Patrick Cramer (P Cramer)

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 70

Top Topics

Structural Basis

Electron Microscopy

Top Venues

Nature structural & molecular biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Goran Kokic, George Yakoub, Diana van den Heuvel, Annelotte P Wondergem, Paula J van der Meer, Yana van der Weegen, Aleksandar Chernev, Isaac Fianu, Thornton J Fokkens, Sonja Lorenz, Henning Urlaub, Patrick Cramer, Martijn S Luijsterburg
Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Nature structural & molecular biology 31 (3) (2024)
Patrick Cramer
Good reasons for structural biology. Nature structural & molecular biology (2024)
Isaac Fianu, Moritz Ochmann, James L Walshe, Olexandr Dybkov, Joseph Neos Cruz, Henning Urlaub, Patrick Cramer
Structural basis of Integrator-dependent RNA polymerase II termination. Nature (2024)
Isaac Fianu, Moritz Ochmann, James L Walshe, Olexandr Dybkov, Joseph Neos Cruz, Henning Urlaub, Patrick Cramer
Structural basis of Integrator-dependent RNA polymerase II termination. Nature 629 (8010) (2024)
Goran Kokic, George Yakoub, Diana van den Heuvel, Annelotte P Wondergem, Paula J van der Meer, Yana van der Weegen, Aleksandar Chernev, Isaac Fianu, Thornton J Fokkens, Sonja Lorenz, Henning Urlaub, Patrick Cramer, Martijn S Luijsterburg
Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Nature structural & molecular biology 31 (3) (2024)
Patrick Cramer
Good reasons for structural biology. Nature structural & molecular biology 31 (3) (2024)
Goran Kokic, George Yakoub, Diana van den Heuvel, Annelotte P Wondergem, Paula J van der Meer, Yana van der Weegen, Aleksandar Chernev, Isaac Fianu, Thornton J Fokkens, Sonja Lorenz, Henning Urlaub, Patrick Cramer, Martijn S Luijsterburg
Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Nature structural & molecular biology 31 (3) (2024)
Goran Kokic, George Yakoub, Diana van den Heuvel, Annelotte P Wondergem, Paula J van der Meer, Yana van der Weegen, Aleksandar Chernev, Isaac Fianu, Thornton J Fokkens, Sonja Lorenz, Henning Urlaub, Patrick Cramer, Martijn S Luijsterburg
Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Nature structural & molecular biology (2024)
Patrick Cramer
Good reasons for structural biology. Nature structural & molecular biology 31 (3) (2024)
Isaac Fianu, Moritz Ochmann, James L Walshe, Olexandr Dybkov, Joseph Neos Cruz, Henning Urlaub, Patrick Cramer
Structural basis of Integrator-dependent RNA polymerase II termination. Nature 629 (8010) (2024)
Isaac Fianu, Moritz Ochmann, James L Walshe, Olexandr Dybkov, Joseph Neos Cruz, Henning Urlaub, Patrick Cramer
Structural basis of Integrator-dependent RNA polymerase II termination. Nature (2024)
Goran Kokic, George Yakoub, Diana van den Heuvel, Annelotte P Wondergem, Paula J van der Meer, Yana van der Weegen, Aleksandar Chernev, Isaac Fianu, Thornton J Fokkens, Sonja Lorenz, Henning Urlaub, Patrick Cramer, Martijn S Luijsterburg
Structural basis for RNA polymerase II ubiquitylation and inactivation in transcription-coupled repair. Nature structural & molecular biology 31 (3) (2024)
Isaac Fianu, Moritz Ochmann, James L Walshe, Olexandr Dybkov, Joseph Neos Cruz, Henning Urlaub, Patrick Cramer
Structural basis of Integrator-dependent RNA polymerase II termination. Nature 629 (8010) (2024)
Ying Chen, Goran Kokic, Christian Dienemann, Olexandr Dybkov, Henning Urlaub, Patrick Cramer
Structure of the transcribing RNA polymerase II-Elongin complex. Nature structural & molecular biology (2023)
Le Xiong, Erik A Tolen, Jinmi Choi, Sergiy Velychko, Livia Caizzi, Taras Velychko, Kenjiro Adachi, Caitlin M MacCarthy, Michael Lidschreiber, Patrick Cramer, Hans Robert Schöler
Oct4 differentially regulates chromatin opening and enhancer transcription in pluripotent stem cells. eLife 11 (2022)
Srinivasan Rengachari, Sandra Schilbach, Thangavelu Kaliyappan, Jerome Gouge, Kristina Zumer, Juliane Schwarz, Henning Urlaub, Christian Dienemann, Alessandro Vannini, Patrick Cramer
Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II. Nature structural & molecular biology (2022)
Liang Xue, Swantje Lenz, Maria Zimmermann-Kogadeeva, Dimitry Tegunov, Patrick Cramer, Peer Bork, Juri Rappsilber, Julia Mahamid
Visualizing translation dynamics at atomic detail inside a bacterial cell. Nature 610 (7930) (2022)
Till Baar, Sebastian Dümcke, Saskia Gressel, Björn Schwalb, Alexander T Dilthey, Patrick Cramer, Achim Tresch
RNA transcription and degradation of Alu retrotransposons depends on sequence features and evolutionary history. G3 (Bethesda, Md.) 12 (5) (2022)
Haibo Wang, Sandra Schilbach, Momchil Ninov, Henning Urlaub, Patrick Cramer
Structures of transcription preinitiation complex engaged with the +1 nucleosome. Nature structural & molecular biology (2022)
G Yahya, P Menges, Prince Saforo Amponsah, D A Ngandiri, D Schulz, A Wallek, N Kulak, Matthias Mann, Patrick Cramer, V Savage, Markus Räschle, Zuzana Storchová
Sublinear scaling of the cellular proteome with ploidy. Nature communications 13 (1) (2022)
Biswajyoti Sahu, Tuomo Hartonen, Päivi Pihlajamaa, Bei Wei, Kashyap Dave, Fangjie Zhu, Eevi Kaasinen, Katja Lidschreiber, Michael Lidschreiber, Carsten O Daub, Patrick Cramer, Teemu Kivioja, Jussi Taipale
Sequence determinants of human gene regulatory elements. Nature genetics 54 (3) (2022)
Rui Shao, Banushree Kumar, Katja Lidschreiber, Michael Lidschreiber, Patrick Cramer, Simon J Elsässer
Distinct transcription kinetics of pluripotent cell states. Molecular systems biology 18 (1) (2022)
Elisa Oberbeckmann, Vanessa Niebauer, Shinya Watanabe, Lucas Farnung, Manuela Moldt, Andrea Schmid, Patrick Cramer, Craig L Peterson, Sebastian Eustermann, Karl-Peter Hopfner, Philipp Korber
Ruler elements in chromatin remodelers set nucleosome array spacing and phasing. Nature communications 12 (1) (2021)
Dimitry Tegunov, Liang Xue, Christian Dienemann, Patrick Cramer, Julia Mahamid
Multi-particle cryo-EM refinement with M visualizes ribosome-antibiotic complex at 3.5 Å in cells. Nature methods 18 (2) (2021)
Anna Sawicka, Gabriel Villamil, Michael Lidschreiber, Xavier Darzacq, Claire Dugast-Darzacq, Björn Schwalb, Patrick Cramer
Transcription activation depends on the length of the RNA polymerase II C-terminal domain. The EMBO journal 40 (9) (2021)
Shintaro Aibara, Christian Dienemann, Patrick Cramer
Structure of an inactive RNA polymerase II dimer. Nucleic acids research 49 (18) (2021)
Hauke S Hillen, Dmitriy A Markov, Ireneusz D Wojtas, Katharina B Hofmann, Michael Lidschreiber, Andrew T Cowan, Julia L Jones, Dmitry Temiakov, Patrick Cramer, Michael Anikin
The pentatricopeptide repeat protein Rmd9 recognizes the dodecameric element in the 3'-UTRs of yeast mitochondrial mRNAs. Proceedings of the National Academy of Sciences of the United States of America 118 (15) (2021)
Lucas Farnung, Moritz Ochmann, Maik Engeholm, Patrick Cramer
Structural basis of nucleosome transcription mediated by Chd1 and FACT. Nature structural & molecular biology 28 (4) (2021)
Isaac Fianu, Christian Dienemann, Shintaro Aibara, Sandra Schilbach, Patrick Cramer
Cryo-EM structure of mammalian RNA polymerase II in complex with human RPAP2. Communications biology 4 (1) (2021)
Arjun Bhatta, Christian Dienemann, Patrick Cramer, Hauke S Hillen
Structural basis of RNA processing by human mitochondrial RNase P. Nature structural & molecular biology 28 (9) (2021)
Srinivasan Rengachari, Sandra Schilbach, Shintaro Aibara, Christian Dienemann, Patrick Cramer
Structure of the human Mediator-RNA polymerase II pre-initiation complex. Nature 594 (7861) (2021)
Goran Kokic, Felix R Wagner, Aleksandar Chernev, Henning Urlaub, Patrick Cramer
Structural basis of human transcription-DNA repair coupling. Nature 598 (7880) (2021)
Katja Lidschreiber, Lisa A Jung, Henrik von der Emde, Kashyap Dave, Jussi Taipale, Patrick Cramer, Michael Lidschreiber
Transcriptionally active enhancers in human cancer cells. Molecular systems biology 17 (1) (2021)
Goran Kokic, Hauke S Hillen, Dimitry Tegunov, Christian Dienemann, Florian Seitz, Jana Schmitzova, Lucas Farnung, Aaron Siewert, Claudia Höbartner, Patrick Cramer
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir. Nature communications 12 (1) (2021)
Haibo Wang, Le Xiong, Patrick Cramer
Structures and implications of TBP-nucleosome complexes. Proceedings of the National Academy of Sciences of the United States of America 118 (30) (2021)
Suyang Zhang, Shintaro Aibara, Seychelle M Vos, Dmitry E Agafonov, Reinhard Lührmann, Patrick Cramer
Structure of a transcribing RNA polymerase II-U1 snRNP complex. Science (New York, N.Y.) 371 (6526) (2021)
Shintaro Aibara, Sandra Schilbach, Patrick Cramer
Structures of mammalian RNA polymerase II pre-initiation complexes. Nature 594 (7861) (2021)
Jinmi Choi, Kseniia Lysakovskaia, Grégoire Stik, Carina Demel, Johannes Söding, Tian V Tian, Thomas Graf, Patrick Cramer
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination. eLife 10 (2021)
Isaac Fianu, Ying Chen, Christian Dienemann, Olexandr Dybkov, Andreas Linden, Henning Urlaub, Patrick Cramer
Structural basis of Integrator-mediated transcription regulation. Science (New York, N.Y.) 374 (6569) (2021)
Florian A Jochheim, Dimitry Tegunov, Hauke S Hillen, Jana Schmitzová, Goran Kokic, Christian Dienemann, Patrick Cramer
The structure of a dimeric form of SARS-CoV-2 polymerase. Communications biology 4 (1) (2021)
Florian Kabinger, Carina Stiller, Jana Schmitzová, Christian Dienemann, Goran Kokic, Hauke S Hillen, Claudia Höbartner, Patrick Cramer
Mechanism of molnupiravir-induced SARS-CoV-2 mutagenesis. Nature structural & molecular biology 28 (9) (2021)
Patrick Cramer
AlphaFold2 and the future of structural biology. Nature structural & molecular biology 28 (9) (2021)
Felix R Wagner, Christian Dienemann, Haibo Wang, Alexandra Stützer, Dimitry Tegunov, Henning Urlaub, Patrick Cramer
Structure of SWI/SNF chromatin remodeller RSC bound to a nucleosome. Nature 579 (7799) (2020)
Seychelle M Vos, Lucas Farnung, Andreas Linden, Henning Urlaub, Patrick Cramer
Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation. Nature structural & molecular biology 27 (7) (2020)
Nina A Bonekamp, Bradley Peter, Hauke S Hillen, Andrea Felser, Tim Bergbrede, Axel Choidas, Moritz Horn, Anke Unger, Raffaella Di Lucrezia, Ilian Atanassov, Xinping Li, Uwe Koch, Sascha Menninger, Joanna Boros, Peter Habenberger, Patrick Giavalisco, Patrick Cramer, Martin S Denzel, Peter Nussbaumer, Bert Klebl, Maria Falkenberg, Claes M Gustafsson, Nils-Göran Larsson
Small-molecule inhibitors of human mitochondrial DNA transcription. Nature 588 (7839) (2020)
Martin G Jaeger, Björn Schwalb, Sebastian D Mackowiak, Taras Velychko, Alexander Hanzl, Hana Imrichova, Matthias Brand, Benedikt Agerer, Someth Chorn, Behnam Nabet, Fleur M Ferguson, André C Müller, Andreas Bergthaler, Nathanael S Gray, James E Bradner, Christoph Bock, Denes Hnisz, Patrick Cramer, Georg E Winter
Selective Mediator dependence of cell-type-specifying transcription. Nature genetics 52 (7) (2020)
Lucas Farnung, Moritz Ochmann, Patrick Cramer
Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations. eLife 9 (2020)
Svetlana O Dodonova, Fangjie Zhu, Christian Dienemann, Jussi Taipale, Patrick Cramer
Nucleosome-bound SOX2 and SOX11 structures elucidate pioneer factor function. Nature 580 (7805) (2020)
Francis J O'Reilly, Liang Xue, Andrea Graziadei, Ludwig R Sinn, Swantje Lenz, Dimitry Tegunov, Cedric Blötz, Neil Singh, Wim J H Hagen, Patrick Cramer, Oliver Brock, Julia Mahamid, Juri Rappsilber
In-cell architecture of an actively transcribing-translating expressome. Science (New York, N.Y.) 369 (6503) (2020)
Kerstin C Maier, Saskia Gressel, Patrick Cramer, Björn Schwalb
Native molecule sequencing by nano-ID reveals synthesis and stability of RNA isoforms. Genome research 30 (9) (2020)
Kee-Pyo Kim, Jinmi Choi, Juyong Yoon, Jan M Bruder, Borami Shin, Jonghun Kim, Marcos Jesus Araúzo-Bravo, Dong Han, Guangming Wu, Dong Wook Han, Johnny Kim, Patrick Cramer, Hans Robert Schöler
Permissive epigenomes endow reprogramming competence to transcriptional regulators. Nature chemical biology 17 (1) (2020)
Hauke S Hillen, Goran Kokic, Lucas Farnung, Christian Dienemann, Dimitry Tegunov, Patrick Cramer
Structure of replicating SARS-CoV-2 polymerase. Nature 584 (7819) (2020)
Grégoire Stik, Enrique Vidal, Mercedes Barrero, Sergi Cuartero, Maria Vila-Casadesús, Julen Mendieta-Esteban, Tian V Tian, Jinmi Choi, Clara Berenguer, Amaya Abad, Beatrice Borsari, François Le Dily, Patrick Cramer, Marc A Marti-Renom, Ralph Stadhouders, Thomas Graf
CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response. Nature genetics 52 (7) (2020)
Salma Sohrabi-Jahromi, Katharina B Hofmann, Andrea Boltendahl, Christian Roth, Saskia Gressel, Carlo Baejen, Johannes Soeding, Patrick Cramer
Transcriptome maps of general eukaryotic RNA degradation factors. eLife 8 (2019)
Haibo Wang, Lucas Farnung, Christian Dienemann, Patrick Cramer
Structure of H3K36-methylated nucleosome-PWWP complex reveals multivalent cross-gyre binding. Nature structural & molecular biology 27 (1) (2019)
Goran Kokic, Aleksandar Chernev, Dimitry Tegunov, Christian Dienemann, Henning Urlaub, Patrick Cramer
Structural basis of TFIIH activation for nucleotide excision repair. Nature communications 10 (1) (2019)
Dimitry Tegunov, Patrick Cramer
Real-time cryo-electron microscopy data preprocessing with Warp. Nature methods 16 (11) (2019)
Leonhard Wachutka, Livia Caizzi, Julien Gagneur, Patrick Cramer
Global donor and acceptor splicing site kinetics in human cells. eLife 8 (2019)
Gert-Jan Hendriks, Lisa A Jung, Anton J M Larsson, Michael Lidschreiber, Oscar Andersson Forsman, Katja Lidschreiber, Patrick Cramer, Rickard Sandberg
NASC-seq monitors RNA synthesis in single cells. Nature communications 10 (1) (2019)
Saskia Gressel, Björn Schwalb, Patrick Cramer
The pause-initiation limit restricts transcription activation in human cells. Nature communications 10 (1) (2019)
Lucas Farnung, Seychelle M Vos, Patrick Cramer
Structure of transcribing RNA polymerase II-nucleosome complex. Nature communications 9 (1) (2018)
Hauke S Hillen, Dmitry Temiakov, Patrick Cramer
Structural basis of mitochondrial transcription. Nature structural & molecular biology 25 (9) (2018)
Marc Boehning, Claire Dugast-Darzacq, Marija Rankovic, Anders S Hansen, Taekyung Yu, Herve Marie-Nelly, David T McSwiggen, Goran Kokic, Gina M Dailey, Patrick Cramer, Xavier Darzacq, Markus Zweckstetter
RNA polymerase II clustering through carboxy-terminal domain phase separation. Nature structural & molecular biology 25 (9) (2018)
R Kohler, R A Mooney, D J Mills, Robert Landick, Patrick Cramer
Architecture of a transcribing-translating expressome. Science (New York, N.Y.) 356 (6334) (2017)
Saskia Gressel, Björn Schwalb, Tim Michael Decker, Weihua Qin, Heinrich Leonhardt, Dirk Eick, Patrick Cramer
CDK9-dependent RNA polymerase II pausing controls transcription initiation. eLife 6 (2017)
Carrie Bernecky, Jürgen M Plitzko, Patrick Cramer
Structure of a transcribing RNA polymerase II-DSIF complex reveals a multidentate DNA-RNA clamp. Nature structural & molecular biology 24 (10) (2017)
Sofia Battaglia, Michael Lidschreiber, Carlo Baejen, Phillipp Torkler, Seychelle M Vos, Patrick Cramer
RNA-dependent chromatin association of transcription elongation factors and Pol II CTD kinases. eLife 6 (2017)
Margaux Michel, Carina Demel, Benedikt Zacher, Björn Schwalb, Stefan Krebs, Helmut Blum, Julien Gagneur, Patrick Cramer
TT-seq captures enhancer landscapes immediately after T-cell stimulation. Molecular systems biology 13 (3) (2017)
Patrick Hillenbrand, Kerstin C Maier, Patrick Cramer, Ulrich Gerland
Inference of gene regulation functions from dynamic transcriptome data. eLife 5 (2016)
Seychelle M Vos, David Pöllmann, Livia Caizzi, Katharina B Hofmann, Pascaline Rombaut, Tomasz Zimniak, Franz Herzog, Patrick Cramer
Architecture and RNA binding of the human negative elongation factor. eLife 5 (2016)