Tomohiko Ohwada

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 43

Top Topics

Molecular Dynamics Simulations

Top Venues

The Journal of organic chemistry

International journal of molecular sciences

Organic letters

Chemical communications (Cambridge, England)

This page only lists publications with an associated author ORCID identifier.

Publications

Yuko Otani, Asami Ichinose, Xihong Wang, Zhihan Huang, Akitomo Kasahara, Mayumi Ishii, Eri Watanabe, Kayoko Kanamitsu, Kempei Tai, Hiroyuki Kusuhara, Takumi Ueda, Koh Takeuchi, Tomohiko Ohwada
An N-ortho -nitrobenzylated benzanilide amino acid enables control of the conformation and membrane permeability of cyclic peptides. Chemical communications (Cambridge, England) (2024)
Yuhe Cheng, Tadashi Hyodo, Kentaro Yamaguchi, Tomohiko Ohwada, Yuko Otani
Complete amide cis - trans switching synchronized with disulfide bond formation and cleavage in a proline-mimicking system. Chemical communications (Cambridge, England) 60 (48) (2024)
Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Jumpei Omi, Hiroki Kawana, Fengjue Hou, Fumiya K Sano, Tatsuki Tanaka, Kazuhiro Kobayashi, Hiroyuki H Okamoto, Yoshiaki Kise, Tomohiko Ohwada, Junken Aoki, Wataru Shihoya, Osamu Nureki
Structural basis for lysophosphatidylserine recognition by GPR34. Nature communications 15 (1) (2024)
Yuhe Cheng, Tadashi Hyodo, Kentaro Yamaguchi, Tomohiko Ohwada, Yuko Otani
Complete amide cis - trans switching synchronized with disulfide bond formation and cleavage in a proline-mimicking system. Chemical communications (Cambridge, England) (2024)
Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Jumpei Omi, Hiroki Kawana, Fengjue Hou, Fumiya K Sano, Tatsuki Tanaka, Kazuhiro Kobayashi, Hiroyuki H Okamoto, Yoshiaki Kise, Tomohiko Ohwada, Junken Aoki, Wataru Shihoya, Osamu Nureki
Structural basis for lysophosphatidylserine recognition by GPR34. Nature communications 15 (1) (2024)
Takayoshi Suzuki, Haruto Kurata, Tomohiko Ohwada, Hideyuki Onodera
Journal of Medicinal Chemistry Collection: Drug Discovery in Japan. Journal of medicinal chemistry (2024)
Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Jumpei Omi, Hiroki Kawana, Fengjue Hou, Fumiya K Sano, Tatsuki Tanaka, Kazuhiro Kobayashi, Hiroyuki H Okamoto, Yoshiaki Kise, Tomohiko Ohwada, Junken Aoki, Wataru Shihoya, Osamu Nureki
Structural basis for lysophosphatidylserine recognition by GPR34. Nature communications 15 (1) (2024)
Tamaki Izume, Ryo Kawahara, Akiharu Uwamizu, Luying Chen, Shun Yaginuma, Jumpei Omi, Hiroki Kawana, Fengjue Hou, Fumiya K Sano, Tatsuki Tanaka, Kazuhiro Kobayashi, Hiroyuki H Okamoto, Yoshiaki Kise, Tomohiko Ohwada, Junken Aoki, Wataru Shihoya, Osamu Nureki
Structural basis for lysophosphatidylserine recognition by GPR34. Nature communications 15 (1) (2024)
Yuko Otani, Asami Ichinose, Xihong Wang, Zhihan Huang, Akitomo Kasahara, Mayumi Ishii, Eri Watanabe, Kayoko Kanamitsu, Kempei Tai, Hiroyuki Kusuhara, Takumi Ueda, Koh Takeuchi, Tomohiko Ohwada
An N-ortho -nitrobenzylated benzanilide amino acid enables control of the conformation and membrane permeability of cyclic peptides. Chemical communications (Cambridge, England) 60 (69) (2024)
Yipu Lu, Akitomo Kasahara, Tadashi Hyodo, Kazuaki Ohara, Kentaro Yamaguchi, Yuko Otani, Tomohiko Ohwada
Isolation and Reactions of Imidoyl Fluorides Generated from Oxime Using the Diethylaminosulfur Trifluoride/Tetrahydrofuran (DAST-THF) System. Organic letters (2023)
Yipu Lu, Akitomo Kasahara, Tadashi Hyodo, Kazuaki Ohara, Kentaro Yamaguchi, Yuko Otani, Tomohiko Ohwada
Isolation and Reactions of Imidoyl Fluorides Generated from Oxime Using the Diethylaminosulfur Trifluoride/Tetrahydrofuran (DAST-THF) System. Organic letters 25 (19) (2023)
Yipu Lu, Akitomo Kasahara, Tadashi Hyodo, Kazuaki Ohara, Kentaro Yamaguchi, Yuko Otani, Tomohiko Ohwada
Isolation and Reactions of Imidoyl Fluorides Generated from Oxime Using the Diethylaminosulfur Trifluoride/Tetrahydrofuran (DAST-THF) System. Organic letters 25 (19) (2023)
Tasia Amelia, Aderian Novito Setiawan, Rahmana Emran Kartasasmita, Tomohiko Ohwada, Daryono Hadi Tjahjono
Computational Prediction of Resistance Induced Alanine-Mutation in ATP Site of Epidermal Growth Factor Receptor. International journal of molecular sciences 23 (24) (2022)
Tasia Amelia, Aderian Novito Setiawan, Rahmana Emran Kartasasmita, Tomohiko Ohwada, Daryono Hadi Tjahjono
Computational Prediction of Resistance Induced Alanine-Mutation in ATP Site of Epidermal Growth Factor Receptor. International journal of molecular sciences 23 (24) (2022)
Tasia Amelia, Aderian Novito Setiawan, Rahmana Emran Kartasasmita, Tomohiko Ohwada, Daryono Hadi Tjahjono
Computational Prediction of Resistance Induced Alanine-Mutation in ATP Site of Epidermal Growth Factor Receptor. International journal of molecular sciences 23 (24) (2022)
Tasia Amelia, Rahmana Emran Kartasasmita, Tomohiko Ohwada, Daryono Hadi Tjahjono
Structural Insight and Development of EGFR Tyrosine Kinase Inhibitors. Molecules (Basel, Switzerland) 27 (3) (2022)
Akinari Sumita, Tomohiko Ohwada
Friedel-Crafts-Type Acylation and Amidation Reactions in Strong Brønsted Acid: Taming Superelectrophiles. Molecules (Basel, Switzerland) 27 (18) (2022)
Tomohiro Fujino, Tadashi Hyodo, Yuko Otani, Kentaro Yamaguchi, Tomohiko Ohwada
Neighboring Group Participation of Nitrogen Cation to Form an Unusual Six-Membered Ring Intermediate During Oxime Rearrangement. The Journal of organic chemistry 87 (19) (2022)
Tasia Amelia, Aderian Novito Setiawan, Rahmana Emran Kartasasmita, Tomohiko Ohwada, Daryono Hadi Tjahjono
Computational Prediction of Resistance Induced Alanine-Mutation in ATP Site of Epidermal Growth Factor Receptor. International journal of molecular sciences 23 (24) (2022)
Tasia Amelia, Aderian Novito Setiawan, Rahmana Emran Kartasasmita, Tomohiko Ohwada, Daryono Hadi Tjahjono
Computational Prediction of Resistance Induced Alanine-Mutation in ATP Site of Epidermal Growth Factor Receptor. International journal of molecular sciences 23 (24) (2022)
Hao Wu, Akinari Sumita, Yuko Otani, Tomohiko Ohwada
Friedel-Crafts Acylation of Aminocarboxylic Acids in Strong Brønsted Acid Promoted by Lewis Base P 4 O 10 . The Journal of organic chemistry 87 (22) (2022)
Tasia Amelia, Aderian Novito Setiawan, Rahmana Emran Kartasasmita, Tomohiko Ohwada, Daryono Hadi Tjahjono
Computational Prediction of Resistance Induced Alanine-Mutation in ATP Site of Epidermal Growth Factor Receptor. International journal of molecular sciences 23 (24) (2022)
Misa Sayama, Akiharu Uwamizu, Masaya Ikubo, Luying Chen, Ge Yan, Yuko Otani, Asuka Inoue, Junken Aoki, Tomohiko Ohwada
Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine. Journal of medicinal chemistry 64 (14) (2021)
Shuyi Song, Tadashi Hyodo, Hirotaka Ikeda, Kim Anh L Vu, Yulan Tang, Erika S Chan, Yuko Otani, Satoshi Inagaki, Kentaro Yamaguchi, Tomohiko Ohwada
Contribution of Solvents to Geometrical Preference in the Z/E Equilibrium of N-Phenylthioacetamide. The Journal of organic chemistry (2021)
Iori Morita, Takahiro Mori, Takaaki Mitsuhashi, Shotaro Hoshino, Yoshimasa Taniguchi, Takashi Kikuchi, Kei Nagae, Norihiro Nasu, Makoto Fujita, Tomohiko Ohwada, Leonard Kaysser
Exploiting a C-N Bond Forming Cytochrome P450 Monooxygenase for C-S Bond Formation. Angewandte Chemie (International ed. in English) 59 (10) (2020)
Camilo Mahecha-Mahecha, Frédéric Lecornué, Sumita Akinari, Thomas Charote, Diego Gamba-Sánchez, Tomohiko Ohwada, Sébastien Thibaudeau
Sequential Suzuki-Miyaura Coupling/Lewis Acid-Catalyzed Cyclization: An Entry to Functionalized Cycloalkane-Fused Naphthalenes. Organic letters 22 (16) (2020)
Misa Sayama, Akiharu Uwamizu, Yuko Otani, Asuka Inoue, Junken Aoki, Masakazu Sekijima, Tomohiko Ohwada
Membrane Phospholipid Analogues as Molecular Rulers to Probe the Position of the Hydrophobic Contact Point of Lysophospholipid Ligands on the Surface of G-Protein-Coupled Receptor during Membrane Approach. Biochemistry 59 (11) (2020)
Yuko Otani, Seokhwi Park, Tomohiko Ohwada
Conformational preference of bicyclic β-amino acid dipeptides. Chirality 32 (6) (2020)
Sho Nakamura, Misa Sayama, Akiharu Uwamizu, Sejin Jung, Masaya Ikubo, Yuko Otani, Kuniyuki Kano, Jumpei Omi, Asuka Inoue, Junken Aoki, Tomohiko Ohwada
Non-naturally Occurring Regio Isomer of Lysophosphatidylserine Exhibits Potent Agonistic Activity toward G Protein-Coupled Receptors. Journal of medicinal chemistry 63 (17) (2020)
Siyuan Wang, Yuko Otani, Luhan Zhai, Aoze Su, Masayuki Nara, Masatoshi Kawahata, Kentaro Yamaguchi, Akane Sada, Rieko Ohki, Tomohiko Ohwada
Overall Shape Constraint of Alternating α/β-Hybrid Peptides Containing Bicyclic β-Proline. Organic letters 21 (19) (2019)
Hiroaki Kurouchi, Tomohiko Ohwada
Synthesis of Medium-Ring-Sized Benzolactams by Using Strong Electrophiles and Quantitative Evaluation of Ring-Size Dependency of the Cyclization Reaction Rate. The Journal of organic chemistry 85 (2) (2019)
Luhan Zhai, Yuko Otani, Tomohiko Ohwada
Uncovering the Networks of Topological Neighborhoods in β-Strand and Amyloid β-Sheet Structures. Scientific reports 9 (1) (2019)
Yuko Otani, Xin Liu, Hisashi Ohno, Siyuan Wang, Luhan Zhai, Aoze Su, Masatoshi Kawahata, Kentaro Yamaguchi, Tomohiko Ohwada
Amide nitrogen pyramidalization changes lactam amide spinning. Nature communications 10 (1) (2019)
Jin Tatsuzaki, Tomohiko Ohwada, Yuko Otani, Reiko Inagi, Tsutomu Ishikawa
A simple and effective preparation of quercetin pentamethyl ether from quercetin. Beilstein journal of organic chemistry 14 (2018)
Luhan Zhai, Siyuan Wang, Masayuki Nara, Koh Takeuchi, Ichio Shimada, Yuko Otani, Tomohiko Ohwada
Application of C-Terminal 7-Azabicyclo[2.2.1]heptane to Stabilize β-Strand-like Extended Conformation of a Neighboring α-Amino Acid. The Journal of organic chemistry 83 (21) (2018)
Diego Antonio Ocampo Gutiérrez de Velasco, Aoze Su, Luhan Zhai, Satowa Kinoshita, Yuko Otani, Tomohiko Ohwada
Unexpected Resistance to Base-Catalyzed Hydrolysis of Nitrogen Pyramidal Amides Based on the 7-Azabicyclic[2.2.1]heptane Scaffold. Molecules (Basel, Switzerland) 23 (9) (2018)
Yingtang Ning, Tomoya Fukuda, Hirotaka Ikeda, Yuko Otani, Masatoshi Kawahata, Kentaro Yamaguchi, Tomohiko Ohwada
Revisiting secondary interactions in neighboring group participation, exemplified by reactivity changes of iminylium intermediates. Organic & biomolecular chemistry 15 (6) (2018)
Akinari Sumita, Yuko Otani, Tomohiko Ohwada
Chemoselective generation of acyl phosphates, acylium ion equivalents, from carboxylic acids and an organophosphate ester in the presence of a Brønsted acid. Chemical communications (Cambridge, England) 53 (9) (2018)
Yuka Takahashi, Hirotaka Ikeda, Yuki Kanase, Kosho Makino, Hidetsugu Tabata, Tetsuta Oshitari, Satoshi Inagaki, Yuko Otani, Hideaki Natsugari, Hideyo Takahashi, Tomohiko Ohwada
Elucidation of the E-Amide Preference of N-Acyl Azoles. The Journal of organic chemistry 82 (21) (2018)
Misa Sayama, Asuka Inoue, Sho Nakamura, Sejin Jung, Masaya Ikubo, Yuko Otani, Akiharu Uwamizu, Takayuki Kishi, Kumiko Makide, Junken Aoki, Takatsugu Hirokawa, Tomohiko Ohwada
Probing the Hydrophobic Binding Pocket of G-Protein-Coupled Lysophosphatidylserine Receptor GPR34/LPS1 by Docking-Aided Structure-Activity Analysis. Journal of medicinal chemistry 60 (14) (2017)
Makafui Gasonoo, Akinari Sumita, Kenneth N Boblak, Kristen Giuffre, Tomohiko Ohwada, Douglas A Klumpp
Synthesis of Heterocycle-Containing 9,9-Diarylfluorenes Using Superelectrophiles. The Journal of organic chemistry 82 (12) (2017)
Yingtang Ning, Yuko Otani, Tomohiko Ohwada
Contrasting C- and O-Atom Reactivities of Neutral Ketone and Enolate Forms of 3-Sulfonyloxyimino-2-methyl-1-phenyl-1-butanones. The Journal of organic chemistry 83 (1) (2017)
Yingtang Ning, Yuko Otani, Tomohiko Ohwada
Base-Induced Transformation of 2-Acyl-3-alkyl-2H-azirines to Oxazoles: Involvement of Deprotonation-Initiated Pathways. The Journal of organic chemistry 82 (12) (2017)