John H Brumell (John Brumell, John H Brummel)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 35

Top Venues

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

bioRxiv : the preprint server for biology

Science advances

Hospital for Sick Children

University of Toronto (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Hospital for Sick Children Jun 01 2018

Canada

Program Head :: Cell Biology

Hospital for Sick Children Jul 01 2009

Canada

Senior Scientist :: Cell Biology

Hospital for Sick Children Jul 01 2002 - Jul 01 2009

Canada

Scientist :: Cell Biology

University of British Columbia Jul 01 1998 - Jun 01 2002

Canada

Postdoctoral fellow :: Biotechnology Laboratory

Mount Sinai Hospital Jun 01 1997 - May 31 1998

Canada

Postdoctoral fellow :: Lunenfeld Research Institute

Education History

University of Toronto Jan 01 1993 - May 01 1997

Canada

PHD :: Biochemistry

University of Western Ontario Sep 01 1987 - May 01 1992

Canada

BSC :: Biochemistry

Publications

Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, Jiexi Chen, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, Jiexi Chen, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, Jiexi Chen, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, Jiexi Chen, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, Jiexi Chen, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Hongxian Zhu, Andrew Michael Sydor, Kirsten C Boddy, Etienne Coyaud, Estelle M N Laurent, Aaron Au, Joel M J Tan, Bing-Ru Yan, Jason Moffat, Aleixo M Muise, Christopher M Yip, Sergio Grinstein, Brian Raught, John H Brumell
Salmonella exploits membrane reservoirs for invasion of host cells. Nature communications 15 (1) (2024)
Erika Jang, Tse Wing Winnie Ho, John H Brumell, François Lefebvre, Changsen Wang, Warren L Lee
IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a. Arteriosclerosis, thrombosis, and vascular biology 44 (9) (2024)
Hongxian Zhu, Andrew Michael Sydor, Kirsten C Boddy, Etienne Coyaud, Estelle M N Laurent, Aaron Au, Joel M J Tan, Bing-Ru Yan, Jason Moffat, Aleixo M Muise, Christopher M Yip, Sergio Grinstein, Brian Raught, John H Brumell
Salmonella exploits membrane reservoirs for invasion of host cells. Nature communications 15 (1) (2024)
Erika Jang, Tse Wing Winnie Ho, John H Brumell, François Lefebvre, Changsen Wang, Warren L Lee
IL-1β Induces LDL Transcytosis by a Novel Pathway Involving LDLR and Rab27a. Arteriosclerosis, thrombosis, and vascular biology (2024)
Hongxian Zhu, Andrew Michael Sydor, Kirsten C Boddy, Etienne Coyaud, Estelle M N Laurent, Aaron Au, Joel M J Tan, Bing-Ru Yan, Jason Moffat, Aleixo M Muise, Christopher M Yip, Sergio Grinstein, Brian Raught, John H Brumell
Salmonella exploits membrane reservoirs for invasion of host cells. Nature communications 15 (1) (2024)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, Jiexi Chen, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. Proceedings of the National Academy of Sciences of the United States of America 121 (25) (2024)
Hongxian Zhu, Andrew Michael Sydor, Kirsten C Boddy, Etienne Coyaud, Estelle M N Laurent, Aaron Au, Joel M J Tan, Bing-Ru Yan, Jason Moffat, Aleixo M Muise, Christopher M Yip, Sergio Grinstein, Brian Raught, John H Brumell
Salmonella exploits membrane reservoirs for invasion of host cells. Nature communications 15 (1) (2024)
Vikrant K Bhosle, Joel M J Tan, Taoyingnan Li, Rong Hua, Hyunwoo Kwon, Zhubing Li, Sajedabanu Patel, Marc Tessier-Lavigne, Lisa A Robinson, Peter Kijun Kim, John H Brumell
SLIT2/ROBO1 signaling suppresses mTORC1 for organelle control and bacterial killing. Life science alliance 6 (8) (2023)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. bioRxiv : the preprint server for biology (2023)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. bioRxiv : the preprint server for biology (2023)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. bioRxiv : the preprint server for biology (2023)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. bioRxiv : the preprint server for biology (2023)
Alfa Herrera, Megan M Packer, Monica Rosas-Lemus, George Minasov, John H Brumell, Karla J F Satchell
Vibrio MARTX toxin processing and degradation of cellular Rab GTPases by the cytotoxic effector Makes Caterpillars Floppy. bioRxiv : the preprint server for biology (2023)
Sourav Bhattacharya, Rachel A Idol, Wei Yang, Jorge David Rojas Márquez, Yan'an Li, Guangming Huang, Wandy L Beatty, Jeffrey J Atkinson, John H Brumell, Juhi Bagaitkar, Jeffrey A Magee, Mary C Dinauer
Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice. Blood 139 (19) (2022)
Kirsty M Hooper, Elise Jacquin, Taoyingnan Li, Jonathan M Goodwin, John H Brumell, Joanne Durgan, Oliver Florey
V-ATPase is a universal regulator of LC3-associated phagocytosis and non-canonical autophagy. The Journal of cell biology 221 (6) (2022)
Glenn F W Walpole, Jonathan Pacheco, Neha Chauhan, Jonathan Clark, Karen E Anderson, Yazan M Abbas, Danielle Brabant-Kirwan, Fernando Montaño-Rendón, Zetao Liu, Hongxian Zhu, John H Brumell, Alexander Deiters, Len R Stephens, Phillip T Hawkins, Gerald R V Hammond, Sergio Grinstein, Gregory D Fairn
Kinase-independent synthesis of 3-phosphorylated phosphoinositides by a phosphotransferase. Nature cell biology 24 (5) (2022)
Bing-Ru Yan, Taoyingnan Li, Etienne Coyaud, Estelle M N Laurent, Jonathan St-Germain, Yuhuan Zhou, Peter Kijun Kim, Brian Raught, John H Brumell
C5orf51 is a component of the MON1-CCZ1 complex and controls RAB7A localization and stability during mitophagy. Autophagy (2021)
Evan Amalfitano, Margot Karlikow, Masoud Norouzi, Katariina Jaenes, Seray Cicek, Fahim Masum, Peivand Sadat Mousavi, Yuxiu Guo, Laura Tang, Andrew Michael Sydor, Duo Ma, Joel D Pearson, Daniel Trcka, Mathieu Pinette, Aruna Ambagala, Shawn Babiuk, Bradley Pickering, Jeff Wrana, Rod Bremner, Tony Mazzulli, David Sinton, John H Brumell, Alexander A Green, Keith Pardee
A glucose meter interface for point-of-care gene circuit-based diagnostics. Nature communications 12 (1) (2021)
Jonathan M Goodwin, Ward G Walkup, Kirsty M Hooper, Taoyingnan Li, Chieko Kishi-Itakura, Aylwin Ng, Timothy Lehmberg, Archana Jha, Sravya Kommineni, Katherine Fletcher, Jorge Garcia-Fortanet, Yaya Fan, Qing Tang, Menghao Wei, Asmita Agrawal, Sagar R Budhe, Sreekanth R Rouduri, Dan Baird, Jeff Saunders, Janna Kiselar, Mark R Chance, Andrea Balabio, Brent A Appleton, John H Brumell, Oliver Florey, Leon O Murphy
GABARAP sequesters the FLCN-FNIP tumor suppressor complex to couple autophagy with lysosomal biogenesis. Science advances 7 (40) (2021)
Kirsten C Boddy, Hongxian Zhu, Vanessa M D'Costa, Caishuang Xu, Ksenia Beyrakhova, Miroslaw Cygler, Sergio Grinstein, Etienne Coyaud, Estelle M N Laurent, Jonathan St-Germain, Brian Raught, John H Brumell
Salmonella effector SopD promotes plasma membrane scission by inhibiting Rab10. Nature communications 12 (1) (2021)
Yi Xin Iris Tu, Andrew Michael Sydor, Etienne Coyaud, Estelle M N Laurent, Diana Dyer, Nora Mellouk, Jonathan St-Germain, Robert M Vernon, Julie Deborah Forman-Kay, Taoyingnan Li, Rong Hua, Kexin Zhao, Neale D Ridgway, Peter Kijun Kim, Brian Raught, John H Brumell
Global Proximity Interactome of the Human Macroautophagy Pathway. Autophagy (2021)
Sabah Haq, Huaqing Wang, Jensine A Grondin, Suhrid Banskota, John K Marshall, Irfan I Khan, Usha Chauhan, Francine Cote, Yun Han Kwon, Dana J Philpott, John H Brumell, Michael Surette, Gregory R Steinberg, Waliul I Khan
Disruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn's disease. Science advances 7 (45) (2021)
Joel M J Tan, Monica E Garner, James M Regeimbal, Catherine J Greene, Jorge D Rojas Márquez, Dustin A Ammendolia, Adam R R McCluggage, Taoyingnan Li, Katherine J Wu, Marija Cemma, Philip P Ostrowski, Brian Raught, Michael S. Diamond, Sergio Grinstein, Robin Michael Yates, Darren E Higgins, John H Brumell
Listeria exploits IFITM3 to suppress antibacterial activity in phagocytes. Nature communications 12 (1) (2021)
Jorge David Rojas Márquez, Taoyingnan Li, Adam R R McCluggage, Joel M J Tan, Aleixo M Muise, Darren E Higgins, John H Brumell
Cutting Edge: NOX2 NADPH Oxidase Controls Infection by an Intracellular Bacterial Pathogen through Limiting the Type 1 IFN Response. Journal of immunology (Baltimore, Md. : 1950) 206 (2) (2020)
Keith A Lawson, Cristovão M Sousa, Xiaoyu Zhang, Eiru Kim, Rummy Akthar, Joseph J Caumanns, Yuxi Yao, Nicholas Mikolajewicz, Catherine Ross, Kevin R Brown, Abdelrahman Abou Zid, Zi Peng Fan, Shirley Hui, Jordan A Krall, Donald M Simons, Chloe J Slater, Victor De Jesus, Lujia Tang, Richa Singh, Joshua E Goldford, Sarah Martin, Qian Huang, Elizabeth A Francis, Andrea Habsid, Ryan Climie, David Tieu, Jiarun Wei, Ren Li, Amy Hin Yan Tong, Michael Aregger, Katherine S Chan, Hong Han, Xiaowei Wang, Patricia Mero, John H Brumell, Antonio Finelli, Laurie Ailles, Gary D Baider, Gromoslaw A Smolen, Gillian A Kingsbury, Traver Hart, Charles Kung, Jason Moffat
Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Nature 586 (7827) (2020)
Vanessa M D'Costa, Etienne Coyaud, Kirsten C Boddy, Estelle M N Laurent, Jonathan St-Germain, Taoyingnan Li, Sergio Grinstein, Brian Raught, John H Brumell
BioID screen of Salmonella type 3 secreted effectors reveals host factors involved in vacuole positioning and stability during infection. Nature microbiology 4 (12) (2019)
Dorothy Truong, Kirsten C Boddy, Veronica Canadien, Danielle Brabant, Gregory D Fairn, Vanessa M D'Costa, Etienne Coyaud, Brian Raught, Dolores Perez-Sala, Wei Sun Park, Won Do Heo, Sergio Grinstein, John H Brumell
Salmonella exploits host Rho GTPase signalling pathways through the phosphatase activity of SopB. Cellular microbiology 20 (10) (2018)
Joel M J Tan, Nora Mellouk, Suzanne E Osborne, Dustin A Ammendolia, Diana N Dyer, Ren Li, Diede Brunen, Jorik M van Rijn, Ju Huang, Mark A Czuczman, Marija A Cemma, Amy M Won, Christopher M Yip, Ramnik J Xavier, Donna A MacDuff, Fulvio Reggiori, Jayanta Debnath, Tamotsu Yoshimori, Peter K Kim, Gregory D Fairn, Etienne Coyaud, Brian Raught, Aleixo M Muise, Darren E Higgins, John H Brumell
An ATG16L1-dependent pathway promotes plasma membrane repair and limits Listeria monocytogenes cell-to-cell spread. Nature microbiology 3 (12) (2018)
Kirsten C Boddy, Aggie Duan Gao, Dorothy Truong, Moshe S Kim, Carol D Froese, William S Trimble, John H Brumell
Septin-regulated actin dynamics promote Salmonella invasion of host cells. Cellular microbiology 20 (10) (2018)
Suzanne E Osborne, John H Brumell
Listeriolysin O: from bazooka to Swiss army knife. Philosophical transactions of the Royal Society of London. Series B, Biological sciences 372 (1726) (2018)

John H Brumell.css-eqlu8i{font-size:small;padding-left:4px;} (John Brumell, John H Brummel)

Publication Activity (10 Years)

Top Topics

Top Venues

John H Brumell (John Brumell, John H Brummel)