Michael J Blackman

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 35

Top Topics

Plasmodium Falciparum

Structural Basis

Monoclonal Antibody

Top Venues

Journal of medicinal chemistry

bioRxiv : the preprint server for biology

This page only lists publications with an associated author ORCID identifier.

Publications

John M Bennett, Sunil K Narwal, Stephanie Kabeche, Daniel Abegg, Fiona Hackett, Tomas Yeo, Veronica L Li, Ryan K Muir, Franco F Faucher, Scott Lovell, Michael J Blackman, Alexander Adibekian, Ellen Yeh, David A Fidock, Matthew M Bogyo
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets. bioRxiv : the preprint server for biology (2024)
John M Bennett, Sunil K Narwal, Stephanie Kabeche, Daniel Abegg, Fiona Hackett, Tomas Yeo, Veronica L Li, Ryan K Muir, Franco F Faucher, Scott Lovell, Michael J Blackman, Alexander Adibekian, Ellen Yeh, David A Fidock, Matthew M Bogyo
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets. bioRxiv : the preprint server for biology (2024)
John M Bennett, Sunil K Narwal, Stephanie Kabeche, Daniel Abegg, Fiona Hackett, Tomas Yeo, Veronica L Li, Ryan K Muir, Franco F Faucher, Scott Lovell, Michael J Blackman, Alexander Adibekian, Ellen Yeh, David A Fidock, Matthew M Bogyo
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets. bioRxiv : the preprint server for biology (2024)
Chrislaine Withers-Martinez, Elina Lidumniece, Fiona Hackett, Christine R Collins, Zahie Taha, Michael J Blackman, Aigars Jirgensons
Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome. Journal of medicinal chemistry (2024)
Chrislaine Withers-Martinez, Elina Lidumniece, Fiona Hackett, Christine R Collins, Zahie Taha, Michael J Blackman, Aigars Jirgensons
Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome. Journal of medicinal chemistry 67 (15) (2024)
John M Bennett, Sunil K Narwal, Stephanie Kabeche, Daniel Abegg, Fiona Hackett, Tomas Yeo, Veronica L Li, Ryan K Muir, Franco F Faucher, Scott Lovell, Michael J Blackman, Alexander Adibekian, Ellen Yeh, David A Fidock, Matthew M Bogyo
Mixed Alkyl/Aryl Phosphonates Identify Metabolic Serine Hydrolases as Antimalarial Targets. bioRxiv : the preprint server for biology (2024)
Chrislaine Withers-Martinez, Elina Lidumniece, Fiona Hackett, Christine R Collins, Zahie Taha, Michael J Blackman, Aigars Jirgensons
Peptidic Boronic Acid Plasmodium falciparum SUB1 Inhibitors with Improved Selectivity over Human Proteasome. Journal of medicinal chemistry 67 (15) (2024)
Vadims Kovada, Chrislaine Withers-Martinez, Raitis Bobrovs, Hele Na Ce Rule, Edgars Liepins, Solveiga Grinberga, Fiona Hackett, Christine R Collins, Agrita Kreicberga, María Belén Jiménez-Díaz, Iñigo Angulo-Barturen, Dace Rasina, Edgars Suna, Kristaps Jaudzems, Michael J Blackman, Aigars Jirgensons
Macrocyclic Peptidomimetic Plasmepsin X Inhibitors with Potent In Vitro and In Vivo Antimalarial Activity. Journal of medicinal chemistry (2023)
Paul-Christian Burda, Abhinay Ramaprasad, Sabrina Bielfeld, Emma Pietsch, Anna Woitalla, Christoph Söhnchen, Mehar Nihal Singh, Jan Strauss, Aaron Sait, Lucy M Collinson, Dominik Schwudke, Michael J Blackman, Tim-Wolf Gilberger
Global analysis of putative phospholipases in Plasmodium falciparum reveals an essential role of the phosphoinositide-specific phospholipase C in parasite maturation. mBio (2023)
Arne Alder, Cecilia Palmira Sanchez, Matthew Robert Geoffrey Russell, Lucy M Collinson, Michael Lanzer, Michael J Blackman, Tim-Wolf Gilberger, Joachim M Matz
The role of Plasmodium V-ATPase in vacuolar physiology and antimalarial drug uptake. Proceedings of the National Academy of Sciences of the United States of America 120 (30) (2023)
Abhinay Ramaprasad, Paul-Christian Burda, Konstantinos Koussis, James A Thomas, Emma Pietsch, Enrica Calvani, Steven A Howell, James I MacRae, Ambrosius P Snijders, Tim-Wolf Gilberger, Michael J Blackman
A malaria parasite phospholipase facilitates efficient asexual blood stage egress. PLoS pathogens 19 (6) (2023)
Emma Pietsch, Abhinay Ramaprasad, Sabrina Bielfeld, Yvonne Wohlfarter, Bohumil Maco, Korbinian Niedermüller, Louisa Wilcke, Joachim Kloehn, Markus Andreas Keller, Dominique Soldati, Michael J Blackman, Tim-Wolf Gilberger, Paul-Christian Burda
A patatin-like phospholipase is important for mitochondrial function in malaria parasites. mBio (2023)
Abhinay Ramaprasad, Paul-Christian Burda, Enrica Calvani, Aaron J Sait, Susana Alejandra Palma-Duran, Chrislaine Withers-Martinez, Fiona Hackett, James I MacRae, Lucy Collinson, Tim-Wolf Gilberger, Michael J Blackman
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite. eLife 11 (2022)
Abhinay Ramaprasad, Paul-Christian Burda, Enrica Calvani, Aaron J Sait, Susana Alejandra Palma-Duran, Chrislaine Withers-Martinez, Fiona Hackett, James I MacRae, Lucy Collinson, Tim-Wolf Gilberger, Michael J Blackman
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite. eLife 11 (2022)
Abhinay Ramaprasad, Paul-Christian Burda, Enrica Calvani, Aaron J Sait, Susana Alejandra Palma-Duran, Chrislaine Withers-Martinez, Fiona Hackett, James I MacRae, Lucy Collinson, Tim-Wolf Gilberger, Michael J Blackman
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite. eLife 11 (2022)
Abhinay Ramaprasad, Paul-Christian Burda, Enrica Calvani, Aaron J Sait, Susana Alejandra Palma-Duran, Chrislaine Withers-Martinez, Fiona Hackett, James I MacRae, Lucy Collinson, Tim-Wolf Gilberger, Michael J Blackman
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite. eLife 11 (2022)
Elina Lidumniece, Chrislaine Withers-Martinez, Fiona Hackett, Michael J Blackman, Aigars Jirgensons
Subtilisin-like Serine Protease 1 (SUB1) as an Emerging Antimalarial Drug Target: Current Achievements in Inhibitor Discovery. Journal of medicinal chemistry 65 (19) (2022)
Abhinay Ramaprasad, Paul-Christian Burda, Enrica Calvani, Aaron J Sait, Susana Alejandra Palma-Duran, Chrislaine Withers-Martinez, Fiona Hackett, James I MacRae, Lucy Collinson, Tim-Wolf Gilberger, Michael J Blackman
A choline-releasing glycerophosphodiesterase essential for phosphatidylcholine biosynthesis and blood stage development in the malaria parasite. eLife 11 (2022)
Aurélia C Balestra, Konstantinos Koussis, Natacha Klages, Steven A Howell, Helen R Flynn, Marcus Bantscheff, Carla Pasquarello, Abigail J Perrin, Lorenzo Brusini, Patrizia Arboit, Olalla Sanz, Laura Peces-Barba Castaño, Chrislaine Withers-Martinez, Alexandre Hainard, Sonja Ghidelli-Disse, Ambrosius P Snijders, David Andrew Baker, Michael J Blackman, Mathieu Brochet
Ca2+ signals critical for egress and gametogenesis in malaria parasites depend on a multipass membrane protein that interacts with PKG. Science advances 7 (13) (2021)
Elina Lidumniece, Chrislaine Withers-Martinez, Fiona Hackett, Christine R Collins, Abigail J Perrin, Konstantinos Koussis, Claudine Bisson, Michael J Blackman, Aigars Jirgensons
Peptidic boronic acids are potent cell-permeable inhibitors of the malaria parasite egress serine protease SUB1. Proceedings of the National Academy of Sciences of the United States of America 118 (20) (2021)
Michele S Y Tan, Konstantinos Koussis, Chrislaine Withers-Martinez, Steven A Howell, James A Thomas, Fiona Hackett, Ellen Knuepfer, Min Shen, Matthew D Hall, Ambrosius P Snijders, Michael J Blackman
Autocatalytic activation of a malarial egress protease is druggable and requires a protein cofactor. The EMBO journal 40 (11) (2021)
Abigail J Perrin, Claudine Bisson, Peter A Faull, Matthew J Renshaw, Rebecca A Lees, Roland A Fleck, Helen R Saibil, Ambrosius P Snijders, David Andrew Baker, Michael J Blackman
Malaria Parasite Schizont Egress Antigen-1 Plays an Essential Role in Nuclear Segregation during Schizogony. mBio 12 (2) (2021)
Michele S Y Tan, Michael J Blackman
Malaria parasite egress at a glance. Journal of cell science 134 (5) (2021)
Konstantinos Koussis, Chrislaine Withers-Martinez, David A Baker, Michael J Blackman
Simultaneous multiple allelic replacement in the malaria parasite enables dissection of PKG function. Life science alliance 3 (4) (2020)
Joachim M Matz, Josh R Beck, Michael J Blackman
The parasitophorous vacuole of the blood-stage malaria parasite. Nature reviews. Microbiology 18 (7) (2020)
Christine R Collins, Fiona Hackett, Steven A Howell, Ambrosius P Snijders, Matthew Robert Geoffrey Russell, Lucy M Collinson, Michael J Blackman
The malaria parasite sheddase SUB2 governs host red blood cell membrane sealing at invasion. eLife 9 (2020)
Christian Flueck, Laura G Drought, Andrew Jones, Avnish Patel, Abigail J Perrin, Eloise M Walker, Stephanie D Nofal, Ambrosius P Snijders, Michael J Blackman, David Andrew Baker
Phosphodiesterase beta is the master regulator of cAMP signalling during malaria parasite invasion. PLoS biology 17 (2) (2019)
Avnish Patel, Abigail J Perrin, Helen R Flynn, Claudine Bisson, Chrislaine Withers-Martinez, Moritz Treeck, Christian Flueck, Giuseppe Nicastro, Stephen R Martin, Andres Ramos, Tim W Gilberger, Ambrosius P Snijders, Michael J Blackman, David Andrew Baker
Cyclic AMP signalling controls key components of malaria parasite host cell invasion machinery. PLoS biology 17 (5) (2019)
Emma S Sherling, Abigail J Perrin, Ellen Knuepfer, Matthew Robert Geoffrey Russell, Lucy M Collinson, Louis H Miller, Michael J Blackman
The Plasmodium falciparum rhoptry bulb protein RAMA plays an essential role in rhoptry neck morphogenesis and host red blood cell invasion. PLoS pathogens 15 (9) (2019)
Paco Pino, Reto Caldelari, Budhaditya Mukherjee, Juha Vahokoski, Natacha Klages, Bohumil Maco, Christine R Collins, Michael J Blackman, Inari Kursula, Volker T Heussler, Mathieu Brochet, Dominique Soldati
A multistage antimalarial targets the plasmepsins IX and X essential for invasion and egress. Science (New York, N.Y.) 358 (6362) (2018)
Nonlawat Boonyalai, Christine R Collins, Fiona Hackett, Chrislaine Withers-Martinez, Michael J Blackman
Essentiality of Plasmodium falciparum plasmepsin V. PloS one 13 (12) (2018)
James A Thomas, Michele S Y Tan, Claudine Bisson, Aaron Borg, Trishant R Umrekar, Fiona Hackett, Victoria L Hale, Gema Vizcay-Barrena, Roland A Fleck, Ambrosius P Snijders, Helen R Saibil, Michael J Blackman
A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells. Nature microbiology 3 (4) (2018)
Ernest Diez Benavente, Paola Florez de Sessions, Robert William Moon, Anthony A Holder, Michael J Blackman, Cally Roper, Christopher J Drakeley, Arnab Pain, Colin J Sutherland, Martin Lloyd Hibberd, Susana Campino, Taane Gregory Clark
Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations. PLoS genetics 13 (9) (2017)
Christine R Collins, Fiona Hackett, Jonathan Atid, Michele Ser Ying Tan, Michael J Blackman
The Plasmodium falciparum pseudoprotease SERA5 regulates the kinetics and efficiency of malaria parasite egress from host erythrocytes. PLoS pathogens 13 (7) (2017)
Emma S Sherling, Ellen Knuepfer, Joseph A Brzostowski, Louis H Miller, Michael J Blackman, Christiaan van Ooij
The Plasmodium falciparum rhoptry protein RhopH3 plays essential roles in host cell invasion and nutrient uptake. eLife 6 (2017)