Jeffrey W Keillor

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 41

Top Topics

Molecular Dynamics Simulations

Breast Cancer Cells

Top Venues

Organic & biomolecular chemistry

RSC medicinal chemistry

Molecules (Basel, Switzerland)

This page only lists publications with an associated author ORCID identifier.

Publications

Pauline Navals, Alana M M Rangaswamy, Petr Kasyanchyk, Maxim V Berezovski, Jeffrey W Keillor
Conformational Modulation of Tissue Transglutaminase via Active Site Thiol Alkylating Agents: Size Does Not Matter. Biomolecules 14 (4) (2024)
Lavleen K Mader, Jeffrey W Keillor
Fitting of k inact and K I Values from Endpoint Pre-incubation IC 50 Data. ACS medicinal chemistry letters 15 (5) (2024)
Lavleen K Mader, Jeffrey W Keillor
Fitting of k inact and K I Values from Endpoint Pre-incubation IC 50 Data. ACS medicinal chemistry letters 15 (5) (2024)
Pauline Navals, Alana M M Rangaswamy, Petr Kasyanchyk, Maxim V Berezovski, Jeffrey W Keillor
Conformational Modulation of Tissue Transglutaminase via Active Site Thiol Alkylating Agents: Size Does Not Matter. Biomolecules 14 (4) (2024)
Pauline Navals, Alana M M Rangaswamy, Petr Kasyanchyk, Maxim V Berezovski, Jeffrey W Keillor
Conformational Modulation of Tissue Transglutaminase via Active Site Thiol Alkylating Agents: Size Does Not Matter. Biomolecules 14 (4) (2024)
Sarah K I Watt, Janique G Charlebois, Christopher N Rowley, Jeffrey W Keillor
A mechanistic study of thiol addition to N -acryloylpiperidine. Organic & biomolecular chemistry (2023)
Eric W J Gates, Adrien Prince-Hallée, Yasaman Heidari, Abootaleb Sedighi, Jeffrey W Keillor
High-Affinity Fluorogenic Substrate for Tissue Transglutaminase Reveals Enzymatic Hysteresis. Biochemistry (2023)
Eric W J Gates, Nicholas David Calvert, Nicholas J Cundy, Federica Brugnoli, Pauline Navals, Alexia Kirby, Nicoletta Bianchi, Gautam Adhikary, Adam J Shuhendler, Richard L Eckert, Jeffrey W Keillor
Cell-Impermeable Inhibitors Confirm That Intracellular Human Transglutaminase 2 Is Responsible for the Transglutaminase-Associated Cancer Phenotype. International journal of molecular sciences 24 (16) (2023)
Xian-Yang Qin, Yutaka Furutani, Kento Yonezawa, Nobutaka Shimizu, Miyuki Kato-Murayama, Mikako Shirouzu, Yali Xu, Yumiko Yamano, Akimori Wada, Luc Gailhouste, Rajan Shrestha, Masataka Takahashi, Jeffrey W Keillor, Ting Su, Wenkui Yu, Shinya Fujii, Hiroyuki Kagechika, Naoshi Dohmae, Yohei Shirakami, Masahito Shimizu, Takahiro Masaki, Tomokazu Matsuura, Harukazu Suzuki, Soichi Kojima
Targeting transglutaminase 2 mediated exostosin glycosyltransferase 1 signaling in liver cancer stem cells with acyclic retinoid. Cell death & disease 14 (6) (2023)
Sarah K I Watt, Janique G Charlebois, Christopher N Rowley, Jeffrey W Keillor
A kinetic study of thiol addition to N -phenylchloroacetamide. Organic & biomolecular chemistry (2023)
Eric W J Gates, Kian Mansour, Sahar Ebrahimi Samani, Sammir Shad, Mari T Kaartinen, Jeffrey W Keillor
Peptidic Inhibitors and a Fluorescent Probe for the Selective Inhibition and Labelling of Factor XIIIa Transglutaminase. Molecules (Basel, Switzerland) 28 (4) (2023)
Ariel Buchler, Uzair S Ismailani, Nicole MacMullin, Faduma Abdirahman, Myriam Adi, Christina Bi, Catherine Jany, Jeffrey W Keillor, Benjamin H Rotstein
Quinazoline-2-Carboxamides as Selective PET Radiotracers for Matrix Metalloproteinase-13 Imaging in Atherosclerosis. Journal of medicinal chemistry (2023)
Eric W J Gates, Kian Mansour, Sahar Ebrahimi Samani, Sammir Shad, Mari T Kaartinen, Jeffrey W Keillor
Peptidic Inhibitors and a Fluorescent Probe for the Selective Inhibition and Labelling of Factor XIIIa Transglutaminase. Molecules (Basel, Switzerland) 28 (4) (2023)
Sarah K I Watt, Janique G Charlebois, Christopher N Rowley, Jeffrey W Keillor
A mechanistic study of thiol addition to N -acryloylpiperidine. Organic & biomolecular chemistry 21 (10) (2023)
Sarah K I Watt, Janique G Charlebois, Christopher N Rowley, Jeffrey W Keillor
A mechanistic study of thiol addition to N -acryloylpiperidine. Organic & biomolecular chemistry 21 (10) (2023)
Eric W J Gates, Kian Mansour, Sahar Ebrahimi Samani, Sammir Shad, Mari T Kaartinen, Jeffrey W Keillor
Peptidic Inhibitors and a Fluorescent Probe for the Selective Inhibition and Labelling of Factor XIIIa Transglutaminase. Molecules (Basel, Switzerland) 28 (4) (2023)
Sarah K I Watt, Janique G Charlebois, Christopher N Rowley, Jeffrey W Keillor
A mechanistic study of thiol addition to N -acryloylpiperidine. Organic & biomolecular chemistry 21 (10) (2023)
Xi Chen, Gautam Adhikary, John J Newland, Wen Xu, Jeffrey W Keillor, David J Weber, Richard L Eckert
Transglutaminase 2 binds to the CD44v6 cytoplasmic domain to stimulate CD44v6/ERK1/2 signaling and maintain an aggressive cancer phenotype. Molecular cancer research : MCR (2023)
Lavleen K Mader, Sarah K I Watt, Harish R Iyer, Linh Nguyen, Harpreet Kaur, Jeffrey W Keillor
The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors. RSC medicinal chemistry 14 (2) (2022)
Nicholas J Cundy, Jane Arciszewski, Eric W J Gates, Sydney L Acton, Kyle D Passley, Ernest Awoonor-Williams, Elizabeth K Boyd, Nancy Xu, Élise Pierson, Catalina Fernandez-Ansieta, Marie R Albert, Nicole M R McNeil, Gautam Adhikary, Richard L Eckert, Jeffrey W Keillor
Novel irreversible peptidic inhibitors of transglutaminase 2. RSC medicinal chemistry 14 (2) (2022)
Rita Canella, Federica Brugnoli, Mariana Gallo, Jeffrey W Keillor, Anna Terrazzan, Elena Ferrari, Silvia Grassilli, Eric W J Gates, Stefano Volinia, Valeria Bertagnolo, Nicoletta Bianchi, Carlo M Bergamini
A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent K + Channel in Breast Cancer. Cancers 15 (1) (2022)
Alana M M Rangaswamy, Pauline Navals, Eric W J Gates, Sammir Shad, Sarah K I Watt, Jeffrey W Keillor
Structure-activity relationships of hydrophobic alkyl acrylamides as tissue transglutaminase inhibitors. RSC medicinal chemistry 13 (4) (2022)
Sarah K I Watt, Janique G Charlebois, Christopher N Rowley, Jeffrey W Keillor
A mechanistic study of thiol addition to N -phenylacrylamide. Organic & biomolecular chemistry 20 (45) (2022)
Rita Canella, Federica Brugnoli, Mariana Gallo, Jeffrey W Keillor, Anna Terrazzan, Elena Ferrari, Silvia Grassilli, Eric W J Gates, Stefano Volinia, Valeria Bertagnolo, Nicoletta Bianchi, Carlo M Bergamini
A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent K + Channel in Breast Cancer. Cancers 15 (1) (2022)
Rita Canella, Federica Brugnoli, Mariana Gallo, Jeffrey W Keillor, Anna Terrazzan, Elena Ferrari, Silvia Grassilli, Eric W J Gates, Stefano Volinia, Valeria Bertagnolo, Nicoletta Bianchi, Carlo M Bergamini
A Multidisciplinary Approach Establishes a Link between Transglutaminase 2 and the Kv10.1 Voltage-Dependent K + Channel in Breast Cancer. Cancers 15 (1) (2022)
Nicholas J Cundy, Jane Arciszewski, Eric W J Gates, Sydney L Acton, Kyle D Passley, Ernest Awoonor-Williams, Elizabeth K Boyd, Nancy Xu, Élise Pierson, Catalina Fernandez-Ansieta, Marie R Albert, Nicole M R McNeil, Gautam Adhikary, Richard L Eckert, Jeffrey W Keillor
Novel irreversible peptidic inhibitors of transglutaminase 2. RSC medicinal chemistry 14 (2) (2022)
Lavleen K Mader, Sarah K I Watt, Harish R Iyer, Linh Nguyen, Harpreet Kaur, Jeffrey W Keillor
The war on hTG2: warhead optimization in small molecule human tissue transglutaminase inhibitors. RSC medicinal chemistry 14 (2) (2022)
Ellen A Rorke, Gautam Adhikary, Henryk Szmacinski, Joseph R Lakowicz, David J Weber, Raquel Godoy-Ruiz, Purushottamachar Puranik, Jeffrey W Keillor, Eric W J Gates, Richard L Eckert
Sulforaphane covalently interacts with the transglutaminase 2 cancer maintenance protein to alter its structure and suppress its activity. Molecular carcinogenesis 61 (1) (2021)
Nicoletta Bianchi, Federica Brugnoli, Silvia Grassilli, Karine Bourgeois, Jeffrey W Keillor, Carlo M Bergamini, Gianluca Aguiari, Stefano Volinia, Valeria Bertagnolo
The Motility and Mesenchymal Features of Breast Cancer Cells Correlate with the Levels and Intracellular Localization of Transglutaminase Type 2. Cells 10 (11) (2021)
Xi Chen, Gautam Adhikary, Suruchi Shrestha, Wen Xu, Jeffrey W Keillor, Warren Naselsky, Richard L Eckert
Transglutaminase 2 Maintains Hepatocyte Growth Factor Signaling to Enhance the Cancer Cell Phenotype. Molecular cancer research : MCR 19 (12) (2021)
Anissa Elahi, Jacen Emerson, Jacob Rudlong, Jeffrey W Keillor, Garrick Salois, Adam Visca, Peter Girardi, Gail V W Johnson, Christoph Pröschel
Deletion or Inhibition of Astrocytic Transglutaminase 2 Promotes Functional Recovery after Spinal Cord Injury. Cells 10 (11) (2021)
Soo-Youl Kim, Jeffrey W Keillor
A Precision Strategy to Cure Renal Cell Carcinoma by Targeting Transglutaminase 2. International journal of molecular sciences 21 (7) (2020)
Benoit Maffei, Marc Laverrière, Yongzheng Wu, Sébastien Triboulet, Stéphanie Perrinet, Magalie Duchateau, Mariette Matondo, Robert L Hollis, Charlie Gourley, Jan Rupp, Jeffrey W Keillor, Agathe Subtil
Infection-driven activation of transglutaminase 2 boosts glucose uptake and hexosamine biosynthesis in epithelial cells. The EMBO journal 39 (8) (2020)
Kelvin K Tsao, Ann C Lee, Karl É Racine, Jeffrey W Keillor
Site-Specific Fluorogenic Protein Labelling Agent for Bioconjugation. Biomolecules 10 (3) (2020)
Yingche Chen, Kelvin Tsao, Sydney L Acton, Jeffrey W Keillor
A Green BODIPY-Based, Super-Fluorogenic, Protein-Specific Labelling Agent. Angewandte Chemie (International ed. in English) 57 (38) (2018)
Mark A R Raycroft, Karl É Racine, Christopher N Rowley, Jeffrey W Keillor
Mechanisms of Alkyl and Aryl Thiol Addition to N-Methylmaleimide. The Journal of organic chemistry 83 (19) (2018)
Samuel K Oteng-Pabi, Christopher M Clouthier, Jeffrey W Keillor
Design of a glutamine substrate tag enabling protein labelling mediated by Bacillus subtilis transglutaminase. PloS one 13 (5) (2018)
Manuela Bassoi, Huan Huan Chen, Debasmita Tripathy, Mariarosaria Conte, Kim Y P Apperley, Angela De Simone, Jeffrey W Keillor, Rajiv Ratan, Angela Nebbioso, Federica Sarno, Lucia Altucci, Andrea Milelli
Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death. ChemMedChem 13 (3) (2018)
Abdullah Akbar, Nicole M R McNeil, Marie R Albert, Viviane Ta, Gautam Adhikary, Karine Bourgeois, Richard L Eckert, Jeffrey W Keillor
Structure-Activity Relationships of Potent, Targeted Covalent Inhibitors That Abolish Both the Transamidation and GTP Binding Activities of Human Tissue Transglutaminase. Journal of medicinal chemistry 60 (18) (2017)
Gleb G Mironov, Christopher M Clouthier, Abdullah Akbar, Jeffrey W Keillor, Maxim V Berezovski
Simultaneous analysis of enzyme structure and activity by kinetic capillary electrophoresis-MS. Nature chemical biology 12 (11) (2016)
Kim Y P Apperley, Isabelle Roy, Vincent Saucier, Nicholas Brunet-Filion, Sara-Pier Piscopo, Christophe Pardin, Élise De Francesco, Catherine Hao, Jeffrey W Keillor
Development of new scaffolds as reversible tissue transglutaminase inhibitors, with improved potency or resistance to glutathione addition. MedChemComm 8 (2) (2016)