Matthew P Crump (M P Crump)

Scopus Author ID ORCID

Publication Activity (10 Years)

Years Active: 2015-2024
Publications (10 Years): 43

Top Topics

Molecular Docking

Structural Basis

Top Venues

Angewandte Chemie (Weinheim an der Bergstrasse, Germany)

Angewandte Chemie (International ed. in English)

Chemical science

Scientific reports

This page only lists publications with an associated author ORCID identifier.

Publications

James I Bowen, Xiaotong Zhong, Kaining Gao, Benjamin Reed, Matthew P Crump, Luoyi Wang, Christine L Willis
Combining total synthesis and genetic engineering to probe dihydropyran formation in ambruticin biosynthesis. Chemical science 15 (14) (2024)
James I Bowen, Xiaotong Zhong, Kaining Gao, Benjamin Reed, Matthew P Crump, Luoyi Wang, Christine L Willis
Combining total synthesis and genetic engineering to probe dihydropyran formation in ambruticin biosynthesis. Chemical science 15 (14) (2024)
Ashley J Winter, R Nisha Khanizeman, Abigail M C Barker-Mountford, Andrew J Devine, Luoyi Wang, Zhongshu Song, Jonathan A Davies, Paul R Race, Christopher Williams, Thomas J Simpson, Christine L Willis, Matthew P Crump
Structure and Function of the α-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 135 (47) (2023)
George H Hutchins, Claire E M Noble, H Adrian Bunzel, Christopher Williams, Paulina Dubiel, Sathish K N Yadav, Paul M Molinaro, Rob Barringer, Hector Blackburn, Benjamin J Hardy, Alice E Parnell, Charles Landau, Paul R Race, Thomas A A Oliver, Ronald L Koder, Matthew P Crump, Christiane Schaffitzel, Ana Sofia F Oliveira, Adrian J Mulholland, John Leslie Ross Anderson
An expandable, modular de novo protein platform for precision redox engineering. Proceedings of the National Academy of Sciences of the United States of America 120 (31) (2023)
Ashley J Winter, R Nisha Khanizeman, Abigail M C Barker-Mountford, Andrew J Devine, Luoyi Wang, Zhongshu Song, Jonathan A Davies, Paul R Race, Christopher Williams, Thomas J Simpson, Christine L Willis, Matthew P Crump
Structure and Function of the α-Hydroxylation Bimodule of the Mupirocin Polyketide Synthase. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 135 (47) (2023)
Ashley J Winter, Matthew T Rowe, Angus N M Weir, Nahida Akter, Sbusisiwe Z Mbatha, Paul D Walker, Christopher Williams, Zhongshu Song, Paul R Race, Christine L Willis, Matthew P Crump
Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (50) (2022)
Andrew J Devine, Alice E Parnell, Catherine R Back, Nicholas R Lees, Samuel T Johns, Ainul Z Zulkepli, Rob Barringer, Katja Zorn, James E M Stach, Matthew P Crump, Martin A Hayes, Marc W Van der Kamp, Paul R Race, Christine L Willis
The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 135 (3) (2022)
James I Bowen, Luoyi Wang, Matthew P Crump, Christine L Willis
Synthetic and biosynthetic methods for selective cyclisations of 4,5-epoxy alcohols to tetrahydropyrans. Organic & biomolecular chemistry 20 (6) (2022)
Andrew J Devine, Alice E Parnell, Catherine R Back, Nicholas R Lees, Samuel T Johns, Ainul Z Zulkepli, Rob Barringer, Katja Zorn, James E M Stach, Matthew P Crump, Martin A Hayes, Marc W Van der Kamp, Paul R Race, Christine L Willis
The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 135 (3) (2022)
Ashley J Winter, Matthew T Rowe, Angus N M Weir, Nahida Akter, Sbusisiwe Z Mbatha, Paul D Walker, Christopher Williams, Zhongshu Song, Paul R Race, Christine L Willis, Matthew P Crump
Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin. Angewandte Chemie (International ed. in English) 61 (50) (2022)
Ashley J Winter, Matthew T Rowe, Angus N M Weir, Nahida Akter, Sbusisiwe Z Mbatha, Paul D Walker, Christopher Williams, Zhongshu Song, Paul R Race, Christine L Willis, Matthew P Crump
Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (50) (2022)
Ashley J Winter, Matthew T Rowe, Angus N M Weir, Nahida Akter, Sbusisiwe Z Mbatha, Paul D Walker, Christopher Williams, Zhongshu Song, Paul R Race, Christine L Willis, Matthew P Crump
Programmed Iteration Controls the Assembly of the Nonanoic Acid Side Chain of the Antibiotic Mupirocin. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 134 (50) (2022)
Andrew J Devine, Alice E Parnell, Catherine R Back, Nicholas R Lees, Samuel T Johns, Ainul Z Zulkepli, Rob Barringer, Katja Zorn, James E M Stach, Matthew P Crump, Martin A Hayes, Marc W Van der Kamp, Paul R Race, Christine L Willis
The Role of Cytochrome P450 AbyV in the Final Stages of Abyssomicin C Biosynthesis. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 135 (3) (2022)
James I Bowen, Luoyi Wang, Matthew P Crump, Christine L Willis
Ambruticins: tetrahydropyran ring formation and total synthesis. Organic & biomolecular chemistry 19 (28) (2022)
Stefano Artin Serapian, John Crosby, Matthew P Crump, Marc W Van der Kamp
Path to Actinorhodin: Regio- and Stereoselective Ketone Reduction by a Type II Polyketide Ketoreductase Revealed in Atomistic Detail. JACS Au 2 (4) (2022)
Paul D Walker, Angus N M Weir, Christine L Willis, Matthew P Crump
Polyketide β-branching: diversity, mechanism and selectivity. Natural product reports 38 (4) (2021)
William M Dawson, Eric J M Lang, Guto G Rhys, Kathryn L Shelley, Christopher Williams, R Leo Brady, Matthew P Crump, Adrian J Mulholland, Derek N Woolfson
Structural resolution of switchable states of a de novo peptide assembly. Nature communications 12 (1) (2021)
Thitapa Thongkawphueak, Ashley J Winter, Christopher Williams, Hannah J Maple, Siriwat Soontaranon, Chonthicha Kaewhan, Dominic J Campopiano, Matthew P Crump, Pakorn Wattana-Amorn
Solution Structure and Conformational Dynamics of a Doublet Acyl Carrier Protein from Prodigiosin Biosynthesis. Biochemistry 60 (3) (2021)
Zuriñe Antón, Johannes F Weijman, Christopher Williams, Edmund R R Moody, Judith M Mantell, Yan Y Yip, Jessica A Cross, Tom A Williams, Roberto A Steiner, Matthew P Crump, Derek N Woolfson, Mark P Dodding
Molecular mechanism for kinesin-1 direct membrane recognition. Science advances 7 (31) (2021)
Paul D Walker, Matthew T Rowe, Ashley J Winter, Angus N M Weir, Nahida Akter, Luoyi Wang, Paul R Race, Christopher Williams, Zhongshu Song, Thomas J Simpson, Christine L Willis, Matthew P Crump
A Priming Cassette Generates Hydroxylated Acyl Starter Units in Mupirocin and Thiomarinol Biosynthesis. ACS chemical biology 15 (2) (2020)
Luoyi Wang, Zhongshu Song, Paul R Race, James Spencer, Thomas J Simpson, Matthew P Crump, Christine L Willis
Mixing and matching genes of marine and terrestrial origin in the biosynthesis of the mupirocin antibiotics. Chemical science 11 (20) (2020)
Jonathan A Davies, Freya M Bull, Paul D Walker, Angus N M Weir, Rob Lavigne, Joleen Masschelein, Thomas J Simpson, Paul R Race, Matthew P Crump, Christine L Willis
Total Synthesis of Kalimantacin A. Organic letters 22 (16) (2020)
Christopher D Fage, Thomas Lathouwers, Michiel Vanmeert, Ling-Jie Gao, Kristof Vrancken, Eveline-Marie Lammens, Angus N M Weir, Ruben Degroote, Harry Cuppens, Simone Kosol, Thomas J Simpson, Matthew P Crump, Christine L Willis, Piet Herdewijn, Eveline Lescrinier, Rob Lavigne, Jozef Anné, Joleen Masschelein
The Kalimantacin Polyketide Antibiotics Inhibit Fatty Acid Biosynthesis in Staphylococcus aureus by Targeting the Enoyl-Acyl Carrier Protein Binding Site of FabI. Angewandte Chemie (International ed. in English) 59 (26) (2020)
Catherine R Back, Victoria A Higman, Kristian Le Vay, Viren V Patel, Alice E Parnell, Daniel Frankel, Howard F Jenkinson, Steven G Burston, Matthew P Crump, Angela H Nobbs, Paul R Race
The streptococcal multidomain fibrillar adhesin CshA has an elongated polymeric architecture. The Journal of biological chemistry 295 (19) (2020)
Waraporn Bunnak, Ashley J Winter, Colin M Lazarus, Matthew P Crump, Paul R Race, Pakorn Wattana-Amorn
SAXS reveals highly flexible interdomain linkers of tandem acyl carrier protein-thioesterase domains from a fungal nonreducing polyketide synthase. FEBS letters 595 (1) (2020)
Jack A Connolly, Amber Wilson, Malgorzata Macioszek, Zhongshu Song, Luoyi Wang, Hadi H Mohammad, Mukul Yadav, Maura di Martino, Claire E Miller, Joanne Hothersall, Anthony S Haines, Elton R Stephens, Matthew P Crump, Christine L Willis, Thomas J Simpson, Peter J Winn, Christopher M Thomas
Defining the genes for the final steps in biosynthesis of the complex polyketide antibiotic mupirocin by Pseudomonas fluorescens NCIMB10586. Scientific reports 9 (1) (2019)
Paul D Walker, Christopher Williams, Angus N M Weir, Luoyi Wang, John Crosby, Paul R Race, Thomas J Simpson, Christine L Willis, Matthew P Crump
Control of β-Branching in Kalimantacin Biosynthesis: Application of 13 C NMR to Polyketide Programming. Angewandte Chemie (International ed. in English) 58 (36) (2019)
Erik J B Landin, Silvia Lovera, Gianni De Fabritiis, Alastair D G Lawson, Joël Mercier, David McMillan, Richard B Sessions, Richard J Taylor, Zara A Sands, Lisa Joedicke, Matthew P Crump
The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor. Angewandte Chemie (International ed. in English) 58 (28) (2019)
Jennifer Hughes, Mirvat Surakhy, Sermet Can, Martin Ducker, Nick Davies, Francis Szele, Claudia Bühnemann, Emma J Carter, Roman Trikin, Matthew P Crump, Susana Frago, A Bassim Hassan
Maternal transmission of an Igf2r domain 11: IGF2 binding mutant allele (Igf2rI1565A) results in partial lethality, overgrowth and intestinal adenoma progression. Scientific reports 9 (1) (2019)
Kathryn L Porter Goff, Debbie Nicol, Christopher Williams, Matthew P Crump, Francis Zieleniewski, Jennifer L Samphire, Emily G Baker, Derek N Woolfson
Stabilizing and Understanding a Miniprotein by Rational Redesign. Biochemistry 58 (28) (2019)
Sarah A Smith, Richard B Sessions, Deborah K Shoemark, Christopher Williams, Reza Ebrahimighaei, Madeleine C McNeill, Matthew P Crump, Tristan R McKay, Gemma Harris, Andrew C Newby, Mark Bond
Antiproliferative and Antimigratory Effects of a Novel YAP-TEAD Interaction Inhibitor Identified Using in Silico Molecular Docking. Journal of medicinal chemistry 62 (3) (2019)
Emmanuelle Casanova, Timothy D J Knowles, Christopher Williams, Matthew P Crump, Richard P Evershed
Practical Considerations in High-Precision Compound-Specific Radiocarbon Analyses: Eliminating the Effects of Solvent and Sample Cross-Contamination on Accuracy and Precision. Analytical chemistry 90 (18) (2018)
Christophe J Lalaurie, Virginie Dufour, Anna Meletiou, Sarah Ratcliffe, Abigail Harland, Olivia Wilson, Chiratchaya Vamasiri, Deborah K Shoemark, Christopher Williams, Christopher J Arthur, Richard B Sessions, Matthew P Crump, J L Ross Anderson, Paul Curnow
The de novo design of a biocompatible and functional integral membrane protein using minimal sequence complexity. Scientific reports 8 (1) (2018)
Ashley J Winter, Christopher Williams, Michail N Isupov, Hannah Crocker, Mariya Gromova, Philip Marsh, Oliver J Wilkinson, Mark S Dillingham, Nicholas J Harmer, Richard W Titball, Matthew P Crump
The molecular basis of protein toxin HicA-dependent binding of the protein antitoxin HicB to DNA. The Journal of biological chemistry 293 (50) (2018)
Robert A Tromans, Tom S Carter, Laurent Chabanne, Matthew P Crump, Hongyu Li, Johnathan V Matlock, Michael G Orchard, Anthony P Davis
A biomimetic receptor for glucose. Nature chemistry 11 (1) (2018)
Bryan D Ellis, Jacob C Milligan, Alexander R White, Vy Duong, Pilar X Altman, Lina Y Mohammed, Matthew P Crump, John Crosby, Ray Luo, Christopher D Vanderwal, Shiou-Chuan Tsai
An Oxetane-Based Polyketide Surrogate To Probe Substrate Binding in a Polyketide Synthase. Journal of the American Chemical Society 140 (15) (2018)
Daniel W Watkins, Jonathan M X Jenkins, Katie J Grayson, Nicola Wood, Jack W Steventon, Kristian Kyle Le Vay, Matthew I Goodwin, Anna S Mullen, Henry J Bailey, Matthew P Crump, Fraser MacMillan, Adrian J Mulholland, Gus Cameron, Richard B Sessions, Stephen Mann, J L Ross Anderson
Construction and in vivo assembly of a catalytically proficient and hyperthermostable de novo enzyme. Nature communications 8 (1) (2017)
Iain R G Thistlethwaite, Freya M Bull, Chengsen Cui, Paul D Walker, Shu-Shan Gao, Luoyi Wang, Zhongshu Song, Joleen Masschelein, Rob Lavigne, Matthew P Crump, Paul R Race, Thomas J Simpson, Christine L Willis
Elucidation of the relative and absolute stereochemistry of the kalimantacin/batumin antibiotics. Chemical science 8 (9) (2017)
Shu-Shan Gao, Luoyi Wang, Zhongshu Song, Joanne Hothersall, Elton R Stevens, Jack Connolly, Peter J Winn, Russell J Cox, Matthew P Crump, Paul R Race, Christopher M Thomas, Thomas J Simpson, Christine L Willis
Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics. Angewandte Chemie (International ed. in English) 56 (14) (2017)
Emily G Baker, Christopher Williams, Kieran L Hudson, Gail J Bartlett, Jack W Heal, Kathryn L Porter Goff, Richard B Sessions, Matthew P Crump, Derek N Woolfson
Engineering protein stability with atomic precision in a monomeric miniprotein. Nature chemical biology 13 (7) (2017)
David R Jackson, Gaurav Shakya, Avinash B Patel, Lina Y Mohammed, Kostas Vasilakis, Pakorn Wattana-Amorn, Timothy R Valentic, Jacob C Milligan, Matthew P Crump, John Crosby, Shiou-Chuan Tsai
Structural and Functional Studies of the Daunorubicin Priming Ketosynthase DpsC. ACS chemical biology 13 (1) (2017)
Pablo Ríos, Tiddo Jonathan Mooibroek, Tom S Carter, Christopher Williams, Miriam R Wilson, Matthew P Crump, Anthony P Davis
Enantioselective carbohydrate recognition by synthetic lectins in water. Chemical science 8 (5) (2017)
Tom S Carter, Tiddo J Mooibroek, Patrick F N Stewart, Matthew P Crump, M Carmen Galan, Anthony P Davis
Platform Synthetic Lectins for Divalent Carbohydrate Recognition in Water. Angewandte Chemie (International ed. in English) 55 (32) (2016)
Xu Dong, Christopher D Bailey, Christopher Williams, John Crosby, Thomas J Simpson, Christine L Willis, Matthew P Crump
Recognition of extended linear and cyclised polyketide mimics by a type II acyl carrier protein. Chemical science 7 (3) (2015)