Jacob Piehler

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 45

Top Topics

Acute Lymphoblastic Leukemia

Tyrosine Kinase

Top Venues

Nature communications

The EMBO journal

Nature biotechnology

This page only lists publications with an associated author ORCID identifier.

Publications

Scott Gardner, Yibo Jin, Paul K Fyfe, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nature communications 15 (1) (2024)
Scott Gardner, Yibo Jin, Paul K Fyfe, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nature communications 15 (1) (2024)
Scott Gardner, Yibo Jin, Paul K Fyfe, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nature communications 15 (1) (2024)
Hauke Winkelmann, Christian P Richter, Jasper Eising, Jacob Piehler, Rainer Kurre
Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane. Nature communications 15 (1) (2024)
Hauke Winkelmann, Christian P Richter, Jasper Eising, Jacob Piehler, Rainer Kurre
Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane. Nature communications 15 (1) (2024)
Hauke Winkelmann, Christian P Richter, Jasper Eising, Jacob Piehler, Rainer Kurre
Correlative single-molecule and structured illumination microscopy of fast dynamics at the plasma membrane. Nature communications 15 (1) (2024)
Scott Gardner, Yibo Jin, Paul K Fyfe, Tomas B Voisin, Junel Sotolongo Bellón, Elizabeth Pohler, Jacob Piehler, Ignacio Moraga, Doryen Bubeck
Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency. Nature communications 15 (1) (2024)
Deniz Saltukoglu, Buğra Özdemir, Michael Holtmannspötter, Ralf Reski, Jacob Piehler, Rainer Kurre, Michael Reth
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters. The EMBO journal 42 (4) (2023)
Deniz Saltukoglu, Buğra Özdemir, Michael Holtmannspötter, Ralf Reski, Jacob Piehler, Rainer Kurre, Michael Reth
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters. The EMBO journal (2023)
Xinbo Yang, Daisuke Nishimiya, Sara Löchte, Kevin M Jude, Marta Borowska, Christina S Savvides, Michael Dougan, Leon L Su, Xiang Zhao, Jacob Piehler, K Christopher Garcia
Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy. Nature biotechnology (2023)
Xinbo Yang, Daisuke Nishimiya, Sara Löchte, Kevin M Jude, Marta Borowska, Christina S Savvides, Michael Dougan, Leon L Su, Xiang Zhao, Jacob Piehler, K Christopher Garcia
Facile repurposing of peptide-MHC-restricted antibodies for cancer immunotherapy. Nature biotechnology (2023)
Michael Holtmannspötter, Eike Wienbeuker, Timo Dellmann, Isabelle Watrinet, Ana J Garcia-Saez, Kai Johnsson, Rainer Kurre, Jacob Piehler
Reversible Live-Cell Labeling with Retro-engineered HaloTags Enables Long-Term High- and Super-Resolution Imaging. Angewandte Chemie (International ed. in English) (2023)
Deniz Saltukoglu, Buğra Özdemir, Michael Holtmannspötter, Ralf Reski, Jacob Piehler, Rainer Kurre, Michael Reth
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters. The EMBO journal 42 (4) (2023)
Deniz Saltukoglu, Buğra Özdemir, Michael Holtmannspötter, Ralf Reski, Jacob Piehler, Rainer Kurre, Michael Reth
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters. The EMBO journal 42 (4) (2023)
Pramod C Nair, Jacob Piehler, Denis Tvorogov, David Morrall Ross, Angel F Lopez, Jason Gotlib, Daniel Thomas
Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches. Blood cancer discovery (2023)
Alexandra Tsirigotaki, Ann Dansercoer, Koen H G Verschueren, Iva Marković, Christoph Pollmann, Maximillian Hafer, Jan Felix, Catherine Birck, Wouter Van Putte, Dominiek Catteeuw, Jan Tavernier, J Fernando Bazan, Jacob Piehler, Savvas N Savvides, Kenneth Verstraete
Mechanism of receptor assembly via the pleiotropic adipokine Leptin. Nature structural & molecular biology (2023)
Deniz Saltukoglu, Buğra Özdemir, Michael Holtmannspötter, Ralf Reski, Jacob Piehler, Rainer Kurre, Michael Reth
Plasma membrane topography governs the 3D dynamic localization of IgM B cell antigen receptor clusters. The EMBO journal 42 (4) (2023)
Han-Po Shih, Jing-Ya Ding, Junel Sotolongo Bellón, Yu-Fang Lo, Pei-Han Chung, He-Ting Ting, Jhan-Jie Peng, Tsai-Yi Wu, Chia-Hao Lin, Chia-Chi Lo, You-Ning Lin, Chun-Fu Yeh, Jiun-Bo Chen, Ting-Shu Wu, Yuag-Meng Liu, Chen-Yen Kuo, Shang Yu Wang, Kun-Hua Tu, Chau Yee Ng, Wei-Te Lei, Yu-Huan Tsai, Jou-Han Chen, Ya-Ting Chuang, Jing-Yi Huang, Felix A Rey, Hung-Kai Chen, Tse-Wen Chang, Jacob Piehler, Chih-Yu Chi, Cheng-Lung Ku
Pathogenic autoantibodies to IFN-γ act through the impedance of receptor assembly and Fc-mediated response. The Journal of experimental medicine 219 (9) (2022)
Silvia Gaggero, Jonathan Martínez-Fábregas, Adeline Cozzani, Paul K Fyfe, Malo Leprohon, Jie Yang, F Emil Thomasen, Hauke Winkelmann, Romain Magnez, Alberto G Conti, Stephan Wilmes, Elizabeth Pohler, Manuel van Gijsel Bonnello, Xavier Thuru, Bruno Quesnel, Fabrice Soncin, Jacob Piehler, Kresten Lindorff-Larsen, Rahul Roychoudhuri, Ignacio Moraga, Suman Mitra
IL-2 is inactivated by the acidic pH environment of tumors enabling engineering of a pH-selective mutein. Science immunology 7 (78) (2022)
Michael Philippi, Christian P Richter, Marie Kappen, Isabelle Watrinet, Yi Miao, Mercedes Runge, Lara Jorde, Sergej Korneev, Michael Holtmannspötter, Rainer Kurre, Joost C M Holthuis, K Christopher Garcia, Andreas Plückthun, Martin Steinhart, Jacob Piehler, Changjiang You
Biofunctional Nanodot Arrays in Living Cells Uncover Synergistic Co-Condensation of Wnt Signalodroplets. Small (Weinheim an der Bergstrasse, Germany) (2022)
Tolulope Sokoya, Jan Parolek, Mads Møller Foged, Dmytro I Danylchuk, Manuel Bozan, Bingshati Sarkar, Angelika Hilderink, Michael Philippi, Lorenzo D Botto, Paulien A Terhal, Outimaija Mäkitie, Jacob Piehler, Yeongho Kim, Christopher G Burd, Andrey S Klymchenko, Kenji Maeda, Joost C M Holthuis
Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway. eLife 11 (2022)
Jieqiong Gao, Raffaele Nicastro, Marie-Pierre Péli-Gulli, Sophie Grziwa, Zilei Chen, Rainer Kurre, Jacob Piehler, Claudio De Virgilio, Florian Fröhlich, Christian Ungermann
The HOPS tethering complex is required to maintain signaling endosome identity and TORC1 activity. The Journal of cell biology 221 (5) (2022)
Steven C Wilson, Nathanael A Caveney, Michelle Yen, Christoph Pollmann, Xinyu Xiang, Kevin M Jude, Maximillian Hafer, Naotaka Tsutsumi, Jacob Piehler, K Christopher Garcia
Organizing structural principles of the IL-17 ligand-receptor axis. Nature 609 (7927) (2022)
Cindy Dirscherl, Sara Löchte, Zeynep Hein, Janine-Denise Kopicki, Antonia Regina Harders, Noemi Linden, Andreas Karner, Johannes Preiner, Julian Weghuber, Maria M Garcia Alai, Charlotte Uetrecht, Martin Zacharias, Jacob Piehler, Peter Lanzerstorfer, Sebastian Springer
Dissociation of β2m from MHC class I triggers formation of noncovalent transient heavy chain dimers. Journal of cell science 135 (9) (2022)
Nadia Füllbrunn, Zehao Li, Lara Jorde, Christian P Richter, Rainer Kurre, Lars Langemeyer, Changyuan Yu, Carola Meyer, Jörg Enderlein, Christian Ungermann, Jacob Piehler, Changjiang You
Nanoscopic anatomy of dynamic multi-protein complexes at membranes resolved by graphene-induced energy transfer. eLife 10 (2021)
Parminder Kaur, Ryan P Barnes, Hai Pan, Ariana C Detwiler, Ming Liu, Chelsea Mahn, Jonathan R Hall, Zach Messenger, Changjiang You, Jacob Piehler, Robert C Smart, Robert Riehn, Patricia L Opresko, Hong Wang
TIN2 is an architectural protein that facilitates TRF2-mediated trans- and cis-interactions on telomeric DNA. Nucleic acids research (2021)
Jakob C Stüber, Christian P Richter, Junel Sotolongo Bellón, Martin Schwill, Iwo König, Benjamin Schuler, Jacob Piehler, Andreas Plückthun
Apoptosis-inducing anti-HER2 agents operate through oligomerization-induced receptor immobilization. Communications biology 4 (1) (2021)
Christoph Drees, Philipp Rühl, Jacqueline Czerny, Gemini Chandra, Janosch Bajorath, Markus Haase, Stefan H Heinemann, Jacob Piehler
Diffraction-Unlimited Photomanipulation at the Plasma Membrane via Specifically Targeted Upconversion Nanoparticles. Nano letters 21 (19) (2021)
Stephan Wilmes, Polly-Anne Jeffrey, Jonathan Martínez-Fábregas, Maximillian Hafer, Paul K Fyfe, Elizabeth Pohler, Silvia Gaggero, Martín López-García, Grant Lythe, Charles Taylor, Thomas Guerrier, David Launay, Suman Mitra, Jacob Piehler, Carmen Molina-París, Ignacio Moraga
Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses. eLife 10 (2021)
Caleb R Glassman, Leon L Su, Sonia S Majri-Morrison, Hauke Winkelmann, Fei Mo, Peng Li, Magdiel Pérez-Cruz, Peggy P Ho, Ievgen Koliesnik, Nadine Nagy, Tereza Hnizdilova, Lora K Picton, Marek Kovář, Paul L Bollyky, Lawrence Steinman, Everett Meyer, Jacob Piehler, Warren J Leonard, K Christopher Garcia
Calibration of cell-intrinsic interleukin-2 response thresholds guides design of a regulatory T cell biased agonist. eLife 10 (2021)
Maya Shemesh, Sara Lochte, Jacob Piehler, Gideon Schreiber
IFNAR1 and IFNAR2 play distinct roles in initiating type I interferon-induced JAK-STAT signaling and activating STATs. Science signaling 14 (710) (2021)
Lu Cui, Ignacio Moraga, Tristan Lerbs, Camille Van Neste, Stephan Wilmes, Naotaka Tsutsumi, Aaron Claudius Trotman-Grant, Milica Gakovic, Sarah Andrews, Jason Gotlib, Spyros Darmanis, Martin Enge, Stephen Quake, Ian S Hitchcock, Jacob Piehler, K Christopher Garcia, Gerlinde Wernig
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors. Proceedings of the National Academy of Sciences of the United States of America 118 (2) (2021)
Jennie B Altman, Justin Taft, Tim Wedeking, Conor N Gruber, Michael Holtmannspötter, Jacob Piehler, Dusan Bogunovic
Type I IFN is siloed in endosomes. Proceedings of the National Academy of Sciences of the United States of America 117 (30) (2020)
Claire Gorby, Junel Sotolongo Bellón, Stephan Wilmes, Walid Warda, Elizabeth Pohler, Paul K Fyfe, Adeline Cozzani, Christophe Ferrand, Mark R Walter, Suman Mitra, Jacob Piehler, Ignacio Moraga
Engineered IL-10 variants elicit potent immunomodulatory effects at low ligand doses. Science signaling 13 (649) (2020)
Maud Bongaerts, Koceila Aizel, Emilie Secret, Audric Jan, Tasmin Nahar, Fabian Raudzus, Sebastian Neumann, Neil Telling, Rolf Heumann, Jean-Michel Siaugue, Christine Ménager, Jérôme Fresnais, Catherine Villard, Alicia El Haj, Jacob Piehler, Monte A Gates, Mathieu Coppey
Parallelized Manipulation of Adherent Living Cells by Magnetic Nanoparticles-Mediated Forces. International journal of molecular sciences 21 (18) (2020)
Stephan Wilmes, Maximillian Hafer, Joni Vuorio, Julie A Tucker, Hauke Winkelmann, Sara Löchte, Tess A Stanly, Katiuska D Pulgar Prieto, Chetan S Poojari, Vivek Sharma, Christian P Richter, Rainer Kurre, Stevan R Hubbard, K Christopher Garcia, Ignacio Moraga, Ilpo Vattulainen, Ian S Hitchcock, Jacob Piehler
Mechanism of homodimeric cytokine receptor activation and dysregulation by oncogenic mutations. Science (New York, N.Y.) 367 (6478) (2020)
Michael Philippi, Changjiang You, Christian P Richter, Mercedes Schmidt, Jannis Thien, Domenik Liße, Joachim Wollschläger, Jacob Piehler, Martin Steinhart
Close-packed silane nanodot arrays by capillary nanostamping coupled with heterocyclic silane ring opening. RSC advances 9 (43) (2019)
Jonathan Martínez-Fábregas, Stephan Wilmes, Luopin Wang, Maximillian Hafer, Elizabeth Pohler, Juliane Lokau, Christoph Garbers, Adeline Cozzani, Paul K Fyfe, Jacob Piehler, Majid Kazemian, Suman Mitra, Ignacio Moraga
Kinetics of cytokine receptor trafficking determine signaling and functional selectivity. eLife 8 (2019)
Kritika Mohan, George Ueda, Ah Ram Kim, Kevin M Jude, Jorge A Fallas, Yu Guo, Maximillian Hafer, Yi Miao, Robert A Saxton, Jacob Piehler, Vijay G Sankaran, Julien S Baker, K Christopher Garcia
Topological control of cytokine receptor signaling induces differential effects in hematopoiesis. Science (New York, N.Y.) 364 (6442) (2019)
Matthieu Chavent, Anna L Duncan, Patrice Rassam, Oliver Birkholz, Jean Hélie, Tyler Reddy, Dmitry Beliaev, Ben Hambly, Jacob Piehler, Colin Kleanthous, Mark S P Sansom
How nanoscale protein interactions determine the mesoscale dynamic organisation of bacterial outer membrane proteins. Nature communications 9 (1) (2018)
Oliver Birkholz, Jonathan R Burns, Christian P Richter, Olympia E Psathaki, Stefan Howorka, Jacob Piehler
Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials. Nature communications 9 (1) (2018)
Fred Etoc, Elie Balloul, Chiara Vicario, Davide Normanno, Domenik Liße, Assa Sittner, Jacob Piehler, Maxime Dahan, Mathieu Coppey
Non-specific interactions govern cytosolic diffusion of nanosized objects in mammalian cells. Nature materials 17 (8) (2018)
David Richter, Ignacio Moraga, Hauke Winkelmann, Oliver Birkholz, Stephan Wilmes, Markos Schulte, Michael Kraich, Hella Kenneweg, Oliver Beutel, Philipp Selenschik, Dirk Paterok, Martynas Gavutis, Thomas Schmidt, K Christopher Garcia, Thomas D Müller, Jacob Piehler
Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments. Nature communications 8 (2017)
Christoph Drees, Athira Naduviledathu Raj, Rainer Kurre, Karin B Busch, Markus Haase, Jacob Piehler
Engineered Upconversion Nanoparticles for Resolving Protein Interactions inside Living Cells. Angewandte Chemie (International ed. in English) 55 (38) (2016)
Changjiang You, Tatiana T Marquez-Lago, Christian Paolo Richter, Stephan Wilmes, Ignacio Moraga, K Christopher Garcia, André Leier, Jacob Piehler
Receptor dimer stabilization by hierarchical plasma membrane microcompartments regulates cytokine signaling. Science advances 2 (12) (2016)