Erik De Clercq

Publication Activity (10 Years)

Years Active: 2019-2024
Publications (10 Years): 70

Top Topics

Molecular Docking

Hepatitis C Virus Infection

Men Who Have Sex With Men

Top Venues

Journal of medicinal chemistry

Molecules (Basel, Switzerland)

International journal of molecular sciences

This page only lists publications with an associated author ORCID identifier.

Publications

Erik De Clercq
Selected Milestones in Antiviral Drug Development. Viruses 16 (2) (2024)
Erik De Clercq
Selected Milestones in Antiviral Drug Development. Viruses 16 (2) (2024)
Xuan-De Zhu, Angela Corona, Stefania Maloccu, Enzo Tramontano, Shuai Wang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Fen-Er Chen
Structure-Based Design of Novel Thiazolone[3,2- a ]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy. Molecules (Basel, Switzerland) 29 (9) (2024)
Zihao Sang, Tao Zhang, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Design and synthesis of Fsp 3 -enriched spirocyclic-substituted diarylpyrimidine derivatives as novel HIV-1 NNRTIs. Chemical biology & drug design 103 (3) (2024)
Erik De Clercq
Selected Milestones in Antiviral Drug Development. Viruses 16 (2) (2024)
Zihao Sang, Tao Zhang, Zhao Wang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Design and synthesis of Fsp 3 -enriched spirocyclic-substituted diarylpyrimidine derivatives as novel HIV-1 NNRTIs. Chemical biology & drug design 103 (3) (2024)
Kun Zhang, Yu-Jie Zhang, Min Li, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Xiangtao Chen
Deciphering the enigmas of non-nucleoside reverse transcriptase inhibitors (NNRTIs): A medicinal chemistry expedition towards combating HIV drug resistance. Medicinal research reviews (2024)
Xuan-De Zhu, Angela Corona, Stefania Maloccu, Enzo Tramontano, Shuai Wang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Fen-Er Chen
Structure-Based Design of Novel Thiazolone[3,2- a ]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy. Molecules (Basel, Switzerland) 29 (9) (2024)
Zongji Zhuo, Zhao Wang, Lanlan Jing, Tao Zhang, Anchao Ge, Zhenzhen Zhou, Ying Liu, Xin Li, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang
Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2- d ]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation. International journal of molecular sciences 25 (16) (2024)
Zongji Zhuo, Zhao Wang, Lanlan Jing, Tao Zhang, Anchao Ge, Zhenzhen Zhou, Ying Liu, Xin Li, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang
Discovery of Novel Amino Acids (Analogues)-Substituted Thiophene[3,2- d ]pyrimidine Derivatives as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Design, Synthesis, and Biological Evaluation. International journal of molecular sciences 25 (16) (2024)
Xuan-De Zhu, Angela Corona, Stefania Maloccu, Enzo Tramontano, Shuai Wang, Christophe Pannecouque, Erik De Clercq, Ge Meng, Fen-Er Chen
Structure-Based Design of Novel Thiazolone[3,2- a ]pyrimidine Derivatives as Potent RNase H Inhibitors for HIV Therapy. Molecules (Basel, Switzerland) 29 (9) (2024)
Erik De Clercq
Selected Milestones in Antiviral Drug Development. Viruses 16 (2) (2024)
Yanying Sun, Zhenzhen Zhou, Na Wang, Fabao Zhao, Ying Liu, Xiaoxuan Xu, Xiaohan Wang, Zhenbang Gou, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs. Journal of medicinal chemistry (2024)
Yanying Sun, Zhenzhen Zhou, Na Wang, Fabao Zhao, Ying Liu, Xiaoxuan Xu, Xiaohan Wang, Zhenbang Gou, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Discovery of Novel Aryl Triazolone Dihydropyridines (ATDPs) Targeting Highly Conserved Residue W229 as Promising HIV-1 NNRTIs. Journal of medicinal chemistry 67 (8) (2024)
Fabao Zhao, Heng Zhang, Minghui Xie, Bairu Meng, Na Liu, Caiyun Dun, Yanyang Qin, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Ya-Jie Tang, Peng Zhan, Xinyong Liu, Dongwei Kang
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. Journal of medicinal chemistry 66 (3) (2023)
Xujie Zhang, Lin Sun, Shujing Xu, Tianguang Huang, Fabao Zhao, Dang Ding, Chuanfeng Liu, Xiangyi Jiang, Yucen Tao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Alexej Dick, Xinyong Liu, Peng Zhan
Design, synthesis, and mechanistic study of 2-piperazineone-bearing peptidomimetics as novel HIV capsid modulators. RSC medicinal chemistry 14 (7) (2023)
Erik De Clercq
The development of BVDU: An odyssey. Antiviral chemistry & chemotherapy 31 (2023)
Zhao Wang, Prem Prakash Sharma, Brijesh Rathi, Minghui Xie, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Escaping from Flatland: Multiparameter Optimization Leads to the Discovery of Novel Tetrahydropyrido[4,3- d ]pyrimidine Derivatives as Human Immunodeficiency Virus-1 Non-nucleoside Reverse Transcriptase Inhibitors with Superior Antiviral Activities against Non-nucleoside Reverse Transcriptase Inhibitor-Resistant Variants and Favorable Drug-like Profiles. Journal of medicinal chemistry (2023)
Guangdi Li, Rolf Hilgenfeld, Richard J Whitley, Erik De Clercq
Therapeutic strategies for COVID-19: progress and lessons learned. Nature reviews. Drug discovery (2023)
Zhenzhen Zhou, Bairu Meng, Jiaqi An, Fabao Zhao, Yanying Sun, Dan Zeng, Wenna Wang, Shenghua Gao, Yu Xia, Caiyun Dun, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study. International journal of molecular sciences 24 (2) (2023)
Shujing Xu, Lin Sun, Michael Barnett, Xujie Zhang, Dang Ding, Anushka Gattu, Dazhou Shi, Jamie R H Taka, Wenli Shen, Xiangyi Jiang, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, David C Goldstone, Xinyong Liu, Alexej Dick, Peng Zhan
Discovery, Crystallographic Studies, and Mechanistic Investigations of Novel Phenylalanine Derivatives Bearing a Quinazolin-4-one Scaffold as Potent HIV Capsid Modulators. Journal of medicinal chemistry (2023)
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors. Communications chemistry 6 (1) (2023)
Zhenzhen Zhou, Bairu Meng, Jiaqi An, Fabao Zhao, Yanying Sun, Dan Zeng, Wenna Wang, Shenghua Gao, Yu Xia, Caiyun Dun, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study. International journal of molecular sciences 24 (2) (2023)
Fabao Zhao, Heng Zhang, Minghui Xie, Bairu Meng, Na Liu, Caiyun Dun, Yanyang Qin, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Ya-Jie Tang, Peng Zhan, Xinyong Liu, Dongwei Kang
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. Journal of medicinal chemistry 66 (3) (2023)
Zhenzhen Zhou, Bairu Meng, Jiaqi An, Fabao Zhao, Yanying Sun, Dan Zeng, Wenna Wang, Shenghua Gao, Yu Xia, Caiyun Dun, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study. International journal of molecular sciences 24 (2) (2023)
Ya-Li Sang, Christophe Pannecouque, Erik De Clercq, Shuai Wang, Xiangtao Chen
Fragment Hopping-Based Design of Novel Biphenyl-DAPY Derivatives as Potent Non-Nucleoside Reverse Transcriptase Inhibitors Featuring Significantly Improved Anti-Resistance Efficacy. Journal of medicinal chemistry (2023)
Erik De Clercq
The development of BVDU: An odyssey. Antiviral chemistry & chemotherapy 31 (2023)
Erik De Clercq
Hydrogen Bonding (Base Pairing) in Antiviral Activity. Viruses 15 (5) (2023)
Fabao Zhao, Heng Zhang, Minghui Xie, Bairu Meng, Na Liu, Caiyun Dun, Yanyang Qin, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Ya-Jie Tang, Peng Zhan, Xinyong Liu, Dongwei Kang
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. Journal of medicinal chemistry 66 (3) (2023)
Xiangyi Jiang, Boshi Huang, Shawn Rumrill, David Pople, Waleed A Zalloum, Dongwei Kang, Fabao Zhao, Xiangkai Ji, Zhen Gao, Lide Hu, Zhao Wang, Minghui Xie, Erik De Clercq, Francesc X Ruiz, Eddy Arnold, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Discovery of diarylpyrimidine derivatives bearing piperazine sulfonyl as potent HIV-1 nonnucleoside reverse transcriptase inhibitors. Communications chemistry 6 (1) (2023)
Fabao Zhao, Heng Zhang, Minghui Xie, Bairu Meng, Na Liu, Caiyun Dun, Yanyang Qin, Shenghua Gao, Erik De Clercq, Christophe Pannecouque, Ya-Jie Tang, Peng Zhan, Xinyong Liu, Dongwei Kang
Structure-Based Optimization of 2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: Exploiting the Tolerant Regions of the Non-Nucleoside Reverse Transcriptase Inhibitors' Binding Pocket. Journal of medicinal chemistry (2023)
Zhenzhen Zhou, Bairu Meng, Jiaqi An, Fabao Zhao, Yanying Sun, Dan Zeng, Wenna Wang, Shenghua Gao, Yu Xia, Caiyun Dun, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Dongwei Kang, Xinyong Liu
Covalently Targeted Highly Conserved Tyr318 to Improve the Drug Resistance Profiles of HIV-1 NNRTIs: A Proof-of-Concept Study. International journal of molecular sciences 24 (2) (2023)
Erik De Clercq
The development of BVDU: An odyssey. Antiviral chemistry & chemotherapy 31 (2023)
Li Ding, Christophe Pannecouque, Erik De Clercq, Chun-Lin Zhuang, Xiangtao Chen
Discovery of Novel Pyridine-Dimethyl-Phenyl-DAPY Hybrids by Molecular Fusing of Methyl-Pyrimidine-DAPYs and Difluoro-Pyridinyl-DAPYs: Improving the Druggability toward High Inhibitory Activity, Solubility, Safety, and PK. Journal of medicinal chemistry 65 (3) (2022)
Erik De Clercq
Cidofovir for the Treatment of Molluscum Contagiosum Virus. Viruses 14 (11) (2022)
Shujing Xu, Lin Sun, Waleed A Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators. Molecules (Basel, Switzerland) 27 (23) (2022)
Shujing Xu, Lin Sun, Waleed A Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators. Molecules (Basel, Switzerland) 27 (23) (2022)
Xujie Zhang, Lin Sun, Shujing Xu, Xiaoyu Shao, Ziyi Li, Dang Ding, Xiangyi Jiang, Shujie Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Design, Synthesis, and Mechanistic Study of 2-Pyridone-Bearing Phenylalanine Derivatives as Novel HIV Capsid Modulators. Molecules (Basel, Switzerland) 27 (21) (2022)
Erik De Clercq
FV-100 for the Treatment of Varicella-Virus (VZV) Infections: Quo Vadis? Viruses 14 (4) (2022)
Yanying Sun, Zhenzhen Zhou, Da Feng, Lanlan Jing, Fabao Zhao, Zhao Wang, Tao Zhang, Hao Lin, Hao Song, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu, Dongwei Kang
Lead Optimization and Avoidance of Metabolic-perturbing Motif Developing Novel Diarylpyrimidines as Potent HIV-1 NNRTIs. Journal of medicinal chemistry 65 (23) (2022)
Shujing Xu, Lin Sun, Waleed A Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators. Molecules (Basel, Switzerland) 27 (23) (2022)
Xiangkai Ji, Jing Li, Prem Prakash Sharma, Xiangyi Jiang, Brijesh Rathi, Zhen Gao, Lide Hu, Dongwei Kang, Erik De Clercq, Simon Cocklin, Chuanfeng Liu, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Design, Synthesis and Structure-Activity Relationships of Phenylalanine-Containing Peptidomimetics as Novel HIV-1 Capsid Binders Based on Ugi Four-Component Reaction. Molecules (Basel, Switzerland) 27 (18) (2022)
Zhao Wang, Srinivasulu Cherukupalli, Minghui Xie, Wenbo Wang, Xiangyi Jiang, Ruifang Jia, Christophe Pannecouque, Erik De Clercq, Dongwei Kang, Peng Zhan, Xinyong Liu
Contemporary Medicinal Chemistry Strategies for the Discovery and Development of Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors. Journal of medicinal chemistry 65 (5) (2022)
Erik De Clercq
Reflections on the Rega Institute for Medical Research, at the fiftieth anniversary of the Rega Stichting vzw (Rega Instituut vzw, Rega Foundation). Antiviral chemistry & chemotherapy 30 (2022)
Dongwei Kang, Yanying Sun, Da Feng, Shenghua Gao, Zhao Wang, Lanlan Jing, Tao Zhang, Xiangyi Jiang, Hao Lin, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Development of Novel Dihydrofuro[3,4- d ]pyrimidine Derivatives as HIV-1 NNRTIs to Overcome the Highly Resistant Mutant Strains F227L/V106A and K103N/Y181C. Journal of medicinal chemistry 65 (3) (2022)
Erik De Clercq
The Elegance of the Acyclic Nucleoside Phosphonates (ANPs), Honorary Tribute to Antonín Holý, Who Passed Away on 16 July 2012, at the 10th Anniversary of His Death. Viruses 14 (9) (2022)
Tao Zhang, Zhongxia Zhou, Fabao Zhao, Zihao Sang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Identification of Novel Diarylpyrimidines as Potent HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors by Exploring the Primer Grip Region. Pharmaceuticals (Basel, Switzerland) 15 (11) (2022)
Shujing Xu, Lin Sun, Waleed A Zalloum, Tianguang Huang, Xujie Zhang, Dang Ding, Xiaoyu Shao, Xiangyi Jiang, Fabao Zhao, Simon Cocklin, Erik De Clercq, Christophe Pannecouque, Alexej Dick, Xinyong Liu, Peng Zhan
Discovery and Mechanistic Investigation of Piperazinone Phenylalanine Derivatives with Terminal Indole or Benzene Ring as Novel HIV-1 Capsid Modulators. Molecules (Basel, Switzerland) 27 (23) (2022)
Da Feng, Hao Lin, Liyang Jiang, Zhao Wang, Yanying Sun, Zhongxia Zhou, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Identification of Boronate-Containing Diarylpyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors. Molecules (Basel, Switzerland) 27 (21) (2022)
Xin Jin, Li-Min Zhao, Shuai Wang, Wen-Juan Huang, Yin-Xiang Zhang, Christophe Pannecouque, Erik De Clercq, Xiangtao Chen
Structure-Based Discovery of Novel NH 2 -Biphenyl-Diarylpyrimidines as Potent Non-Nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Safety: From NH 2 -Naphthyl-Diarylpyrimidine to NH 2 -Biphenyl-Diarylpyrimidine. Journal of medicinal chemistry 65 (12) (2022)
Miao Miao, Erik De Clercq, Guangdi Li
Towards Efficient and Accurate SARS-CoV-2 Genome Sequence Typing Based on Supervised Learning Approaches. Microorganisms 10 (9) (2022)
Zhao Wang, Waleed A Zalloum, Wenbo Wang, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Dongwei Kang, Peng Zhan, Xinyong Liu
Discovery of Novel Dihydrothiopyrano[4,3-d]pyrimidine Derivatives as Potent HIV-1 NNRTIs with Significantly Reduced hERG Inhibitory Activity and Improved Resistance Profiles. Journal of medicinal chemistry 64 (18) (2021)
Li Ding, Christophe Pannecouque, Erik De Clercq, Chun-Lin Zhuang, Xiangtao Chen
Hydrophobic Pocket Occupation Design of Difluoro-Biphenyl-Diarylpyrimidines as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors: from N-Alkylation to Methyl Hopping on the Pyrimidine Ring. Journal of medicinal chemistry 64 (8) (2021)
Erik De Clercq
Tribute to John C. Martin at the Twentieth Anniversary of the Breakthrough of Tenofovir in the Treatment of HIV Infections. Viruses 13 (12) (2021)
Dongwei Kang, Francesc X Ruiz, Yanying Sun, Da Feng, Lanlan Jing, Zhao Wang, Tao Zhang, Shenghua Gao, Lin Sun, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Peng Zhan, Xinyong Liu
2,4,5-Trisubstituted Pyrimidines as Potent HIV-1 NNRTIs: Rational Design, Synthesis, Activity Evaluation, and Crystallographic Studies. Journal of medicinal chemistry 64 (7) (2021)
Li Ding, Christophe Pannecouque, Erik De Clercq, Chun-Lin Zhuang, Xiangtao Chen
Improving Druggability of Novel Diarylpyrimidine NNRTIs by a Fragment-Based Replacement Strategy: From Biphenyl-DAPYs to Heteroaromatic-Biphenyl-DAPYs. Journal of medicinal chemistry 64 (14) (2021)
Erik De Clercq
1984-Discovery of the First Anti-HIV Drug, Suramin. Viruses 13 (8) (2021)
Boshi Huang, Tiziana Ginex, Francisco Javier Luque, Xiangyi Jiang, Ping Gao, Jian Zhang, Dongwei Kang, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Structure-Based Design and Discovery of Pyridyl-Bearing Fused Bicyclic HIV-1 Inhibitors: Synthesis, Biological Characterization, and Molecular Modeling Studies. Journal of medicinal chemistry 64 (18) (2021)
Miao Miao, Erik De Clercq, Guangdi Li
Genetic Diversity of SARS-CoV-2 over a One-Year Period of the COVID-19 Pandemic: A Global Perspective. Biomedicines 9 (4) (2021)
Ting-Ting Li, Christophe Pannecouque, Erik De Clercq, Chun-Lin Zhuang, Fen-Er Chen
Scaffold Hopping in Discovery of HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors: From CH(CN)-DABOs to CH(CN)-DAPYs. Molecules (Basel, Switzerland) 25 (7) (2020)
Lin Sun, Alexej Dick, Megan E Meuser, Tianguang Huang, Waleed A Zalloum, Chin-Ho Chen, Srinivasulu Cherukupalli, Shujing Xu, Xiao Ding, Ping Gao, Dongwei Kang, Erik De Clercq, Christophe Pannecouque, Simon Cocklin, Kuo-Hsiung Lee, Xinyong Liu, Peng Zhan
Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities. Journal of medicinal chemistry 63 (9) (2020)
Miao Miao, Xixi Jing, Erik De Clercq, Guangdi Li
Danoprevir for the Treatment of Hepatitis C Virus Infection: Design, Development, and Place in Therapy. Drug design, development and therapy 14 (2020)
Dongwei Kang, Da Feng, Yanying Sun, Zengjun Fang, Fenju Wei, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan
Structure-Based Bioisosterism Yields HIV-1 NNRTIs with Improved Drug-Resistance Profiles and Favorable Pharmacokinetic Properties. Journal of medicinal chemistry 63 (9) (2020)
Dongwei Kang, Yanying Sun, Murugan Natarajan Arul, Da Feng, Fenju Wei, Jing Li, Xiangyi Jiang, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu
Structure-Activity Relationship Exploration of NNIBP Tolerant Region I Leads to Potent HIV-1 NNRTIs. ACS infectious diseases 6 (8) (2020)
Dongwei Kang, F Xavier Ruiz, Da Feng, Alyssa Pilch, Tong Zhao, Fenju Wei, Zhao Wang, Yanying Sun, Zengjun Fang, Erik De Clercq, Christophe Pannecouque, Eddy Arnold, Xinyong Liu, Peng Zhan
Discovery and Characterization of Fluorine-Substituted Diarylpyrimidine Derivatives as Novel HIV-1 NNRTIs with Highly Improved Resistance Profiles and Low Activity for the hERG Ion Channel. Journal of medicinal chemistry 63 (3) (2020)
Yuan Lei, Sheng Han, Yang Yang, Christophe Pannecouque, Erik De Clercq, Chun-Lin Zhuang, Fen-Er Chen
Design of Biphenyl-Substituted Diarylpyrimidines with a Cyanomethyl Linker as HIV-1 NNRTIs via a Molecular Hybridization Strategy. Molecules (Basel, Switzerland) 25 (5) (2020)
Gaochan Wu, Tong Zhao, Dongwei Kang, Jian Zhang, Yuning Song, Vigneshwaran Namasivayam, Jacob Kongsted, Christophe Pannecouque, Erik De Clercq, Vasanthanathan Poongavanam, Xinyong Liu, Peng Zhan
Overview of Recent Strategic Advances in Medicinal Chemistry. Journal of medicinal chemistry 62 (21) (2019)
Erik De Clercq
Fifty Years in Search of Selective Antiviral Drugs. Journal of medicinal chemistry 62 (16) (2019)
Yali Sang, Sheng Han, Christophe Pannecouque, Erik De Clercq, Chun-Lin Zhuang, Xiangtao Chen
Ligand-Based Design of Nondimethylphenyl-Diarylpyrimidines with Improved Metabolic Stability, Safety, and Oral Pharmacokinetic Profiles. Journal of medicinal chemistry 62 (24) (2019)
Erik De Clercq
New Nucleoside Analogues for the Treatment of Hemorrhagic Fever Virus Infections. Chemistry, an Asian journal 14 (22) (2019)