Linda Partridge

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 62

Top Topics

Histone Deacetylase

Gene Expression

Top Venues

Proceedings of the National Academy of Sciences of the United States of America

Science advances

This page only lists publications with an associated author ORCID identifier.

Publications

Enric Ureña, Bowen Xu, Jennifer C Regan, Magda L Atilano, Lucy J Minkley, Danny Filer, Yu-Xuan Lu, Ekin Bolukbasi, Mobina Khericha, Nazif Alic, Linda Partridge
Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Pingze Zhang, James H Catterson, Sebastian Grönke, Linda Partridge
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature aging 4 (4) (2024)
Enric Ureña, Bowen Xu, Jennifer C Regan, Magda L Atilano, Lucy J Minkley, Danny Filer, Yu-Xuan Lu, Ekin Bolukbasi, Mobina Khericha, Nazif Alic, Linda Partridge
Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Pingze Zhang, James H Catterson, Sebastian Grönke, Linda Partridge
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature aging (2024)
Pingze Zhang, James H Catterson, Sebastian Grönke, Linda Partridge
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature aging 4 (4) (2024)
Pingze Zhang, James H Catterson, Sebastian Grönke, Linda Partridge
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature aging 4 (4) (2024)
Enric Ureña, Bowen Xu, Jennifer C Regan, Magda L Atilano, Lucy J Minkley, Danny Filer, Yu-Xuan Lu, Ekin Bolukbasi, Mobina Khericha, Nazif Alic, Linda Partridge
Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Pingze Zhang, James H Catterson, Sebastian Grönke, Linda Partridge
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature aging 4 (4) (2024)
Enric Ureña, Bowen Xu, Jennifer C Regan, Magda L Atilano, Lucy J Minkley, Danny Filer, Yu-Xuan Lu, Ekin Bolukbasi, Mobina Khericha, Nazif Alic, Linda Partridge
Trametinib ameliorates aging-associated gut pathology in Drosophila females by reducing Pol III activity in intestinal stem cells. Proceedings of the National Academy of Sciences of the United States of America 121 (4) (2024)
Pingze Zhang, James H Catterson, Sebastian Grönke, Linda Partridge
Inhibition of S6K lowers age-related inflammation and increases lifespan through the endolysosomal system. Nature aging 4 (4) (2024)
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J Withers, Sebastian Grönke, Linda Partridge
Reduced insulin signaling in neurons induces sex-specific health benefits. Science advances 9 (8) (2023)
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J Withers, Sebastian Grönke, Linda Partridge
Reduced insulin signaling in neurons induces sex-specific health benefits. Science advances 9 (8) (2023)
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J Withers, Sebastian Grönke, Linda Partridge
Reduced insulin signaling in neurons induces sex-specific health benefits. Science advances 9 (8) (2023)
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J Withers, Sebastian Grönke, Linda Partridge
Reduced insulin signaling in neurons induces sex-specific health benefits. Science advances 9 (8) (2023)
Cédric Debès, Antonios Papadakis, Sebastian Grönke, Özlem Karalay, Luke S Tain, Athanasia Mizi, Shuhei Nakamura, Oliver Hahn, Carina Weigelt, Natasa Josipovic, Anne Zirkel, Isabell Brusius, Konstantinos Sofiadis, Mantha Lamprousi, Yu-Xuan Lu, Wenming Huang, Reza Esmaillie, Torsten Kubacki, Martin Richard Späth, Bernhard Schermer, Thomas Benzing, Roman-Ulrich Müller, Roberto Ripa, Linda Partridge, Argyris Papantonis, Andreas Beyer
Ageing-associated changes in transcriptional elongation influence longevity. Nature (2023)
Javier Morón-Oset, Lilly Ks Fischer, Mireia Carcolé, Ashling Giblin, Pingze Zhang, Adrian M Isaacs, Sebastian Grönke, Linda Partridge
Toxicity of C9orf72 -associated dipeptide repeat peptides is modified by commonly used protein tags. Life science alliance 6 (9) (2023)
Maarouf Baghdadi, Tobias Nespital, Andrea Mesaros, Sandra Buschbaum, Dominic J Withers, Sebastian Grönke, Linda Partridge
Reduced insulin signaling in neurons induces sex-specific health benefits. Science advances 9 (8) (2023)
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature aging 2 (9) (2022)
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature aging 2 (9) (2022)
Jennifer C Regan, Yu-Xuan Lu, Enric Ureña, Ralf Leslie Meilenbrock, James H Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk, Linda Partridge
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature aging 2 (12) (2022)
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature aging 2 (9) (2022)
Jennifer C Regan, Yu-Xuan Lu, Enric Ureña, Ralf Leslie Meilenbrock, James H Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk, Linda Partridge
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature aging 2 (12) (2022)
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature aging 2 (9) (2022)
Jennifer C Regan, Yu-Xuan Lu, Enric Ureña, Ralf Leslie Meilenbrock, James H Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk, Linda Partridge
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature aging 2 (12) (2022)
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature aging 2 (9) (2022)
Jennifer C Regan, Yu-Xuan Lu, Enric Ureña, Ralf Leslie Meilenbrock, James H Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk, Linda Partridge
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature aging 2 (12) (2022)
Helen C Fraser, Valerie Kuan, Ronja Johnen, Magdalena Zwierzyna, Aroon D Hingorani, Andreas Beyer, Linda Partridge
Biological mechanisms of aging predict age-related disease co-occurrence in patients. Aging cell 21 (4) (2022)
Paula Juricic, Yu-Xuan Lu, Thomas Leech, Lisa F Drews, Jonathan Paulitz, Jiongming Lu, Tobias Nespital, Sina Azami, Jennifer C Regan, Emilie Funk, Jenny Fröhlich, Sebastian Grönke, Linda Partridge
Long-lasting geroprotection from brief rapamycin treatment in early adulthood by persistently increased intestinal autophagy. Nature aging 2 (9) (2022)
Jennifer C Regan, Yu-Xuan Lu, Enric Ureña, Ralf Leslie Meilenbrock, James H Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk, Linda Partridge
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature aging 2 (12) (2022)
Mihails Laskovs, Linda Partridge, Cathy Slack
Molecular inhibition of RAS signalling to target ageing and age-related health. Disease models & mechanisms 15 (10) (2022)
Jennifer C Regan, Yu-Xuan Lu, Enric Ureña, Ralf Leslie Meilenbrock, James H Catterson, Disna Kißler, Jenny Fröhlich, Emilie Funk, Linda Partridge
Sexual identity of enterocytes regulates autophagy to determine intestinal health, lifespan and responses to rapamycin. Nature aging 2 (12) (2022)
Yahyah Aman, Tomas Schmauck-Medina, Malene Hansen, Richard I Morimoto, Anna Katharina Simon, Ivana Bjedov, Konstantinos Palikaras, Anne Simonsen, Terje Johansen, Nektarios Tavernarakis, David C Rubinsztein, Linda Partridge, Guido Kroemer, Johnathan Labbadia, Evandro Fei Fang
Autophagy in healthy aging and disease. Nature aging 1 (8) (2021)
Andromachi Pouikli, Swati Parekh, Monika Maleszewska, Chrysa Nikopoulou, Maarouf Baghdadi, Ignacio Tripodi, Kat Folz-Donahue, Yvonne Hinze, Andrea Mesaros, David A Hoey, Patrick Giavalisco, Robin Dowell, Linda Partridge, Peter Tessarz
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature aging 1 (9) (2021)
Stephan A Kaeser, Daniela Berdnik, Mikael Thinggaard, Lisa M Häsler, Anja Apel, Carina Bergmann, Daniela Berdnik, Bernard Jeune, Kaare Christensen, Sebastian Grönke, Linda Partridge, Tony Wyss-Coray, Jonas Mengel-From, Mathias Jucker
A neuronal blood marker is associated with mortality in old age. Nature aging 1 (2) (2021)
Andromachi Pouikli, Swati Parekh, Monika Maleszewska, Chrysa Nikopoulou, Maarouf Baghdadi, Ignacio Tripodi, Kat Folz-Donahue, Yvonne Hinze, Andrea Mesaros, David A Hoey, Patrick Giavalisco, Robin Dowell, Linda Partridge, Peter Tessarz
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature aging 1 (9) (2021)
Ekin Bolukbasi, Nathaniel S Woodling, Dobril K Ivanov, Jennifer Adcott, Andrea Foley, Arjunan Rajasingam, Lauren M Gittings, Benjamin Aleyakpo, Teresa Niccoli, Janet M Thornton, Linda Partridge
Cell type-specific modulation of healthspan by Forkhead family transcription factors in the nervous system. Proceedings of the National Academy of Sciences of the United States of America 118 (8) (2021)
Andromachi Pouikli, Swati Parekh, Monika Maleszewska, Chrysa Nikopoulou, Maarouf Baghdadi, Ignacio Tripodi, Kat Folz-Donahue, Yvonne Hinze, Andrea Mesaros, David A Hoey, Patrick Giavalisco, Robin Dowell, Linda Partridge, Peter Tessarz
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature aging 1 (9) (2021)
Li Li, Devon M Conradson, Vinita Bharat, Min Joo Kim, Chung-Han Hsieh, Paras S Minhas, Amanda M Papakyrikos, Aarooran Sivakumaran Durairaj, Anthony Ludlam, Katrin I Andreasson, Linda Partridge, Michael A Cianfrocco, Xinnan Wang
A mitochondrial membrane-bridging machinery mediates signal transduction of intramitochondrial oxidation. Nature metabolism 3 (9) (2021)
Andromachi Pouikli, Swati Parekh, Monika Maleszewska, Chrysa Nikopoulou, Maarouf Baghdadi, Ignacio Tripodi, Kat Folz-Donahue, Yvonne Hinze, Andrea Mesaros, David A Hoey, Patrick Giavalisco, Robin Dowell, Linda Partridge, Peter Tessarz
Chromatin remodeling due to degradation of citrate carrier impairs osteogenesis of aged mesenchymal stem cells. Nature aging 1 (9) (2021)
Magda L Atilano, Sebastian Grönke, Teresa Niccoli, Liam Kempthorne, Oliver Hahn, Javier Morón-Oset, Oliver Hendrich, Miranda Dyson, Mirjam Lisette Adams, Alexander Hull, Marie-Therese Salcher-Konrad, Amy Monaghan, Magda Bictash, Idoia Glaria, Adrian M Isaacs, Linda Partridge
Enhanced insulin signalling ameliorates C9orf72 hexanucleotide repeat expansion toxicity in Drosophila. eLife 10 (2021)
Stephan A Kaeser, Daniela Berdnik, Mikael Thinggaard, Lisa M Häsler, Anja Apel, Carina Bergmann, Daniela Berdnik, Bernard Jeune, Kaare Christensen, Sebastian Grönke, Linda Partridge, Tony Wyss-Coray, Jonas Mengel-From, Mathias Jucker
A neuronal blood marker is associated with mortality in old age. Nature aging 1 (2) (2021)
Luke Stephen Tain, Robert Sehlke, Ralf Leslie Meilenbrock, Thomas Leech, Jonathan Paulitz, Manopriya Chokkalingam, Nagarjuna Nagaraj, Sebastian Grönke, Jenny Fröhlich, Ilian Atanassov, Matthias Mann, Andreas Beyer, Linda Partridge
Tissue-specific modulation of gene expression in response to lowered insulin signalling in Drosophila. eLife 10 (2021)
Yu-Xuan Lu, Jennifer C Regan, Jacqueline Eßer, Lisa F Drews, Thomas Weinseis, Julia Stinn, Oliver Hahn, Richard A Miller, Sebastian Grönke, Linda Partridge
A TORC1-histone axis regulates chromatin organisation and non-canonical induction of autophagy to ameliorate ageing. eLife 10 (2021)
Tobias Nespital, Brit Neuhaus, Andrea Mesaros, André Pahl, Linda Partridge
Lithium can mildly increase health during ageing but not lifespan in mice. Aging cell 20 (10) (2021)
Parisa Kakanj, Sabine A Eming, Linda Partridge, Maria Leptin
Long-term in vivo imaging of Drosophila larvae. Nature protocols 15 (3) (2020)
Linda Partridge, Matias Fuentealba, Brian K Kennedy
The quest to slow ageing through drug discovery. Nature reviews. Drug discovery 19 (8) (2020)
Ivana Bjedov, Helena M Cochemé, Andrea Foley, Daniela Wieser, Nathaniel S Woodling, Jorge Iván Castillo-Quan, Povilas Norvaisas, Celia Lujan, Jennifer C Regan, Janne Markus Toivonen, Michael P Murphy, Janet M Thornton, Kerri J Kinghorn, Thomas P Neufeld, Filipe Cabreiro, Linda Partridge
Fine-tuning autophagy maximises lifespan and is associated with changes in mitochondrial gene expression in Drosophila. PLoS genetics 16 (11) (2020)
Jiongming Lu, Ulrike Temp, Andrea Müller-Hartmann, Jacqueline Esser, Sebastian Grönke, Linda Partridge
Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature aging 1 (1) (2020)
Jiongming Lu, Ulrike Temp, Andrea Müller-Hartmann, Jacqueline Esser, Sebastian Grönke, Linda Partridge
Sestrin is a key regulator of stem cell function and lifespan in response to dietary amino acids. Nature aging 1 (1) (2020)
Oliver Hahn, Lisa F Drews, An Nguyen, Takashi Tatsuta, Lisonia Gkioni, Oliver Hendrich, Qifeng Zhang, Thomas Langer, Scott Pletcher, Michael J O Wakelam, Andreas Beyer, Sebastian Grönke, Linda Partridge
A nutritional memory effect counteracts benefits of dietary restriction in old mice. Nature metabolism 1 (11) (2019)
Shizuka B Yamada, Tania F Gendron, Teresa Niccoli, Naomi R Genuth, Rosslyn Grosely, Yingxiao Shi, Idoia Glaria, Nicholas J Kramer, Lisa Nakayama, Shirleen Fang, Tai J I Dinger, Annora Thoeng, Gabriel Rocha, Maria Barna, Joseph D Puglisi, Linda Partridge, Justin K Ichida, Adrian M Isaacs, Leonard Petrucelli, Aaron D Gitler
RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nature neuroscience 22 (9) (2019)
Jorge Iván Castillo-Quan, Luke S Tain, Kerri J Kinghorn, Li Li, Sebastian Grönke, Yvonne Hinze, T Keith Blackwell, Ivana Bjedov, Linda Partridge
A triple drug combination targeting components of the nutrient-sensing network maximizes longevity. Proceedings of the National Academy of Sciences of the United States of America 116 (42) (2019)
Matías Fuentealba Valenzuela, Handan Melike Dönertaş, Rhianna Williams, Johnathan Labbadia, Janet M Thornton, Linda Partridge
Using the drug-protein interactome to identify anti-ageing compounds for humans. PLoS computational biology 15 (1) (2019)
Roberto Simone, Rubika Balendra, Thomas G Moens, Elisavet Preza, Katherine M Wilson, Amanda Heslegrave, Nathan S Woodling, Teresa Niccoli, Javier Gilbert-Jaramillo, Samir Abdelkarim, Emma L Clayton, Mica Clarke, Marie-Therese Konrad, Andrew J Nicoll, Jamie S Mitchell, Andrea Calvo, Adriano Chio, Henry Houlden, James M Polke, Mohamed A Ismail, Chad E Stephens, Tam Vo, Abdelbasset A Farahat, W David Wilson, David W Boykin, Henrik Zetterberg, Linda Partridge, Selina Wray, Gary Parkinson, Stephen Neidle, Rickie Patani, Pietro Fratta, Adrian M Isaacs
G-quadruplex-binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo. EMBO molecular medicine 10 (1) (2019)
Carina M Weigelt, Oliver Hahn, Katharina Arlt, Matthias Gruhn, Annika J Jahn, Jacqueline Eßer, Jennifer A Werner, Corinna Klein, Ansgar Büschges, Sebastian Grönke, Linda Partridge
Loss of miR-210 leads to progressive retinal degeneration in Drosophila melanogaster. Life science alliance 2 (1) (2019)
Luke Stephen Tain, Chirag Jain, Tobias Nespital, Jenny Froehlich, Yvonne Hinze, Sebastian Grönke, Linda Partridge
Longevity in response to lowered insulin signaling requires glycine N-methyltransferase-dependent spermidine production. Aging cell 19 (1) (2019)
Handan Melike Dönertaş, Matías Fuentealba Valenzuela, Linda Partridge, Janet M Thornton
Gene expression-based drug repurposing to target aging. Aging cell 17 (5) (2018)
Hrvoje Augustin, Kieran McGourty, Joern R Steinert, Helena M Cochemé, Jennifer Adcott, Melissa Cabecinha, Alec Vincent, Els F Halff, Josef T Kittler, Emmanuel Boucrot, Linda Partridge
Myostatin-like proteins regulate synaptic function and neuronal morphology. Development (Cambridge, England) 144 (13) (2017)
Kerri J Kinghorn, Sebastian Grönke, Jorge Iván Castillo-Quan, Nathaniel S Woodling, Li Li, Ernestas Sirka, Matthew E Gegg, Kevin Mills, John Hardy, Ivana Bjedov, Linda Partridge
A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin. The Journal of neuroscience : the official journal of the Society for Neuroscience 36 (46) (2017)
Hrvoje Augustin, Jennifer Adcott, Christopher J H Elliott, Linda Partridge
Complex roles of myoglianin in regulating adult performance and lifespan. Fly 11 (4) (2017)
Fiona Kerr, Oyinkan Sofola-Adesakin, Dobril K Ivanov, Jemma Gatliff, Beatriz Gomez Perez-Nievas, Hélène C Bertrand, Pedro Martinez, Rebecca Callard, Inge Snoeren, Helena M Cochemé, Jennifer Adcott, Mobina Khericha, Jorge Iván Castillo-Quan, Geoffrey Wells, Wendy Noble, Janet Thornton, Linda Partridge
Direct Keap1-Nrf2 disruption as a potential therapeutic target for Alzheimer's disease. PLoS genetics 13 (3) (2017)
Luke S Tain, Robert Sehlke, Chirag Jain, Manopriya Chokkalingam, Nagarjuna Nagaraj, Paul Essers, Mark Rassner, Sebastian Grönke, Jenny Froelich, Christoph Dieterich, Matthias Mann, Nazif Alic, Andreas Beyer, Linda Partridge
A proteomic atlas of insulin signalling reveals tissue-specific mechanisms of longevity assurance. Molecular systems biology 13 (9) (2017)