Jun Xu

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 54

Top Venues

Journal of chemical information and modeling

Journal of medicinal chemistry

Journal of natural products

Science advances

Sun Yat-Sen University

University of Science and Technology of China (PHD)

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Sun Yat-Sen University Mar 03 2009

China

Prof/Director :: School of Pharmaceutical Sciences

Boehringer Ingelheim Corp USA

United States

Principal Scientist :: Medcinal Chemistry

Education History

University of Science and Technology of China Sep 08 1983 - May 06 1989

China

PHD :: Chemistry

Publications

Yating Lin, Jun Xu, Qiong Gu
FerroLigandDB: A Ferroptosis Ligand Database of Structure-Activity Relations. Journal of chemical information and modeling 64 (13) (2024)
Haopeng Ai, Deyin Wu, Huihao Zhou, Jun Xu, Qiong Gu
dMXP: A De Novo Small-Molecule 3D Structure Predictor with Graph Attention Networks. Journal of chemical information and modeling (2024)
Dane Huang, Chao Zhao, Ruyue Li, Nan Yao, Jun Xu, Qiong Gu
Discovery of Novel Antiosteoporosis Leads with Bone Resorption Inhibition and Anabolic Promotion through a Chemotype-Assembly Approach. Journal of medicinal chemistry (2024)
Yating Lin, Jun Xu, Qiong Gu
FerroLigandDB: A Ferroptosis Ligand Database of Structure-Activity Relations. Journal of chemical information and modeling (2024)
Clément Larrue, Sarah Mouche, Paolo Angelino, Maxime Sajot, Rudy Birsen, Olivier Kosmider, Thomas A McKee, François Vergez, Christian Recher, Véronique Mansat-De Mas, Qiong Gu, Jun Xu, Petros K Tsantoulis, Jean-Emmanuel Sarry, Jérome Tamburini
Targeting ferritinophagy impairs quiescent cancer stem cells in acute myeloid leukemia in vitro and in vivo models. Science translational medicine 16 (757) (2024)
Xing Peng, Zhikang Zhang, Yuting Zhang, Huihao Zhou, Wenqi Li, Minxian Dai, Jinsai Shang, Jun Xu, Qiong Gu
Discovery of Novel Neo -Clerodane Derivatives as Potent Dual-Functional Antiosteoporosis Agents through Targeting Peroxisome Proliferator-Activated Receptor-γ. Journal of medicinal chemistry (2024)
Haopeng Ai, Deyin Wu, Huihao Zhou, Jun Xu, Qiong Gu
dMXP: A De Novo Small-Molecule 3D Structure Predictor with Graph Attention Networks. Journal of chemical information and modeling 64 (9) (2024)
Lu Han, Zhiteng Luo, Yingchen Ju, Bingyi Chen, Taotao Zou, Jun-Jian Wang, Jun Xu, Qiong Gu, Xiang-Lei Yang, Paul Schimmel, Huihao Zhou
The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements. Science advances 9 (6) (2023)
Lu Han, Zhiteng Luo, Yingchen Ju, Bingyi Chen, Taotao Zou, Jun-Jian Wang, Jun Xu, Qiong Gu, Xiang-Lei Yang, Paul Schimmel, Huihao Zhou
The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements. Science advances 9 (6) (2023)
Xing Peng, Qingyun Tan, Zhikang Zhang, Deyin Wu, Jun Xu, Huihao Zhou, Qiong Gu
Discovery of neo -Clerodane Diterpenoids from Ajuga campylantha as Neuroprotective Agents against Ferroptosis and Neuroinflammation. Journal of natural products (2023)
Lu Han, Zhiteng Luo, Yingchen Ju, Bingyi Chen, Taotao Zou, Jun-Jian Wang, Jun Xu, Qiong Gu, Xiang-Lei Yang, Paul Schimmel, Huihao Zhou
The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements. Science advances 9 (6) (2023)
Lu Han, Zhiteng Luo, Yingchen Ju, Bingyi Chen, Taotao Zou, Jun-Jian Wang, Jun Xu, Qiong Gu, Xiang-Lei Yang, Paul Schimmel, Huihao Zhou
The binding mode of orphan glycyl-tRNA synthetase with tRNA supports the synthetase classification and reveals large domain movements. Science advances 9 (6) (2023)
Hao Chen, Pei Hua, Dane Huang, Yuting Zhang, Huihao Zhou, Jun Xu, Qiong Gu
Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis. Journal of medicinal chemistry 66 (1) (2022)
Zhengjun Cai, Bingyi Chen, Ying Yu, Junsong Guo, Zhiteng Luo, Bao Cheng, Jun Xu, Qiong Gu, Huihao Zhou
Design, Synthesis, and Proof-of-Concept of Triple-Site Inhibitors against Aminoacyl-tRNA Synthetases. Journal of medicinal chemistry 65 (7) (2022)
Bao Cheng, Zhengjun Cai, Ziqing Luo, Siting Luo, Zhiteng Luo, Yanfang Cheng, Ying Yu, Junsong Guo, Yingchen Ju, Qiong Gu, Jun Xu, Xianxing Jiang, Geng Li, Huihao Zhou
Structure-Guided Design of Halofuginone Derivatives as ATP-Aided Inhibitors Against Bacterial Prolyl-tRNA Synthetase. Journal of medicinal chemistry 65 (23) (2022)
Hao Chen, Pei Hua, Dane Huang, Yuting Zhang, Huihao Zhou, Jun Xu, Qiong Gu
Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis. Journal of medicinal chemistry 66 (1) (2022)
Xing Peng, Qingyun Tan, Leiming Wu, Deyin Wu, Jun Xu, Huihao Zhou, Qiong Gu
Ferroptosis Inhibitory Aromatic Abietane Diterpenoids from Ajuga decumbens and Structural Revision of Two 3,4-Epoxy Group-Containing Abietanes. Journal of natural products 85 (7) (2022)
Dane Huang, Chao Zhao, Ruyue Li, Bingyi Chen, Yuting Zhang, Zhejun Sun, Junkang Wei, Huihao Zhou, Qiong Gu, Jun Xu
Identification of a binding site on soluble RANKL that can be targeted to inhibit soluble RANK-RANKL interactions and treat osteoporosis. Nature communications 13 (1) (2022)
Hao Chen, Pei Hua, Dane Huang, Yuting Zhang, Huihao Zhou, Jun Xu, Qiong Gu
Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis. Journal of medicinal chemistry 66 (1) (2022)
Hao Chen, Pei Hua, Dane Huang, Yuting Zhang, Huihao Zhou, Jun Xu, Qiong Gu
Discovery of Spiro[pyrrolidine-3,3'-oxindole] LXRβ Agonists for the Treatment of Osteoporosis. Journal of medicinal chemistry (2022)
Yuying Fang, Xiucai Chen, Qingyun Tan, Huihao Zhou, Jun Xu, Qiong Gu
Inhibiting Ferroptosis through Disrupting the NCOA4-FTH1 Interaction: A New Mechanism of Action. ACS central science 7 (6) (2021)
Bingyi Chen, Siting Luo, Songxuan Zhang, Yingchen Ju, Qiong Gu, Jun Xu, Xiang-Lei Yang, Huihao Zhou
Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase. Nature communications 12 (1) (2021)
Yingchen Ju, Lu Han, Bingyi Chen, Zhiteng Luo, Qiong Gu, Jun Xu, Xiang-Lei Yang, Paul Schimmel, Huihao Zhou
X-shaped structure of bacterial heterotetrameric tRNA synthetase suggests cryptic prokaryote functions and a rationale for synthetase classifications. Nucleic acids research 49 (17) (2021)
Dongming Lan, Shu Li, Wei Tang, Zexin Zhao, Mupeng Luo, Shuguang Yuan, Jun Xu, Yonghua Wang
Glycerol is Released from a New Path in MGL Lipase Catalytic Process. Journal of chemical information and modeling (2021)
Mengjiao Hao, Zhikang Zhang, Yijun Guo, Huihao Zhou, Qiong Gu, Jun Xu
Rubidium chloride increases lifespan through an AMPK/FOXO-dependent pathway in Caenorhabditis elegans. The journals of gerontology. Series A, Biological sciences and medical sciences (2021)
Mengyang Xu, Chao Zhao, Biying Zhu, Liangyue Wang, Huihao Zhou, Daoguang Yan, Qiong Gu, Jun Xu
Discovering High Potent Hsp90 Inhibitors as Antinasopharyngeal Carcinoma Agents through Fragment Assembling Approach. Journal of medicinal chemistry 64 (4) (2021)
Bingyi Chen, Siting Luo, Songxuan Zhang, Yingchen Ju, Qiong Gu, Jun Xu, Xiang-Lei Yang, Huihao Zhou
Author Correction: Inhibitory mechanism of reveromycin A at the tRNA binding site of a class I synthetase. Nature communications 12 (1) (2021)
Shimin Su, Yuyao Yang, Hanlin Gan, Shuangjia Zheng, Fenglong Gu, Chao Zhao, Jun Xu
Predicting the Feasibility of Copper(I)-Catalyzed Alkyne-Azide Cycloaddition Reactions Using a Recurrent Neural Network with a Self-Attention Mechanism. Journal of chemical information and modeling 60 (3) (2020)
Mengyang Xu, Biying Zhu, Xiuye Cao, Shannai Li, Dan Li, Huihao Zhou, Vesa M Olkkonen, Wenbin Zhong, Jun Xu, Daoguang Yan
OSBP-Related Protein 5L Maintains Intracellular IP3/Ca2+ Signaling and Proliferation in T Cells by Facilitating PIP2 Hydrolysis. Journal of immunology (Baltimore, Md. : 1950) 204 (5) (2020)
Yuyao Yang, Shuangjia Zheng, Shimin Su, Chao Zhao, Jun Xu, Hongming Chen
SyntaLinker: automatic fragment linking with deep conditional transformer neural networks. Chemical science 11 (31) (2020)
Chan-Juan Li, Pei-Nan Chen, Hou-Jin Li, Takeshi Tsunoda, Dong-Lan Wu, Jun Xu, Wen-Jian Lan
Potential Antidiabetic Fumiquinazoline Alkaloids from the Marine-Derived Fungus Scedosporium apiospermum F41-1. Journal of natural products 83 (4) (2020)
Shengheng Yuan, Pei Hua, Chao Zhao, Huihao Zhou, Jiake Xu, Jun Xu, Qiong Gu
Jatrophane Diterpenoids from Euphorbia esula as Inhibitors of RANKL-Induced Osteoclastogenesis. Journal of natural products 83 (4) (2020)
Yanwen Li, Chanjuan Li, Jiaqiang Wu, Wenfeng Liu, Dong-Li Li, Jun Xu
Harmane ameliorates obesity though inhibiting lipid accumulation and inducing adipocyte browning. RSC advances 10 (8) (2020)
Jieyu Tang, Yingchen Ju, Jingwei Zhou, Junsong Guo, Qiong Gu, Jun Xu, Huihao Zhou
Structural and Biochemical Characterization of SbnC as a Representative Type B Siderophore Synthetase. ACS chemical biology 15 (10) (2020)
Xiuming Li, Xin Yan, Yuedong Yang, Qiong Gu, Huihao Zhou, Yunfei Du, Yutong Lu, Jielou Liao, Jun Xu
LSA: a local-weighted structural alignment tool for pharmaceutical virtual screening. RSC advances 9 (7) (2019)
Chang Wen, Xin Yan, Qiong Gu, Jiewen Du, Di Wu, Yutong Lu, Huihao Zhou, Jun Xu
Systematic Studies on the Protocol and Criteria for Selecting a Covalent Docking Tool. Molecules (Basel, Switzerland) 24 (11) (2019)
Shuangjia Zheng, Xin Yan, Qiong Gu, Yuedong Yang, Yunfei Du, Yutong Lu, Jun Xu
QBMG: quasi-biogenic molecule generator with deep recurrent neural network. Journal of cheminformatics 11 (1) (2019)
Xiuming Li, Xin Yan, Qiong Gu, Huihao Zhou, Di Wu, Jun Xu
DeepChemStable: Chemical Stability Prediction with an Attention-Based Graph Convolution Network. Journal of chemical information and modeling 59 (3) (2019)
Chao Zhao, Dane Huang, Ruyue Li, Yida Xu, Shimin Su, Qiong Gu, Jun Xu
Identifying Novel Anti-Osteoporosis Leads with a Chemotype-Assembly Approach. Journal of medicinal chemistry 62 (12) (2019)
Pan Luo, Yanfang Cheng, Zhiyong Yin, Chanjuan Li, Jun Xu, Qiong Gu
Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum. Journal of natural products 82 (2) (2019)
Peng Ding, Ziyang Chen, Hao Chen, Zizhen Zhang, Zhihong Liu, Xin Yan, Huihao Zhou, Qiong Gu, Chanjuan Li, Jun Xu
Structurally Selective Mechanism of Liver X Receptor Ligand: In Silico and In Vitro Studies. Journal of chemical information and modeling 59 (7) (2019)
Shuangjia Zheng, Jiahua Rao, Zhongyue Zhang, Jun Xu, Yuedong Yang
Predicting Retrosynthetic Reactions Using Self-Corrected Transformer Neural Networks. Journal of chemical information and modeling 60 (1) (2019)
Shuangjia Zheng, Xin Yan, Yuedong Yang, Jun Xu
Identifying Structure-Property Relationships through SMILES Syntax Analysis with Self-Attention Mechanism. Journal of chemical information and modeling 59 (2) (2019)
Hongao Zhang, Wei Liu, Zhihong Liu, Yingchen Ju, Mengyang Xu, Yue Zhang, Xinyu Wu, Qiong Gu, Zhong Wang, Jun Xu
Discovery of indoleamine 2,3-dioxygenase inhibitors using machine learning based virtual screening. MedChemComm 9 (6) (2018)
Wenjuan Xia, Pan Luo, Pei Hua, Peng Ding, Chanjuan Li, Jun Xu, Huihao Zhou, Qiong Gu
Discovery of a New Pterocarpan-Type Antineuroinflammatory Compound from Sophora tonkinensis through Suppression of the TLR4/NFκB/MAPK Signaling Pathway with PU.1 as a Potential Target. ACS chemical neuroscience 10 (1) (2018)
Miao Yu, Qiong Gu, Jun Xu
Discovering new PI3Kα inhibitors with a strategy of combining ligand-based and structure-based virtual screening. Journal of computer-aided molecular design 32 (2) (2018)
Zhihong Liu, Jiewen Du, Xin Yan, Jiali Zhong, Lu Cui, Jinyuan Lin, Lizhu Zeng, Peng Ding, Pin Chen, Xinxin Zhou, Huihao Zhou, Qiong Gu, Jun Xu
TCMAnalyzer: A Chemo- and Bioinformatics Web Service for Analyzing Traditional Chinese Medicine. Journal of chemical information and modeling 58 (3) (2018)
Xiaojie Huang, Junsong Guo, Qi Liu, Qiong Gu, Jun Xu, Huihao Zhou
Identification of an auxiliary druggable pocket in the DNA gyrase ATPase domain using fragment probes. MedChemComm 9 (10) (2018)
Xiang-Kun Luo, Jie Cai, Zhi-Yong Yin, Pan Luo, Chan-Juan Li, Hang Ma, Navindra P Seeram, Qiong Gu, Jun Xu
Fluvirosaones A and B, Two Indolizidine Alkaloids with a Pentacyclic Skeleton from Flueggea virosa. Organic letters 20 (4) (2018)
Jie Cai, Chanjuan Li, Zhihong Liu, Jiewen Du, Jiming Ye, Qiong Gu, Jun Xu
Predicting DPP-IV inhibitors with machine learning approaches. Journal of computer-aided molecular design 31 (4) (2017)
Yongsheng Lin, Qian Wang, Qiong Gu, Hongao Zhang, Cheng Jiang, Jiayuan Hu, Yan Wang, Yuan Yan, Jun Xu
Semisynthesis of (-)-Rutamarin Derivatives and Their Inhibitory Activity on Epstein-Barr Virus Lytic Replication. Journal of natural products 80 (1) (2017)
Li-Hong Huang, Meng-Yang Xu, Hou-Jin Li, Jin-Qian Li, Yan-Xiu Chen, Wen-Zhe Ma, Yi-Ping Li, Jun Xu, De-Po Yang, Wen-Jian Lan
Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41-1 to Maximize Alkaloid Diversity. Organic letters 19 (18) (2017)
Pan Luo, Wenjuan Xia, Susan L Morris-Natschke, Kuo-Hsiung Lee, Yu Zhao, Qiong Gu, Jun Xu
Vitepyrroloids A-D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia. Journal of natural products 80 (5) (2017)
Xiangkun Luo, Chanjuan Li, Pan Luo, Xin Lin, Hang Ma, Navindra P Seeram, Ching Song, Jun Xu, Qiong Gu
Pterosin Sesquiterpenoids from Pteris cretica as Hypolipidemic Agents via Activating Liver X Receptors. Journal of natural products 79 (12) (2016)

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Publication Activity (10 Years)

Top Topics

Top Venues

Jun Xu