James Bruce Stewart (J B Stewart, James B Stewart, James Stewart)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 13

Top Venues

Nature communications

Science advances

Nature medicine

Journal of inherited metabolic disease

Max Planck Institute for the Biology of Ageing

Simon Fraser University (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Max Planck Institute for the Biology of Ageing Feb 01 2014 - Oct 14 2020

Germany

Research Group Leader

Max Planck Institute for Biology of Ageing Mar 01 2009 - Jan 31 2014

Germany

Post Doc :: Mitochondrial Biology

Karolinska Institutet Oct 01 2005 - Dec 31 2010

Sweden

Post-Doc :: Mitochondrial Medecine

Education History

Simon Fraser University Jan 01 2002 - Feb 16 2006

Canada

PHD :: Department of Molecular Biolofy and Biochemistry

Simon Fraser University Sep 01 1997 - Dec 31 2001

Canada

MSC :: Department of Molecular Biology and Biochemistry

University of Waterloo Sep 01 1992 - May 01 1997

Canada

BSC

Publications

Juan Cruz Landoni, Semin Erkul, Tuomas Laalo, Steffi Goffart, Riikka Kivelä, Karlo Skube, Anni I Nieminen, Sara A Wickström, James Bruce Stewart, Anu Suomalainen
Overactive mitochondrial DNA replication disrupts perinatal cardiac maturation. Nature communications 15 (1) (2024)
Angelos Glynos, Lyuba V Bozhilova, Michele Frison, Stephen P Burr, James Bruce Stewart, Patrick F Chinnery
High-throughput single-cell analysis reveals progressive mitochondrial DNA mosaicism throughout life. Science advances 9 (43) (2023)
Ugne Zekonyte, Sandra R Bacman, Jeff Smith, Wendy Shoop, Claudia V Pereira, Ginger Tomberlin, James Bruce Stewart, Derek Jantz, Carlos T Moraes
Mitochondrial targeted meganuclease as a platform to eliminate mutant mtDNA in vivo. Nature communications 12 (1) (2021)
Haixin Zhang, Marco Esposito, Mikael G Pezet, Juvid Aryaman, Wei Wei, Florian Klimm, Claudia Calabrese, Stephen P Burr, Carolina Habermann Macabelli, Carlo Viscomi, Mitinori Saitou, Marcos Roberto Chiaratti, James Bruce Stewart, Nick S Jones, Patrick F Chinnery
Mitochondrial DNA heteroplasmy is modulated during oocyte development propagating mutation transmission. Science advances 7 (50) (2021)
Swaraj Basu, Xie Xie, Jay P Uhler, Carola Hedberg-Oldfors, Dusanka Milenkovic, Olivier R Baris, Sammy Kimoloi, Stanka Matic, James Bruce Stewart, Nils-Göran Larsson, Rudolf J Wiesner, Anders Oldfors, Claes M Gustafsson, Maria Falkenberg, Erik Larsson Lekholm
Accurate mapping of mitochondrial DNA deletions and duplications using deep sequencing. PLoS genetics 16 (12) (2020)
James Bruce Stewart, Patrick F Chinnery
Extreme heterogeneity of human mitochondrial DNA from organelles to populations. Nature reviews. Genetics 22 (2) (2020)
James Bruce Stewart
Current progress with mammalian models of mitochondrial DNA disease. Journal of inherited metabolic disease 44 (2) (2020)
R Filograna, Camilla Koolmeister, Mamta Upadhyay, Aleksandra Pajak, P Clemente, R Wibom, Marie-Lune Simard, A Wredenberg, C Freyer, James Bruce Stewart, N G Larsson
Modulation of mtDNA copy number ameliorates the pathological consequences of a heteroplasmic mtDNA mutation in the mouse. Science advances 5 (4) (2019)
Uwe Richter, Kah Ying Ng, Fumi Suomi, Paula Marttinen, Taina Turunen, Christopher Jackson, Anu Suomalainen, Helena Vihinen, Eija Jokitalo, Tuula Anneli Nyman, Marita A Isokallio, James Bruce Stewart, Cecilia Mancini, Alfredo Brusco, Sara Seneca, Anne Lombes, Robert W Taylor, Brendan J Battersby
Mitochondrial stress response triggered by defects in protein synthesis quality control. Life science alliance 2 (1) (2019)
Marie-Lune Simard, Arnaud Mourier, Laura C Greaves, Robert W Taylor, James Bruce Stewart
A novel histochemistry assay to assess and quantify focal cytochrome c oxidase deficiency. The Journal of pathology 245 (3) (2018)
Sandra R Bacman, Johanna H K Kauppila, Claudia V Pereira, Nadee Nissanka, Maria Miranda, Milena Pinto, Sion L Williams, Nils-Göran Larsson, James Bruce Stewart, Carlos T Moraes
MitoTALEN reduces mutant mtDNA load and restores tRNAAla levels in a mouse model of heteroplasmic mtDNA mutation. Nature medicine 24 (11) (2018)
Payam A Gammage, Carlos Pardo-Hernández, Marie-Lune Simard, Ana S H Costa, Edoardo Gaude, Christopher A Powell, Lindsey Van Haute, Beverly J McCann, Pedro Rebelo-Guiomar, Raffaele Cerutti, Lei Zhang, Edward J Rebar, Massimo Zeviani, Christian Frezza, James Bruce Stewart, Michal Minczuk
Genome editing in mitochondria corrects a pathogenic mtDNA mutation in vivo. Nature medicine 24 (11) (2018)
Stanka Matic, Min Jiang, Thomas J Nicholls, Jay P Uhler, Caren Dirksen-Schwanenland, Paola Loguercio Polosa, Marie-Lune Simard, Xinping Li, Ilian Atanassov, Oliver Rackham, Aleksandra Filipovska, James Bruce Stewart, Maria Falkenberg, Nils-Göran Larsson, Dusanka Milenkovic
Mice lacking the mitochondrial exonuclease MGME1 accumulate mtDNA deletions without developing progeria. Nature communications 9 (1) (2018)
Bertil Macao, Jay P Uhler, Triinu Siibak, Xuefeng Zhu, Yonghong Shi, Wenwen Sheng, Monica Olsson, James Bruce Stewart, Claes M Gustafsson, Maria Falkenberg
The exonuclease activity of DNA polymerase γ is required for ligation during mitochondrial DNA replication. Nature communications 6 (2015)
Ana Bratic, Timo E S Kauppila, Bertil Macao, Sebastian Grönke, Triinu Siibak, James Bruce Stewart, Francesca Baggio, Jacqueline Dols, Linda Partridge, Maria Falkenberg, Anna Wredenberg, Nils-Göran Larsson
Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies. Nature communications 6 (2015)

James Bruce Stewart.css-eqlu8i{font-size:small;padding-left:4px;} (J B Stewart, James B Stewart, James Stewart)

Publication Activity (10 Years)

Top Topics

Top Venues

James Bruce Stewart (J B Stewart, James B Stewart, James Stewart)