Lai-Xi Wang

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 41

Top Venues

Bioconjugate chemistry

ACS chemical biology

Nature communications

Proceedings of the National Academy of Sciences of the United States of America

University of Maryland at College Park

This page only lists publications with an associated author ORCID identifier.

Affiliation History

University of Maryland at College Park

United States

Professor :: Department of Chemistry and Biochemistry

Publications

Kun Huang, Eleanor E Bashian, Guanghui Zong, Corwin M Nycholat, Ryan McBride, Margaryta Gomozkova, Shengyang Wang, Chin Huang, Digantkumar G Chapla, Edward N Schmidt, Matthew Scott Macauley, Kelley W Moremen, James C Paulson, Lai-Xi Wang
Chemoenzymatic Synthesis of Sulfated N -Glycans Recognized by Siglecs and Other Glycan-Binding Proteins. JACS Au 4 (8) (2024)
Thomas C Donahue, Chong Ou, Qiang Yang, Robin Flinko, Xiao Zhang, Guanghui Zong, George K Lewis, Lai-Xi Wang
Synthetic Site-Specific Antibody-Ligand Conjugates Promote Asialoglycoprotein Receptor-Mediated Degradation of Extracellular Human PCSK9. ACS chemical biology (2023)
Beatriz Trastoy, Jonathan J Du, Javier O Cifuente, Lorena Rudolph, Mikel García-Alija, Erik H Klontz, Daniel J Deredge, Nazneen Sultana, Chau G Huynh, Maria W Flowers, Chao Li, Diego E Sastre, Lai-Xi Wang, Francisco Corzana, Alvaro Mallagaray, Eric John Sundberg, Marcelo E Guerin
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases. Nature communications 14 (1) (2023)
Miloslav Sanda, Qiang Yang, Guanghui Zong, He Chen, Zhihao Zheng, Harmeet Dhani, Khalid Khan, Alexander Kroemer, Lai-Xi Wang, Radoslav Goldman
LC-MS/MS-PRM Quantification of IgG Glycoforms Using Stable Isotope Labeled IgG1 Fc Glycopeptide Standard. Journal of proteome research (2023)
Thomas C Donahue, Guanghui Zong, Chong Ou, Philip DeShong, Lai-Xi Wang
Catanionic Vesicles as a Facile Scaffold to Display Natural N-Glycan Ligands for Probing Multivalent Carbohydrate-Lectin Interactions. Bioconjugate chemistry (2023)
Diana Campos, Michael Girgis, Qiang Yang, Guanghui Zong, Radoslav Goldman, Lai-Xi Wang, Miloslav Sanda
"Ghost" Fragment Ions in Structure and Site-Specific Glycoproteomics Analysis. Analytical chemistry (2023)
Xinhai Chen, Haley Gula, Tonu Pius, Chong Ou, Margaryta Gomozkova, Lai-Xi Wang, Olaf Schneewind, Dominique Missiakas
Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (14) (2023)
Beatriz Trastoy, Jonathan J Du, Javier O Cifuente, Lorena Rudolph, Mikel García-Alija, Erik H Klontz, Daniel J Deredge, Nazneen Sultana, Chau G Huynh, Maria W Flowers, Chao Li, Diego E Sastre, Lai-Xi Wang, Francisco Corzana, Alvaro Mallagaray, Eric John Sundberg, Marcelo E Guerin
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases. Nature communications 14 (1) (2023)
Miloslav Sanda, Qiang Yang, Guanghui Zong, He Chen, Zhihao Zheng, Harmeet Dhani, Khalid Khan, Alexander Kroemer, Lai-Xi Wang, Radoslav Goldman
LC-MS/MS-PRM Quantification of IgG Glycoforms Using Stable Isotope Labeled IgG1 Fc Glycopeptide Standard. Journal of proteome research (2023)
Thomas C Donahue, Guanghui Zong, Chong Ou, Philip DeShong, Lai-Xi Wang
Catanionic Vesicles as a Facile Scaffold to Display Natural N-Glycan Ligands for Probing Multivalent Carbohydrate-Lectin Interactions. Bioconjugate chemistry 34 (2) (2023)
Xinhai Chen, Haley Gula, Tonu Pius, Chong Ou, Margaryta Gomozkova, Lai-Xi Wang, Olaf Schneewind, Dominique Missiakas
Immunoglobulin G subclasses confer protection against Staphylococcus aureus bloodstream dissemination through distinct mechanisms in mouse models. Proceedings of the National Academy of Sciences of the United States of America 120 (14) (2023)
Thomas C Donahue, Guanghui Zong, Chong Ou, Philip DeShong, Lai-Xi Wang
Catanionic Vesicles as a Facile Scaffold to Display Natural N-Glycan Ligands for Probing Multivalent Carbohydrate-Lectin Interactions. Bioconjugate chemistry 34 (2) (2023)
Beatriz Trastoy, Jonathan J Du, Javier O Cifuente, Lorena Rudolph, Mikel García-Alija, Erik H Klontz, Daniel J Deredge, Nazneen Sultana, Chau G Huynh, Maria W Flowers, Chao Li, Diego E Sastre, Lai-Xi Wang, Francisco Corzana, Alvaro Mallagaray, Eric John Sundberg, Marcelo E Guerin
Mechanism of antibody-specific deglycosylation and immune evasion by Streptococcal IgG-specific endoglycosidases. Nature communications 14 (1) (2023)
Thomas C Donahue, Guanghui Zong, Chong Ou, Philip DeShong, Lai-Xi Wang
Catanionic Vesicles as a Facile Scaffold to Display Natural N-Glycan Ligands for Probing Multivalent Carbohydrate-Lectin Interactions. Bioconjugate chemistry 34 (2) (2023)
Rosa L Cordeiro, Camila R Santos, Mariane N Domingues, Tatiani B Lima, Renan A S Pirolla, Mariana A B Morais, Felippe Mariano Colombari, Renan Y Miyamoto, Gabriela Felix Persinoti, Antonio Carlos Borges, Marcelo A de Farias, Fabiane Stoffel, Chao Li, Fabio C Gozzo, Marin van Heel, Marcelo E Guerin, Eric John Sundberg, Lai-Xi Wang, Rodrigo V Portugal, Priscila Oliveira de Giuseppe, Mário Tyago Murakami
Mechanism of high-mannose N-glycan breakdown and metabolism by Bifidobacterium longum. Nature chemical biology (2022)
Chong Ou, Sunaina Kiran Prabhu, Xiao Zhang, Guanghui Zong, Qiang Yang, Lai-Xi Wang
Synthetic Antibody-Rhamnose Cluster Conjugates Show Potent Complement-Dependent Cell Killing by Recruiting Natural Antibodies. Chemistry (Weinheim an der Bergstrasse, Germany) 28 (16) (2022)
Kevin S Kao, Aaron Gupta, Guanghui Zong, Chao Li, Isabell Kerschbaumer, Sara Borghi, Jacqueline M Achkar, Stylianos Bournazos, Lai-Xi Wang, Jeffrey V Ravetch
Synthetic nanobodies as tools to distinguish IgG Fc glycoforms. Proceedings of the National Academy of Sciences of the United States of America 119 (48) (2022)
Mikel García-Alija, Jonathan J Du, Izaskun Ordóñez, Asier Diz-Vallenilla, Alicia Moraleda-Montoya, Nazneen Sultana, Chau G Huynh, Chao Li, Thomas Connor Donahue, Lai-Xi Wang, Beatriz Trastoy, Eric John Sundberg, Marcelo E Guerin
Mechanism of cooperative N-glycan processing by the multi-modular endoglycosidase EndoE. Nature communications 13 (1) (2022)
Thomas C Donahue, Guanghui Zong, Nicholas A O'Brien, Chong Ou, Jeffrey C Gildersleeve, Lai-Xi Wang
Synthesis and Immunological Study of N-Glycan-Bacteriophage Qβ Conjugates Reveal Dominant Antibody Responses to the Conserved Chitobiose Core. Bioconjugate chemistry 33 (7) (2022)
Xiao Zhang, Huiying Liu, Jia He, Chong Ou, Thomas C Donahue, Musleh M Muthana, Lishan Su, Lai-Xi Wang
Site-Specific Chemoenzymatic Conjugation of High-Affinity M6P Glycan Ligands to Antibodies for Targeted Protein Degradation. ACS chemical biology 17 (11) (2022)
Yongjun Sui, Jianping Li, Hanne A Elyard, Roushu Zhang, Sunaina Kiran Prabhu, Tanya Hoang, David J Venzon, Anthony Cook, Renita Brown, Elyse Teow, Jason Velasco, Laurent Pessaint, Ian N Moore, Laurel Lagenaur, Jim Talton, Matthew W Breed, Josh Kramer, Kevin W Bock, Mahnaz Minai, Bianca M Nagata, Hyoyoung Choo-Wosoba, Mark G Lewis, Lai-Xi Wang, David M Moore
An intranasally administrated SARS-CoV-2 beta variant subunit booster vaccine prevents beta variant replication in rhesus macaques. PNAS nexus 1 (3) (2022)
Xiao Zhang, Chong Ou, Huiying Liu, Lai-Xi Wang
Synthesis and Evaluation of Three Azide-Modified Disaccharide Oxazolines as Enzyme Substrates for Single-Step Fc Glycan-Mediated Antibody-Drug Conjugation. Bioconjugate chemistry 33 (6) (2022)
Chong Ou, Chao Li, Roushu Zhang, Qiang Yang, Guanghui Zong, Yuanwei Dai, Rebecca L Francis, Stylianos Bournazos, Jeffrey V Ravetch, Lai-Xi Wang
One-Pot Conversion of Free Sialoglycans to Functionalized Glycan Oxazolines and Efficient Synthesis of Homogeneous Antibody-Drug Conjugates through Site-Specific Chemoenzymatic Glycan Remodeling. Bioconjugate chemistry 32 (8) (2021)
Qiong Wang, Tiexin Wang, Roushu Zhang, Shuang Yang, Kevin S McFarland, Cheng-Yu Chung, Hongpeng Jia, Lai-Xi Wang, John F Cipollo, Michael J Betenbaugh
The interplay of protein engineering and glycoengineering to fine-tune antibody glycosylation and its impact on effector functions. Biotechnology and bioengineering 119 (1) (2021)
Guanghui Zong, Chao Li, Sunaina Kiran Prabhu, Roushu Zhang, Xiao Zhang, Lai-Xi Wang
A facile chemoenzymatic synthesis of SARS-CoV-2 glycopeptides for probing glycosylation functions. Chemical communications (Cambridge, England) 57 (55) (2021)
Chao Li, Gene Chong, Guanghui Zong, David A Knorr, Stylianos Bournazos, Asaminew Haile Aytenfisu, Grace K Henry, Jeffrey V Ravetch, Alexander D MacKerell, Lai-Xi Wang
Site-Selective Chemoenzymatic Modification on the Core Fucose of an Antibody Enhances Its Fcγ Receptor Affinity and ADCC Activity. Journal of the American Chemical Society 143 (20) (2021)
Dana Motabar, Jinyang Li, Sally Wang, Chen-Yu Tsao, Xin Tong, Lai-Xi Wang, Gregory F Payne, William E Bentley
Simple, rapidly electroassembled thiolated PEG-based sensor interfaces enable rapid interrogation of antibody titer and glycosylation. Biotechnology and bioengineering 118 (7) (2021)
Yang Yang, Xiao Li, Zhihai Ma, Chunlin Wang, Qunying Yang, Miranda Byrne-Steele, Rongjian Hong, Qing Min, Gao Zhou, Yong Cheng, Guang Qin, Justin V Youngyunpipatkul, James Badger Wing, Shimon Sakaguchi, Christian Toonstra, Lai-Xi Wang, Jose G Vilches-Moure, Denong Wang, Michael Paul Snyder, Ji-Yang Wang, Jian Han, Leonore A Herzenberg
CTLA-4 expression by B-1a B cells is essential for immune tolerance. Nature communications 12 (1) (2021)
Xiao Zhang, Huiying Liu, Naresh Meena, Chao Li, Guanghui Zong, Nina Raben, Rosa Puertollano, Lai-Xi Wang
Chemoenzymatic glycan-selective remodeling of a therapeutic lysosomal enzyme with high-affinity M6P-glycan ligands. Enzyme substrate specificity is the name of the game. Chemical science 12 (37) (2021)
Xiao Zhang, Chong Ou, Huiying Liu, Sunaina Kiran Prabhu, Chao Li, Qiang Yang, Lai-Xi Wang
General and Robust Chemoenzymatic Method for Glycan-Mediated Site-Specific Labeling and Conjugation of Antibodies: Facile Synthesis of Homogeneous Antibody-Drug Conjugates. ACS chemical biology 16 (11) (2021)
Xinhai Chen, Miaomiao Shi, Xin Tong, Hwan Keun Kim, Lai-Xi Wang, Olaf Schneewind, Dominique Missiakas
Glycosylation-dependent opsonophagocytic activity of staphylococcal protein A antibodies. Proceedings of the National Academy of Sciences of the United States of America 117 (37) (2020)
Sara Borghi, Stylianos Bournazos, Natalie K Thulin, Chao Li, Anna Gajewski, Robert W Sherwood, Sheng Zhang, Eva Harris, Prasanna Jagannathan, Lai-Xi Wang, Jeffrey V Ravetch, Taia T Wang
FcRn, but not FcγRs, drives maternal-fetal transplacental transport of human IgG antibodies. Proceedings of the National Academy of Sciences of the United States of America 117 (23) (2020)
Yuanwei Dai, Ruth Hartke, Chao Li, Qiang Yang, Jun O Liu, Lai-Xi Wang
Synthetic Fluorinated l-Fucose Analogs Inhibit Proliferation of Cancer Cells and Primary Endothelial Cells. ACS chemical biology 15 (10) (2020)
Christian Toonstra, Lisa Wu, Chao Li, Denong Wang, Lai-Xi Wang
Top-Down Chemoenzymatic Approach to Synthesizing Diverse High-Mannose N-Glycans and Related Neoglycoproteins for Carbohydrate Microarray Analysis. Bioconjugate chemistry 29 (6) (2018)
Hui Cai, Rou-Shu Zhang, Jared Orwenyo, John Giddens, Qiang Yang, Celia C LaBranche, David C Montefiori, Lai-Xi Wang
Synthetic HIV V3 Glycopeptide Immunogen Carrying a N334 N-Glycan Induces Glycan-Dependent Antibodies with Promiscuous Site Recognition. Journal of medicinal chemistry 61 (22) (2018)
Xin Tong, Tiezheng Li, Chao Li, Lai-Xi Wang
Generation and Comparative Kinetic Analysis of New Glycosynthase Mutants from Streptococcus pyogenes Endoglycosidases for Antibody Glycoengineering. Biochemistry 57 (35) (2018)
Chao Li, Lai-Xi Wang
Chemoenzymatic Methods for the Synthesis of Glycoproteins. Chemical reviews 118 (17) (2018)
Jared Orwenyo, Hui Cai, John Giddens, Mohammed N Amin, Christian Toonstra, Lai-Xi Wang
Systematic Synthesis and Binding Study of HIV V3 Glycopeptides Reveal the Fine Epitopes of Several Broadly Neutralizing Antibodies. ACS chemical biology 12 (6) (2017)
Chao Li, Shilei Zhu, Christopher Ma, Lai-Xi Wang
Designer α1,6-Fucosidase Mutants Enable Direct Core Fucosylation of Intact N-Glycopeptides and N-Glycoproteins. Journal of the American Chemical Society 139 (42) (2017)
Hui Cai, Jared Orwenyo, Javier Guenaga, John Giddens, Christian Toonstra, Richard T Wyatt, Lai-Xi Wang
Synthetic multivalent V3 glycopeptides display enhanced recognition by glycan-dependent HIV-1 broadly neutralizing antibodies. Chemical communications (Cambridge, England) 53 (39) (2017)
Qiang Yang, Yanming An, Shilei Zhu, Roushu Zhang, Chun Mun Loke, John F Cipollo, Lai-Xi Wang
Glycan Remodeling of Human Erythropoietin (EPO) Through Combined Mammalian Cell Engineering and Chemoenzymatic Transglycosylation. ACS chemical biology 12 (6) (2017)

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Publication Activity (10 Years)

Top Topics

Top Venues

Lai-Xi Wang