Darren John Creek (Darren J Creek, Darren Creek)

Scopus Author ID Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 59

Top Topics

Plasmodium Falciparum

Hypertensive Patients

Top Venues

Antimicrobial agents and chemotherapy

Journal of medicinal chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D Suraweera, Ric N Price, Sergio Wittlin, Vicky Marie Avery, Nyssa Drinkwater, Susan A Charman, Darren John Creek, Tania F de Koning-Ward, Peter J Scammells, Sheena McGowan
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio 15 (6) (2024)
Darren John Creek, Carlo Giannangelo, Matthew Challis, Ghizal Siddiqui, Rebecca Edgar, Tess Malcolm, Chaille Webb, Nyssa Drinkwater, Natalie Vinh, Christopher MacRaild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky Avery, Tania de Koning-Ward, Peter Scammells, Sheena McGowan
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. Research square (2024)
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie A Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren John Creek
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. eLife 13 (2024)
Jessica R Tait, Dovile Anderson, Roger L Nation, Darren John Creek, Cornelia B Landersdorfer
Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa . Antimicrobial agents and chemotherapy (2024)
Darren John Creek, Carlo Giannangelo, Matthew Challis, Ghizal Siddiqui, Rebecca Edgar, Tess Malcolm, Chaille Webb, Nyssa Drinkwater, Natalie Vinh, Christopher MacRaild, Natalie Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky Avery, Tania de Koning-Ward, Peter Scammells, Sheena McGowan
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. Research square (2024)
Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D Suraweera, Ric N Price, Sergio Wittlin, Vicky Marie Avery, Nyssa Drinkwater, Susan A Charman, Darren John Creek, Tania F de Koning-Ward, Peter J Scammells, Sheena McGowan
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio 15 (6) (2024)
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie A Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren John Creek
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. eLife 13 (2024)
Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D Suraweera, Ric N Price, Sergio Wittlin, Vicky Marie Avery, Nyssa Drinkwater, Susan A Charman, Darren John Creek, Tania F de Koning-Ward, Peter J Scammells, Sheena McGowan
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio 15 (6) (2024)
Trent D Ashton, Petar P S Calic, Madeline G Dans, Zi Kang Ooi, Qingmiao Zhou, Josephine Palandri, Katie Loi, Kate E Jarman, Deyun Qiu, Adele M Lehane, Bikash Chandra Maity, Nirupam De, Carlo Giannangelo, Christopher A MacRaild, Darren John Creek, Emma Y Mao, Maria R Gancheva, Danny W Wilson, Mrittika Chowdury, Tania F de Koning-Ward, Mufuliat T Famodimu, Michael J Delves, Harry Pollard, Colin J Sutherland, Delphine Baud, Stephen Brand, Paul F Jackson, Alan F Cowman, Robin B Gasser
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4. Journal of medicinal chemistry 67 (16) (2024)
Trent D Ashton, Petar P S Calic, Madeline G Dans, Zi Kang Ooi, Qingmiao Zhou, Josephine Palandri, Katie Loi, Kate E Jarman, Deyun Qiu, Adele M Lehane, Bikash Chandra Maity, Nirupam De, Carlo Giannangelo, Christopher A MacRaild, Darren John Creek, Emma Y Mao, Maria R Gancheva, Danny W Wilson, Mrittika Chowdury, Tania F de Koning-Ward, Mufuliat T Famodimu, Michael J Delves, Harry Pollard, Colin J Sutherland, Delphine Baud, Stephen Brand, Paul F Jackson, Alan F Cowman, Robin B Gasser
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4. Journal of medicinal chemistry 67 (16) (2024)
Jessica R Tait, Dovile Anderson, Roger L Nation, Darren John Creek, Cornelia B Landersdorfer
Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa . Antimicrobial agents and chemotherapy 68 (4) (2024)
Trent D Ashton, Petar P S Calic, Madeline G Dans, Zi Kang Ooi, Qingmiao Zhou, Josephine Palandri, Katie Loi, Kate E Jarman, Deyun Qiu, Adele M Lehane, Bikash Chandra Maity, Nirupam De, Carlo Giannangelo, Christopher A MacRaild, Darren John Creek, Emma Y Mao, Maria R Gancheva, Danny W Wilson, Mrittika Chowdury, Tania F de Koning-Ward, Mufuliat T Famodimu, Michael J Delves, Harry Pollard, Colin J Sutherland, Delphine Baud, Stephen Brand, Paul F Jackson, Alan F Cowman, Robin B Gasser
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4. Journal of medicinal chemistry 67 (16) (2024)
Hamdi A Jama, Malathi S I Dona, Evany Dinakis, Michael Nakai, Madeleine R Paterson, Waled A Shihata, Crisdion Krstevski, Charles D Cohen, Kate L Weeks, Gabriella E Farrugia, Chad Johnson, Ekaterina Salimova, Daniel G Donner, Helen Kiriazis, Harikrishnan Kaipananickal, Jun Okabe, Dovile Anderson, Darren John Creek, Charles R Mackay, Assam El-Osta, Alexander R Pinto, David M Kaye, Francine Z Marques
Maternal Diet and Gut Microbiota Influence Predisposition to Cardiovascular Disease in Offspring. Circulation research 135 (4) (2024)
Trent D Ashton, Petar P S Calic, Madeline G Dans, Zi Kang Ooi, Qingmiao Zhou, Josephine Palandri, Katie Loi, Kate E Jarman, Deyun Qiu, Adele M Lehane, Bikash Chandra Maity, Nirupam De, Carlo Giannangelo, Christopher A MacRaild, Darren John Creek, Emma Y Mao, Maria R Gancheva, Danny W Wilson, Mrittika Chowdury, Tania F de Koning-Ward, Mufuliat T Famodimu, Michael J Delves, Harry Pollard, Colin J Sutherland, Delphine Baud, Stephen Brand, Paul F Jackson, Alan F Cowman, Robin B Gasser
Property and Activity Refinement of Dihydroquinazolinone-3-carboxamides as Orally Efficacious Antimalarials that Target PfATP4. Journal of medicinal chemistry (2024)
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie A Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren John Creek
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. eLife 13 (2024)
Rebecca C S Edgar, Tess R Malcolm, Ghizal Siddiqui, Carlo Giannangelo, Natalie A Counihan, Matthew Challis, Sandra Duffy, Mrittika Chowdhury, Jutta Marfurt, Madeline Dans, Grennady Wirjanata, Rintis Noviyanti, Kajal Daware, Chathura D Suraweera, Ric N Price, Sergio Wittlin, Vicky Marie Avery, Nyssa Drinkwater, Susan A Charman, Darren John Creek, Tania F de Koning-Ward, Peter J Scammells, Sheena McGowan
On-target, dual aminopeptidase inhibition provides cross-species antimalarial activity. mBio (2024)
Carlo Giannangelo, Matthew P Challis, Ghizal Siddiqui, Rebecca Edgar, Tess R Malcolm, Chaille T Webb, Nyssa Drinkwater, Natalie Vinh, Christopher Macraild, Natalie A Counihan, Sandra Duffy, Sergio Wittlin, Shane M Devine, Vicky M Avery, Tania De Koning-Ward, Peter Scammells, Sheena McGowan, Darren John Creek
Chemoproteomics validates selective targeting of Plasmodium M1 alanyl aminopeptidase as an antimalarial strategy. eLife 13 (2024)
Jessica R Tait, Dovile Anderson, Roger L Nation, Darren John Creek, Cornelia B Landersdorfer
Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa . Antimicrobial agents and chemotherapy 68 (4) (2024)
Michelle Q Phan, Indu R Chandrashekaran, Naureen Akhtar, Evgenia Konstantinidou, Shane M Devine, Bradley C Doak, Thomas Nebl, Darren John Creek, Martin J Scanlon, Raymond S Norton
Multiplexed Native Mass Spectrometry Determination of Ligand Selectivity for Fatty Acid-Binding Proteins. ACS medicinal chemistry letters 15 (7) (2024)
Michelle Q Phan, Indu R Chandrashekaran, Naureen Akhtar, Evgenia Konstantinidou, Shane M Devine, Bradley C Doak, Thomas Nebl, Darren John Creek, Martin J Scanlon, Raymond S Norton
Multiplexed Native Mass Spectrometry Determination of Ligand Selectivity for Fatty Acid-Binding Proteins. ACS medicinal chemistry letters 15 (7) (2024)
Hamdi A Jama, Malathi S I Dona, Evany Dinakis, Michael Nakai, Madeleine R Paterson, Waled A Shihata, Crisdion Krstevski, Charles D Cohen, Kate L Weeks, Gabriella E Farrugia, Chad Johnson, Ekaterina Salimova, Daniel G Donner, Helen Kiriazis, Harikrishnan Kaipananickal, Jun Okabe, Dovile Anderson, Darren John Creek, Charles R Mackay, Assam El-Osta, Alexander R Pinto, David M Kaye, Francine Z Marques
Maternal Diet and Gut Microbiota Influence Predisposition to Cardiovascular Disease in Offspring. Circulation research (2024)
Jessica R Tait, Dovile Anderson, Roger L Nation, Darren John Creek, Cornelia B Landersdorfer
Identifying and mathematically modeling the time-course of extracellular metabolic markers associated with resistance to ceftolozane/tazobactam in Pseudomonas aeruginosa . Antimicrobial agents and chemotherapy 68 (4) (2024)
Hamdi A Jama, Dakota Rhys-Jones, Michael Nakai, Chu K Yao, Rachel E Climie, Yusuke Sata, Dovile Anderson, Darren John Creek, Geoffrey A Head, David M Kaye, Charles R Mackay, Jane Muir, Francine Z Marques
Prebiotic intervention with HAMSAB in untreated essential hypertensive patients assessed in a phase II randomized trial. Nature cardiovascular research 2 (1) (2023)
Lianne I M Lansink, Oliver P Skinner, Jessica A Engel, Hyun Jae Lee, Megan S F Soon, Cameron G Williams, Arya SheelaNair, Clara P S Pernold, Pawat Laohamonthonkul, Jasmin Akter, Thomas Stoll, Michelle M Hill, Arthur M Talman, Andrew Russell, Mara Lawniczak, Xiaoxiao Jia, Brendon Chua, Dovile Anderson, Darren John Creek, Miles P Davenport, David S Khoury, Ashraful Haque
Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites. mBio (2023)
Ghizal Siddiqui, Carlo Giannangelo, Amanda De Paoli, Anna Katharina Schuh, Kim C Heimsch, Dovile Anderson, Timothy G Brown, Christopher A MacRaild, Jianbo Wu, Xiaofang Wang, Yuxiang Dong, Jonathan L Vennerstrom, Katja Becker, Darren John Creek
Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells. ACS infectious diseases 8 (1) (2022)
Rebecca C S Edgar, Ghizal Siddiqui, Katheryn Hjerrild, Tess R Malcolm, Natalie B Vinh, Chaille T Webb, Clare Holmes, Christopher A MacRaild, Hope C Chernih, Willy W Suen, Natalie A Counihan, Darren John Creek, Peter J Scammells, Sheena McGowan, Tania F de Koning-Ward
Genetic and chemical validation of Plasmodium falciparum aminopeptidase Pf A-M17 as a drug target in the hemoglobin digestion pathway. eLife 11 (2022)
Alexander C Lewis, Victoria S Pope, Melinda N Tea, Manjun Li, Gus O Nwosu, Thao M Nguyen, Craig T Wallington-Beddoe, Paul A B Moretti, Dovile Anderson, Darren John Creek, Maurizio Costabile, Saira R Ali, Chloe A L Thompson-Peach, B Kate Dredge, Andrew G Bert, Gregory J Goodall, Paul G Ekert, Anna L Brown, Richard J J D'Andrea, Nirmal Robinson, Melissa R Pitman, Daniel Thomas, David Morrall Ross, Briony L Gliddon, Jason A Powell, Stuart M Pitson
Ceramide-induced integrated stress response overcomes Bcl-2 inhibitor resistance in acute myeloid leukemia. Blood 139 (26) (2022)
Ghizal Siddiqui, Amanda De Paoli, Christopher A MacRaild, Anna E Sexton, Coralie Boulet, Anup D Shah, Mitchell B Batty, Ralf Bernd Schittenhelm, Teresa G Carvalho, Darren John Creek
A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum-infected red blood cell proteome. GigaScience 11 (2022)
Stanley C Xie, Riley D Metcalfe, Elyse A Dunn, Craig J Morton, Shih-Chung Huang, Tanya Puhalovich, Yawei Du, Sergio Wittlin, Shuai Nie, Madeline R Luth, Liting Ma, Mi-Sook Kim, Charisse Flerida A Pasaje, Krittikorn Kumpornsin, Carlo Giannangelo, Fiona J Houghton, Alisje Churchyard, Mufuliat T Famodimu, Daniel C Barry, David L Gillett, Sumanta Dey, Clara C Kosasih, William Newman, Jacquin C Niles, Marcus Chee San Lee, Jake Baum, Sabine Ottilie, Elizabeth A Winzeler, Darren John Creek, Nicholas A Williamson, Michael W Parker, Stephen Brand, Steven P Langston, Lawrence R Dick, Michael D W Griffin, Alexandra E Gould, Leann Tilley
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science (New York, N.Y.) 376 (6597) (2022)
Alexander J McAuley, Petrus Jansen van Vuren, Muzaffar-Ur-Rehman Mohammed, Faheem Faheem, Sarah Goldie, Shane Riddell, Nathan J Gödde, Ian K Styles, Matthew P Bruce, Simran Chahal, Stephanie Keating, Kim R Blasdell, Mary Tachedjian, Carmel M O'Brien, Nagendrakumar Balasubramanian Singanallur, John Noel Viana, Aditya V Vashi, Carl M Kirkpatrick, Christopher A MacRaild, Rohan M Shah, Elizabeth Vincan, Eugene Athan, Darren John Creek, Natalie L Trevaskis, Sankaranarayanan Murugesan, Anupama Kumar, Seshadri S Vasan
Use of Human Lung Tissue Models for Screening of Drugs against SARS-CoV-2 Infection. Viruses 14 (11) (2022)
Thomas Kralj, Raju Khatri, Kenneth R Brouwer, Kim L R Brouwer, Darren John Creek
Lipidomics profiles in hepatocytes from nonalcoholic steatohepatitis patients differ markedly from in vitro-induced steatotic hepatocytes. FEBS letters 596 (11) (2022)
Yawei Du, Carlo Giannangelo, Wei He, Gerald J Shami, Wenya Zhou, Tuo Yang, Darren John Creek, Con Dogovski, Xinsong Li, Leann Tilley
Dimeric Artesunate Glycerophosphocholine Conjugate Nano-Assemblies as Slow-Release Antimalarials to Overcome Kelch 13 Mutant Artemisinin Resistance. Antimicrobial agents and chemotherapy 66 (5) (2022)
Christopher A MacRaild, Muzaffar-Ur-Rehman Mohammed, Faheem Faheem, Sankaranarayanan Murugesan, Ian K Styles, Amanda L Peterson, Carl M J Kirkpatrick, Matthew A Cooper, Enzo A Palombo, Moana M Simpson, Hardik A Jain, Vinti Agarwal, Alexander J McAuley, Anupama Kumar, Darren John Creek, Natalie L Trevaskis, Seshadri S Vasan
Systematic Down-Selection of Repurposed Drug Candidates for COVID-19. International journal of molecular sciences 23 (19) (2022)
Mitchell Acland, Noor A Lokman, Clifford Young, Dovile Anderson, Mark Condina, Chris Desire, Tannith M Noye, Wanqi Wang, Carmela Ricciardelli, Darren John Creek, Martin K Oehler, Peter Hoffmann, Manuela Klingler-Hoffmann
Chemoresistant Cancer Cell Lines Are Characterized by Migratory, Amino Acid Metabolism, Protein Catabolism and IFN1 Signalling Perturbations. Cancers 14 (11) (2022)
Coralie Boulet, Ghizal Siddiqui, Taylah L Gaynor, Christian Doerig, Darren John Creek, Teresa G Carvalho
Red Blood Cell BCL-x L Is Required for Plasmodium falciparum Survival: Insights into Host-Directed Malaria Therapies. Microorganisms 10 (4) (2022)
Nusaibah Abdul Rahim, Yan Zhu, Soon-Ee Cheah, Matthew D Johnson, Heidi H Yu, Hanna E Sidjabat, Mark S Butler, Matthew A Cooper, Jing Fu, David L Paterson, Roger L Nation, John D Boyce, Darren John Creek, Phillip J Bergen, Xukai Jiang, Hsin-Hui Shen
Synergy of the Polymyxin-Chloramphenicol Combination against New Delhi Metallo-β-Lactamase-Producing Klebsiella pneumoniae Is Predominately Driven by Chloramphenicol. ACS infectious diseases 7 (6) (2021)
Daniel L Priebbenow, Mitch Mathiew, Da-Hua Shi, Jitendra R Harjani, Julia G Beveridge, Marina Chavchich, Michael D Edstein, Sandra Duffy, Vicky M Avery, Robert T Jacobs, Stephen Brand, David M Shackleford, Wen Wang, Longjin Zhong, Given Lee, Erin Tay, Helena Barker, Elly Crighton, Karen L White, Susan A Charman, Amanda De Paoli, Darren John Creek, Jonathan B Baell
Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines. Journal of medicinal chemistry 64 (7) (2021)
Thomas Kralj, Kim L R Brouwer, Darren John Creek
Analytical and Omics-Based Advances in the Study of Drug-Induced Liver Injury. Toxicological sciences : an official journal of the Society of Toxicology 183 (1) (2021)
John A Adegoke, Amanda De Paoli, Isaac O Afara, Kamilla Kochan, Darren John Creek, Philip Heraud, Bayden R Wood
Ultraviolet/Visible and Near-Infrared Dual Spectroscopic Method for Detection and Quantification of Low-Level Malaria Parasitemia in Whole Blood. Analytical chemistry 93 (39) (2021)
Enyuan Cao, Matthew J Watt, Cameron J Nowell, Tim Quach, Jamie S Simpson, Vilena De Melo Ferreira, Sonya Agarwal, Hannah Chu, Anubhav Srivastava, Dovile Anderson, Gracia Gracia, Alina Lam, Gabriela Segal, Jiwon Hong, Luojuan Hu, Kian Liun Phang, Alistair B J Escott, John A Windsor, Anthony R J Phillips, Darren John Creek, Natasha L Harvey, Christopher J H Porter, Natalie L Trevaskis
Mesenteric lymphatic dysfunction promotes insulin resistance and represents a potential treatment target in obesity. Nature metabolism 3 (9) (2021)
Aparna Nandakumar, Wei Wei, Ghizal Siddiqui, Huayuan Tang, Yuhuan Li, Aleksandr Kakinen, Xulin Wan, Kairi Koppel, Sijie Lin, Thomas P Davis, David Tai Leong, Darren John Creek, Feng Ding, Yang Song, Pu Chun Ke
Dynamic Protein Corona of Gold Nanoparticles with an Evolving Morphology. ACS applied materials & interfaces 13 (48) (2021)
Katherine M Ellis, Leonardo Lucantoni, Marina Chavchich, Matthew Abraham, Amanda De Paoli, Madeline R Luth, Anne-Marie Zeeman, Michael J Delves, Fernando Sánchez-Román Terán, Ursula Straschil, Jake Baum, Clemens H M Kocken, Stuart A Ralph, Elizabeth A Winzeler, Vicky M Avery, Michael D Edstein, Jonathan B Baell, Darren John Creek
The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite. Antimicrobial agents and chemotherapy 65 (11) (2021)
Annie Langston-Cox, Dovile Anderson, Darren John Creek, Kirsten Palmer, Euan Morrison Wallace, Sarah A Marshall
Measuring Sulforaphane and Its Metabolites in Human Plasma: A High Throughput Method. Molecules (Basel, Switzerland) 25 (4) (2020)
Karma Yeshi, Darren John Creek, Dovile Anderson, Edita Ritmejerytė, Luke Becker, Alex Loukas, Phurpa Wangchuk
Metabolomes and Lipidomes of the Infective Stages of the Gastrointestinal nematodes, Nippostrongylus brasiliensis and Trichuris muris. Metabolites 10 (11) (2020)
Carlo Giannangelo, Ghizal Siddiqui, Amanda De Paoli, Bethany M Anderson, Laura E Edgington-Mitchell, Susan A Charman, Darren John Creek
System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion. PLoS pathogens 16 (6) (2020)
Anna E Sexton, Christian Doerig, Darren John Creek, Teresa G Carvalho
Post-Genomic Approaches to Understanding Malaria Parasite Biology: Linking Genes to Biological Functions. ACS infectious diseases 5 (8) (2019)
Lian Xue, Da-Hua Shi, Jitendra R Harjani, Fei Huang, Julia G Beveridge, Tamir Dingjan, Kung Ban, Sarah Diab, Sandra Duffy, Leonardo Lucantoni, Sabine Fletcher, Francis C K Chiu, Scott Blundell, Katherine Ellis, Stuart A Ralph, Grennady Wirjanata, Silvia Teguh, Rintis Noviyanti, Marina Chavchich, Darren John Creek, Ric N Price, Jutta Marfurt, Susan A Charman, Matthew E Cuellar, Jessica M Strasser, Jayme L Dahlin, Michael A Walters, Michael D Edstein, Vicky M Avery, Jonathan B Baell
3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity. Journal of medicinal chemistry 62 (5) (2019)
Mei-Ling Han, Yan Zhu, Darren John Creek, Yu-Wei Lin, Alina D Gutu, Paul Hertzog, Tony Purcell, Hsin-Hui Shen, Samuel M Moskowitz, Tony Velkov, Jian Li
Comparative Metabolomics and Transcriptomics Reveal Multiple Pathways Associated with Polymyxin Killing in Pseudomonas aeruginosa. mSystems 4 (1) (2019)
Carlo Giannangelo, Dovile Anderson, Xiaofang Wang, Jonathan L Vennerstrom, Susan A Charman, Darren John Creek
Ozonide Antimalarials Alkylate Heme in the Malaria Parasite Plasmodium falciparum. ACS infectious diseases 5 (12) (2019)
Maytham Hussein, Mei-Ling Han, Yan Zhu, Qi Zhou, Yu-Wei Lin, Robert E W Hancock, Daniel Hoyer, Darren John Creek, Jian Li, Tony Velkov
Metabolomics Study of the Synergistic Killing of Polymyxin B in Combination with Amikacin against Polymyxin-Susceptible and -Resistant Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy 64 (1) (2019)
Trent D Ashton, Shane M Devine, Jörg J Möhrle, Benoît Laleu, Jeremy N Burrows, Susan A Charman, Darren John Creek, Robin B Gasser
The Development Process for Discovery and Clinical Advancement of Modern Antimalarials. Journal of medicinal chemistry 62 (23) (2019)
Carlo Giannangelo, Lukas Stingelin, Tuo Yang, Leann Tilley, Susan A Charman, Darren John Creek
Parasite-Mediated Degradation of Synthetic Ozonide Antimalarials Impacts In Vitro Antimalarial Activity. Antimicrobial agents and chemotherapy 62 (3) (2018)
Mei-Ling Han, Yan Zhu, Darren John Creek, Yu-Wei Lin, Dovile Anderson, Hsin-Hui Shen, Brian Tsuji, Alina D Gutu, Samuel M Moskowitz, Tony Velkov, Jian Li
Alterations of Metabolic and Lipid Profiles in Polymyxin-Resistant Pseudomonas aeruginosa. Antimicrobial agents and chemotherapy 62 (6) (2018)
Anubhav Srivastava, Darren John Creek
Discovery and Validation of Clinical Biomarkers of Cancer: A Review Combining Metabolomics and Proteomics. Proteomics 19 (10) (2018)
Erick T Tjhin, Christina Spry, Alan L Sewell, Annabelle Hoegl, Leanne Barnard, Anna E Sexton, Ghizal Siddiqui, Vanessa M Howieson, Alexander G Maier, Darren John Creek, Erick Strauss, Rodolfo Marquez, Karine Auclair, Kevin J Saliba
Mutations in the pantothenate kinase of Plasmodium falciparum confer diverse sensitivity profiles to antiplasmodial pantothenate analogues. PLoS pathogens 14 (4) (2018)
Pieter C Steketee, Isabel M Vincent, Fiona Achcar, Federica Giordani, Dong-Hyun Kim, Darren John Creek, Yvonne Freund, Robert Jacobs, Kevin M Rattigan, David Horn, Mark C Field, Annette MacLeod, Michael P Barrett
Benzoxaborole treatment perturbs S-adenosyl-L-methionine metabolism in Trypanosoma brucei. PLoS neglected tropical diseases 12 (5) (2018)
Anubhav Srivastava, Krystal J Evans, Anna E Sexton, Louis Schofield, Darren John Creek
Metabolomics-Based Elucidation of Active Metabolic Pathways in Erythrocytes and HSC-Derived Reticulocytes. Journal of proteome research 16 (4) (2017)
Darren John Creek, Hwa H Chua, Simon A Cobbold, Brunda Nijagal, James I MacRae, Benjamin K Dickerman, Paul R Gilson, Stuart A Ralph, Malcolm J McConville
Metabolomics-Based Screening of the Malaria Box Reveals both Novel and Established Mechanisms of Action. Antimicrobial agents and chemotherapy 60 (11) (2016)
Anubhav Srivastava, Nisha Philip, Katie R Hughes, Konstantina Georgiou, James I MacRae, Michael P Barrett, Darren John Creek, Malcolm J McConville, Andrew P Waters
Stage-Specific Changes in Plasmodium Metabolism Required for Differentiation and Adaptation to Different Host and Vector Environments. PLoS pathogens 12 (12) (2016)