K Christopher Garcia

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 90

Top Topics

Regulatory T Cells

Endoscopic Submucosal Dissection

Binding Protein

Top Venues

Science (New York, N.Y.)

Nature communications

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

Hunter A Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K Reid, Nadine Nagy, Graham L Barlow, Ben A Falk, Carlos O Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H Meyer, Lucile E Wrenshall, James D Lord, K Christopher Garcia, Theo D Palmer, Lawrence Steinman, Gerald T Nepom, Thomas N Wight, Paul L Bollyky, Hedwich F Kuipers
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nature communications 15 (1) (2024)
Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi, Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien, Elizabeth D Mellins, K Christopher Garcia, Po-Ssu Huang
A general platform for targeting MHC-II antigens via a single loop. bioRxiv : the preprint server for biology (2024)
Hanlun Jiang, Kevin M Jude, Kejia Wu, Jorge Fallas, George Ueda, T J Brunette, Derrick R Hicks, Harley Pyles, Aerin Yang, Lauren Carter, Mila Lamb, Xinting Li, Paul M Levine, Lance J Stewart, K Christopher Garcia, Julien S Baker
De novo design of buttressed loops for sculpting protein functions. Nature chemical biology (2024)
Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi, Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien, Elizabeth D Mellins, K Christopher Garcia, Po-Ssu Huang
A general platform for targeting MHC-II antigens via a single loop. bioRxiv : the preprint server for biology (2024)
Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi, Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien, Elizabeth D Mellins, K Christopher Garcia, Po-Ssu Huang
A general platform for targeting MHC-II antigens via a single loop. bioRxiv : the preprint server for biology (2024)
Hunter A Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K Reid, Nadine Nagy, Graham L Barlow, Ben A Falk, Carlos O Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H Meyer, Lucile E Wrenshall, James D Lord, K Christopher Garcia, Theo D Palmer, Lawrence Steinman, Gerald T Nepom, Thomas N Wight, Paul L Bollyky, Hedwich F Kuipers
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nature communications 15 (1) (2024)
Hunter A Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K Reid, Nadine Nagy, Graham L Barlow, Ben A Falk, Carlos O Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H Meyer, Lucile E Wrenshall, James D Lord, K Christopher Garcia, Theo D Palmer, Lawrence Steinman, Gerald T Nepom, Thomas N Wight, Paul L Bollyky, Hedwich F Kuipers
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nature communications 15 (1) (2024)
Buwei Huang, Brian Coventry, Marta T Borowska, Dimitrios C Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M Jude, Samer F Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Margaret Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance J Stewart, Deborah Heydenburg Fuller, Ying Mei, K Christopher Garcia, Julien S Baker
De novo design of miniprotein antagonists of cytokine storm inducers. Nature communications 15 (1) (2024)
Hanlun Jiang, Kevin M Jude, Kejia Wu, Jorge Fallas, George Ueda, T J Brunette, Derrick R Hicks, Harley Pyles, Aerin Yang, Lauren Carter, Mila Lamb, Xinting Li, Paul M Levine, Lance J Stewart, K Christopher Garcia, Julien S Baker
De novo design of buttressed loops for sculpting protein functions. Nature chemical biology 20 (8) (2024)
Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi, Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien, Elizabeth D Mellins, K Christopher Garcia, Po-Ssu Huang
A general platform for targeting MHC-II antigens via a single loop. bioRxiv : the preprint server for biology (2024)
Buwei Huang, Brian Coventry, Marta T Borowska, Dimitrios C Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M Jude, Samer F Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Margaret Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance J Stewart, Deborah Heydenburg Fuller, Ying Mei, K Christopher Garcia, Julien S Baker
De novo design of miniprotein antagonists of cytokine storm inducers. Nature communications 15 (1) (2024)
Buwei Huang, Brian Coventry, Marta T Borowska, Dimitrios C Arhontoulis, Marc Exposit, Mohamad Abedi, Kevin M Jude, Samer F Halabiya, Aza Allen, Cami Cordray, Inna Goreshnik, Margaret Ahlrichs, Sidney Chan, Hillary Tunggal, Michelle DeWitt, Nathaniel Hyams, Lauren Carter, Lance J Stewart, Deborah Heydenburg Fuller, Ying Mei, K Christopher Garcia, Julien S Baker
De novo design of miniprotein antagonists of cytokine storm inducers. Nature communications 15 (1) (2024)
Hunter A Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K Reid, Nadine Nagy, Graham L Barlow, Ben A Falk, Carlos O Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H Meyer, Lucile E Wrenshall, James D Lord, K Christopher Garcia, Theo D Palmer, Lawrence Steinman, Gerald T Nepom, Thomas N Wight, Paul L Bollyky, Hedwich F Kuipers
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nature communications 15 (1) (2024)
Hunter A Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K Reid, Nadine Nagy, Graham L Barlow, Ben A Falk, Carlos O Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H Meyer, Lucile E Wrenshall, James D Lord, K Christopher Garcia, Theo D Palmer, Lawrence Steinman, Gerald T Nepom, Thomas N Wight, Paul L Bollyky, Hedwich F Kuipers
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nature communications 15 (1) (2024)
Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi, Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien, Elizabeth D Mellins, K Christopher Garcia, Po-Ssu Huang
A general platform for targeting MHC-II antigens via a single loop. bioRxiv : the preprint server for biology (2024)
Hunter A Martinez, Ievgen Koliesnik, Gernot Kaber, Jacqueline K Reid, Nadine Nagy, Graham L Barlow, Ben A Falk, Carlos O Medina, Aviv Hargil, Svenja Zihsler, Israel Vlodavsky, Jin-Ping Li, Magdiel Pérez-Cruz, Sai-Wen Tang, Everett H Meyer, Lucile E Wrenshall, James D Lord, K Christopher Garcia, Theo D Palmer, Lawrence Steinman, Gerald T Nepom, Thomas N Wight, Paul L Bollyky, Hedwich F Kuipers
Regulatory T cells use heparanase to access IL-2 bound to extracellular matrix in inflamed tissue. Nature communications 15 (1) (2024)
Hanlun Jiang, Kevin M Jude, Kejia Wu, Jorge Fallas, George Ueda, T J Brunette, Derrick R Hicks, Harley Pyles, Aerin Yang, Lauren Carter, Mila Lamb, Xinting Li, Paul M Levine, Lance J Stewart, K Christopher Garcia, Julien S Baker
De novo design of buttressed loops for sculpting protein functions. Nature chemical biology 20 (8) (2024)
Haotian Du, Jingjia Liu, Kevin M Jude, Xinbo Yang, Ying Li, Braxton Bell, Hongli Yang, Audrey Kassardjian, Ali Mobedi, Udit Parekh, R Andres Parra Sperberg, Jean-Philippe Julien, Elizabeth D Mellins, K Christopher Garcia, Po-Ssu Huang
A general platform for targeting MHC-II antigens via a single loop. bioRxiv : the preprint server for biology (2024)
Nan Wang, Deepa Waghray, Nathanael A Caveney, Kevin M Jude, K Christopher Garcia
Structural insights into human MHC-II association with invariant chain. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Nan Wang, Deepa Waghray, Nathanael A Caveney, Kevin M Jude, K Christopher Garcia
Structural insights into human MHC-II association with invariant chain. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Hanlun Jiang, Kevin M Jude, Kejia Wu, Jorge Fallas, George Ueda, T J Brunette, Derrick R Hicks, Harley Pyles, Aerin Yang, Lauren Carter, Mila Lamb, Xinting Li, Paul M Levine, Lance J Stewart, K Christopher Garcia, Julien S Baker
De novo design of buttressed loops for sculpting protein functions. Nature chemical biology 20 (8) (2024)
Nan Wang, Deepa Waghray, Nathanael A Caveney, Kevin M Jude, K Christopher Garcia
Structural insights into human MHC-II association with invariant chain. Proceedings of the National Academy of Sciences of the United States of America 121 (19) (2024)
Hanlun Jiang, Kevin M Jude, Kejia Wu, Jorge Fallas, George Ueda, T J Brunette, Derrick R Hicks, Harley Pyles, Aerin Yang, Lauren Carter, Mila Lamb, Xinting Li, Paul M Levine, Lance J Stewart, K Christopher Garcia, Julien S Baker
De novo design of buttressed loops for sculpting protein functions. Nature chemical biology (2024)
Nathanael A Caveney, Naotaka Tsutsumi, K Christopher Garcia
Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. bioRxiv : the preprint server for biology (2023)
Waipan Chan, Yuqi M Cao, Xiang Zhao, Edward C Schrom, Dongya Jia, Jian Song, Leah V Sibener, Shen Dong, Ricardo A Fernandes, Clinton J Bradfield, Margery G Smelkinson, Juraj Kabat, Jyh Liang Hor, Grégoire Altan-Bonnet, K Christopher Garcia, Ronald N Germain
TCR ligand potency differentially impacts PD-1 inhibitory effects on diverse signaling pathways. The Journal of experimental medicine 220 (12) (2023)
Hanlun Jiang, Kevin M Jude, Kejia Wu, Jorge Fallas, George Ueda, T J Brunette, Derrick R Hicks, Harley Pyles, Aerin Yang, Lauren Carter, Mila Lamb, Xinting Li, Paul M Levine, Lance Stewart, K Christopher Garcia, Julien S Baker
De novo design of buttressed loops for sculpting protein functions. bioRxiv : the preprint server for biology (2023)
Xinbo Yang, Daisuke Nishimiya, Sara Löchte, Kevin M Jude, Marta Borowska, Christina S Savvides, Michael Dougan, Leon L Su, Xiang Zhao, Jacob Piehler, K Christopher Garcia
Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy. Nature biotechnology (2023)
Aerin Yang, Kevin M Jude, Ben Lai, Mason Minot, Anna M Kocyla, Caleb R Glassman, Daisuke Nishimiya, Yoon Seok Kim, Sai T Reddy, Aly A Khan, K Christopher Garcia
Deploying synthetic coevolution and machine learning to engineer protein-protein interactions. Science (New York, N.Y.) 381 (6656) (2023)
Emma C Dean, Daniel F Ditoro, Duy Pham, Min Gao, Carlene L Zindl, Blake Frey, Stacey N Harbour, David A Figge, Aidan T Miller, Caleb R Glassman, K Christopher Garcia, Robin D Hatton, Casey T Weaver
IL-2-induced Stat3 Signaling is Critical for Effector Treg Cell Programming. bioRxiv : the preprint server for biology (2023)
Robert A Saxton, Nathanael A Caveney, Maria Dolores Moya-Garzon, Karsten D Householder, Grayson E Rodriguez, Kylie A Burdsall, Jonathan Z Long, K Christopher Garcia
Structural insights into the mechanism of leptin receptor activation. Nature communications 14 (1) (2023)
Dirk H Siepe, Lora K Picton, K Christopher Garcia
Receptor Elimination by E3 Ubiquitin Ligase Recruitment (REULR): A Targeted Protein Degradation Toolbox. ACS synthetic biology (2023)
Naotaka Tsutsumi, Sunhee Hwang, Deepa Waghray, Simon Hansen, Kevin M Jude, Nan Wang, Yi Miao, Caleb R Glassman, Nathanael A Caveney, Claudia Y Janda, Rami N Hannoush, K Christopher Garcia
Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Nils Wellhausen, Ryan P O'Connell, Stefanie Lesch, Nils Wolfgang Engel, Austin K Rennels, Donna M Gonzales, Friederike Herbst, Regina M Young, K Christopher Garcia, David B Weiner, Carl H June, Saar I Gill
Epitope base editing CD45 in hematopoietic cells enables universal blood cancer immune therapy. Science translational medicine (2023)
Xinbo Yang, Daisuke Nishimiya, Sara Löchte, Kevin M Jude, Marta Borowska, Christina S Savvides, Michael Dougan, Leon L Su, Xiang Zhao, Jacob Piehler, K Christopher Garcia
Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy. Nature biotechnology (2023)
Nathanael A Caveney, Naotaka Tsutsumi, K Christopher Garcia
Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. bioRxiv : the preprint server for biology (2023)
Nathanael A Caveney, Naotaka Tsutsumi, K Christopher Garcia
Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. bioRxiv : the preprint server for biology (2023)
Robert A Saxton, Nathanael A Caveney, Maria Dolores Moya-Garzon, Karsten D Householder, Grayson E Rodriguez, Kylie A Burdsall, Jonathan Z Long, K Christopher Garcia
Structural insights into the mechanism of leptin receptor activation. Nature communications 14 (1) (2023)
Nathanael A Caveney, Naotaka Tsutsumi, K Christopher Garcia
Structural insight into guanylyl cyclase receptor hijacking of the kinase-Hsp90 regulatory mechanism. eLife 12 (2023)
Naotaka Tsutsumi, Sunhee Hwang, Deepa Waghray, Simon Hansen, Kevin M Jude, Nan Wang, Yi Miao, Caleb R Glassman, Nathanael A Caveney, Claudia Y Janda, Rami N Hannoush, K Christopher Garcia
Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proceedings of the National Academy of Sciences of the United States of America 120 (11) (2023)
Huilin Yang, Umut Y Ulge, Alfredo Quijano-Rubio, Zachary J Bernstein, David R Maestas, Jung-Ho Chun, Wentao Wang, Jian-Xin Lin, Kevin M Jude, Srujan Singh, Brian T Orcutt-Jahns, Peng Li, Jody Mou, Liam Chung, Yun-Huai Kuo, Yasmin H Ali, Aaron S Meyer, Warren L Grayson, Nicola M Heller, K Christopher Garcia, Warren J Leonard, Daniel Adriano Silva, Jennifer H Elisseeff, Julien S Baker, Jamie B Spangler
Design of cell-type-specific hyperstable IL-4 mimetics via modular de novo scaffolds. Nature chemical biology (2023)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Martti Maimets, Marianne Terndrup Pedersen, Jordi Guiu, Jes Dreier, Malte Thodberg, Yasuko Antoku, Pawel J Schweiger, Leonor Rib, Raul Bardini Bressan, Yi Miao, K Christopher Garcia, Albin Sandelin, Palle Serup, Kim Bak Jensen
Mesenchymal-epithelial crosstalk shapes intestinal regionalisation via Wnt and Shh signalling. Nature communications 13 (1) (2022)
Naotaka Tsutsumi, Shoji Maeda, Qianhui Qu, Martin Vögele, Kevin M Jude, Carl-Mikael Suomivuori, Ouliana Panova, Deepa Waghray, Hideaki E Kato, Andrew Velasco, Ron O Dror, Georgios Skiniotis, Brian K Kobilka, K Christopher Garcia
Atypical structural snapshots of human cytomegalovirus GPCR interactions with host G proteins. Science advances 8 (3) (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Caleb R Glassman, Naotaka Tsutsumi, Robert A Saxton, Patrick J Lupardus, Kevin M Jude, K Christopher Garcia
Structure of a Janus kinase cytokine receptor complex reveals the basis for dimeric activation. Science (New York, N.Y.) 376 (6589) (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Junming Ren, Yeara Jo, Lora K Picton, Leon L Su, David H Raulet, K Christopher Garcia
Induced CD45 Proximity Potentiates Natural Killer Cell Receptor Antagonism. ACS synthetic biology 11 (10) (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Dirk H Siepe, Lukas T Henneberg, Steven C Wilson, Gaelen T Hess, Michael C Bassik, Kai Zinn, K Christopher Garcia
Identification of orphan ligand-receptor relationships using a cell-based CRISPRa enrichment screening platform. eLife 11 (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Anusha Kalbasi, Mikko Siurala, Leon L Su, Mito Tariveranmoshabad, Lora K Picton, Pranali Ravikumar, Peng Li, Jian-Xin Lin, Helena Escuin-Ordinas, Tong Da, Sarah V Kremer, Amy L Sun, María Sofía Castelli, Sangya Agarwal, John Scholler, Decheng Song, Philipp C Rommel, Enrico Radaelli, Regina M Young, Warren J Leonard, Antoni Ribas, Carl H June, K Christopher Garcia
Potentiating adoptive cell therapy using synthetic IL-9 receptors. Nature 607 (7918) (2022)
Robert A Saxton, Caleb R Glassman, K Christopher Garcia
Emerging principles of cytokine pharmacology and therapeutics. Nature reviews. Drug discovery (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Xiang Zhao, Elizabeth Motunrayo Kolawole, Waipan Chan, Yinnian Feng, Xinbo Yang, Marvin H Gee, Kevin M Jude, Leah V Sibener, Polly Morrell Fordyce, Ronald N Germain, Brian D Evavold, K Christopher Garcia
Tuning T cell receptor sensitivity through catch bond engineering. Science (New York, N.Y.) 376 (6589) (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Xinbo Yang, Lee I Garner, Ivan V Zvyagin, Michael A Paley, Ekaterina A Komech, Kevin M Jude, Xiang Zhao, Ricardo A Fernandes, Lynn M Hassman, Grace L Paley, Christina S Savvides, Simon Brackenridge, Max N Quastel, Dmitriy M Chudakov, Paul Bowness, Wayne M Yokoyama, Andrew J McMichael, Geraldine M Gillespie, K Christopher Garcia
Autoimmunity-associated T cell receptors recognize HLA-B*27-bound peptides. Nature (2022)
Steven C Wilson, Nathanael A Caveney, Michelle Yen, Christoph Pollmann, Xinyu Xiang, Kevin M Jude, Maximillian Hafer, Naotaka Tsutsumi, Jacob Piehler, K Christopher Garcia
Organizing structural principles of the IL-17 ligand-receptor axis. Nature 609 (7927) (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Tobias V Lanz, R Camille Brewer, Peggy Pui-Kay Ho, Jae-Seung Moon, Kevin M Jude, Daniel Fernández, Ricardo A Fernandes, Alejandro M Gomez, Gabriel-Stefan Nadj, Christopher M Bartley, Ryan D Schubert, Isobel A Hawes, Sara E Vazquez, Manasi Iyer, J Bradley Zuchero, Bianca Teegen, Jeffrey E Dunn, Christopher B Lock, Lucas B Kipp, Victoria C Cotham, Beatrix M Ueberheide, Blake T Aftab, Mark S Anderson, Joseph L DeRisi, Michael R Wilson, Rachael J M Bashford-Rogers, Michael Platten, K Christopher Garcia, Lawrence Steinman, William H Robinson
Clonally expanded B cells in multiple sclerosis bind EBV EBNA1 and GlialCAM. Nature 603 (7900) (2022)
Nathanael A Caveney, Caleb R Glassman, Kevin M Jude, Naotaka Tsutsumi, K Christopher Garcia
Structure of the IL-27 quaternary receptor signaling complex. eLife 11 (2022)
Greg M Allen, Nicholas W Frankel, Nishith R Reddy, Hersh K Bhargava, Maia A Yoshida, Sierra R Stark, Megan Purl, Jungmin Lee, Jacqueline L Yee, Wei Yu, Aileen W Li, K Christopher Garcia, Hana El-Samad, Kole T Roybal, Matthew H Spitzer, Wendell A Lim
Synthetic cytokine circuits that drive T cells into immune-excluded tumors. Science (New York, N.Y.) 378 (6625) (2022)
Longxing Cao, Brian Coventry, Inna Goreshnik, Buwei Huang, William Sheffler, Joon Sung Park, Kevin M Jude, Iva Marković, Rameshwar U Kadam, Koen H G Verschueren, Kenneth Verstraete, Scott Thomas Russell Walsh, Nathaniel Bennett, Ashish Phal, Aerin Yang, Lisa Kozodoy, Michelle DeWitt, Lora K Picton, Lauren Miller, Eva-Maria Strauch, Nicholas D DeBouver, Allison Pires, Asim K Bera, Samer Halabiya, Bradley Hammerson, Wei Yang, Steffen Bernard, Lance J Stewart, Ian A Wilson, Hannele Ruohola-Baker, Joseph Schlessinger, Sangwon Lee, Savvas N Savvides, K Christopher Garcia, Julien S Baker
Design of protein-binding proteins from the target structure alone. Nature 605 (7910) (2022)
Muhammad Ali, Eirini Giannakopoulou, Yingqian Li, Madeleine Lehander, Stina Virding Culleton, Weiwen Yang, Cathrine Knetter, Mete Can Odabasi, Ravi Chand Bollineni, Xinbo Yang, Zsofia Foldvari, Maxi-Lu Böschen, Eli Taraldsrud, Erlend Strønen, Mireille Toebes, Amy Hillen, Stefania Mazzi, Arnoud H de Ru, George M C Janssen, Arne Kolstad, Geir Erland Tjønnfjord, Benedicte A Lie, Marieke Griffioen, Sören Lehmann, Liv Toril Osnes, Jochen Buechner, K Christopher Garcia, Ton N M Schumacher, Peter A van Veelen, Matthias Leisegang, Sten Eirik W Jacobsen, Petter S Woll, Johanna Olweus
T cells targeted to TdT kill leukemic lymphoblasts while sparing normal lymphocytes. Nature biotechnology (2021)
Minkyung Baek, Frank Dimaio, David Baker, Justas Dauparas, Sergey Ovchinnikov, Gyu Rie Lee, Jue Wang, Nick V Grishin, Lisa N Kinch, R Dustin Schaeffer, Claudia Millán, Hahnbeom Park, Carson Adams, Caleb R Glassman, Andy DeGiovanni, Jose Henrique Pereira, Andria V Rodrigues, Alberdina A van Dijk, Ana C Ebrecht, Diederik Johannes Opperman, Theo Sagmeister, Christoph Buhlheller, Tea Pavkov-Keller, Manoj K Rathinaswamy, Udit Dalwadi, Calvin K Yip, John E Burke, K Christopher Garcia, Nick V Grishin, Paul D Adams, Randy J Read, Julien S Baker
Accurate prediction of protein structures and interactions using a three-track neural network. Science (New York, N.Y.) 373 (6557) (2021)
Qian Zhang, Morgan E Hresko, Lora K Picton, Leon L Su, Michael J Hollander, Selene Nunez-Cruz, Zheng Zhang, Charles-Antoine Assenmacher, Jonathan T Sockolosky, K Christopher Garcia, Michael C Milone
A human orthogonal IL-2 and IL-2Rβ system enhances CAR T cell expansion and antitumor activity in a murine model of leukemia. Science translational medicine 13 (625) (2021)
Caleb R Glassman, Leon L Su, Sonia S Majri-Morrison, Hauke Winkelmann, Fei Mo, Peng Li, Magdiel Pérez-Cruz, Peggy P Ho, Ievgen Koliesnik, Nadine Nagy, Tereza Hnizdilova, Lora K Picton, Marek Kovář, Paul L Bollyky, Lawrence Steinman, Everett Meyer, Jacob Piehler, Warren J Leonard, K Christopher Garcia
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. eLife 10 (2021)
Robert A Saxton, Naotaka Tsutsumi, Leon L Su, Gita C Abhiraman, Kritika Mohan, Lukas T Henneberg, Nanda Gowtham Aduri, Cornelius Gati, K Christopher Garcia
Structure-based decoupling of the pro- and anti-inflammatory functions of interleukin-10. Science (New York, N.Y.) 371 (6535) (2021)
Huan-Chang Liang, Mariantonia Costanza, Nicole Prutsch, Mark W Zimmerman, Elisabeth Gurnhofer, Ivonne-Aidee Montes-Mojarro, Brian J Abraham, Nina Prokoph, Stefan Stoiber, Simone Tangermann, Cosimo Lobello, Jan Oppelt, Ioannis Anagnostopoulos, Thomas Hielscher, Shahid Pervez, Wolfram Klapper, Francesca Zammarchi, Daniel Adriano Silva, K Christopher Garcia, Julien S Baker, Martin Janz, Nikolai Schleussner, Falko Fend, Šárka Pospíšilová, Andrea Janiková, Jacqueline Wallwitz, Dagmar Stoiber, Ingrid Simonitsch-Klupp, Lorenzo Cerroni, Stefano Pileri, Laurence L de Leval, David Sibon, Virginie Fataccioli, Philippe Gaulard, Chalid Assaf, Fabian Knörr, Christine Damm-Welk, Wilhelm Woessmann, Suzanne D Turner, A Thomas Look, Stephan Mathas, Lukas Kenner, Olaf Merkel
Super-enhancer-based identification of a BATF3/IL-2R-module reveals vulnerabilities in anaplastic large cell lymphoma. Nature communications 12 (1) (2021)
Fei Mo, Zhiya Yu, Peng Li, Jangsuk Oh, Rosanne Spolski, Liang Zhao, Caleb R Glassman, Tori N Yamamoto, Yun Chen, Filip M Golebiowski, Dalton Hermans, Sonia Majri-Morrison, Lora K Picton, Wei Liao, Min Ren, Xiaoxuan Zhuang, Suman Mitra, Jian-Xin Lin, Luca Gattinoni, Jonathan D Powell, Nicholas P Restifo, K Christopher Garcia, Warren J Leonard
An engineered IL-2 partial agonist promotes CD8+ T cell stemness. Nature 597 (7877) (2021)
Timo W M De Groof, Nick D Bergkamp, Raimond Heukers, Truc Giap, Maarten P Bebelman, Richard Goeij-de Haas, Sander R Piersma, Connie R Jimenez, K Christopher Garcia, Hidde L Ploegh, Marco Siderius, Martine J Smit
Selective targeting of ligand-dependent and -independent signaling by GPCR conformation-specific anti-US28 intrabodies. Nature communications 12 (1) (2021)
Ameen A Salahudeen, Shannon S Choi, Arjun Rustagi, Junjie Zhu, Vincent van Unen, Sean M de la O, Ryan A Flynn, Mar Margalef-Català, António J M Santos, Jihang Ju, Arpit Batish, Tatsuya Usui, Grace X Y Zheng, Caitlin E Edwards, Lisa E Wagar, Vincent Luca, Benedict Anchang, Monica Nagendran, Khanh Nguyen, Daniel J Hart, Jessica M Terry, Phillip Belgrader, Solongo B Ziraldo, Tarjei S Mikkelsen, Pehr B Harbury, Jeffrey S Glenn, K Christopher Garcia, Mark M Davis, Ralph S Baric, Chiara Sabatti, Manuel R Amieva, Catherine A Blish, Tushar J Desai, Calvin J Kuo
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids. Nature 588 (7839) (2020)
Juan L Mendoza, Suzanne Fischer, Marvin H Gee, Lilian H Lam, Simon Brackenridge, Fiona M Powrie, Michael Birnbaum, Andrew J McMichael, K Christopher Garcia, Geraldine M Gillespie
Interrogating the recognition landscape of a conserved HIV-specific TCR reveals distinct bacterial peptide cross-reactivity. eLife 9 (2020)
Naotaka Tsutsumi, Somnath Mukherjee, Deepa Waghray, Claudia Y Janda, Kevin M Jude, Yi Miao, John S Burg, Nanda Gowtham Aduri, Anthony A Kossiakoff, Cornelius Gati, K Christopher Garcia
Structure of human Frizzled5 by fiducial-assisted cryo-EM supports a heterodimeric mechanism of canonical Wnt signaling. eLife 9 (2020)
Ricardo A Fernandes, Chaoran Li, Gang Wang, Xinbo Yang, Christina S Savvides, Caleb R Glassman, Shen Dong, Eric Luxenberg, Leah V Sibener, Michael E Birnbaum, Christophe Benoist, Diane Mathis, K Christopher Garcia
Discovery of surrogate agonists for visceral fat Treg cells that modulate metabolic indices in vivo. eLife 9 (2020)
Shoji Maeda, Jun Xu, Francois Marie N Kadji, Mary J Clark, Jiawei Zhao, Naotaka Tsutsumi, Junken Aoki, Roger K Sunahara, Asuka Inoue, K Christopher Garcia, Brian K Kobilka
Structure and selectivity engineering of the M1 muscarinic receptor toxin complex. Science (New York, N.Y.) 369 (6500) (2020)
Ricardo A Fernandes, Leon L Su, Yoko Nishiga, Junming Ren, M Aladdin Bhuiyan, Ning Cheng, Calvin J Kuo, Lora K Picton, Shozo Ohtsuki, Robbie G Majzner, Skyler P Rietberg, Crystal L Mackall, Qian Yin, Lestat R Ali, Xinbo Yang, Christina S Savvides, Julien Sage, Michael Dougan, K Christopher Garcia
Immune receptor inhibition through enforced phosphatase recruitment. Nature 586 (7831) (2020)
Stephan Wilmes, Maximillian Hafer, Joni Vuorio, Julie A Tucker, Hauke Winkelmann, Sara Löchte, Tess A Stanly, Katiuska D Pulgar Prieto, Chetan S Poojari, Vivek Sharma, Christian P Richter, Rainer Kurre, Stevan R Hubbard, K Christopher Garcia, Ignacio Moraga, Ilpo Vattulainen, Ian S Hitchcock, Jacob Piehler
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science (New York, N.Y.) 367 (6478) (2020)
Jamie B Spangler, Ignacio Moraga, Kevin M Jude, Christina S Savvides, K Christopher Garcia
A strategy for the selection of monovalent antibodies that span protein dimer interfaces. The Journal of biological chemistry 294 (38) (2019)
Kritika Mohan, George Ueda, Ah Ram Kim, Kevin M Jude, Jorge A Fallas, Yu Guo, Maximillian Hafer, Yi Miao, Robert A Saxton, Jacob Piehler, Vijay G Sankaran, Julien S Baker, K Christopher Garcia
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science (New York, N.Y.) 364 (6442) (2019)
Yeteng Zhong, Zhuoran Ma, Feifei Wang, Xi Wang, Yijun Yang, Yulai Liu, Xiang Zhao, Jiachen Li, Haotian Du, Mingxi Zhang, Qiuhong Cui, Shoujun Zhu, Qinchao Sun, Hao Wan, Ye Tian, Qiang Liu, Weizhi Wang, K Christopher Garcia, Hongjie Dai
In vivo molecular imaging for immunotherapy using ultra-bright near-infrared-IIb rare-earth nanoparticles. Nature biotechnology 37 (11) (2019)
Kalliopi Pervolaraki, Soheil Rastgou Talemi, Dorothee Albrecht, Felix Bormann, Connor G G Bamford, Juan L Mendoza, K Christopher Garcia, John McLauchlan, Thomas Höfer, Megan L Stanifer, Steeve Boulant
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance. PLoS pathogens 14 (11) (2018)
Timothy F Miles, Katja Spiess, Kevin M Jude, Naotaka Tsutsumi, John S Burg, Jessica R Ingram, Deepa Waghray, Gertrud M Hjorto, Olav Larsen, Hidde L Ploegh, Mette M Rosenkilde, K Christopher Garcia
Viral GPCR US28 can signal in response to chemokine agonists of nearly unlimited structural degeneracy. eLife 7 (2018)
Jonathan T Sockolosky, Eleonora Trotta, Giulia Parisi, Lora K Picton, Leon L Su, Alan C Le, Akanksha Chhabra, Stephanie L Silveria, Benson M George, Indigo C King, Matthew R Tiffany, Kevin M Jude, Leah V Sibener, Julien S Baker, Judith A Shizuru, Antoni Ribas, Jeffrey A Bluestone, K Christopher Garcia
Selective targeting of engineered T cells using orthogonal IL-2 cytokine-receptor complexes. Science (New York, N.Y.) 359 (6379) (2018)
Jamie B Spangler, Eleonora Trotta, Jakub Tomala, Ariana Peck, Tracy A Young, Christina S Savvides, Stephanie Silveria, Petra Votavova, Joshua Salafsky, Vijay S Pande, Marek Kovar, Jeffrey A Bluestone, K Christopher Garcia
Engineering a Single-Agent Cytokine/Antibody Fusion That Selectively Expands Regulatory T Cells for Autoimmune Disease Therapy. Journal of immunology (Baltimore, Md. : 1950) 201 (7) (2018)
Ignacio Moraga, Jamie B Spangler, Juan L Mendoza, Milica Gakovic, Tom S Wehrman, Peter Krutzik, K Christopher Garcia
Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers. eLife 6 (2017)
Vincent C Luca, Byoung Choul Kim, Chenghao Ge, Shinako Kakuda, Di Wu, Mehdi Roein-Peikar, Robert S Haltiwanger, Cheng Zhu, Taekjip Ha, K Christopher Garcia
Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity. Science (New York, N.Y.) 355 (6331) (2017)
Hanqing Li, Ash Watson, Agnieszka Olechwier, Michael Anaya, Siamak K Sorooshyari, Dermott P Harnett, Hyung-Kook Peter Lee, Jost Vielmetter, Mario A Fares, K Christopher Garcia, Engin Özkan, Juan-Pablo Labrador, Kai Zinn
Deconstruction of the beaten Path-Sidestep interaction network provides insights into neuromuscular system development. eLife 6 (2017)