Jason E Gestwicki (Jason Gestwicki)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 70

Top Topics

Cerebrospinal Fluid

Radical Prostatectomy

Top Venues

Nature communications

bioRxiv : the preprint server for biology

Research square

This page only lists publications with an associated author ORCID identifier.

Publications

Taiasean Wu, Zachary J Gale-Day, Jason E Gestwicki
DSFworld: A flexible and precise tool to analyze differential scanning fluorimetry data. Protein science : a publication of the Protein Society 33 (6) (2024)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Finn D Wolfreys, Jia Yang, Jason E Gestwicki, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nature communications 15 (1) (2024)
Julian R Braxton, Hao Shao, Eric Tse, Jason E Gestwicki, Daniel R Southworth
Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Nature structural & molecular biology (2024)
Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu, Chengfei Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Oncogene 43 (30) (2024)
Taiasean Wu, Joshua C Yu, Arundhati Suresh, Zachary J Gale-Day, Matthew G Alteen, Amanda S Woo, Zoe Millbern, Oleta T Johnson, Emma C Carroll, Carrie L Partch, Denis Fourches, Nelson R Vinueza, David J Vocadlo, Jason E Gestwicki
Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes. Nature biotechnology (2024)
Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu, Chengfei Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Oncogene 43 (30) (2024)
Taiasean Wu, Joshua C Yu, Arundhati Suresh, Zachary J Gale-Day, Matthew G Alteen, Amanda S Woo, Zoe Millbern, Oleta T Johnson, Emma C Carroll, Carrie L Partch, Denis Fourches, Nelson R Vinueza, David J Vocadlo, Jason E Gestwicki
Protein-adaptive differential scanning fluorimetry using conformationally responsive dyes. Nature biotechnology (2024)
Pengfei Xu, Joy C Yang, Bo Chen, Shu Ning, Xiong Zhang, Leyi Wang, Christopher Nip, Yuqiu Shen, Oleta T Johnson, Gabriela Grigorean, Brett S Phinney, Liangren Liu, Qiang Wei, Eva Corey, Clifford G Tepper, Hong-Wu Chen, Christopher P Evans, Marc A Dall'Era, Allen C Gao, Jason E Gestwicki, Chengfei Liu
Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer. Nature communications 15 (1) (2024)
Taiasean Wu, Zachary J Gale-Day, Jason E Gestwicki
DSFworld: A flexible and precise tool to analyze differential scanning fluorimetry data. Protein science : a publication of the Protein Society 33 (6) (2024)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Finn D Wolfreys, Jia Yang, Jason E Gestwicki, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nature communications 15 (1) (2024)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Finn D Wolfreys, Jia Yang, Jason E Gestwicki, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nature communications 15 (1) (2024)
Julian R Braxton, Hao Shao, Eric Tse, Jason E Gestwicki, Daniel R Southworth
Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. Nature structural & molecular biology (2024)
Chengfei Liu, Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Research square (2024)
Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu, Chengfei Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Oncogene 43 (30) (2024)
Chengfei Liu, Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Research square (2024)
Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu, Chengfei Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Oncogene (2024)
Pengfei Xu, Joy C Yang, Bo Chen, Shu Ning, Xiong Zhang, Leyi Wang, Christopher Nip, Yuqiu Shen, Oleta T Johnson, Gabriela Grigorean, Brett S Phinney, Liangren Liu, Qiang Wei, Eva Corey, Clifford G Tepper, Hong-Wu Chen, Christopher P Evans, Marc A Dall'Era, Allen C Gao, Jason E Gestwicki, Chengfei Liu
Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer. Nature communications 15 (1) (2024)
Sook Wah Yee, Luis Ferrández-Peral, Pol Alentorn-Moron, Claudia Fontsere, Merve Ceylan, Megan L Koleske, Niklas Handin, Virginia M Artegoitia, Giovanni Lara, Huan-Chieh Chien, Xujia Zhou, Jacques Dainat, Arthur O Zalevsky, Andrej Sali, Colin M Brand, Finn D Wolfreys, Jia Yang, Jason E Gestwicki, Anthony Capra, Per Artursson, John W Newman, Tomas Marques-Bonet, Kathleen M Giacomini
Illuminating the function of the orphan transporter, SLC22A10, in humans and other primates. Nature communications 15 (1) (2024)
Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu, Chengfei Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Oncogene 43 (30) (2024)
Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu, Chengfei Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Oncogene (2024)
Pengfei Xu, Joy C Yang, Bo Chen, Shu Ning, Xiong Zhang, Leyi Wang, Christopher Nip, Yuqiu Shen, Oleta T Johnson, Gabriela Grigorean, Brett S Phinney, Liangren Liu, Qiang Wei, Eva Corey, Clifford G Tepper, Hong-Wu Chen, Christopher P Evans, Marc A Dall'Era, Allen C Gao, Jason E Gestwicki, Chengfei Liu
Proteostasis perturbation of N-Myc leveraging HSP70 mediated protein turnover improves treatment of neuroendocrine prostate cancer. Nature communications 15 (1) (2024)
Chengfei Liu, Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Research square (2024)
Afraah Javed, Oleta T Johnson, Aaron T Balana, Regan F Volk, Andreas Langen, Benjamin S Ahn, Balyn W Zaro, Jason E Gestwicki, Matthew R Pratt
O-GlcNAc modification of HSP27 alters its protein interactions and promotes refolding of proteins through the BAG3/HSP70 co-chaperone. Protein science : a publication of the Protein Society 33 (10) (2024)
Chengfei Liu, Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Research square (2024)
Chengfei Liu, Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Research square (2024)
Cory M Nadel, Saugat Pokhrel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Matthew D Callahan, Daniel R Southworth, Daniel A Mordes, Charles S Craik, Jason E Gestwicki
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP. Nature communications 15 (1) (2024)
Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu, Chengfei Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Oncogene (2024)
Emma C Carroll, Hyunjun Yang, Julia G Jones, Abby Oehler, Annemarie F Charvat, Kelly M Montgomery, Anthony Yung, Zoe Millbern, Nelson R Vinueza, William F DeGrado, Daniel A Mordes, Carlo Condello, Jason E Gestwicki
Methods for high throughput discovery of fluoroprobes that recognize tau fibril polymorphs. bioRxiv : the preprint server for biology (2024)
Chengfei Liu, Bo Chen, Pengfei Xu, Joy C Yang, Christopher Nip, Leyi Wang, Yuqiu Shen, Shu Ning, Yufeng Shang, Eva Corey, Allen C Gao, Jason E Gestwicki, Qiang Wei, Liangren Liu
Plexin D1 emerges as a novel target in the development of neural lineage plasticity in treatment-resistant prostate cancer. Research square (2024)
Kelly M Montgomery, Emma C Carroll, Aye C Thwin, Athena Y Quddus, Paige Hodges, Daniel R Southworth, Jason E Gestwicki
Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States. Journal of the American Chemical Society (2023)
Jason Z Zhang, Nathan Greenwood, Jason Hernandez, Josh T Cuperus, Buwei Huang, Bryan D Ryder, Christine Queitsch, Jason E Gestwicki, Julien S Baker
De novo designed Hsp70 activator dissolves intracellular condensates. bioRxiv : the preprint server for biology (2023)
Kelly M Montgomery, Emma C Carroll, Aye C Thwin, Athena Y Quddus, Paige Hodges, Daniel R Southworth, Jason E Gestwicki
Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States. Journal of the American Chemical Society (2023)
Kelly M Montgomery, Emma C Carroll, Aye C Thwin, Athena Y Quddus, Paige Hodges, Daniel R Southworth, Jason E Gestwicki
Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States. Journal of the American Chemical Society (2023)
null null, null null, Suzanne Elsasser, Lisa P Elia, Richard I Morimoto, Evan T Powers, null null, Suzanne Elsasser, Daniel Finley, null null, Beatrice Costa, Maher Budron, Zachary Tokuno, Shijie Wang, Rajshri G Iyer, Bianca Barth, Eric Mockler, Lisa P Elia, Steven Finkbeiner, null null, Jason E Gestwicki, null null, Reese A K Richardson, Thomas Stoeger, Richard I Morimoto, null null, Ee Phie Tan, Qiang Xiao, Christian M Cole, Lynée A Massey, Dan Garza, Evan T Powers, Jeffrey W Kelly, null null, T Kelly Rainbolt, Ching-Chieh Chou, Vincent B Masto, Judith Frydman, null null, Ralph A Nixon
A Comprehensive Enumeration of the Human Proteostasis Network. 2. Components of the Autophagy-Lysosome Pathway. bioRxiv : the preprint server for biology (2023)
Cory M Nadel, Kristin Wucherer, Abby Oehler, Aye C Thwin, Koli Basu, Matthew D Callahan, Daniel R Southworth, Daniel A Mordes, Charles S Craik, Jason E Gestwicki
Phosphorylation of a Cleaved Tau Proteoform at a Single Residue Inhibits Binding to the E3 Ubiquitin Ligase, CHIP. bioRxiv : the preprint server for biology (2023)
Kelly M Montgomery, Emma C Carroll, Aye C Thwin, Athena Y Quddus, Paige Hodges, Daniel R Southworth, Jason E Gestwicki
Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States. Journal of the American Chemical Society (2023)
Kelly M Montgomery, Emma C Carroll, Aye C Thwin, Athena Y Quddus, Paige Hodges, Daniel R Southworth, Jason E Gestwicki
Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States. Journal of the American Chemical Society (2023)
Julian R Braxton, Hao Shao, Eric Tse, Jason E Gestwicki, Daniel R Southworth
Asymmetric apical domain states of mitochondrial Hsp60 coordinate substrate engagement and chaperonin assembly. bioRxiv : the preprint server for biology (2023)
Morrie Lam, Szu-Yu Kuo, Surya Reis, Jason E Gestwicki, M Catarina Silva, Stephen J Haggarty
Cholesterol Dysregulation Drives Seed-Dependent Tau Aggregation in Patient Stem Cell-Derived Models of Tauopathy. bioRxiv : the preprint server for biology (2023)
Taiasean Wu, Joshua C Yu, Arundhati Suresh, Zachary J Gale-Day, Matthew G Alteen, Amanda S Woo, Zoe Millbern, Oleta T Johnson, Emma C Carroll, Carrie L Partch, Denis Fourches, Nelson R Vinueza, David J Vocadlo, Jason E Gestwicki
Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry. bioRxiv : the preprint server for biology (2023)
Kelly M Montgomery, Emma C Carroll, Aye C Thwin, Athena Y Quddus, Paige Hodges, Daniel R Southworth, Jason E Gestwicki
Chemical Features of Polyanions Modulate Tau Aggregation and Conformational States. Journal of the American Chemical Society (2023)
Taiasean Wu, Joshua C Yu, Arundhati Suresh, Zachary J Gale-Day, Matthew G Alteen, Amanda S Woo, Zoe Millbern, Oleta T Johnson, Emma C Carroll, Carrie L Partch, Denis Fourches, Nelson R Vinueza, David J Vocadlo, Jason E Gestwicki
Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry. bioRxiv : the preprint server for biology (2023)
Taiasean Wu, Joshua C Yu, Arundhati Suresh, Zachary J Gale-Day, Matthew G Alteen, Amanda S Woo, Zoe Millbern, Oleta T Johnson, Emma C Carroll, Carrie L Partch, Denis Fourches, Nelson R Vinueza, David J Vocadlo, Jason E Gestwicki
Conformationally responsive dyes enable protein-adaptive differential scanning fluorimetry. bioRxiv : the preprint server for biology (2023)
Daniel C Carrettiero, Maria Camila Almeida, Andrew P Longhini, Jennifer N Rauch, Dasol Han, Xuemei Zhang, Saeed Najafi, Jason E Gestwicki, Kenneth S Kosik
Stress routes clients to the proteasome via a BAG2 ubiquitin-independent degradation condensate. Nature communications 13 (1) (2022)
Duygu Kuzuoğlu-Öztürk, Ozlem Aksoy, Christin Schmidt, Robin Lea, Jon D Larson, Ryan R L Phelps, Nicole Nasholm, Megan Holt, Adrian Contreras, Miller Huang, Shannon Wong-Michalak, Hao Shao, Robert J Wechsler-Reya, Joanna J Phillips, Jason E Gestwicki, Davide Ruggero, William A Weiss
N-myc mediated translation control is a therapeutic vulnerability in medulloblastoma. Cancer research (2022)
Chao Wang, Li Fan, Rabia R Khawaja, Bangyan Liu, Lihong Zhan, Lay Kodama, Marcus Y Chin, Yaqiao Li, David Le, Yungui Zhou, Carlo Condello, Lea Tenenholz Grinberg, William W Seeley, Bruce L Miller, Sue-Ann Mok, Jason E Gestwicki, Ana Maria Cuervo, Wenjie Luo, Li Gan
Microglial NF-κB drives tau spreading and toxicity in a mouse model of tauopathy. Nature communications 13 (1) (2022)
Kwadwo A Opoku-Nsiah, Andres H de la Pena, Sarah K Williams, Nikita Chopra, Andrej Sali, Gabriel C Lander, Jason E Gestwicki
The YΦ motif defines the structure-activity relationships of human 20S proteasome activators. Nature communications 13 (1) (2022)
Stefan Gahbauer, Galen J Correy, Marion Schuller, Matteo P Ferla, Yagmur Umay Doruk, Moira M Rachman, Taiasean Wu, Morgan E Diolati, Siyi Wang, R Jeffrey Neitz, Daren Fearon, Dmytro S Radchenko, Yurii S Moroz, John J Irwin, Adam R Renslo, Jenny C Taylor, Jason E Gestwicki, Frank von Delft, Alan Ashworth, Ivan Ahel, Brian K Shoichet, Brian K Shoichet
Structure-based inhibitor optimization for the Nsp3 Macrodomain of SARS-CoV-2. bioRxiv : the preprint server for biology (2022)
Christopher G Evans, Jason E Gestwicki
Retraction of "Enantioselective Organocatalytic Hantzsch Synthesis of Polyhydroquinolines". Organic letters 23 (9) (2021)
Benjamin Caballero, Mathieu Bourdenx, Enrique Luengo, Antonio Diaz, Peter Dongmin Sohn, Xu Chen, Chao Wang, Yves R Juste, Susanne Wegmann, Bindi Patel, Zapporah T Young, Szu Yu Kuo, Jose Antonio Rodriguez-Navarro, Hao Shao, Manuela G López, Celeste M Karch, Alison Mary Goate, Jason E Gestwicki, Bradley T Hyman, Li Gan, Ana Maria Cuervo
Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature communications 12 (1) (2021)
Hao Shao, Keely Oltion, Taia Wu, Jason E Gestwicki
Differential scanning fluorimetry (DSF) screen to identify inhibitors of Hsp60 protein-protein interactions. Organic & biomolecular chemistry 18 (22) (2021)
Arielle Shkedi, Michael Adkisson, Andrew Schroeder, Walter L Eckalbar, Szu-Yu Kuo, Leonard Neckers, Jason E Gestwicki
Inhibitor Combinations Reveal Wiring of the Proteostasis Network in Prostate Cancer Cells. Journal of medicinal chemistry 64 (19) (2021)
Jennifer Abrams, Taylor Arhar, Sue Ann Mok, Isabelle R Taylor, Martin Kampmann, Jason E Gestwicki
Functional genomics screen identifies proteostasis targets that modulate prion protein (PrP) stability. Cell stress & chaperones 26 (2) (2021)
Isabelle R Taylor, Victoria A Assimon, Szu Yu Kuo, Silvia Rinaldi, Xiaokai Li, Zapporah T Young, Giulia Morra, Keith Green, Daniel Nguyen, Hao Shao, Sylvie Garneau-Tsodikova, Giorgio Colombo, Jason E Gestwicki
Tryptophan scanning mutagenesis as a way to mimic the compound-bound state and probe the selectivity of allosteric inhibitors in cells. Chemical science 11 (7) (2020)
Pui-Kei Wu, Seung-Keun Hong, Dmytro Starenki, Kiyoko Oshima, Hao Shao, Jason E Gestwicki, Susan Tsai, Jong-In Park
Mortalin/HSPA9 targeting selectively induces KRAS tumor cell death by perturbing mitochondrial membrane permeability. Oncogene 39 (21) (2020)
Yangjie Huang, Ning Zhao, Yung-Hua Wang, Charles Truillet, Junnian Wei, Joseph E Blecha, Henry F VanBrocklin, Youngho Seo, Mohd Sayeed, Brian J Feldman, Rahul Aggarwal, Spencer C Behr, Hao Shao, David M Wilson, Javier E Villanueva-Meyer, Jason E Gestwicki, Kenneth W Bayles
A Novel Radioligand Reveals Tissue Specific Pharmacological Modulation of Glucocorticoid Receptor Expression with Positron Emission Tomography. ACS chemical biology 15 (6) (2020)
Matthew Ravalin, Koli Basu, Jason E Gestwicki, Charles S Craik
End-Binding E3 Ubiquitin Ligases Enable Protease Signaling. ACS chemical biology 16 (11) (2019)
John J Chen, Diane L Nathaniel, Preethi Raghavan, Maxine Nelson, Ruilin Tian, Eric Tse, Jason Y Hong, Stephanie K See, Sue-Ann Mok, Marco Y Hein, Daniel R Southworth, Lea T Grinberg, Jason E Gestwicki, Manuel D Leonetti, Martin Edward Kampmann
Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. The Journal of biological chemistry 294 (50) (2019)
Bahareh Eftekharzadeh, Varuna C Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N Rauch, Samir R Nath, Daniel M C Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C Felli, Isabelle Brun-Heath, Jesús García, Ángel R Nebreda, Jason E Gestwicki, Andrew P Lieberman, Xavier Salvatella
Author Correction: Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nature communications 10 (1) (2019)
Matthew Ravalin, Panagiotis Theofilas, Koli Basu, Kwadwo A Opoku-Nsiah, Victoria A Assimon, Daniel Medina-Cleghorn, Yi-Fan Chen, Markus F Bohn, Michelle Arkin, Lea T Grinberg, Charles S Craik, Jason E Gestwicki
Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nature chemical biology 15 (8) (2019)
Bahareh Eftekharzadeh, Varuna C Banduseela, Giulio Chiesa, Paula Martínez-Cristóbal, Jennifer N Rauch, Samir R Nath, Daniel M C Schwarz, Hao Shao, Marta Marin-Argany, Claudio Di Sanza, Elisa Giorgetti, Zhigang Yu, Roberta Pierattelli, Isabella C Felli, Isabelle Brun-Heath, Jesús García, Ángel R Nebreda, Jason E Gestwicki, Andrew P Lieberman, Xavier Salvatella
Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. Nature communications 10 (1) (2019)
Rebecca Freilich, Miguel Betegon, Eric Tse, Sue-Ann Mok, Olivier Julien, David A Agard, Daniel R Southworth, Koh Takeuchi, Jason E Gestwicki
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau. Nature communications 9 (1) (2018)
Rebecca Freilich, Taylor Arhar, Jennifer L Abrams, Jason E Gestwicki
Protein-Protein Interactions in the Molecular Chaperone Network. Accounts of chemical research 51 (4) (2018)
Melanie Meister-Broekema, Rebecca Freilich, Chandhuru Jagadeesan, Jennifer N Rauch, Rocio Bengoechea, William W Motley, E F Elsiena Kuiper, Melania Minoia, Gabriel V Furtado, Maria A W H van Waarde, Shawn J Bird, Adriana Rebelo, Stephan Zuchner, Peter Pytel, Steven S Scherer, Federica F Morelli, Serena Carra, Conrad C Weihl, Steven Bergink, Jason E Gestwicki, Harm H Kampinga
Myopathy associated BAG3 mutations lead to protein aggregation by stalling Hsp70 networks. Nature communications 9 (1) (2018)
Isabelle R Taylor, Atta Ahmad, Taia Wu, Bryce A Nordhues, Anup Bhullar, Jason E Gestwicki, Erik R P Zuiderweg
The disorderly conduct of Hsc70 and its interaction with the Alzheimer's-related Tau protein. The Journal of biological chemistry 293 (27) (2018)
Silvia Rinaldi, Victoria A Assimon, Zapporah T Young, Giulia Morra, Hao Shao, Isabelle R Taylor, Jason E Gestwicki, Giorgio Colombo
A Local Allosteric Network in Heat Shock Protein 70 (Hsp70) Links Inhibitor Binding to Enzyme Activity and Distal Protein-Protein Interactions. ACS chemical biology 13 (11) (2018)
Hao Shao, Xiaokai Li, Michael A Moses, Luke A Gilbert, Chakrapani Kalyanaraman, Zapporah T Young, Margarita Chernova, Sara N Journey, Jonathan S Weissman, Byron Hann, Matthew P Jacobson, Len Neckers, Jason E Gestwicki
Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70). Journal of medicinal chemistry 61 (14) (2018)
Jason E Gestwicki, Hao Shao
Inhibitors and chemical probes for molecular chaperone networks. The Journal of biological chemistry 294 (6) (2018)
Samantha S Zaiter, Yuantao Huo, Fong Y Tiew, Jason E Gestwicki, Shelli R McAlpine
Designing de Novo Small Molecules That Control Heat Shock Protein 70 (Hsp70) and Heat Shock Organizing Protein (HOP) within the Chaperone Protein-Folding Machinery. Journal of medicinal chemistry 62 (2) (2018)
Sue-Ann Mok, Carlo Condello, Rebecca Freilich, Anne Gillies, Taylor Arhar, Javier Oroz, Harindranath Kadavath, Olivier Julien, Victoria A Assimon, Jennifer N Rauch, Bryan M Dunyak, Jungsoon Lee, Francis T F Tsai, Mark R Wilson, Markus Zweckstetter, Chad A Dickey, Jason E Gestwicki
Mapping interactions with the chaperone network reveals factors that protect against tau aggregation. Nature structural & molecular biology 25 (5) (2018)