John A Porco

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 40

Top Topics

Extracellular Matrix

Top Venues

Journal of the American Chemical Society

Angewandte Chemie (International ed. in English)

The Journal of organic chemistry

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Zihao Wang, Ritesh P Thakare, Shalaka Chitale, Alok K Mishra, Stanley I Goldstein, Alice C Fan, Rui Li, Lihua Julie Zhu, Lauren E Brown, Regina Cencic, Sidong Huang, Michael R Green, Nahum Sonenberg, Sunil K Malonia, John A Porco
Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. ACS central science 10 (8) (2024)
Zihao Wang, Ritesh P Thakare, Shalaka Chitale, Alok K Mishra, Stanley I Goldstein, Alice C Fan, Rui Li, Lihua Julie Zhu, Lauren E Brown, Regina Cencic, Sidong Huang, Michael R Green, Nahum Sonenberg, Sunil K Malonia, John A Porco
Identification of Rocaglate Acyl Sulfamides as Selective Inhibitors of Glioblastoma Stem Cells. ACS central science 10 (8) (2024)
Kaijie Ji, Richard P Johnson, James McNeely, Md Al Faruk, John A Porco
Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society (2024)
Feng Yang, Amira Oladokun, John A Porco
Evolution of a Strategy for the Unified, Asymmetric Total Syntheses of DMOA-Derived Spiromeroterpenoids. The Journal of organic chemistry (2024)
Kaijie Ji, Richard P Johnson, James McNeely, Md Al Faruk, John A Porco
Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society 146 (7) (2024)
Hannah L Thirman, Madeline J Hayes, Lauren E Brown, John A Porco, Jonathan Michael Irish
Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv : the preprint server for biology (2024)
Kaijie Ji, Richard P Johnson, James McNeely, Md Al Faruk, John A Porco
Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society 146 (7) (2024)
Hannah L Thirman, Madeline J Hayes, Lauren E Brown, John A Porco, Jonathan Michael Irish
Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv : the preprint server for biology (2024)
Kaijie Ji, Richard P Johnson, James McNeely, Md Al Faruk, John A Porco
Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society 146 (7) (2024)
Kaijie Ji, Richard P Johnson, James McNeely, Md Al Faruk, John A Porco
Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society 146 (7) (2024)
Hannah L Thirman, Madeline J Hayes, Lauren E Brown, John A Porco, Jonathan Michael Irish
Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv : the preprint server for biology (2024)
Kaijie Ji, Richard P Johnson, James McNeely, Md Al Faruk, John A Porco
Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt. Journal of the American Chemical Society 146 (7) (2024)
Alexandra M Millimaci, Richard V Trilles, James H McNeely, Lauren E Brown, Aaron B Beeler, John A Porco
Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions. The Journal of organic chemistry (2023)
Lee Shaashua, Aviad Ben-Shmuel, Meirav Pevsner-Fischer, Gil Friedman, Oshrat Levi-Galibov, Subhiksha Nandakumar, Debra Barki, Reinat Nevo, Lauren E Brown, Wenhan Zhang, Yaniv Stein, Chen Lior, Han Sang Kim, Linda Bojmar, William R Jarnagin, Nicolas Lecomte, Shimrit Mayer, Roni Stok, Hend Bishara, Rawand Hamodi, Ephrat Levy-Lahad, Talia Golan, John A Porco, Christine A Iacobuzio-Donahue, Nikolaus Schultz, David A Tuveson, David C Lyden, David P Kelsen, Ruth Scherz-Shouval
BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling. Nature communications 13 (1) (2022)
Stacey L Lehman, Theresa Wechsler, Kayla Schwartz, Lauren E Brown, John A Porco, William G Devine, Nahum Sonenberg, Uma T Shankavaram, Kevin Camphausen, Philip J Tofilon
Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity. Molecular cancer therapeutics 21 (9) (2022)
Feng Yang, John A Porco
Unified, Asymmetric Total Synthesis of the Asnovolins and Related Spiromeroterpenoids: A Fragment Coupling Approach. Journal of the American Chemical Society 144 (28) (2022)
Yuki Nishida, Ran Zhao, Lauren E Heese, Hiroki Akiyama, Shreya Patel, Alex M Jaeger, Rodrigo O Jacamo, Kensuke Kojima, Man Chun John Ma, Vivian R Ruvolo, Dhruv Chachad, William Devine, Susan Lindquist, R Eric Davis, John A Porco, Luke Whitesell, Michael Andreeff, Jo Ishizawa
Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia 35 (9) (2021)
Wenqing Xu, Lauren E Brown, John A Porco
Divergent, C-C Bond Forming Macrocyclizations Using Modular Sulfonylhydrazone and Derived Substrates. The Journal of organic chemistry 86 (23) (2021)
Christina Skofler, Florian Kleinegger, Stefanie Krassnig, Anna Maria Birkl-Toeglhofer, Georg Singer, Holger Till, Martin Benesch, Regina Cencic, John A Porco, Jerry Pelletier, Christoph Castellani, Andrea Raicht, Ewa Iżycka-Świeszewska, Piotr Czapiewski, Johannes Haybaeck
Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma. Cells 10 (2) (2021)
Kali R Iyer, Kaddy Camara, Martin Daniel-Ivad, Richard Trilles, Sheila M Pimentel-Elardo, Jen L Fossen, Karen Marchillo, Zhongle Liu, Shakti Singh, Jose F Muñoz, Sang Hu Kim, John A Porco, Christina A Cuomo, Noelle S Williams, Ashraf S Ibrahim, John E Edwards, David R Andes, Justin R Nodwell, Lauren E Brown, Luke Whitesell, Nicole Robbins, Leah E Cowen
An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris. Nature communications 11 (1) (2020)
Jonathan H Boyce, Benjamin J Reisman, Brian O Bachmann, John A Porco
Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds. Angewandte Chemie (International ed. in English) 60 (3) (2020)
Oshrat Levi-Galibov, Hagar Lavon, Rina Wassermann-Dozorets, Meirav Pevsner-Fischer, Shimrit Mayer, Esther Wershof, Yaniv Stein, Lauren E Brown, Wenhan Zhang, Gil Friedman, Reinat Nevo, Ofra Golani, Lior H Katz, Rona Yaeger, Ido Laish, John A Porco, Erik Sahai, Dror S Shouval, David P Kelsen, Ruth Scherz-Shouval
Heat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer. Nature communications 11 (1) (2020)
Richard Trilles, Dmitri Beglov, Qiujia Chen, Hongzhen He, Randall Wireman, April Reed, Spandan Chennamadhavuni, James S Panek, Lauren E Brown, Sandor Vajda, John A Porco, Mark R Kelley, Millie M Georgiadis
Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1. Journal of medicinal chemistry 62 (4) (2019)
Ana Cláudia Gonçalves, Emily R Towers, Naila Haq, John A Porco, Jerry Pelletier, Sally J Dawson, Jonathan E Gale
Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity. Scientific reports 9 (1) (2019)
Zachary Powers, Adam Scharf, Andrea Cheng, Feng Yang, Martin Himmelbauer, Takaaki Mitsuhashi, Lena Barra, Yoshimasa Taniguchi, Takashi Kikuchi, Makoto Fujita, Leonard Kaysser, John A Porco
Biomimetic Synthesis of Meroterpenoids by Dearomatization-Driven Polycyclization. Angewandte Chemie (International ed. in English) 58 (45) (2019)
Wenhan Zhang, Jennifer Chu, Andrew M Cyr, Han Yueh, Lauren E Brown, Tony T Wang, Jerry Pelletier, John A Porco
Intercepted Retro-Nazarov Reaction: Syntheses of Amidino-Rocaglate Derivatives and Their Biological Evaluation as eIF4A Inhibitors. Journal of the American Chemical Society 141 (32) (2019)
Saishuai Wen, Jonathan H Boyce, Sunil K Kandappa, Jayaraman Sivaguru, John A Porco
Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6-epi-Garcimultiflorone A. Journal of the American Chemical Society 141 (28) (2019)
Wenhan Zhang, Shufeng Liu, Rayelle I Maiga, Jerry Pelletier, Lauren E Brown, Tony T Wang, John A Porco
Chemical Synthesis Enables Structural Reengineering of Aglaroxin C Leading to Inhibition Bias for Hepatitis C Viral Infection. Journal of the American Chemical Society 141 (3) (2019)
Xu-Jie Qin, Tyler J Rauwolf, Pan-Pan Li, Hui Liu, James McNeely, Yan Hua, Hai-Yang Liu, John A Porco
Isolation and Synthesis of Novel Meroterpenoids from Rhodomyrtus tomentosa: Investigation of a Reactive Enetrione Intermediate. Angewandte Chemie (International ed. in English) 58 (13) (2019)
Karina Chan, Francis Robert, Christian Oertlin, Dana Kapeller-Libermann, Daina Avizonis, Johana Gutierrez, Abram Handly-Santana, Mikhail Doubrovin, Julia Park, Christina Schoepfer, Brandon Da Silva, Melissa A Yao, Faith Gorton, Junwei Shi, Craig J Thomas, Lauren E Brown, John A Porco, Michael Pollak, Ola Larsson, Jerry Pelletier, Iok In Christine Chio
eIF4A supports an oncogenic translation program in pancreatic ductal adenocarcinoma. Nature communications 10 (1) (2019)
Thomas J Purgett, Matthew W Dyer, Bryce Bickel, James McNeely, John A Porco
Gold(I)-Mediated Cycloisomerization/Cycloaddition Enables Bioinspired Syntheses of Neonectrolides B-E and Analogues. Journal of the American Chemical Society 141 (38) (2019)
Xiaowei Wu, Takayuki Iwata, Adam Scharf, Tian Qin, Kyle D Reichl, John A Porco
Asymmetric Synthesis of Gonytolide A: Strategic Use of an Aryl Halide Blocking Group for Oxidative Coupling. Journal of the American Chemical Society 140 (18) (2018)
Chao Qi, Wenyu Wang, Kyle D Reichl, James McNeely, John A Porco
Total Synthesis of Aurofusarin: Studies on the Atropisomeric Stability of Bis-Naphthoquinones. Angewandte Chemie (International ed. in English) 57 (8) (2018)
Michael J Smith, Kyle D Reichl, Randolph A Escobar, Thomas J Heavey, David F Coker, Scott E Schaus, John A Porco
Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition. Journal of the American Chemical Society 141 (1) (2018)
Salomon Manier, Daisy Huynh, Yu J Shen, Jia Zhou, Timur Yusufzai, Karma Z Salem, Richard Y Ebright, Jiantao Shi, Jihye Park, Siobhan V Glavey, William G Devine, Chia-Jen Liu, Xavier Leleu, Bruno Quesnel, Catherine Roche-Lestienne, John K Snyder, Lauren E Brown, Nathanael Gray, James E Bradner, Luke Whitesell, John A Porco, Irene M Ghobrial
Inhibiting the oncogenic translation program is an effective therapeutic strategy in multiple myeloma. Science translational medicine 9 (389) (2018)
Xu-Jie Qin, Mi-Yan Feng, Hui Liu, Wei Ni, Tyler Rauwolf, John A Porco, Huan Yan, Li He, Hai-Yang Liu
Eucalyptusdimers A-C, Dimeric Phloroglucinol-Phellandrene Meroterpenoids from Eucalyptus robusta. Organic letters 20 (16) (2018)
Spandan Chennamadhavuni, James S Panek, John A Porco, Lauren E Brown
Diastereodivergent Synthesis of Chiral Tetrahydropyrrolodiazepinediones via a One-Pot Intramolecular aza-Michael/Lactamization Sequence. The Journal of organic chemistry 83 (24) (2018)
Wenyu Wang, Anthony Clay, Retheesh Krishnan, Neil J Lajkiewicz, Lauren E Brown, Jayaraman Sivaguru, John A Porco
Total Syntheses of the Isomeric Aglain Natural Products Foveoglin A and Perviridisin B: Selective Excited-State Intramolecular Proton-Transfer Photocycloaddition. Angewandte Chemie (International ed. in English) 56 (46) (2017)
Kyle D Reichl, Michael J Smith, Min K Song, Richard P Johnson, John A Porco
Biomimetic Total Synthesis of (±)-Griffipavixanthone via a Cationic Cycloaddition-Cyclization Cascade. Journal of the American Chemical Society 139 (40) (2017)
Wenyu Wang, Regina Cencic, Luke Whitesell, Jerry Pelletier, John A Porco
Synthesis of Aza-Rocaglates via ESIPT-Mediated (3+2) Photocycloaddition. Chemistry (Weinheim an der Bergstrasse, Germany) 22 (34) (2016)