Ignacio Moraga

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 15

Top Venues

Nature communications

eLife

Science signaling

The Journal of biological chemistry

University of Dundee

Institut Pasteur (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Dundee Sep 01 2016

United Kingdom

Principal Investigator :: Cell Signalling and Immunology

Stanford University Oct 01 2010 - May 31 2015

United States

Postdoctoral Fellow :: Dept. of Molecular and Cellular Physiology

Education History

Institut Pasteur Dec 01 2006 - Dec 31 2009

France

PHD :: Immunology

Publications

Scott Gardner, Yibo Jin, Paul K Fyfe, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nature communications 15 (1) (2024)
Scott Gardner, Yibo Jin, Paul K Fyfe, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nature communications 15 (1) (2024)
Scott Gardner, Yibo Jin, Paul K Fyfe, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nature communications 15 (1) (2024)
Scott Gardner, Yibo Jin, Paul K Fyfe, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nature communications 15 (1) (2024)
Silvia Gaggero, Jonathan Martínez-Fábregas, Adeline Cozzani, Paul K Fyfe, Malo Leprohon, Jie Yang, F Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff-Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Science immunology 7 (78) (2022)
Lawrence A Stern, Sharareh Gholamin, Ignacio Moraga, Xin Yang, Supraja Saravanakumar, Joseph R Cohen, Renate Starr, Brenda Aguilar, Vanessa Salvary, Jonathan C Hibbard, Anusha Kalbasi, Jennifer K Shepphird, James O'Hearn, K Christopher Garcia, Christine E Brown
Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy. Proceedings of the National Academy of Sciences of the United States of America 119 (33) (2022)
Yibo Jin, Paul K Fyfe, Scott Gardner, Stephan Wilmes, Doryen Bubeck, Ignacio Moraga
Structural insights into the assembly and activation of the IL-27 signaling complex. EMBO reports 23 (10) (2022)
Alison McFarlane, Elizabeth Pohler, Ignacio Moraga
Molecular and cellular factors determining the functional pleiotropy of cytokines. The FEBS journal (2022)
Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martínez-Fábregas, Maximillian Hafer, Paul K Fyfe, Elizabeth Pohler, Silvia Gaggero, Martín López-García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-París, Ignacio Moraga
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses. eLife 10 (2021)
Claire Gorby, Junel Sotolongo Bellón, Stephan Wilmes, Walid Warda, Elizabeth Pohler, Paul K Fyfe, Adeline Cozzani, Christophe Ferrand, Mark R Walter, Suman Mitra, Jacob Piehler, Ignacio Moraga
Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses. Science signaling 13 (649) (2020)
Stephan Wilmes, Maximillian Hafer, Joni Vuorio, Julie A Tucker, Hauke Winkelmann, Sara Löchte, Tess A Stanly, Katiuska D Pulgar Prieto, Chetan S Poojari, Vivek Sharma, Christian P Richter, Rainer Kurre, Stevan R Hubbard, K Christopher Garcia, Ignacio Moraga, Ilpo Vattulainen, Ian S Hitchcock, Jacob Piehler
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science (New York, N.Y.) 367 (6478) (2020)
Jonathan Martínez-Fábregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity. eLife 8 (2019)
Jamie B Spangler, Ignacio Moraga, Kevin M Jude, Christina S Savvides, K Christopher Garcia
A strategy for the selection of monovalent antibodies that span protein dimer interfaces. The Journal of biological chemistry 294 (38) (2019)
Yu Chen, Maud Vandereyken, Ian Paterson Newton, Ignacio Moraga, Inke S Näthke, Mahima Swamy
Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22. PLoS biology 17 (11) (2019)
Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia
Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers. eLife 6 (2017)

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Publication Activity (10 Years)

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Ignacio Moraga