Xukai Jiang (Tony Velkov)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 52

Top Topics

Molecular Dynamics Simulations

Oxidative Stress

Top Venues

ACS infectious diseases

Journal of medicinal chemistry

Antibiotics (Basel, Switzerland)

Antioxidants (Basel, Switzerland)

This page only lists publications with an associated author ORCID identifier.

Publications

Baofu Xie, Yue Liu, Chunhong Chen, Xukai Jiang, Shusheng Tang, Jianzhong Shen, Chongshan Dai
Colistin Induces Oxidative Stress and Apoptotic Cell Death through the Activation of the AhR/CYP1A1 Pathway in PC12 Cells. Antioxidants (Basel, Switzerland) 13 (7) (2024)
Baofu Xie, Yue Liu, Chunhong Chen, Xukai Jiang, Shusheng Tang, Jianzhong Shen, Chongshan Dai
Colistin Induces Oxidative Stress and Apoptotic Cell Death through the Activation of the AhR/CYP1A1 Pathway in PC12 Cells. Antioxidants (Basel, Switzerland) 13 (7) (2024)
Varsha Jagannath Thombare, Yimin Wu, Kavya Pamulapati, Meiling Han, Julien Tailhades, Max J Cryle, Kade D Roberts, Xukai Jiang, Jian Li, Nitin A Patil
Advancing Nitrile-Aminothiol Strategy for Dual and Sequential Bioconjugation. Chemistry (Weinheim an der Bergstrasse, Germany) 30 (46) (2024)
Varsha Jagannath Thombare, Yimin Wu, Kavya Pamulapati, Meiling Han, Julien Tailhades, Max J Cryle, Kade D Roberts, Xukai Jiang, Jian Li, Nitin A Patil
Advancing Nitrile-Aminothiol Strategy for Dual and Sequential Bioconjugation. Chemistry (Weinheim an der Bergstrasse, Germany) (2024)
Baofu Xie, Yue Liu, Chunhong Chen, Xukai Jiang, Shusheng Tang, Jianzhong Shen, Chongshan Dai
Colistin Induces Oxidative Stress and Apoptotic Cell Death through the Activation of the AhR/CYP1A1 Pathway in PC12 Cells. Antioxidants (Basel, Switzerland) 13 (7) (2024)
Mengyao Li, Mohammad A K Azad, Philip E Thompson, Kade D Roberts, Xukai Jiang, Yan Zhu, Jian Li
Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells. Antibiotics (Basel, Switzerland) 12 (2) (2023)
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Xukai Jiang, Kade D Roberts, Hsin-Hui Shen
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity. Journal of medicinal chemistry (2023)
Ilona Turek, Trang H Nguyen, Charles Galea, Isaiah Abad, Lubna Freihat, David T Manallack, Xukai Jiang, Helen R Irving
Mutations in the Vicinity of the IRAK3 Guanylate Cyclase Center Impact Its Subcellular Localization and Ability to Modulate Inflammatory Signaling in Immortalized Cell Lines. International journal of molecular sciences 24 (10) (2023)
Mengyao Li, Mohammad A K Azad, Philip E Thompson, Kade D Roberts, Xukai Jiang, Yan Zhu, Jian Li
Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells. Antibiotics (Basel, Switzerland) 12 (2) (2023)
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Xukai Jiang, Kade D Roberts, Hsin-Hui Shen
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity. Journal of medicinal chemistry 66 (4) (2023)
Maytham H Hussein, Rafah Allobawi, Jinxin Zhao, Heidi Yu, Stephanie L Neville, Jonathan Wilksch, Labell J M Wong, Mark Baker, Christopher A McDevitt, Gauri G Rao, Hsin-Hui Shen, Xukai Jiang
Integrated Transcriptomic and Metabolomic Mapping Reveals the Mechanism of Action of Ceftazidime/Avibactam against Pan-Drug-Resistant Klebsiella pneumoniae . ACS infectious diseases (2023)
Xukai Jiang, Nitin A Patil, Yuwen Xu, Hasini Wickremasinghe, Qi Tony Zhou, Fanfan Zhou, Philip E Thompson, Lushan Wang, Min Xiao, Kade D Roberts, Xukai Jiang, Hsin-Hui Shen
Structure-Interaction Relationship of Polymyxins with Lung Surfactant. Journal of medicinal chemistry (2023)
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Xukai Jiang, Kade D Roberts, Hsin-Hui Shen
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity. Journal of medicinal chemistry 66 (4) (2023)
Maytham H Hussein, Zetao Sun, Jane Hawkey, Rafah Allobawi, Lousie M Judd, Vincenzo Carbone, Rajnikant Sharma, Varsha Thombare, Mark Baker, Gauri G Rao, Hsin-Hui Shen, Kathryn E Holt, Xukai Jiang
High-level nitrofurantoin resistance in a clinical isolate of Klebsiella pneumoniae: a comparative genomics and metabolomics analysis. mSystems (2023)
Mengyao Li, Mohammad A K Azad, Philip E Thompson, Kade D Roberts, Xukai Jiang, Yan Zhu, Jian Li
Transcriptomic Responses to Polymyxin B and Analogues in Human Kidney Tubular Cells. Antibiotics (Basel, Switzerland) 12 (2) (2023)
Nitin A Patil, Wendong Ma, Xukai Jiang, Xiaoji He, Heidi H Yu, Hasini Wickremasinghe, Jiping Wang, Philip E Thompson, Xukai Jiang, Kade D Roberts, Hsin-Hui Shen
Critical Role of Position 10 Residue in the Polymyxin Antimicrobial Activity. Journal of medicinal chemistry 66 (4) (2023)
Augustine Koh Jing Jie, Maytham H Hussein, Gauri G Rao, Jian Li, Xukai Jiang
Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations. Pathogens (Basel, Switzerland) 11 (12) (2022)
Xukai Jiang, Mei-Ling Han, Kevin Tran, Nitin A Patil, Wendong Ma, Kade D Roberts, Min Xiao, Björn Sommer, Falk Schreiber, Lushan Wang, Xukai Jiang, Hsin-Hui Shen
An Intelligent Strategy with All-Atom Molecular Dynamics Simulations for the Design of Lipopeptides against Multidrug-Resistant Pseudomonas aeruginosa . Journal of medicinal chemistry 65 (14) (2022)
Mengyao Li, Mohammad A K Azad, Maizbha Uddin Ahmed, Yan Zhu, Jiangning Song, Fanfan Zhou, Hak-Kim Chan, Xukai Jiang, Qi Tony Zhou, Jian Li
Polymyxin Induces Significant Transcriptomic Perturbations of Cellular Signalling Networks in Human Lung Epithelial Cells. Antibiotics (Basel, Switzerland) 11 (3) (2022)
Maytham H Hussein, Rafah Allobawi, Irini Levou, Mark A T Blaskovich, Gauri G Rao, Jian Li, Xukai Jiang
Mechanisms Underlying Synergistic Killing of Polymyxin B in Combination with Cannabidiol against Acinetobacter baumannii : A Metabolomic Study. Pharmaceutics 14 (4) (2022)
Jing Lu, Yan Zhu, Helena C Parkington, Maytham Hussein, Jinxin Zhao, Phillip Bergen, David Rudd, Mary A Deane, Sara Oberrauch, Linda Cornthwaite-Duncan, Rafah Allobawi, Rajnikant Sharma, Gauri Rao, Jian Li, Xukai Jiang
Transcriptomic Mapping of Neurotoxicity Pathways in the Rat Brain in Response to Intraventricular Polymyxin B. Molecular neurobiology (2022)
Kade D Roberts, Yan Zhu, Mohammad A K Azad, Mei-Ling Han, Jiping Wang, Lynn Wang, Heidi H Yu, Andrew S Horne, Jo-Anne Pinson, David Rudd, Nicolas Hans Voelcker, Nitin A Patil, Jinxin Zhao, Xukai Jiang, Jing Lu, Ke Chen, Olga Lomovskaya, Scott J Hecker, Philip E Thompson, Roger L Nation, Michael N Dudley, David C Griffith, Xukai Jiang, Hsin-Hui Shen
A synthetic lipopeptide targeting top-priority multidrug-resistant Gram-negative pathogens. Nature communications 13 (1) (2022)
Augustine Koh Jing Jie, Maytham H Hussein, Gauri G Rao, Jian Li, Xukai Jiang
Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations. Pathogens (Basel, Switzerland) 11 (12) (2022)
Augustine Koh Jing Jie, Maytham H Hussein, Gauri G Rao, Jian Li, Xukai Jiang
Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations. Pathogens (Basel, Switzerland) 11 (12) (2022)
Augustine Koh Jing Jie, Maytham H Hussein, Gauri G Rao, Jian Li, Xukai Jiang
Drug Repurposing Approaches towards Defeating Multidrug-Resistant Gram-Negative Pathogens: Novel Polymyxin/Non-Antibiotic Combinations. Pathogens (Basel, Switzerland) 11 (12) (2022)
Chongshan Dai, Jiahao Lin, Hui Li, Zhangqi Shen, Yang Wang, Xukai Jiang, Jianzhong Shen
The Natural Product Curcumin as an Antibacterial Agent: Current Achievements and Problems. Antioxidants (Basel, Switzerland) 11 (3) (2022)
Nusaibah Abdul Rahim, Yan Zhu, Soon-Ee Cheah, Matthew D Johnson, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Darren John Creek, Phillip J Bergen, Xukai Jiang, Hsin-Hui Shen
Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae Is Predominately Driven by Chloramphenicol. ACS infectious diseases 7 (6) (2021)
Chongshan Dai, Hui Li, Yang Wang, Shusheng Tang, Xukai Jiang, Jianzhong Shen
Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury. Antioxidants (Basel, Switzerland) 10 (6) (2021)
Guido Veit, Xukai Jiang, Haijin Xu, Nathalie Vadeboncoeur, Lara Bilodeau, Elias Matouk, Gergely L Lukacs
A Precision Medicine Approach to Optimize Modulator Therapy for Rare CFTR Folding Mutants. Journal of personalized medicine 11 (7) (2021)
Hasini Wickremasinghe, Heidi H Yu, Mohammad A K Azad, Jin-Xin Zhao, Phillip J Bergen, Xukai Jiang, Qi Tony Zhou, Yan Zhu, Jian Li
Clinically Relevant Concentrations of Polymyxin B and Meropenem Synergistically Kill Multidrug-Resistant Pseudomonas aeruginosa and Minimize Biofilm Formation. Antibiotics (Basel, Switzerland) 10 (4) (2021)
Xukai Jiang, Kai Yang, Mei-Ling Han, Bing Yuan, Jingliang Li, Bin Gong, Tony Velkov, Falk Schreiber, Lushan Wang, Hsin-Hui Shen
Outer Membranes of Polymyxin-Resistant Acinetobacter baumannii with Phosphoethanolamine-Modified Lipid A and Lipopolysaccharide Loss Display Different Atomic-Scale Interactions with Polymyxins. ACS infectious diseases 6 (10) (2020)
Jin-Xin Zhao, Yan Zhu, Jiru Han, Yu-Wei Lin, Michael Aichem, Jiping Wang, Ke Chen, Xukai Jiang, Falk Schreiber, Jian Li
Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-Resistant Acinetobacter baumannii in a Murine Bloodstream Infection Model. Microorganisms 8 (11) (2020)
Xukai Jiang, Shuo Zhang, Mohammad A K Azad, Kade D Roberts, Lin Wan, Bin Gong, Kai Yang, Bing Yuan, Hemayet Uddin, Jingliang Li, Philip E Thompson, Tony Velkov, Jing Fu, Lushan Wang, Hsin-Hui Shen
Structure-Interaction Relationship of Polymyxins with the Membrane of Human Kidney Proximal Tubular Cells. ACS infectious diseases 6 (8) (2020)
John A Karas, Glen P Carter, Benjamin P Howden, Adrianna M Turner, Olivia K A Paulin, James D Swarbrick, Mark A Baker, Hsin-Hui Shen, Xukai Jiang
Structure-Activity Relationships of Daptomycin Lipopeptides. Journal of medicinal chemistry 63 (22) (2020)
Chongshan Dai, Xilong Xiao, Yuan Zhang, Biao Xiang, Daniel Hoyer, Jianzhong Shen, Xukai Jiang, Shusheng Tang
Curcumin Attenuates Colistin-Induced Peripheral Neurotoxicity in Mice. ACS infectious diseases 6 (4) (2020)
Maytham H Hussein, Elena K Schneider, Olivia K A Paulin, Rafah Allobawi, Simon Crawford, Qi Tony Zhou, Adil Hanif, Mark Baker, Yan Zhu, Hsin-Hui Shen, Xukai Jiang
Effective Strategy Targeting Polymyxin-Resistant Gram-Negative Pathogens: Polymyxin B in Combination with the Selective Serotonin Reuptake Inhibitor Sertraline. ACS infectious diseases 6 (6) (2020)
Chongshan Dai, Jianli Xiong, Yang Wang, Jianzhong Shen, Xukai Jiang, Xilong Xiao
Nerve Growth Factor Confers Neuroprotection against Colistin-Induced Peripheral Neurotoxicity. ACS infectious diseases 6 (6) (2020)
James L Grace, Maite Amado, Janet C Reid, Alysha G Elliott, Cornelia B Landersdorfer, Nghia Phuoc Truong, Kristian Kempe, Matthew A Cooper, Thomas P Davis, Véronique Montembault, Sagrario Pascual, Laurent Fontaine, Xukai Jiang, John F Quinn, Michael Raymond Whittaker
An optimised Cu(0)-RDRP approach for the synthesis of lipidated oligomeric vinyl azlactone: toward a versatile antimicrobial materials screening platform. Journal of materials chemistry. B 7 (43) (2019)
Xukai Jiang, James D Swarbrick, Maytham H Hussein, Elena K Schneider, Daniel Hoyer, Hsin-Hui Shen, John A Karas
The impact of backbone N-methylation on the structure-activity relationship of Leu10 -teixobactin. Journal of peptide science : an official publication of the European Peptide Society 25 (9) (2019)
Chongshan Dai, Giuseppe Donato Ciccotosto, Roberto Cappai, Yang Wang, Shusheng Tang, Daniel Hoyer, Elena K Schneider, Xukai Jiang, Xilong Xiao
Rapamycin Confers Neuroprotection against Colistin-Induced Oxidative Stress, Mitochondria Dysfunction, and Apoptosis through the Activation of Autophagy and mTOR/Akt/CREB Signaling Pathways. ACS chemical neuroscience 9 (4) (2018)
Raad Jasim, Mark A Baker, Yan Zhu, Mei-Ling Han, Elena K Schneider, Maytham Hussein, Daniel Hoyer, Jian Li, Xukai Jiang
A Comparative Study of Outer Membrane Proteome between Paired Colistin-Susceptible and Extremely Colistin-Resistant Klebsiella pneumoniae Strains. ACS infectious diseases 4 (12) (2018)
Elena K Schneider, Olivia K A Paulin, Daniel Hoyer, Kade D Roberts, James Ziogas, Mark A Baker, John Karas, Jian Li, Xukai Jiang
Sputum Active Polymyxin Lipopeptides: Activity against Cystic Fibrosis Pseudomonas aeruginosa Isolates and Their Interactions with Sputum Biomolecules. ACS infectious diseases 4 (5) (2018)
Elena K Schneider, Daniel Hoyer, Alexander A Khromykh, Jonathan B Baell, Glenn A Marsh, Mark A Baker, Jian Li, Xukai Jiang
Contemporary Anti-Ebola Drug Discovery Approaches and Platforms. ACS infectious diseases 5 (1) (2018)
Chongshan Dai, Xilong Xiao, Jichang Li, Giuseppe Donato Ciccotosto, Roberto Cappai, Shusheng Tang, Elena K Schneider, Daniel Hoyer, Xukai Jiang, Jianzhong Shen
Molecular Mechanisms of Neurotoxicity Induced by Polymyxins and Chemoprevention. ACS chemical neuroscience 10 (1) (2018)
Chongyu Zhu, Elena K Schneider, Vasiliki Nikolaou, Tobias Klein, Jian Li, Thomas P Davis, Michael Raymond Whittaker, Paul Wilson, Kristian Kempe, Xukai Jiang, David M Haddleton
Hydrolyzable Poly[Poly(Ethylene Glycol) Methyl Ether Acrylate]-Colistin Prodrugs through Copper-Mediated Photoinduced Living Radical Polymerization. Bioconjugate chemistry 28 (7) (2017)
Elena K Schneider, Johnny X Huang, Vincenzo Carbone, Meiling Han, Yan Zhu, Sue Nang, Keith K Khoo, Johnson Mak, Matthew A Cooper, Jian Li, Xukai Jiang
Plasma Protein Binding Structure-Activity Relationships Related to the N-Terminus of Daptomycin. ACS infectious diseases 3 (3) (2017)
Mei-Ling Han, Xukai Jiang, Yan Zhu, Kade D Roberts, Anton P Le Brun, Seong Hoong Chow, Alina D Gutu, Samuel M Moskowitz, Hsin-Hui Shen, Hsin-Hui Shen
Polymyxin-Induced Lipid A Deacylation in Pseudomonas aeruginosa Perturbs Polymyxin Penetration and Confers High-Level Resistance. ACS chemical biology 13 (1) (2017)
Charles A Galea, Meiling Han, Yan Zhu, Kade Roberts, Jiping Wang, Philip E Thompson, Jian L, Xukai Jiang
Characterization of the Polymyxin D Synthetase Biosynthetic Cluster and Product Profile of Paenibacillus polymyxa ATCC 10401. Journal of natural products 80 (5) (2017)
Mei-Ling Han, Hsin-Hui Shen, Karl A Hansford, Elena K Schneider, Sivashangarie Sivanesan, Kade D Roberts, Philip E Thompson, Anton P Le Brun, Yan Zhu, Marc-Antoine Sani, Frances Separovic, Mark A T Blaskovich, Mark A Baker, Samuel M Moskowitz, Matthew A Cooper, Jian Li, Xukai Jiang
Investigating the Interaction of Octapeptin A3 with Model Bacterial Membranes. ACS infectious diseases 3 (8) (2017)
Xukai Jiang, Kade D Roberts, Jian Li
Rediscovering the octapeptins. Natural product reports 34 (3) (2017)
Sivashangarie Sivanesan, Kade Roberts, Jiping Wang, Soon-Ee Chea, Philip E Thompson, Jian Li, Roger L Nation, Xukai Jiang
Pharmacokinetics of the Individual Major Components of Polymyxin B and Colistin in Rats. Journal of natural products 80 (1) (2017)
Charles A Galea, Kade D Roberts, Yan Zhu, Philip E Thompson, Jian Li, Xukai Jiang
Functional Characterization of the Unique Terminal Thioesterase Domain from Polymyxin Synthetase. Biochemistry 56 (4) (2017)