Jeremy Charles Mottram (J C Mottram, Jeremy C Mottram)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2023
Publications (10 Years): 40

Top Venues

Wellcome open research

International journal of molecular sciences

PLoS pathogens

mBio

University of York

University of Glasgow (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of York May 01 2018

United Kingdom

Director, York Biomedical Research Institute

University of York Jan 01 2016

United Kingdom

Professor in Pathogen Biology :: Biology

University of Glasgow Jul 01 2000 - Dec 31 2015

United Kingdom

Professor of Molecular and Cellular Parasitology :: Wellcome Trust Centre for Molecular Parasitology

University of Glasgow Oct 01 1993 - Sep 30 2003

United Kingdom

MRC Senior Research Fellow :: Wellcome Centre for Molecular Parasitology

University of Glasgow Oct 01 1987 - Sep 30 1993

United Kingdom

Postdoctoral Research Fellow :: Insitute of Genetics

University of California San Francisco Jan 01 1985 - Sep 30 1987

United States

Postdoctoral Research Fellow :: Intercampus Program in Molecular Parasitology

Education History

University of Glasgow Oct 01 1981 - Nov 01 1984

United Kingdom

PHD :: Zoology

University of Kent Sep 01 1977 - Jun 01 1980

United Kingdom

BSC :: Biochemistry

Publications

Srinivasa P S Rao, Matthew K Gould, Jonas Noeske, Jeremy C Mottram, Rajiv S Jumani, Pearly Shuyi Ng, Olivier René, Yen-Liang Chen, Marcel Kaiser, Ryan Ritchie, Amanda Fortes Francisco, Nila Johnson, Debjani Patra, Harry Cheung, Colin Deniston, Andreas D Schenk, Wilian A Cortopassi, Remo S Schmidt, Natalie Wiedemar, Bryanna Thomas, Rima Palkar, Nahdiyah A Ghafar, Vanessa Manoharan, Catherine Luu, Jonathan E Gable, Kah Fei Wan, Elmarie Myburgh, Jeremy Charles Mottram, S Whitney Barnes, John R Walker, Charles A Wartchow, Natasha Aziz, Colin Osborne, Juergen Wagner, Christopher Sarko, John M Kelly, Ujjini H Manjunatha, Pascal Mäser, Jan Jiricek, Suresh B Lakshminarayana, Michael P Barrett, Thierry Tidiane Diagana
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science (New York, N.Y.) 380 (6652) (2023)
Srinivasa P S Rao, Matthew K Gould, Jonas Noeske, Jeremy C Mottram, Rajiv S Jumani, Pearly Shuyi Ng, Olivier René, Yen-Liang Chen, Marcel Kaiser, Ryan Ritchie, Amanda Fortes Francisco, Nila Johnson, Debjani Patra, Harry Cheung, Colin Deniston, Andreas D Schenk, Wilian A Cortopassi, Remo S Schmidt, Natalie Wiedemar, Bryanna Thomas, Rima Palkar, Nahdiyah A Ghafar, Vanessa Manoharan, Catherine Luu, Jonathan E Gable, Kah Fei Wan, Elmarie Myburgh, Jeremy Charles Mottram, S Whitney Barnes, John R Walker, Charles A Wartchow, Natasha Aziz, Colin Osborne, Juergen Wagner, Christopher Sarko, John M Kelly, Ujjini H Manjunatha, Pascal Mäser, Jan Jiricek, Suresh B Lakshminarayana, Michael P Barrett, Thierry Tidiane Diagana
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science (New York, N.Y.) 380 (6652) (2023)
Srinivasa P S Rao, Matthew K Gould, Jonas Noeske, Jeremy C Mottram, Rajiv S Jumani, Pearly Shuyi Ng, Olivier René, Yen-Liang Chen, Marcel Kaiser, Ryan Ritchie, Amanda Fortes Francisco, Nila Johnson, Debjani Patra, Harry Cheung, Colin Deniston, Andreas D Schenk, Wilian A Cortopassi, Remo S Schmidt, Natalie Wiedemar, Bryanna Thomas, Rima Palkar, Nahdiyah A Ghafar, Vanessa Manoharan, Catherine Luu, Jonathan E Gable, Kah Fei Wan, Elmarie Myburgh, Jeremy Charles Mottram, S Whitney Barnes, John R Walker, Charles A Wartchow, Natasha Aziz, Colin Osborne, Juergen Wagner, Christopher Sarko, John M Kelly, Ujjini H Manjunatha, Pascal Mäser, Jan Jiricek, Suresh B Lakshminarayana, Michael P Barrett, Thierry Tidiane Diagana
Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections. Science (New York, N.Y.) 380 (6652) (2023)
Catherine N Russell, Jennifer L Carter, Juliet M Borgia, Jacob T Bush, Félix Calderón, Raquel Gabarró, Stuart J Conway, Jeremy Charles Mottram, Anthony J Wilkinson, Nathaniel G Jones
Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery. ACS infectious diseases (2023)
Tom Beneke, Ulrich Dobramysl, Carolina Moura Costa Catta-Preta, Jeremy Charles Mottram, Eva Gluenz, Richard John Wheeler
Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase. Wellcome open research 7 (2023)
Tatiana F R Costa, Amy Goundry, Alexandre Morrot, Dennis J Grab, Jeremy Charles Mottram, Ana Paula C A Lima
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. International journal of molecular sciences 24 (1) (2022)
Tom Beneke, Ulrich Dobramysl, Carolina Moura Costa Catta-Preta, Jeremy Charles Mottram, Eva Gluenz, Richard John Wheeler
Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase. Wellcome open research 7 (2022)
Tom Beneke, Ulrich Dobramysl, Carolina Moura Costa Catta-Preta, Jeremy Charles Mottram, Eva Gluenz, Richard John Wheeler
Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase. Wellcome open research 7 (2022)
Tatiana F R Costa, Amy Goundry, Alexandre Morrot, Dennis J Grab, Jeremy Charles Mottram, Ana Paula C A Lima
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. International journal of molecular sciences 24 (1) (2022)
Tatiana F R Costa, Amy Goundry, Alexandre Morrot, Dennis J Grab, Jeremy Charles Mottram, Ana Paula C A Lima
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. International journal of molecular sciences 24 (1) (2022)
Tatiana F R Costa, Amy Goundry, Alexandre Morrot, Dennis J Grab, Jeremy Charles Mottram, Ana Paula C A Lima
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. International journal of molecular sciences 24 (1) (2022)
Vincent Geoghegan, Juliana B T Carnielli, Nathaniel G Jones, Manuel Saldivia, Sergios Antoniou, Charlotte Hughes, Rachel Neish, Adam A Dowle, Jeremy Charles Mottram
CLK1/CLK2-driven signalling at the Leishmania kinetochore is captured by spatially referenced proximity phosphoproteomics. Communications biology 5 (1) (2022)
Tom Beneke, Ulrich Dobramysl, Carolina Moura Costa Catta-Preta, Jeremy Charles Mottram, Eva Gluenz, Richard John Wheeler
Genome sequence of Leishmania mexicana MNYC/BZ/62/M379 expressing Cas9 and T7 RNA polymerase. Wellcome open research 7 (2022)
Sarah Forrester, Amy Goundry, Bruna Torres Dias, Thyago Leal-Calvo, Milton Ozório Moraes, Paul M Kaye, Jeremy Charles Mottram, Ana Paula Cabral de Araujo Lima
Tissue Specific Dual RNA-Seq Defines Host-Parasite Interplay in Murine Visceral Leishmaniasis Caused by Leishmania donovani and Leishmania infantum. Microbiology spectrum 10 (2) (2022)
Cooper Alastair Grace, Kátia Silene Sousa Carvalho, Mayara Ingrid Sousa Lima, Vladimir Costa Silva, João Luís Reis-Cunha, Matthew J Brune, Sarah Forrester, Conceição de Maria Pedrozo E Silva de Azevedo, Dorcas Lamounier Costa, Doug Speed, Jeremy Charles Mottram, Daniel Charlton Jeffares, Carlos H N Costa
Parasite Genotype Is a Major Predictor of Mortality from Visceral Leishmaniasis. mBio (2022)
Nathaniel G Jones, Vincent Geoghegan, Gareth Moore, Juliana B T Carnielli, Katherine Newling, Felix Calderon, Raquel Gabarró, Julio Martín, Rabinder K Prinjha, Inmaculada Rioja, Anthony J Wilkinson, Jeremy Charles Mottram
Bromodomain factor 5 is an essential regulator of transcription in Leishmania. Nature communications 13 (1) (2022)
Tatiana F R Costa, Amy Goundry, Alexandre Morrot, Dennis J Grab, Jeremy Charles Mottram, Ana Paula C A Lima
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. International journal of molecular sciences 24 (1) (2022)
Tatiana F R Costa, Amy Goundry, Alexandre Morrot, Dennis J Grab, Jeremy Charles Mottram, Ana Paula C A Lima
Trypanosoma brucei rhodesiense Inhibitor of Cysteine Peptidase (ICP) Is Required for Virulence in Mice and to Attenuate the Inflammatory Response. International journal of molecular sciences 24 (1) (2022)
N Baker, Carolina Moura Costa Catta-Preta, Rachel Neish, Jovana Sadlova, Ben Powell, E V C Alves-Ferreira, V Geoghegan, Juliana B T Carnielli, Katherine Newling, C Hughes, B Vojtkova, J Anand, A Mihut, Pegine B Walrad, Laurence G Wilson, J W Pitchford, Petr Volf, Jeremy Charles Mottram
Systematic functional analysis of Leishmania protein kinases identifies regulators of differentiation or survival. Nature communications 12 (1) (2021)
Antonio Luis de O A Petersen, Benjamin Cull, Beatriz R S Dias, Luana C Palma, Yasmin da S Luz, Juliana Perrone Bezerra de Menezes, Jeremy Charles Mottram, Patrícia Sampaio Tavares Veras
17-AAG-Induced Activation of the Autophagic Pathway in Leishmania Is Associated with Parasite Death. Microorganisms 9 (5) (2021)
Rosa Milagros Corrales, Slavica Vaselek, Rachel Neish, Laurence Berry, Camille D Brunet, Lucien Crobu, Nada Kuk, Julio Mateos-Langerak, Derrick Roy Robinson, Petr Volf, Jeremy Charles Mottram, Yvon Sterkers, Patrick Bastien
The kinesin of the flagellum attachment zone in Leishmania is required for cell morphogenesis, cell division and virulence in the mammalian host. PLoS pathogens 17 (6) (2021)
Iain W McNae, James Kinkead, Divya Malik, Li-Hsuan Yen, Martin K Walker, Chris Swain, Scott P Webster, Nick Gray, Peter M Fernandes, Elmarie Myburgh, Elizabeth A Blackburn, Ryan Ritchie, Carol Austin, Martin A Wear, Adrian J Highton, Andrew J Keats, Antonio Vong, Jacqueline Dornan, Jeremy Charles Mottram, Paul A M Michels, Simon Pettit, Malcolm D Walkinshaw
Fast acting allosteric phosphofructokinase inhibitors block trypanosome glycolysis and cure acute African trypanosomiasis in mice. Nature communications 12 (1) (2021)
Asma Belbelazi, Rachel Neish, Martin Carr, Jeremy Charles Mottram, Michael L Ginger
Divergent Cytochrome c Maturation System in Kinetoplastid Protists. mBio 12 (3) (2021)
Jeremy C Mottram, Eric Fang, Xiaolei Ma, Elmarie Myburgh, Juliana B T Carnielli, Christopher Bower-Lepts, Elaine Brown, Ryan Ritchie, Suresh B Lakshminarayana, Yen-Liang Chen, Debjani Patra, Elizabeth Ornelas, Hazel X Y Koh, Sarah L Williams, Frantisek Supek, Daniel Paape, Richard McCulloch, Marcel Kaiser, Michael P Barrett, Jan Jiricek, Thierry T Diagana, Jeremy Charles Mottram, Srinivasa P S Rao
Targeting the trypanosome kinetochore with CLK1 protein kinase inhibitors. Nature microbiology 5 (10) (2020)
Srinivasa P S Rao, Suresh B Lakshminarayana, Jan Jiricek, Marcel Kaiser, Ryan Ritchie, Elmarie Myburgh, Frantisek Supek, Tove Tuntland, Advait Nagle, Valentina Molteni, Pascal Mäser, Jeremy Charles Mottram, Michael P Barrett, Thierry T Diagana
Anti-Trypanosomal Proteasome Inhibitors Cure Hemolymphatic and Meningoencephalic Murine Infection Models of African Trypanosomiasis. Tropical medicine and infectious disease 5 (1) (2020)
Clare Halliday, Ryuji Yanase, Carolina Moura Costa Catta-Preta, Flavia Moreira-Leite, Jitka Myskova, Katerina Pruzinova, Petr Volf, Jeremy Charles Mottram, Jack Daniel Sunter
Role for the flagellum attachment zone in Leishmania anterior cell tip morphogenesis. PLoS pathogens 16 (10) (2020)
Emily A Dickie, Federica Giordani, Matthew K Gould, Pascal Mäser, Christian Burri, Jeremy Charles Mottram, Srinivasa P S Rao, Michael P Barrett
New Drugs for Human African Trypanosomiasis: A Twenty First Century Success Story. Tropical medicine and infectious disease 5 (1) (2020)
Rebecca J Burge, Andreas Damianou, Anthony J Wilkinson, Boris Rodenko, Jeremy Charles Mottram
Leishmania differentiation requires ubiquitin conjugation mediated by a UBC2-UEV1 E2 complex. PLoS pathogens 16 (10) (2020)
Andreas Damianou, Rebecca J Burge, Carolina Moura Costa Catta-Preta, Vincent Geoghegan, Yesica Romina Nievas, Katherine Newling, Elaine Brown, Richard J S Burchmore, Boris Rodenko, Jeremy Charles Mottram
Essential roles for deubiquitination in Leishmania life cycle progression. PLoS pathogens 16 (6) (2020)
Jack Daniel Sunter, Ryuji Yanase, Ziyin Wang, Carolina Moura Costa Catta-Preta, Flavia Moreira-Leite, Jitka Myskova, Katerina Pruzinova, Petr Volf, Jeremy Charles Mottram, Keith Gull
Leishmania flagellum attachment zone is critical for flagellar pocket shape, development in the sand fly, and pathogenicity in the host. Proceedings of the National Academy of Sciences of the United States of America 116 (13) (2019)
Sarah Forrester, Karin Siefert, Helen Ashwin, Najmeeyah Brown, Andrea Zelmer, Sally James, Dimitris Lagos, Jon Timmis, Mitali Chatterjee, Jeremy Charles Mottram, Simon L Croft, Paul M Kaye
Tissue-specific transcriptomic changes associated with AmBisome® treatment of BALB/c mice with experimental visceral leishmaniasis. Wellcome open research 4 (2019)
Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy Charles Mottram, Simon L Croft, Paul M Kaye
Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis. Wellcome open research 3 (2019)
Helen Ashwin, Karin Seifert, Sarah Forrester, Najmeeyah Brown, Sandy MacDonald, Sally James, Dimitris Lagos, Jon Timmis, Jeremy Charles Mottram, Simon L Croft, Paul M Kaye
Tissue and host species-specific transcriptional changes in models of experimental visceral leishmaniasis. Wellcome open research (2019)
Giovanni Bussotti, Evi Gouzelou, Mariana Côrtes Boité, Ihcen Kherachi, Zoubir Harrat, Naouel Eddaikra, Jeremy Charles Mottram, Maria Antoniou, Vasiliki Christodoulou, Aymen Bali, Fatma Z Guerfali, Dhafer Laouini, Maowia Mukhtar, Franck Dumetz, Jean-Claude Dujardin, Despina Smirlis, Pierre Lechat, Pascale Pescher, Adil El Hamouchi, Meryem Lemrani, Carmen Chicharro, Ivonne Pamela Llanes-Acevedo, Laura Botana, Israel Cruz, Javier Moreno, Fakhri Jeddi, Karim Aoun, Aïda Bouratbine, Elisa Cupolillo, Gerald F Späth
Leishmania Genome Dynamics during Environmental Adaptation Reveal Strain-Specific Differences in Gene Copy Number Variation, Karyotype Instability, and Telomeric Amplification. mBio 9 (6) (2018)
Srinivasa P S Rao, Michael P Barrett, Glenn Dranoff, Christopher J Faraday, Claudio R Gimpelewicz, Asrat Hailu, Catherine L Jones, John M Kelly, Janis K Lazdins-Helds, Pascal Mäser, Jose Mengel, Jeremy Charles Mottram, Charles E Mowbray, David L Sacks, Phillip Scott, Gerald F Späth, Rick L Tarleton, Jonathan M Spector, Thierry T Diagana
Drug Discovery for Kinetoplastid Diseases: Future Directions. ACS infectious diseases 5 (2) (2018)
Nathaniel G Jones, Carolina M C Catta-Preta, Ana Paula C A Lima, Jeremy Charles Mottram
Genetically Validated Drug Targets in Leishmania: Current Knowledge and Future Prospects. ACS infectious diseases 4 (4) (2018)
Jennifer A Stortz, Tiago D Serafim, Sam Alsford, Jonathan M Wilkes, Fernando Fernández-Cortés, Graham Hamilton, Emma M Briggs, Leandro Lemgruber Soares, David Horn, Jeremy Charles Mottram, Richard McCulloch
Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei. PLoS pathogens 13 (7) (2017)
Fernando Fernández-Cortés, Tiago D Serafim, Jonathan M Wilkes, Nathaniel G Jones, Ryan Ritchie, Richard McCulloch, Jeremy Charles Mottram
RNAi screening identifies Trypanosoma brucei stress response protein kinases required for survival in the mouse. Scientific reports 7 (1) (2017)
Karen McLuskey, Jaspreet S Grewal, Debanu Das, Adam Godzik, Scott A Lesley, Ashley M Deacon, Graham H Coombs, Marc-André Elsliger, Ian A Wilson, Jeremy Charles Mottram
Crystal Structure and Activity Studies of the C11 Cysteine Peptidase from Parabacteroides merdae in the Human Gut Microbiome. The Journal of biological chemistry 291 (18) (2016)
Jaspreet S Grewal, Karen McLuskey, Debanu Das, Elmarie Myburgh, Jonathan Wilkes, Elaine Brown, Leandro Lemgruber, Matthew K Gould, Richard J Burchmore, Graham H Coombs, Achim Schnaufer, Jeremy Charles Mottram
PNT1 Is a C11 Cysteine Peptidase Essential for Replication of the Trypanosome Kinetoplast. The Journal of biological chemistry 291 (18) (2016)

Jeremy Charles Mottram (J C Mottram, Jeremy C Mottram)

Publication Activity (10 Years)

Top Topics

Top Venues