Eddy Arnold

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 39

Top Topics

Men Who Have Sex With Men

Electron Microscopy

Top Venues

Journal of medicinal chemistry

Proceedings of the National Academy of Sciences of the United States of America

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Bin Tan, Xiaoming Zhang, Ahmadullah Ansari, Prakash Jadhav, Haozhou Tan, Kan Li, Ashima Chopra, Alexandra Ford, Xiang Chi, Francesc Xavier Ruiz, Eddy Arnold, Xufang Deng, Jun Wang
Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science (New York, N.Y.) 383 (6690) (2024)
Avik Biswas, Indrani Choudhuri, Eddy Arnold, Dmitry Lyumkis, Allan Haldane, Ronald M Levy
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Avik Biswas, Indrani Choudhuri, Eddy Arnold, Dmitry Lyumkis, Allan Haldane, Ronald M Levy
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Avik Biswas, Indrani Choudhuri, Eddy Arnold, Dmitry Lyumkis, Allan Haldane, Ronald M Levy
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Avik Biswas, Indrani Choudhuri, Eddy Arnold, Dmitry Lyumkis, Allan Haldane, Ronald M Levy
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Bin Tan, Xiaoming Zhang, Ahmadullah Ansari, Prakash Jadhav, Haozhou Tan, Kan Li, Ashima Chopra, Alexandra Ford, Xiang Chi, Francesc Xavier Ruiz, Eddy Arnold, Xufang Deng, Jun Wang
Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science (New York, N.Y.) 383 (6690) (2024)
Avik Biswas, Indrani Choudhuri, Eddy Arnold, Dmitry Lyumkis, Allan Haldane, Ronald M Levy
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Bin Tan, Xiaoming Zhang, Ahmadullah Ansari, Prakash Jadhav, Haozhou Tan, Kan Li, Ashima Chopra, Alexandra Ford, Xiang Chi, Francesc Xavier Ruiz, Eddy Arnold, Xufang Deng, Jun Wang
Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science (New York, N.Y.) 383 (6690) (2024)
Bin Tan, Xiaoming Zhang, Ahmadullah Ansari, Prakash Jadhav, Haozhou Tan, Kan Li, Ashima Chopra, Alexandra Ford, Xiang Chi, Francesc Xavier Ruiz, Eddy Arnold, Xufang Deng, Jun Wang
Design of a SARS-CoV-2 papain-like protease inhibitor with antiviral efficacy in a mouse model. Science (New York, N.Y.) 383 (6690) (2024)
Avik Biswas, Indrani Choudhuri, Eddy Arnold, Dmitry Lyumkis, Allan Haldane, Ronald M Levy
Kinetic coevolutionary models predict the temporal emergence of HIV-1 resistance mutations under drug selection pressure. Proceedings of the National Academy of Sciences of the United States of America 121 (15) (2024)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature 626 (7997) (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions, and adaptations of the human LINE-1 ORF2 protein. Nature (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature 626 (7997) (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature 626 (7997) (2023)
Ashima Chopra, Joseph D Bauman, Francesc Xavier Ruiz, Eddy Arnold
Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. Journal of medicinal chemistry (2023)
Ashima Chopra, Joseph D Bauman, Francesc Xavier Ruiz, Eddy Arnold
Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. Journal of medicinal chemistry 66 (9) (2023)
Ashima Chopra, Joseph D Bauman, Francesc Xavier Ruiz, Eddy Arnold
Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. Journal of medicinal chemistry 66 (9) (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature 626 (7997) (2023)
Mahta Mansouri, Shawn Rumrill, Shane Dawson, Adam Johnson, Jo-Anne Pinson, Menachem J Gunzburg, Catherine F Latham, Nicholas Barlow, George W Mbogo, Paula Ellenberg, Stephen J Headey, Nicolas Sluis-Cremer, David Tyssen, Joseph D Bauman, Francesc Xavier Ruiz, Eddy Arnold, David K Chalmers, Gilda Tachedjian
Targeting HIV-1 Reverse Transcriptase Using a Fragment-Based Approach. Molecules (Basel, Switzerland) 28 (7) (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions, and adaptations of the human LINE-1 ORF2 protein. Nature (2023)
Ashima Chopra, Joseph D Bauman, Francesc Xavier Ruiz, Eddy Arnold
Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. Journal of medicinal chemistry 66 (9) (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature (2023)
Eric T Baldwin, Trevor Van Eeuwen, David Hoyos, Arthur O Zalevsky, Egor P Tchesnokov, Roberto Sánchez, Bryant D Miller, Luciano H Di Stefano, Francesc Xavier Ruiz, Matthew Hancock, Esin Işik, Carlos Mendez-Dorantes, Thomas Walpole, Charles Nichols, Paul Wan, Kirsi Riento, Rowan Halls-Kass, Martin Augustin, Alfred Lammens, Anja Jestel, Paula Upla, Kera Xibinaku, Samantha Congreve, Maximiliaan Hennink, Kacper B Rogala, Anna M Schneider, Jennifer E Fairman, Shawn M Christensen, Brian Desrosiers, Gregory S Bisacchi, Oliver L Saunders, Nafeeza Hafeez, Wenyan Miao, Rosana Kapeller, Dennis M Zaller, Andrej Sali, Oliver Weichenrieder, Kathleen H Burns, Matthias Götte, Michael P Rout, Eddy Arnold, Benjamin D Greenbaum, Donna L Romero, John LaCava, Martin S Taylor
Structures, functions and adaptations of the human LINE-1 ORF2 protein. Nature 626 (7997) (2023)
Ashima Chopra, Joseph D Bauman, Francesc Xavier Ruiz, Eddy Arnold
Halo Library, a Tool for Rapid Identification of Ligand Binding Sites on Proteins Using Crystallographic Fragment Screening. Journal of medicinal chemistry 66 (9) (2023)
Jerry Joe E K Harrison, Dario Oliveira Passos, Jessica F Bruhn, Joseph D Bauman, Lynda Tuberty, Jeffrey J DeStefano, Francesc Xavier Ruiz, Dmitry Lyumkis, Eddy Arnold
Cryo-EM structure of the HIV-1 Pol polyprotein provides insights into virion maturation. Science advances 8 (27) (2022)
Eric T Baldwin, Matthias Götte, Egor P Tchesnokov, Eddy Arnold, Margit Hagel, Charles Nichols, Pam Dossang, Marieke Lamers, Paul Wan, Stefan Steinbacher, Donna L Romero
Human endogenous retrovirus-K (HERV-K) reverse transcriptase (RT) structure and biochemistry reveals remarkable similarities to HIV-1 RT and opportunities for HERV-K-specific inhibition. Proceedings of the National Academy of Sciences of the United States of America 119 (27) (2022)
Ruchi Yadav, Valentine V Courouble, Sanjay Kumar Dey, Jerry Joe E K Harrison, Jennifer Timm, Jesse B Hopkins, Ryan L Slack, Stefan G Sarafianos, Francesc Xavier Ruiz, Patrick R Griffin, Eddy Arnold
Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro. Science advances 8 (49) (2022)
Ruchi Yadav, Valentine V Courouble, Sanjay Kumar Dey, Jerry Joe E K Harrison, Jennifer Timm, Jesse B Hopkins, Ryan L Slack, Stefan G Sarafianos, Francesc Xavier Ruiz, Patrick R Griffin, Eddy Arnold
Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro. Science advances 8 (49) (2022)
Abhimanyu K Singh, Brent De Wijngaert, Marc Bijnens, Kris Uyttersprot, Hoai Nguyen, Sergio E Martinez, Dominique Schols, Piet Herdwijn, Christophe Pannecouque, Eddy Arnold, Kalyan Das
Cryo-EM structures of wild-type and E138K/M184I mutant HIV-1 RT/DNA complexed with inhibitors doravirine and rilpivirine. Proceedings of the National Academy of Sciences of the United States of America 119 (30) (2022)
Ruchi Yadav, Valentine V Courouble, Sanjay Kumar Dey, Jerry Joe E K Harrison, Jennifer Timm, Jesse B Hopkins, Ryan L Slack, Stefan G Sarafianos, Francesc Xavier Ruiz, Patrick R Griffin, Eddy Arnold
Biochemical and structural insights into SARS-CoV-2 polyprotein processing by Mpro. Science advances 8 (49) (2022)
Valentine V Courouble, Sanjay Kumar Dey, Ruchi Yadav, Jennifer Timm, Jerry Joe E K Harrison, Francesc X Ruiz, Eddy Arnold, Patrick R Griffin
Revealing the Structural Plasticity of SARS-CoV-2 nsp7 and nsp8 Using Structural Proteomics. Journal of the American Society for Mass Spectrometry 32 (7) (2021)
Natalie Losada, Francesc X Ruiz, Francesca Curreli, Kevin Gruber, Alyssa Pilch, Kalyan Das, Asim K Debnath, Eddy Arnold
HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites. Journal of medicinal chemistry 64 (22) (2021)
Dongwei Kang, Francesc X Ruiz, Yanying Sun, Da Feng, Lanlan Jing, Zhao Wang, Tao Zhang, Shenghua Gao, Lin Sun, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Peng Zhan, Xinyong Liu
2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. Journal of medicinal chemistry 64 (7) (2021)
Natalie Losada, Francesc X Ruiz, Francesca Curreli, Kevin Gruber, Alyssa Pilch, Andrea Altieri, Alexander V Kurkin, Kalyan Das, Asim K Debnath, Eddy Arnold
Correction to "HIV-1 gp120 Antagonists Also Inhibit HIV-1 Reverse Transcriptase by Bridging the NNRTI and NRTI Sites". Journal of medicinal chemistry 65 (1) (2021)
Dongwei Kang, F Xavier Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Xinyong Liu, Peng Zhan
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. Journal of medicinal chemistry 63 (3) (2020)
Hye Yeon Sagong, Joseph D Bauman, Aitor Nogales, Luis Martínez-Sobrido, Eddy Arnold, Edmond J LaVoie
Aryl and Arylalkyl Substituted 3-Hydroxypyridin-2(1H)-ones: Synthesis and Evaluation as Inhibitors of Influenza A Endonuclease. ChemMedChem 14 (12) (2019)
F Xavier Ruiz, Anthony Hoang, Kalyan Das, Eddy Arnold
Structural Basis of HIV-1 Inhibition by Nucleotide-Competing Reverse Transcriptase Inhibitor INDOPY-1. Journal of medicinal chemistry 62 (21) (2019)