Michael Gregory Kharas (Michael G Kharas)

ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 30

Top Venues

Nature communications

Science (New York, N.Y.)

Blood

Science advances

University of California Irvine (PHD)

This page only lists publications with an associated author ORCID identifier.

Education History

University of California Irvine Sep 17 2001 - Jun 15 2006

United States

PHD :: Molecular Biology and Biochemistry

Publications

Hanzhi Luo, Michael Gregory Kharas
Dotting out AML by targeting Fibrillarin. Cancer research (2024)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Tao Dao, Guangyan Xiong, Sung Soo Mun, Jeremy Meyerberg, Tatyana Korontsvit, Jingyi Xiang, Ziyou Cui, Aaron Y Chang, Casey A Jarvis, Winson Cai, Hanzhi Luo, Aspen J Pierson, Anthony F Daniyan, Sarah Yoo, Sumiko Takao, Michael Gregory Kharas, Alex Kentsis, Cheng Liu, David A Scheinberg
Dual-receptor T cell platform with Ab-TCR and costimulatory receptor achieves specificity and potency against AML. Blood (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Vianne R Gao, Rui Yang, Arnav Das, Renhe Luo, Hanzhi Luo, Dylan R McNally, Ioannis Karagiannidis, Martín A Rivas, Zhong-Min Wang, Darko Barisic, Alireza Karbalayghareh, Wilfred Wong, Yingqian Ada Zhan, Christopher R Chin, William Noble, Jeff A Bilmes, Effie Apostolou, Michael Gregory Kharas, Wendy Béguelin, Aaron D Viny, Danwei Huangfu, Alexander Y Rudensky, Ari M Melnick, Christina S Leslie
ChromaFold predicts the 3D contact map from single-cell chromatin accessibility. bioRxiv : the preprint server for biology (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Andriana G Kotini, Saul Carcamo, Nataly Cruz-Rodriguez, Malgorzata Olszewska, Tiansu Wang, Deniz Demircioglu, Chan-Jung Chang, Elsa Bernard, Mark P Chao, Ravindra Majeti, Hanzhi Luo, Michael Gregory Kharas, Dan Hasson, Eirini P Papapetrou
Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia. Blood cancer discovery (2023)
Coraline Mlynarczyk, Matthew R Teater, Juhee Pae, Christopher R Chin, Ling Wang, Theinmozhi Arulraj, Darko Barisic, Antonin Papin, Kenneth B Hoehn, Ekaterina Kots, Jonatan Ersching, Arnab Bandyopadhyay, Ersilia Barin, Hui Xian Poh, Chiara M Evans, Amy Chadburn, Zhengming Chen, Hao Shen, Hannah M Isles, Benedikt W Pelzer, Ioanna Tsialta, Ashley S Doane, Huimin Geng, Muhammad Hassan Rehman, Jonah Melnick, Wyatt Morgan, Diu T T Nguyen, Olivier Elemento, Michael Gregory Kharas, Samie R Jaffrey, David W Scott, George Khelashvili, Michael Meyer Hermann, Gabriel D Victora, Ari M Melnick
BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.) 379 (6629) (2023)
Coraline Mlynarczyk, Matthew R Teater, Juhee Pae, Christopher R Chin, Ling Wang, Theinmozhi Arulraj, Darko Barisic, Antonin Papin, Kenneth B Hoehn, Ekaterina Kots, Jonatan Ersching, Arnab Bandyopadhyay, Ersilia Barin, Hui Xian Poh, Chiara M Evans, Amy Chadburn, Zhengming Chen, Hao Shen, Hannah M Isles, Benedikt W Pelzer, Ioanna Tsialta, Ashley S Doane, Huimin Geng, Muhammad Hassan Rehman, Jonah Melnick, Wyatt Morgan, Diu T T Nguyen, Olivier Elemento, Michael Gregory Kharas, Samie R Jaffrey, David W Scott, George Khelashvili, Michael Meyer Hermann, Gabriel D Victora, Ari M Melnick
BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.) 379 (6629) (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Coraline Mlynarczyk, Matthew R Teater, Juhee Pae, Christopher R Chin, Ling Wang, Theinmozhi Arulraj, Darko Barisic, Antonin Papin, Kenneth B Hoehn, Ekaterina Kots, Jonatan Ersching, Arnab Bandyopadhyay, Ersilia Barin, Hui Xian Poh, Chiara M Evans, Amy Chadburn, Zhengming Chen, Hao Shen, Hannah M Isles, Benedikt W Pelzer, Ioanna Tsialta, Ashley S Doane, Huimin Geng, Muhammad Hassan Rehman, Jonah Melnick, Wyatt Morgan, Diu T T Nguyen, Olivier Elemento, Michael Gregory Kharas, Samie R Jaffrey, David W Scott, George Khelashvili, Michael Meyer Hermann, Gabriel D Victora, Ari M Melnick
BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.) 379 (6629) (2023)
Coraline Mlynarczyk, Matthew R Teater, Juhee Pae, Christopher R Chin, Ling Wang, Theinmozhi Arulraj, Darko Barisic, Antonin Papin, Kenneth B Hoehn, Ekaterina Kots, Jonatan Ersching, Arnab Bandyopadhyay, Ersilia Barin, Hui Xian Poh, Chiara M Evans, Amy Chadburn, Zhengming Chen, Hao Shen, Hannah M Isles, Benedikt W Pelzer, Ioanna Tsialta, Ashley S Doane, Huimin Geng, Muhammad Hassan Rehman, Jonah Melnick, Wyatt Morgan, Diu T T Nguyen, Olivier Elemento, Michael Gregory Kharas, Samie R Jaffrey, David W Scott, George Khelashvili, Michael Meyer Hermann, Gabriel D Victora, Ari M Melnick
BTG1 mutation yields supercompetitive B cells primed for malignant transformation. Science (New York, N.Y.) 379 (6629) (2023)
Florisela Herrejon Chavez, Hanzhi Luo, Paolo Cifani, Alli Pine, Karen L Chu, Suhasini Joshi, Ersilia Barin, Alexandra Schurer, Mandy Chan, Kathryn Chang, Grace Y Q Han, Aspen J Pierson, Michael Xiao, Xuejing Yang, Lindsey M Kuehm, Yuning Hong, Diu T T Nguyen, Gabriela Chiosis, Alex Kentsis, Christina S Leslie, Ly Phuong Vu, Michael Gregory Kharas
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature communications 14 (1) (2023)
Martin G Klatt, Tao Dao, Zhiyuan Yang, Jianying Liu, Sung Soo Mun, Megan M Dacek, Hanzhi Luo, Thomas J Gardner, Christopher M Bourne, Leila Peraro, Zita E H Aretz, Tanya Korontsvit, Michael Lau, Michael Gregory Kharas, Cheng Liu, David A Scheinberg
A TCR mimic CAR T cell specific for NDC80 is broadly reactive with solid tumors and hematologic malignancies. Blood 140 (8) (2022)
Tatiana Erazo, Chiara M Evans, Daniel Zakheim, Karen L Chu, Alice Yunsi Refermat, Zahra Asgari, Xuejing Yang, Mariana Da Silva Ferreira, Sanjoy Mehta, Marco Vincenzo Russo, Andrea Knezevic, Xi-Ping Zhang, Zhengming Chen, Myles Fennell, Ralph Garippa, Venkatraman E Seshan, Elisa de Stanchina, Olena Barbash, Connie Lee Batlevi, Christina S Leslie, Ari M Melnick, Anas Younes, Michael Gregory Kharas
TP53 mutations and RNA-binding protein MUSASHI-2 drive resistance to PRMT5-targeted therapy in B-cell lymphoma. Nature communications 13 (1) (2022)
Veronica Granatiero, Nicole M Sayles, Angela M Savino, Csaba Konrad, Michael Gregory Kharas, Hibiki Kawamata, Giovanni Manfredi
Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1G93A astrocytes. Autophagy (2021)
Ying Wang, Frederick S Yen, Xiphias Ge Zhu, Rebecca C Timson, Ross Weber, Changrui Xing, Yuyang Liu, Benjamin Allwein, Hanzhi Luo, Hsi-Wen Yeh, Søren Heissel, Gokhan Unlu, Eric R Gamazon, Michael Gregory Kharas, Richard K Hite, Kivanç Birsoy
SLC25A39 is necessary for mitochondrial glutathione import in mammalian cells. Nature 599 (7883) (2021)
Florencia Palacios, Xiao-Jie Yan, Gerardo Ferrer, Shih-Shih Chen, Stefano Vergani, Xuejing Yang, Jeffrey Gardner, Jaqueline C Barrientos, Philip Rock, W Richard Burack, Jonathan E Kolitz, Steven L Allen, Michael Gregory Kharas, Omar Abdel-Wahab, Kanti R Rai, Nicholas Chiorazzi
Musashi 2 influences chronic lymphocytic leukemia cell survival and growth making it a potential therapeutic target. Leukemia 35 (4) (2021)
Montalbano Mauro, Salome A McAllen, Nicha Puangmalai, Urmi Sengupta, Nemil Bhatt, Omar D Johnson, Michael Gregory Kharas, Rakez Kayed
RNA-binding proteins Musashi and tau soluble aggregates initiate nuclear dysfunction. Nature communications 11 (1) (2020)
Diu T T Nguyen, Yuheng Lu, Karen L Chu, Xuejing Yang, Sun-Mi Park, Zi-Ning Choo, Christopher R Chin, Camila Prieto, Alexandra Schurer, Ersilia Barin, Angela M Savino, Saroj Gourkanti, Payal Patel, Ly P Vu, Christina S Leslie, Michael Gregory Kharas
HyperTRIBE uncovers increased MUSASHI-2 RNA binding activity and differential regulation in leukemic stem cells. Nature communications 11 (1) (2020)
Gerard Minuesa, Steven K Albanese, Wei Xie, Yaniv Kazansky, Daniel Worroll, Arthur Chow, Alexandra Schurer, Sun-Mi Park, Christina Z Rotsides, James Taggart, Andrea Rizzi, Levi N Naden, Timothy Chou, Saroj Gourkanti, Daniel Cappel, Maria C Passarelli, Lauren Fairchild, Carolina Adura, J Fraser Glickman, Jessica Schulman, Christopher Famulare, Minal Patel, Joseph K Eibl, Gregory M Ross, Shibani Bhattacharya, Derek S Tan, Christina S Leslie, Thijs Beuming, Dinshaw J Patel, Yehuda Goldgur, John D Chodera, Michael Gregory Kharas
Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia. Nature communications 10 (1) (2019)
Justin Taylor, Maria Sendino, Alexander N Gorelick, Alessandro Pastore, Matthew T Chang, Alexander V Penson, Elena I Gavrila, Connor Stewart, Ella M Melnik, Florisela Herrejon Chavez, Lillian Bitner, Akihide Yoshimi, Stanley Chun-Wei Lee, Daichi Inoue, Bo Liu, Xiao J Zhang, Anthony R Mato, Ahmet Dogan, Michael Gregory Kharas, Yuhong Chen, Demin Wang, Rajesh K Soni, Ronald C Hendrickson, Gorka Prieto, Jose A Rodriguez, Omar Abdel-Wahab
Altered Nuclear Export Signal Recognition as a Driver of Oncogenesis. Cancer discovery 9 (10) (2019)
Kavitha Ramaswamy, Lauren Forbes, Gerard Minuesa, Tatyana Gindin, Fiona Brown, Michael Gregory Kharas, Andrei V Krivtsov, Scott A Armstrong, Eric Still, Elisa de Stanchina, Birgit Knoechel, Richard Koche, Alex Kentsis
Peptidomimetic blockade of MYB in acute myeloid leukemia. Nature communications 9 (1) (2018)
Ly P Vu, Brian F Pickering, Yuanming Cheng, Sara Zaccara, Diu Nguyen, Gerard Minuesa, Timothy Chou, Arthur Chow, Yogesh Saletore, Matthew MacKay, Jessica Schulman, Christopher Famulare, Minal Patel, Virginia M Klimek, Francine E Garrett-Bakelman, Ari Melnick, Martin Carroll, Christopher E Mason, Samie R Jaffrey, Michael Gregory Kharas
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells. Nature medicine 23 (11) (2017)
Ly P Vu, Camila Prieto, Elianna M Amin, Sagar Chhangawala, Andrei Krivtsov, M Nieves Calvo-Vidal, Timothy Chou, Arthur Chow, Gerard Minuesa, Sun Mi Park, Trevor S Barlowe, James Taggart, Patrick Tivnan, Raquel P Deering, Lisa P Chu, Jeong-Ah Kwon, Cem Meydan, Javier Perales-Patón, Arora Arshi, Mithat Gönen, Christopher Famulare, Minal Patel, Elisabeth Paietta, Martin S Tallman, Yuheng Lu, Jacob Lowell Glass, Francine E Garret-Bakelman, Ari Melnick, Ross Levine, Fatima Al-Shahrour, Marcus Järås, Nir Hacohen, Alexia Hwang, Ralph Garippa, Christopher J Lengner, Scott A Armstrong, Leandro Cerchietti, Glenn S Cowley, David Root, John G Doench, Christina Leslie, Benjamin L Ebert, Michael Gregory Kharas
Functional screen of MSI2 interactors identifies an essential role for SYNCRIP in myeloid leukemia stem cells. Nature genetics 49 (6) (2017)
Sangmoo Jeong, Roozbeh Eskandari, Sun Mi Park, Julio Alvarez, Sui Seng Tee, Ralph Weissleder, Michael Gregory Kharas, Hakho Lee, Kayvan R Keshari
Real-time quantitative analysis of metabolic flux in live cells using a hyperpolarized micromagnetic resonance spectrometer. Science advances 3 (6) (2017)
James Taggart, Tzu-Chieh Ho, Elianna Amin, Haiming Xu, Trevor S Barlowe, Alexendar R Perez, Benjamin H Durham, Patrick Tivnan, Rachel Okabe, Arthur Chow, Ly Vu, Sun Mi Park, Camila Prieto, Christopher Famulare, Minal Patel, Christopher J Lengner, Amit Verma, Gail Roboz, Monica Guzman, Virginia M Klimek, Omar Abdel-Wahab, Christina Leslie, Stephen D Nimer, Michael Gregory Kharas
MSI2 is required for maintaining activated myelodysplastic syndrome stem cells. Nature communications 7 (2016)
Maryam Yousefi, Ning Li, Angela Nakauka-Ddamba, Shan Wang, Kimberly Ann Davidow, Jenna Schoenberger, Zhengquan Yu, Shane T Jensen, Michael Gregory Kharas, Christopher J Lengner
Msi RNA-binding proteins control reserve intestinal stem cell quiescence. The Journal of cell biology 215 (3) (2016)

Michael Gregory Kharas.css-eqlu8i{font-size:small;padding-left:4px;} (Michael G Kharas)

Publication Activity (10 Years)

Top Topics

Top Venues

Michael Gregory Kharas (Michael G Kharas)