Hsin-Hui Shen (Jian Li, J Li)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 45

Top Topics

Urinary Tract Infection

Molecular Dynamics Simulations

Top Venues

Journal of medicinal chemistry

Antimicrobial agents and chemotherapy

ACS infectious diseases

This page only lists publications with an associated author ORCID identifier.

Publications

Jingyi Zhu, Limei Xu, Wenxin Wang, Min Xiao, Hsin-Hui Shen, Lushan Wang, Xukai Jiang
Molecular Dynamics Simulations Reveal Octanoylated Hyaluronic Acid Enhances Liposome Stability, Stealth and Targeting. ACS omega 9 (31) (2024)
Jingyi Zhu, Limei Xu, Wenxin Wang, Min Xiao, Hsin-Hui Shen, Lushan Wang, Xukai Jiang
Molecular Dynamics Simulations Reveal Octanoylated Hyaluronic Acid Enhances Liposome Stability, Stealth and Targeting. ACS omega 9 (31) (2024)
Maytham H Hussein, Raad Jasim, Hakan Gocol, Mark Baker, Varsha J Thombare, James Ziogas, Aayush Purohit, Gauri G Rao, Hsin-Hui Shen, Tony Velkov
Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae. mSphere 8 (1) (2023)
Ethel Jeyaseela Jeyaraj, Mei-Ling Han, Hsin-Hui Shen, Wee Sim Choo
Metabolic perturbations and key pathways associated with the bacteriostatic activity of Clitoria ternatea flower anthocyanin fraction against Escherichia coli . Access microbiology 5 (6) (2023)
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Xukai Jiang, Kade D Roberts, Hsin-Hui Shen
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity. Journal of medicinal chemistry (2023)
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Xukai Jiang, Kade D Roberts, Hsin-Hui Shen
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity. Journal of medicinal chemistry 66 (4) (2023)
Maytham H Hussein, Rafah Allobawi, Jinxin Zhao, Heidi Yu, Stephanie L Neville, Jonathan Wilksch, Labell J M Wong, Mark Baker, Christopher A McDevitt, Gauri G Rao, Hsin-Hui Shen, Xukai Jiang
Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae . ACS infectious diseases (2023)
Xukai Jiang, Nitin A Patil, Yuwen Xu, Hasini Wickremasinghe, Qi Tony Zhou, Fanfan Zhou, Philip E Thompson, Lushan Wang, Min Xiao, Kade D Roberts, Xukai Jiang, Hsin-Hui Shen
Structure-Interaction Relationship of Polymyxins with Lung Surfactant. Journal of medicinal chemistry (2023)
Tram Le, Sue C Nang, Jinxin Zhao, Heidi H Yu, Hsin-Hui Shen, Jason J Gill, Mei Liu, Saima Aslam
Therapeutic Potential of Intravenous Phage as Standalone Therapy for Recurrent Drug-Resistant Urinary Tract Infections. Antimicrobial agents and chemotherapy (2023)
Maria Luisa Sorli-Redó, Sonia Luque, Hsin-Hui Shen, Adela Benítez-Cano, Xenia Fernández, Nuria Prim, Victoria Vega, Joan Gómez-Junyent, Inmaculada López-Montesinos, Inmaculada López Montesinos, M Milagro Montero, Santiago Grau, Juan Pablo Horcajada
Colistin plasma concentrations are not associated with better clinical outcomes in patients with pneumonia caused by extremely drug-resistant Pseudomonas aeruginosa . Microbiology spectrum (2023)
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Xukai Jiang, Kade D Roberts, Hsin-Hui Shen
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity. Journal of medicinal chemistry 66 (4) (2023)
Maytham H Hussein, Zetao Sun, Jane Hawkey, Rafah Allobawi, Lousie M Judd, Vincenzo Carbone, Rajnikant Sharma, Varsha Thombare, Mark Baker, Gauri G Rao, Hsin-Hui Shen, Kathryn E Holt, Xukai Jiang
High-level nitrofurantoin resistance in a clinical isolate of Klebsiella pneumoniae: a comparative genomics and metabolomics analysis. mSystems (2023)
Maytham H Hussein, Raad Jasim, Hakan Gocol, Mark Baker, Varsha J Thombare, James Ziogas, Aayush Purohit, Gauri G Rao, Hsin-Hui Shen, Tony Velkov
Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae. mSphere (2023)
Maytham H Hussein, Raad Jasim, Hakan Gocol, Mark Baker, Varsha J Thombare, James Ziogas, Aayush Purohit, Gauri G Rao, Hsin-Hui Shen, Tony Velkov
Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae. mSphere 8 (1) (2023)
Maytham H Hussein, Raad Jasim, Hakan Gocol, Mark Baker, Varsha J Thombare, James Ziogas, Aayush Purohit, Gauri G Rao, Hsin-Hui Shen, Tony Velkov
Comparative Proteomics of Outer Membrane Vesicles from Polymyxin-Susceptible and Extremely Drug-Resistant Klebsiella pneumoniae. mSphere 8 (1) (2023)
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Xukai Jiang, Kade D Roberts, Hsin-Hui Shen
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity. Journal of medicinal chemistry 66 (4) (2023)
Shuo Zhang, Gediminas Gervinskas, Shi Qiu, Hari Venugopal, Ross K W Marceau, Alex de Marco, Hsin-Hui Shen, Jing Fu
Methods of Preparing Nanoscale Vitreous Ice Needles for High-Resolution Cryogenic Characterization. Nano letters 22 (16) (2022)
Xukai Jiang, Mei-Ling Han, Kevin Tran, Nitin A Patil, Wendong Ma, Kade D Roberts, Min Xiao, Björn Sommer, Falk Schreiber, Lushan Wang, Xukai Jiang, Hsin-Hui Shen
An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptides against Multidrug-Resistant Pseudomonas aeruginosa . Journal of medicinal chemistry 65 (14) (2022)
Jing Lu, Mohammad A K Azad, Julie L M Moreau, Yan Zhu, Xukai Jiang, Mary Tonta, Rachel Lam, Hasini Wickremasinghe, Jinxin Zhao, Jiping Wang, Harold A Coleman, Luke E Formosa, Tony Velkov, Helena C Parkington, Alexander N Combes, Joseph Rosenbluh, Hsin-Hui Shen
Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity. Cellular and molecular life sciences : CMLS 79 (6) (2022)
Kade D Roberts, Yan Zhu, Mohammad A K Azad, Mei-Ling Han, Jiping Wang, Lynn Wang, Heidi H Yu, Andrew S Horne, Jo-Anne Pinson, David Rudd, Nicolas Hans Voelcker, Nitin A Patil, Jinxin Zhao, Xukai Jiang, Jing Lu, Ke Chen, Olga Lomovskaya, Scott J Hecker, Philip E Thompson, Roger L Nation, Michael N Dudley, David C Griffith, Xukai Jiang, Hsin-Hui Shen
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens. Nature communications 13 (1) (2022)
Zhi Ying Kho, Mohammad A K Azad, Mei-Ling Han, Yan Zhu, Cheng Huang, Ralf B Schittenhelm, Thomas Naderer, Tony Velkov, Joel Selkrig, Qi Tony Zhou, Hsin-Hui Shen
Correlative proteomics identify the key roles of stress tolerance strategies in Acinetobacter baumannii in response to polymyxin and human macrophages. PLoS pathogens 18 (3) (2022)
Xiangfeng Lai, Mei-Ling Han, Yue Ding, Seong Hoong Chow, Anton P Le Brun, Chun-Ming Wu, Phillip J Bergen, Jhih-Hang Jiang, Hsien-Yi Hsu, Benjamin W Muir, Jacinta F White, Jiangning Song, Hsin-Hui Shen, Hsin-Hui Shen
A polytherapy based approach to combat antimicrobial resistance using cubosomes. Nature communications 13 (1) (2022)
Nusaibah Abdul Rahim, Yan Zhu, Soon-Ee Cheah, Matthew D Johnson, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Darren John Creek, Phillip J Bergen, Xukai Jiang, Hsin-Hui Shen
Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae Is Predominately Driven by Chloramphenicol. ACS infectious diseases 7 (6) (2021)
Mohamad A K Azad, Shuo Zhang, Jiayao Li, Yeonuk Kim, Heidi H Yu, Alex J Fulcher, Daryl L Howard, Martin D de Jonge, Simon A James, Kade D Roberts, Tony Velkov, Jing Fu, Qi Tony Zhou, Hsin-Hui Shen
Synchrotron-based X-ray fluorescence microscopy reveals accumulation of polymyxins in single human alveolar epithelial cells. Antimicrobial agents and chemotherapy (2021)
Xukai Jiang, Nitin A Patil, Mohammad A K Azad, Hasini Wickremasinghe, Heidi Yu, Jinxin Zhao, Xinru Zhang, Mengyao Li, Bin Gong, Lin Wan, Wendong Ma, Philip E Thompson, Kai Yang, Bing Yuan, Falk Schreiber, Lushan Wang, Tony Velkov, Kade D Roberts, Hsin-Hui Shen
A novel chemical biology and computational approach to expedite the discovery of new-generation polymyxins against life-threatening Acinetobacter baumannii. Chemical science 12 (36) (2021)
Wendong Ma, Xukai Jiang, Yujiang Dou, Zhihong Zhang, Hsin-Hui Shen, Bing Yuan, Kai Yang
Biophysical Impact of Lipid A Modification Caused by Mobile Colistin Resistance Gene on Bacterial Outer Membranes. The journal of physical chemistry letters 12 (48) (2021)
San Seint Seint Aye, Zhi-Hong Zhang, Xin Yu, Heidi Yu, Wen-Dong Ma, Kai Yang, Xin Liu, Hsin-Hui Shen, Jing-Liang Li
Silk Hydrogel Electrostatically Functionalized with a Polycationic Antimicrobial Peptide: Molecular Interactions, Gel Properties, and Antimicrobial Activity. Langmuir : the ACS journal of surfaces and colloids 38 (1) (2021)
David M P De Oliveira, Lisa Bohlmann, Trent Conroy, Freda E-C Jen, Arun V Everest-Dass, Karl A Hansford, Raghu Bolisetti, Ibrahim M El-Deeb, Brian M Forde, Minh Duy Phan, Jake A Lacey, Aimee Tan, Tania Rivera-Hernandez, Stephan Brouwer, Nadia Keller, Timothy J Kidd, Amanda J Cork, Michelle J Bauer, Gregory M Cook, Mark R Davies, Scott A Beatson, David L Paterson, Alastair G McEwan, Hsin-Hui Shen, Mark A Schembri, Mark A T Blaskovich, Michael P Jennings, Christopher A McDevitt, Mark von Itzstein, Mark J Walker
Repurposing a neurodegenerative disease drug to treat Gram-negative antibiotic-resistant bacterial sepsis. Science translational medicine 12 (570) (2021)
Brian T Tsuji, Jason M Pogue, Alexandre P Zavascki, Mical Paul, George L Daikos, Alan Forrest, Daniele R Giacobbe, Claudio Viscoli, Helen Giamarellou, Ilias Karaiskos, Donald Kaye, Johan W Mouton, Vincent H Tam, Visanu Thamlikitkul, Richard G Wunderink, Hsin-Hui Shen, Roger L Nation, Keith S Kaye
International Consensus Guidelines for the Optimal Use of the Polymyxins: Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti-infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP). Pharmacotherapy 39 (1) (2020)
Xukai Jiang, Kai Yang, Mei-Ling Han, Bing Yuan, Jingliang Li, Bin Gong, Tony Velkov, Falk Schreiber, Lushan Wang, Hsin-Hui Shen
Outer Membranes of Polymyxin-Resistant Acinetobacter baumannii with Phosphoethanolamine-Modified Lipid A and Lipopolysaccharide Loss Display Different Atomic-Scale Interactions with Polymyxins. ACS infectious diseases 6 (10) (2020)
Xiangfeng Lai, Yue Ding, Chun-Ming Wu, Xiaoyu Chen, Jhih-Hang Jiang, Hsien-Yi Hsu, Yajun Wang, Anton P Le Brun, Jiangning Song, Mei-Ling Han, Jian Li, Hsin-Hui Shen
Phytantriol-Based Cubosome Formulation as an Antimicrobial against Lipopolysaccharide-Deficient Gram-Negative Bacteria. ACS applied materials & interfaces 12 (40) (2020)
Xukai Jiang, Shuo Zhang, Mohammad A K Azad, Kade D Roberts, Lin Wan, Bin Gong, Kai Yang, Bing Yuan, Hemayet Uddin, Jingliang Li, Philip E Thompson, Tony Velkov, Jing Fu, Lushan Wang, Hsin-Hui Shen
Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells. ACS infectious diseases 6 (8) (2020)
John A Karas, Glen P Carter, Benjamin P Howden, Adrianna M Turner, Olivia K A Paulin, James D Swarbrick, Mark A Baker, Hsin-Hui Shen, Xukai Jiang
Structure-Activity Relationships of Daptomycin Lipopeptides. Journal of medicinal chemistry 63 (22) (2020)
Michael Y T Chow, Rachel Yoon Kyung Chang, Mengyu Li, Yuncheng Wang, Yu Lin, Sandra Morales, Andrew J McLachlan, Elizabeth Kutter, Hsin-Hui Shen, Hak-Kim Chan
Pharmacokinetics and Time-Kill Study of Inhaled Antipseudomonal Bacteriophage Therapy in Mice. Antimicrobial agents and chemotherapy 65 (1) (2020)
Shi Qiu, Changxi Zheng, Vivek Garg, Yu Chen, Gediminas Gervinskas, Hsin-Hui Shen, Michelle A Dunstone, Ross K W Marceau, Jing Fu
Three-Dimensional Chemical Mapping of a Single Protein in the Hydrated State with Atom Probe Tomography. Analytical chemistry 92 (7) (2020)
Xueliang Hua, Chen Li, Jason M Pogue, Varun S Sharma, Ilias Karaiskos, Keith S Kaye, Brian T Tsuji, Phillip J Bergen, Yan Zhu, Jiangning Song, Hsin-Hui Shen
Correction: ColistinDose, a Mobile App for Determining Intravenous Dosage Regimens of Colistimethate in Critically Ill Adult Patients: Clinician-Centered Design and Development Study. JMIR mHealth and uHealth 8 (12) (2020)
Yan Zhu, Jing Lu, Mei-Ling Han, Xukai Jiang, Mohammad A K Azad, Nitin A Patil, Yu-Wei Lin, Jinxin Zhao, Yang Hu, Heidi H Yu, Ke Chen, John D Boyce, Rhys A Dunstan, Trevor Lithgow, Christopher K Barlow, Weifeng Li, Elena K Schneider-Futschik, Jiping Wang, Bin Gong, Bjorn Sommer, Darren J Creek, Jing Fu, Lushan Wang, Falk Schreiber, Tony Velkov, Hsin-Hui Shen
Polymyxins Bind to the Cell Surface of Unculturable Acinetobacter baumannii and Cause Unique Dependent Resistance. Advanced science (Weinheim, Baden-Wurttemberg, Germany) 7 (15) (2020)
Ahmed M Fathalla, Seong H Chow, Thomas Naderer, Qi Tony Zhou, Tony Velkov, Mohammad A K Azad, Hsin-Hui Shen
Polymyxin-Induced Cell Death of Human Macrophage-Like THP-1 and Neutrophil-Like HL-60 Cells Associated with the Activation of Apoptotic Pathways. Antimicrobial agents and chemotherapy 64 (9) (2020)
Maytham H Hussein, Elena K Schneider, Olivia K A Paulin, Rafah Allobawi, Simon Crawford, Qi Tony Zhou, Adil Hanif, Mark Baker, Yan Zhu, Hsin-Hui Shen, Xukai Jiang
Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline. ACS infectious diseases 6 (6) (2020)
Xueliang Hua, Chen Li, Jason M Pogue, Varun S Sharma, Ilias Karaiskos, Keith S Kaye, Brian T Tsuji, Phillip J Bergen, Yan Zhu, Jiangning Song, Hsin-Hui Shen
ColistinDose, a Mobile App for Determining Intravenous Dosage Regimens of Colistimethate in Critically Ill Adult Patients: Clinician-Centered Design and Development Study. JMIR mHealth and uHealth 8 (12) (2020)
Yan Zhu, Jinxin Zhao, Mohd Hafidz Mahamad Maifiah, Tony Velkov, Falk Schreiber, Hsin-Hui Shen
Metabolic Responses to Polymyxin Treatment in Acinetobacter baumannii ATCC 19606: Integrating Transcriptomics and Metabolomics with Genome-Scale Metabolic Modeling. mSystems 4 (1) (2019)
Yu-Wei Lin, Nusaibah Abdul Rahim, Jinxin Zhao, Mei-Ling Han, Heidi H Yu, Hasini Wickremasinghe, Ke Chen, Jiping Wang, David L Paterson, Yan Zhu, Gauri G Rao, Qi Tony Zhou, Alan Forrest, Tony Velkov, Hsin-Hui Shen
Novel Polymyxin Combination with the Antiretroviral Zidovudine Exerts Synergistic Killing against NDM-Producing Multidrug-Resistant Klebsiella pneumoniae. Antimicrobial agents and chemotherapy 63 (4) (2019)
Xukai Jiang, James D Swarbrick, Maytham H Hussein, Elena K Schneider, Daniel Hoyer, Hsin-Hui Shen, John A Karas
The impact of backbone N-methylation on the structure-activity relationship of Leu10 -teixobactin. Journal of peptide science : an official publication of the European Peptide Society 25 (9) (2019)
B Yun, T Zhang, M A K Azad, J Wang, C J Nowell, P Kalitsis, T Velkov, D F Hudson, Hsin-Hui Shen
Polymyxin B causes DNA damage in HK-2 cells and mice. Archives of toxicology 92 (7) (2018)
Mei-Ling Han, Xukai Jiang, Yan Zhu, Kade D Roberts, Anton P Le Brun, Seong Hoong Chow, Alina D Gutu, Samuel M Moskowitz, Hsin-Hui Shen, Hsin-Hui Shen
Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance. ACS chemical biology 13 (1) (2017)