)
Jarrett R Remsberg, Radu M Suciu, Noemi A Zambetti, Thomas W Hanigan, Ari J Firestone, Anagha Inguva, Amanda Long, Nhi Ngo, Kenneth M Lum, Cassandra L Henry, Stewart K Richardson, Marina Predovic, Benjamin S Braun, Melissa M Dix, Amy R Howell, Micah J Niphakis, Kevin Shannon, Benjamin F Cravatt
ABHD17 regulation of plasma membrane palmitoylation and N-Ras-dependent cancer growth. Nature chemical biology 17 (8) (2021)
Xiaoyu Zhang, Lena M Luukkonen, Christie L Eissler, Vincent M Crowley, Yu Yamashita, Michael A Schafroth, Shota Kikuchi, David S Weinstein, Kent T Symons, Brian E Nordin, Joe L Rodriguez, Thomas G Wucherpfennig, Ludwig G Bauer, Melissa M Dix, Dean Stamos, Todd M Kinsella, Gabriel M Simon, Kristen A Baltgalvis, Benjamin F Cravatt
DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras. Journal of the American Chemical Society 143 (13) (2021)
Leopold Garnar-Wortzel, Timothy R Bishop, Seiya Kitamura, Natalia Milosevich, Joshua N Asiaban, Xiaoyu Zhang, Qinheng Zheng, Emily Chen, Anissa R Ramos, Christopher J Ackerman, Eric N Hampton, Arnab K Chatterjee, Travis S Young, Mitchell V Hull, K Barry Sharpless, Benjamin F Cravatt, Dennis W Wolan, Michael A Erb
Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia. ACS central science 7 (5) (2021)
Xiaoyu Zhang, Marvin Thielert, Haoxin Li, Benjamin F Cravatt
SPIN4 Is a Principal Endogenous Substrate of the E3 Ubiquitin Ligase DCAF16. Biochemistry 60 (9) (2021)
Jian Rong, Wakana Mori, Xiaotian Xia, Michael A Schafroth, Chunyu Zhao, Richard S Van, Tomoteru Yamasaki, Jiahui Chen, Zhiwei Xiao, Ahmed Haider, Daisuke Ogasawara, Atsuto Hiraishi, Tuo Shao, Yiding Zhang, Zhen Chen, Fuwen Pang, Kuan Hu, Lin Xie, Masayuki Fujinaga, Katsushi Kumata, Yuancheng Gou, Yang Fang, Shuyin Gu, Huiyi Wei, Liang Bao, Hao Xu, Thomas L Collier, Yihan Shao, Richard E Carson, Benjamin F Cravatt, Lu Wang, Ming-Rong Zhang, Steven H Liang
Novel Reversible-Binding PET Ligands for Imaging Monoacylglycerol Lipase Based on the Piperazinyl Azetidine Scaffold. Journal of medicinal chemistry 64 (19) (2021)
Vincent M Crowley, Marvin Thielert, Benjamin F Cravatt
Functionalized Scout Fragments for Site-Specific Covalent Ligand Discovery and Optimization. ACS central science 7 (4) (2021)
Yu Yamashita, Ekaterina V Vinogradova, Xiaoyu Zhang, Radu M Suciu, Benjamin F Cravatt
A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angewandte Chemie (International ed. in English) 59 (10) (2020)
Elliot D Mock, Mohammed Mustafa, Ozge Gunduz-Cinar, Resat Cinar, Gavin N Petrie, Vasudev Kantae, Xinyu Di, Daisuke Ogasawara, Zoltan V Varga, Janos Paloczi, Cristina Miliano, Giulia Donvito, Annelot C M van Esbroeck, Anouk M F van der Gracht, Ioli Kotsogianni, Joshua K Park, Andrea Martella, Tom van der Wel, Marjolein Soethoudt, Ming Jiang, Tiemen J Wendel, Antonius P A Janssen, Alexander T Bakker, Colleen M Donovan, Laura I Castillo, Bogdan I Florea, Jesse Wat, Helma van den Hurk, Matthias Wittwer, Uwe Grether, Andrew Holmes, Constant A A van Boeckel, Thomas Hankemeier, Benjamin F Cravatt, Matthew W Buczynski, Matthew N Hill, Pal Pacher, Aron H Lichtman, Mario van der Stelt
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice. Nature chemical biology 16 (6) (2020)
Luís A R Carvalho, Vanessa T Almeida, José A Brito, Kenneth M Lum, Tânia F Oliveira, Rita C Guedes, Lidia Maria Goncalves, Susana D Lucas, Benjamin F Cravatt, Margarida Archer, Rui Moreira
3-Oxo-β-sultam as a Sulfonylating Chemotype for Inhibition of Serine Hydrolases and Activity-Based Protein Profiling. ACS chemical biology 15 (4) (2020)
Zsófia I László, Zsolt Lele, Miklós Zöldi, Vivien Miczán, Fruzsina Mógor, Gabriel M Simon, Ken Mackie, Imre Kacskovics, Benjamin F Cravatt, István Katona
ABHD4-dependent developmental anoikis safeguards the embryonic brain. Nature communications 11 (1) (2020)
Stefan G Kathman, Benjamin F Cravatt
A masked zinger to block GPX4. Nature chemical biology 16 (5) (2020)
Bernard P Kok, Srijana Ghimire, Woojoo E Kim, Shreyosree Chatterjee, Tyler Johns, Seiya Kitamura, Jerome Eberhardt, Daisuke Ogasawara, Janice H Xu, Ara Sukiasyan, Sean M Kim, Cristina Godio, Julia M Bittencourt, Michael D Cameron, Andrea Galmozzi, Stefano Forli, Dennis W Wolan, Benjamin F Cravatt, Dale L Boger, Enrique Saez
Discovery of small-molecule enzyme activators by activity-based protein profiling. Nature chemical biology 16 (9) (2020)
Claudio Zambaldo, Ekaterina V Vinogradova, Xiaotian Qi, Jonathan Iaconelli, Radu M Suciu, Minseob Koh, Kristine Senkane, Stormi R Chadwick, Brittany B Sanchez, Jason S Chen, Arnab K Chatterjee, Peng Liu, Peter G Schultz, Benjamin F Cravatt, Michael J Bollong
2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. Journal of the American Chemical Society 142 (19) (2020)
Lu Hou, Jian Rong, Ahmed Haider, Daisuke Ogasawara, Cassis Varlow, Michael A Schafroth, Linjing Mu, Jiefeng Gan, Hao Xu, Christopher J Fowler, Ming-Rong Zhang, Neil Vasdev, Simon M Ametamey, Benjamin F Cravatt, Lu Wang, Steven H Liang
Positron Emission Tomography Imaging of the Endocannabinoid System: Opportunities and Challenges in Radiotracer Development. Journal of medicinal chemistry 64 (1) (2020)
Taka-Aki Ichu, Alex Reed, Daisuke Ogasawara, Olesya Ulanovskaya, Amanda Roberts, Carlos A Aguirre, Liron Bar-Peled, Jie Gao, Jason Germain, Sabrina Barbas, Kim Masuda, Bruno Conti, Peter Tontonoz, Benjamin F Cravatt
ABHD12 and LPCAT3 Interplay Regulates a Lyso-phosphatidylserine-C20:4 Phosphatidylserine Lipid Network Implicated in Neurological Disease. Biochemistry 59 (19) (2020)
Joshua N Asiaban, Natalia Milosevich, Emily Chen, Timothy R Bishop, Justin Wang, Yuxiang Zhang, Christopher J Ackerman, Eric N Hampton, Travis S Young, Mitchell V Hull, Benjamin F Cravatt, Michael A Erb
Cell-Based Ligand Discovery for the ENL YEATS Domain. ACS chemical biology 15 (4) (2020)
Stefan G Kathman, Julia Boshart, Hui Jing, Benjamin F Cravatt
Blockade of the Lysophosphatidylserine Lipase ABHD12 Potentiates Ferroptosis in Cancer Cells. ACS chemical biology 15 (4) (2020)
Janice H Xu, Jerome Eberhardt, Brianna Hill-Payne, Gonzalo E González-Páez, José Omar Castellón, Benjamin F Cravatt, Stefano Forli, Dennis W Wolan, Keriann M Backus
Integrative X-ray Structure and Molecular Modeling for the Rationalization of Procaspase-8 Inhibitor Potency and Selectivity. ACS chemical biology 15 (2) (2020)
Alice L Chen, Kenneth M Lum, Pablo Lara-Gonzalez, Daisuke Ogasawara, Armand B Cognetta, Alan To, William H Parsons, Gabriel M Simon, Arshad Desai, Michael Petrascheck, Liron Bar-Peled, Benjamin F Cravatt
Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nature chemical biology 15 (5) (2019)
Zhen Chen, Wakana Mori, Hualong Fu, Michael A Schafroth, Akiko Hatori, Tuo Shao, Genwei Zhang, Richard S Van, Yiding Zhang, Kuan Hu, Masayuki Fujinaga, Lu Wang, Vasily Belov, Daisuke Ogasawara, Pilar Giffenig, Xiaoyun Deng, Jian Rong, Qingzhen Yu, Xiaofei Zhang, Mikhail I Papisov, Yihan Shao, Thomas L Collier, Jun-An Ma, Benjamin F Cravatt, Lee Josephson, Ming-Rong Zhang, Steven H Liang
Design, Synthesis, and Evaluation of 18F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes. Journal of medicinal chemistry 62 (19) (2019)
Yujia Wang, Melissa M Dix, Giulia Bianco, Jarrett R Remsberg, Hsin-Yu Lee, Marian Kalocsay, Steven P Gygi, Stefano Forli, Gregory Vite, R Michael Lawrence, Christopher G Parker, Benjamin F Cravatt
Expedited mapping of the ligandable proteome using fully functionalized enantiomeric probe pairs. Nature chemistry 11 (12) (2019)
Daisuke Ogasawara, Taka-Aki Ichu, Hui Jing, Jonathan J Hulce, Alex Reed, Olesya A Ulanovskaya, Benjamin F Cravatt
Discovery and Optimization of Selective and in Vivo Active Inhibitors of the Lysophosphatidylserine Lipase α/β-Hydrolase Domain-Containing 12 (ABHD12). Journal of medicinal chemistry 62 (3) (2019)
Zhen Huang, Daisuke Ogasawara, Uthpala I Seneviratne, Armand B Cognetta, Christopher W Am Ende, Deane M Nason, Kimberly Lapham, John Litchfield, Douglas S Johnson, Benjamin F Cravatt
Global Portrait of Protein Targets of Metabolites of the Neurotoxic Compound BIA 10-2474. ACS chemical biology 14 (2) (2019)
Kristine Senkane, Ekaterina V Vinogradova, Radu M Suciu, Vincent M Crowley, Balyn W Zaro, J Michael Bradshaw, Ken A Brameld, Benjamin F Cravatt
The Proteome-Wide Potential for Reversible Covalency at Cysteine. Angewandte Chemie (International ed. in English) 58 (33) (2019)
Zhen Chen, Wakana Mori, Xiaoyun Deng, Ran Cheng, Daisuke Ogasawara, Genwei Zhang, Michael A Schafroth, Kenneth Dahl, Hualong Fu, Akiko Hatori, Tuo Shao, Yiding Zhang, Tomoteru Yamasaki, Xiaofei Zhang, Jian Rong, Qingzhen Yu, Kuan Hu, Masayuki Fujinaga, Lin Xie, Katsushi Kumata, Yuancheng Gou, Jingjin Chen, Shuyin Gu, Liang Bao, Lu Wang, Thomas Lee Collier, Neil Vasdev, Yihan Shao, Jun-An Ma, Benjamin F Cravatt, Christopher Fowler, Lee Josephson, Ming-Rong Zhang, Steven H Liang
Design, Synthesis, and Evaluation of Reversible and Irreversible Monoacylglycerol Lipase Positron Emission Tomography (PET) Tracers Using a "Tail Switching" Strategy on a Piperazinyl Azetidine Skeleton. Journal of medicinal chemistry 62 (7) (2019)
Ruedi Aebersold, Jeffrey N Agar, I Jonathan Amster, Mark S Baker, Carolyn R Bertozzi, Emily S Boja, Catherine E Costello, Benjamin F Cravatt, Catherine Fenselau, Benjamin A Garcia, Ying Ge, Jeremy Gunawardena, Ronald C Hendrickson, Paul J Hergenrother, Christian G Huber, Alexander R Ivanov, Ole N Jensen, Michael C Jewett, Michael P Snyder, Laura L Kiessling, Nevan J Krogan, Martin R Larsen, Joseph A Loo, Rachel R Ogorzalek Loo, Emma Lundberg, Michael J MacCoss, Parag Mallick, Vamsi K Mootha, Milan Mrksich, Tom W Muir, Steven M Patrie, James J Pesavento, Sharon J Pitteri, Henry Rodriguez, Alan Saghatelian, Wendy Sandoval, Hartmut Schlüter, Salvatore Sechi, Sarah A Slavoff, Lloyd M Smith, Michael P Snyder, Paul M Thomas, Mathias Uhlén, Jennifer E Van Eyk, Marc Vidal, David R Walt, Forest M White, Evan R Williams, Therese Wohlschlager, Vicki H Wysocki, Nathan A Yates, Nicolas L Young, Bing Zhang
How many human proteoforms are there? Nature chemical biology 14 (3) (2019)
Xiaoyu Zhang, Vincent M Crowley, Thomas G Wucherpfennig, Melissa M Dix, Benjamin F Cravatt
Electrophilic PROTACs that degrade nuclear proteins by engaging DCAF16. Nature chemical biology 15 (7) (2019)
Daisuke Ogasawara, Taka-Aki Ichu, Vincent F Vartabedian, Jacqueline Benthuysen, Hui Jing, Alex Reed, Olesya A Ulanovskaya, Jonathan J Hulce, Amanda Roberts, Steven Brown, Hugh Rosen, John R Teijaro, Benjamin F Cravatt
Selective blockade of the lyso-PS lipase ABHD12 stimulates immune responses in vivo. Nature chemical biology 14 (12) (2018)
Amanda L Gavin, Deli Huang, Christoph Huber, Annica Mårtensson, Virginie Tardif, Patrick D Skog, Tanya R Blane, Therese C Thinnes, Kent Osborn, Hayley S Chong, Farnaz Kargaran, Phoebe Kimm, Armen Zeitjian, Rachel L Sielski, Megan Briggs, Sebastian R Schulz, Alessandro Zarpellon, Benjamin F Cravatt, Ee Shan Pang, John Teijaro, Juan Carlos de la Torre, Meredith O'Keeffe, Hubertus Hochrein, Markus Damme, Luc Teyton, Brian R Lawson, David Nemazee
PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing. Nature immunology 19 (9) (2018)
Joseph D Schonhoft, Cecilia Monteiro, Lars Plate, Yvonne S Eisele, Jeffrey W Kelly, Daniel Boland, Christopher G Parker, Benjamin F Cravatt, Sergio Teruya, Stephen T Helmke, Mathew S Maurer, John L Berk, Yoshiki Sekijima, Marta Novais, Teresa Coelho, Evan T Powers, Jeffery W Kelly
Peptide probes detect misfolded transthyretin oligomers in plasma of hereditary amyloidosis patients. Science translational medicine 9 (407) (2018)
Annelot C M van Esbroeck, Antonius P A Janssen, Armand B Cognetta, Daisuke Ogasawara, Guy Shpak, Mark van der Kroeg, Vasudev Kantae, Marc P Baggelaar, Femke M S de Vrij, Hui Deng, Marco Allarà, Filomena Fezza, Zhanmin Lin, Tom van der Wel, Marjolein Soethoudt, Elliot D Mock, Hans den Dulk, Ilse L Baak, Bogdan I Florea, Giel Hendriks, Luciano De Petrocellis, Herman S Overkleeft, Thomas Hankemeier, Chris I De Zeeuw, Vincenzo Di Marzo, Mauro Maccarrone, Benjamin F Cravatt, Steven A Kushner, Mario van der Stelt
Activity-based protein profiling reveals off-target proteins of the FAAH inhibitor BIA 10-2474. Science (New York, N.Y.) 356 (6342) (2018)
Ran Cheng, Wakana Mori, Longle Ma, Mireille Alhouayek, Akiko Hatori, Yiding Zhang, Daisuke Ogasawara, Gengyang Yuan, Zhen Chen, Xiaofei Zhang, Hang Shi, Tomoteru Yamasaki, Lin Xie, Katsushi Kumata, Masayuki Fujinaga, Yuji Nagai, Takafumi Minamimoto, Mona Svensson, Lu Wang, Yunfei Du, Mary Jo Ondrechen, Neil Vasdev, Benjamin F Cravatt, Christopher Fowler, Ming-Rong Zhang, Steven H Liang
In Vitro and in Vivo Evaluation of 11C-Labeled Azetidinecarboxylates for Imaging Monoacylglycerol Lipase by PET Imaging Studies. Journal of medicinal chemistry 61 (6) (2018)
Jordon M Inloes, Hui Jing, Benjamin F Cravatt
The Spastic Paraplegia-Associated Phospholipase DDHD1 Is a Primary Brain Phosphatidylinositol Lipase. Biochemistry 57 (39) (2018)
De-Wei Gao, Ekaterina V Vinogradova, Sri Krishna Nimmagadda, Jose M Medina, Yiyang Xiao, Radu M Suciu, Benjamin F Cravatt, Keary M Engle
Direct Access to Versatile Electrophiles via Catalytic Oxidative Cyanation of Alkenes. Journal of the American Chemical Society 140 (26) (2018)
Stephan M Hacker, Keriann M Backus, Michael R Lazear, Stefano Forli, Bruno E Correia, Benjamin F Cravatt
Global profiling of lysine reactivity and ligandability in the human proteome. Nature chemistry 9 (12) (2017)
Joanne Tan, Armand B Cognetta Iii, Diego B Diaz, Kenneth M Lum, Shinya Adachi, Soumajit Kundu, Benjamin F Cravatt, Andrei K Yudin
Multicomponent mapping of boron chemotypes furnishes selective enzyme inhibitors. Nature communications 8 (1) (2017)
Jordon M Inloes, William B Kiosses, Huajin Wang, Tobias C Walther, Robert V Farese, Benjamin F Cravatt
Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry 57 (5) (2017)
Landon R Whitby, R Scott Obach, Gabriel M Simon, Matthew M Hayward, Benjamin F Cravatt
Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites. ACS chemical biology 12 (8) (2017)
Anne F Kornahrens, Armand B Cognetta, Daniel M Brody, Megan L Matthews, Benjamin F Cravatt, Dale L Boger
Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor. Journal of the American Chemical Society 139 (20) (2017)
Megan H Touchette, Erik R Van Vlack, Lu Bai, Jia Kim, Armand B Cognetta, Mary L Previti, Keriann M Backus, Dwight W Martin, Benjamin F Cravatt, Jessica C Seeliger
A Screen for Protein-Protein Interactions in Live Mycobacteria Reveals a Functional Link between the Virulence-Associated Lipid Transporter LprG and the Mycolyltransferase Antigen 85A. ACS infectious diseases 3 (5) (2017)
David E Mortenson, Gabriel J Brighty, Lars Plate, Grant Bare, Wentao Chen, Suhua Li, Hua Wang, Benjamin F Cravatt, Stefano Forli, Evan T Powers, K Barry Sharpless, Ian A Wilson, Jeffrey W Kelly
"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates. Journal of the American Chemical Society 140 (1) (2017)
Kenneth M Lum, Yoshiaki Sato, Brittney A Beyer, Warren C Plaisted, Justin L Anglin, Luke L Lairson, Benjamin F Cravatt
Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS chemical biology 12 (10) (2017)
Yuta Shimanaka, Nozomu Kono, Yoshitaka Taketomi, Makoto Arita, Yoshimichi Okayama, Yuki Tanaka, Yasumasa Nishito, Tatsuki Mochizuki, Hiroyuki Kusuhara, Alexander Adibekian, Benjamin F Cravatt, Makoto Murakami, Hiroyuki Arai
Omega-3 fatty acid epoxides are autocrine mediators that control the magnitude of IgE-mediated mast cell activation. Nature medicine 23 (11) (2017)
Ying-Chu Chen, Keriann M Backus, Maria Merkulova, Christina Yang, Dennis Brown, Benjamin F Cravatt, Chao Zhang
Covalent Modulators of the Vacuolar ATPase. Journal of the American Chemical Society 139 (2) (2016)
Hui Deng, Sander Kooijman, Adrianus M C H van den Nieuwendijk, Daisuke Ogasawara, Tom van der Wel, Floris van Dalen, Marc P Baggelaar, Freek J Janssen, Richard J B H N van den Berg, Hans den Dulk, Benjamin F Cravatt, Herman S Overkleeft, Patrick C N Rensen, Mario van der Stelt
Triazole Ureas Act as Diacylglycerol Lipase Inhibitors and Prevent Fasting-Induced Refeeding. Journal of medicinal chemistry 60 (1) (2016)