Nicolas L Fawzi

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 48

Top Topics

Transcription Factor

Amyotrophic Lateral Sclerosis

Top Venues

bioRxiv : the preprint server for biology

Protein science : a publication of the Protein Society

Nature microbiology

The EMBO journal

This page only lists publications with an associated author ORCID identifier.

Publications

Priyesh Mohanty, Azamat Rizuan, Young C Kim, Nicolas L Fawzi, Jeetain Mittal
A complex network of interdomain interactions underlies the conformational ensemble of monomeric TDP-43 and modulates its phase behavior. Protein science : a publication of the Protein Society 33 (2) (2024)
Noah Wake, Shuo-Lin Weng, Tongyin Zheng, Szu-Huan Wang, Valentin Kirilenko, Jeetain Mittal, Nicolas L Fawzi
Expanding the molecular grammar of polar residues and arginine in FUS prion-like domain phase separation and aggregation. bioRxiv : the preprint server for biology (2024)
Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Azamat Rizuan, Titus M Franzmann, Aleksandra V Sergeeva, Patricia M Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L Danielson, Alf Honigmann, Yuna M Ayala, Nicolas L Fawzi, Jeetain Mittal, Simon Alberti, Anthony A Hyman
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. bioRxiv : the preprint server for biology (2024)
Priyesh Mohanty, Azamat Rizuan, Young C Kim, Nicolas L Fawzi, Jeetain Mittal
A complex network of interdomain interactions underlies the conformational ensemble of monomeric TDP-43 and modulates its phase behavior. Protein science : a publication of the Protein Society 33 (2) (2024)
Azamat Rizuan, Jayakrishna Shenoy, Priyesh Mohanty, Patricia M S Dos Passos, José F Mercado Ortiz, Leanna Bai, Renjith Viswanathan, Szu-Huan Wang, Victoria Johnson, Lohany D Mamede, Yuna M Ayala, Rodolfo Ghirlando, Jeetain Mittal, Nicolas L Fawzi
Structural details of helix-mediated TDP-43 C-terminal domain multimerization. bioRxiv : the preprint server for biology (2024)
Noah Wake, Shuo-Lin Weng, Tongyin Zheng, Szu-Huan Wang, Valentin Kirilenko, Jeetain Mittal, Nicolas L Fawzi
Expanding the molecular grammar of polar residues and arginine in FUS prion-like domain phase separation and aggregation. bioRxiv : the preprint server for biology (2024)
Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Azamat Rizuan, Titus M Franzmann, Aleksandra V Sergeeva, Patricia M Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L Danielson, Alf Honigmann, Yuna M Ayala, Nicolas L Fawzi, Jeetain Mittal, Simon Alberti, Anthony A Hyman
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. bioRxiv : the preprint server for biology (2024)
Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Azamat Rizuan, Titus M Franzmann, Aleksandra V Sergeeva, Patricia M Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L Danielson, Alf Honigmann, Yuna M Ayala, Nicolas L Fawzi, Jeetain Mittal, Simon Alberti, Anthony A Hyman
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. bioRxiv : the preprint server for biology (2024)
Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Azamat Rizuan, Titus M Franzmann, Aleksandra V Sergeeva, Patricia M Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L Danielson, Alf Honigmann, Yuna M Ayala, Nicolas L Fawzi, Jeetain Mittal, Simon Alberti, Anthony A Hyman
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. bioRxiv : the preprint server for biology (2024)
Priyesh Mohanty, Azamat Rizuan, Young C Kim, Nicolas L Fawzi, Jeetain Mittal
A complex network of interdomain interactions underlies the conformational ensemble of monomeric TDP-43 and modulates its phase behavior. Protein science : a publication of the Protein Society 33 (2) (2024)
Mukulika Ray, Julia Zaborowsky, Pranav Mahableshwarkar, Smriti Vaidyanathan, Jasmine Shum, Renjith Viswanathan, Annie Huang, Szu-Huan Wang, Victoria Johnson, Noah Wake, Ashley M Conard, Alexander E Conicella, Ryan Puterbaugh, Nicolas L Fawzi, Erica Larschan
Dual DNA/RNA-binding factor regulates dynamics of hnRNP splicing condensates. bioRxiv : the preprint server for biology (2024)
Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Azamat Rizuan, Titus M Franzmann, Aleksandra V Sergeeva, Patricia M Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L Danielson, Alf Honigmann, Yuna M Ayala, Nicolas L Fawzi, Jeetain Mittal, Simon Alberti, Anthony A Hyman
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. bioRxiv : the preprint server for biology (2024)
Azamat Rizuan, Jayakrishna Shenoy, Priyesh Mohanty, Patricia M S Dos Passos, José F Mercado Ortiz, Leanna Bai, Renjith Viswanathan, Szu-Huan Wang, Victoria Johnson, Lohany D Mamede, Yuna M Ayala, Rodolfo Ghirlando, Jeetain Mittal, Nicolas L Fawzi
Structural details of helix-mediated TDP-43 C-terminal domain multimerization. bioRxiv : the preprint server for biology (2024)
Azamat Rizuan, Jayakrishna Shenoy, Priyesh Mohanty, Patricia M S Dos Passos, José F Mercado Ortiz, Leanna Bai, Renjith Viswanathan, Szu-Huan Wang, Victoria Johnson, Lohany D Mamede, Yuna M Ayala, Rodolfo Ghirlando, Jeetain Mittal, Nicolas L Fawzi
Structural details of helix-mediated TDP-43 C-terminal domain multimerization. bioRxiv : the preprint server for biology (2024)
Xiao Yan, David Kuster, Priyesh Mohanty, Jik Nijssen, Karina Pombo-García, Azamat Rizuan, Titus M Franzmann, Aleksandra V Sergeeva, Patricia M Passos, Leah George, Szu-Huan Wang, Jayakrishna Shenoy, Helen L Danielson, Alf Honigmann, Yuna M Ayala, Nicolas L Fawzi, Jeetain Mittal, Simon Alberti, Anthony A Hyman
Intra-condensate demixing of TDP-43 inside stress granules generates pathological aggregates. bioRxiv : the preprint server for biology (2024)
Priyesh Mohanty, Jayakrishna Shenoy, Azamat Rizuan, José F Mercado-Ortiz, Nicolas L Fawzi, Jeetain Mittal
A synergy between site-specific and transient interactions drives the phase separation of a disordered, low-complexity domain. Proceedings of the National Academy of Sciences of the United States of America 120 (34) (2023)
Liam C O'Connell, Victoria Johnson, Anika K Hutton, Jessica P Otis, Anastasia C Murthy, Mark C Liang, Szu-Huan Wang, Nicolas L Fawzi, Kimberly L Mowry
Intrinsically disordered regions and RNA binding domains contribute to protein enrichment in biomolecular condensates in Xenopus oocytes. bioRxiv : the preprint server for biology (2023)
Carola S Krevert, Daniel Chavez, Sayantan Chatterjee, Lukas S Stelzl, Sabine Pütz, Steven J Roeters, Joseph F Rudzinski, Nicolas L Fawzi, Martin Girard, Sapun H Parekh, Johannes Hunger
Liquid-Liquid Phase Separation of the Intrinsically Disordered Domain of the Fused in Sarcoma Protein Results in Substantial Slowing of Hydration Dynamics. The journal of physical chemistry letters (2023)
Mae I Staples, Corey Frazer, Nicolas L Fawzi, Richard J Bennett
Phase separation in fungi. Nature microbiology (2023)
Mae I Staples, Corey Frazer, Nicolas L Fawzi, Richard J Bennett
Phase separation in fungi. Nature microbiology (2023)
Daria Maltseva, Sayantan Chatterjee, Chun-Chieh Yu, Mateusz Brzezinski, Yuki Nagata, Grazia Gonella, Anastasia C Murthy, Jeanne C Stachowiak, Nicolas L Fawzi, Sapun H Parekh, Mischa Bonn
Fibril formation and ordering of disordered FUS LC driven by hydrophobic interactions. Nature chemistry (2023)
Lin Guo, Jacob R Mann, Jocelyn C Mauna, Katie E Copley, Hejia Wang, Jack D Rubien, Hana M Odeh, JiaBei Lin, Bo Lim Lee, Laura Ganser, Emma Robinson, Kevin M Kim, Anastasia C Murthy, Tapas Paul, Bede Portz, Amanda M Gleixner, Zamia Diaz, Jenny L Carey, Ashleigh Smirnov, George Padilla, Ellen Lavorando, Carolann Espy, Yulei Shang, Eric J Huang, Alessandra Chesi, Nicolas L Fawzi, Sua Myong, Christopher J Donnelly, James Shorter
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. bioRxiv : the preprint server for biology (2023)
Mae I Staples, Corey Frazer, Nicolas L Fawzi, Richard J Bennett
Phase separation in fungi. Nature microbiology 8 (3) (2023)
Mae I Staples, Corey Frazer, Nicolas L Fawzi, Richard J Bennett
Phase separation in fungi. Nature microbiology 8 (3) (2023)
Szu-Huan Wang, Tongyin Zheng, Nicolas L Fawzi
Structure and position-specific interactions of prion-like domains in transcription factor Efg1 phase separation. bioRxiv : the preprint server for biology (2023)
Mae I Staples, Corey Frazer, Nicolas L Fawzi, Richard J Bennett
Phase separation in fungi. Nature microbiology 8 (3) (2023)
Priyesh Mohanty, Azamat Rizuan, Young C Kim, Nicolas L Fawzi, Jeetain Mittal
A complex network of interdomain interactions underlies the conformational ensemble of monomeric TDP-43 and modulates its phase behavior. Protein science : a publication of the Protein Society (2023)
Priyesh Mohanty, Azamat Rizuan, Young C Kim, Nicolas L Fawzi, Jeetain Mittal
A complex network of interdomain interactions underlies the conformational ensemble of monomeric TDP-43 and modulates its phase behavior. Protein science : a publication of the Protein Society (2023)
Marissa G Viola, Theodora Myrto Perdikari, Catherine E Trebino, Negar Rahmani, Kaylee L Mathews, Carolina Mejia Pena, Xien Yu Chua, Botai Xuan, Christopher J LaBreck, Nicolas L Fawzi, Jodi L Camberg
An enhancer sequence in the intrinsically disordered region of FtsZ promotes polymer-guided substrate processing by ClpXP protease. Protein science : a publication of the Protein Society 31 (5) (2022)
Anna S Bock, Anastasia C Murthy, Wai Shing Tang, Nina Jovic, Frank Shewmaker, Jeetain Mittal, Nicolas L Fawzi
N-terminal acetylation modestly enhances phase separation and reduces aggregation of the low-complexity domain of RNA-binding protein fused in sarcoma. Protein science : a publication of the Protein Society 30 (7) (2021)
Yen-Chen Lin, Meenakshi Sundaram Kumar, Nandini Ramesh, Eric N Anderson, Aivi T Nguyen, Boram Kim, Simon Cheung, Justin A McDonough, William C Skarnes, Rodrigo Lopez-Gonzalez, John E Landers, Nicolas L Fawzi, Ian R A Mackenzie, Edward B Lee, Jeffrey A Nickerson, David Grünwald, Udai Bhan Pandey, Daryl A Bosco
Interactions between ALS-linked FUS and nucleoporins are associated with defects in the nucleocytoplasmic transport pathway. Nature neuroscience 24 (8) (2021)
Anastasia C Murthy, Wai Shing Tang, Nina Jovic, Abigail M Janke, Da Hee Seo, Theodora Myrto Perdikari, Jeetain Mittal, Nicolas L Fawzi
Molecular interactions contributing to FUS SYGQ LC-RGG phase separation and co-partitioning with RNA polymerase II heptads. Nature structural & molecular biology 28 (11) (2021)
Feng Yuan, Haleh Alimohamadi, Brandon Bakka, Andrea N Trementozzi, Kasey J Day, Nicolas L Fawzi, Padmini Rangamani, Jeanne C Stachowiak
Membrane bending by protein phase separation. Proceedings of the National Academy of Sciences of the United States of America 118 (11) (2021)
Izzy Owen, Debra Yee, Hala Wyne, Theodora Myrto Perdikari, Victoria Johnson, Jeremy T Smyth, Robert L Kortum, Nicolas L Fawzi, Frank Shewmaker
The oncogenic transcription factor FUS-CHOP can undergo nuclear liquid-liquid phase separation. Journal of cell science 134 (17) (2021)
Alexander E Conicella, Gregory L Dignon, Gül H Zerze, Hermann Broder Schmidt, Alexandra M D'Ordine, Young C Kim, Rajat Rohatgi, Yuna M Ayala, Jeetain Mittal, Nicolas L Fawzi
TDP-43 α-helical structure tunes liquid-liquid phase separation and function. Proceedings of the National Academy of Sciences of the United States of America 117 (11) (2020)
Corey Frazer, Mae I Staples, Yoori Kim, Matthew Hirakawa, Maureen A Dowell, Nicole V Johnson, Aaron D Hernday, Veronica H Ryan, Nicolas L Fawzi, Ilya J Finkelstein, Richard J Bennett
Epigenetic cell fate in Candida albicans is controlled by transcription factor condensates acting at super-enhancer-like elements. Nature microbiology 5 (11) (2020)
Theodora Myrto Perdikari, Anastasia C Murthy, Veronica H Ryan, Scott Watters, Mandar T Naik, Nicolas L Fawzi
SARS-CoV-2 nucleocapsid protein phase-separates with RNA and with human hnRNPs. The EMBO journal 39 (24) (2020)
Wai Shing Tang, Nicolas L Fawzi, Jeetain Mittal
Refining All-Atom Protein Force Fields for Polar-Rich, Prion-like, Low-Complexity Intrinsically Disordered Proteins. The journal of physical chemistry. B 124 (43) (2020)
Wenwei Zheng, Gregory L Dignon, Nina Jovic, Xichen Xu, Roshan M Regy, Nicolas L Fawzi, Young C Kim, Robert B Best, Jeetain Mittal
Molecular Details of Protein Condensates Probed by Microsecond Long Atomistic Simulations. The journal of physical chemistry. B 124 (51) (2020)
Veronica H Ryan, Theodora M Perdikari, Mandar T Naik, Camillo F Saueressig, Jeremy Lins, Gregory L Dignon, Jeetain Mittal, Anne C Hart, Nicolas L Fawzi
Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration. The EMBO journal 40 (3) (2020)
Anastasia C Murthy, Gregory L Dignon, Yelena Kan, Gül H Zerze, Sapun H Parekh, Jeetain Mittal, Nicolas L Fawzi
Molecular interactions underlying liquid-liquid phase separation of the FUS low-complexity domain. Nature structural & molecular biology 26 (7) (2019)
Ailin Wang, Alexander E Conicella, Hermann Broder Schmidt, Erik W Martin, Shannon N Rhoads, Ashley N Reeb, Amanda Nourse, Daniel Ramirez Montero, Veronica H Ryan, Rajat Rohatgi, Frank Shewmaker, Mandar T Naik, Tanja Mittag, Yuna M Ayala, Nicolas L Fawzi
A single N-terminal phosphomimic disrupts TDP-43 polymerization, phase separation, and RNA splicing. The EMBO journal 37 (5) (2018)
Joshua Amaya, Veronica H Ryan, Nicolas L Fawzi
The SH3 domain of Fyn kinase interacts with and induces liquid-liquid phase separation of the low-complexity domain of hnRNPA2. The Journal of biological chemistry 293 (51) (2018)
Megan E Dempsey, Hetal D Marble, Tun-Li Shen, Nicolas L Fawzi, Eric M Darling
Synthesis and Characterization of a Magnetically Active 19F Molecular Beacon. Bioconjugate chemistry 29 (2) (2018)
Tatiana Johnston, Daria Van Tyne, Roy F Chen, Nicolas L Fawzi, Bumsup Kwon, Michael J Kelso, Michael S Gilmore, Eleftherios Mylonakis
Propyl-5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carbodithioate (HMPC): a new bacteriostatic agent against methicillin-resistant Staphylococcus aureus. Scientific reports 8 (1) (2018)
Pietro Fratta, Prasanth Sivakumar, Jack Humphrey, Kitty Lo, Thomas Ricketts, Hugo Oliveira, Jose M Brito-Armas, Bernadett Kalmar, Agnieszka Ule, Yichao Yu, Nicol Birsa, Cristian Bodo, Toby Collins, Alexander E Conicella, Alan Mejia Maza, Alessandro Marrero-Gagliardi, Michelle Stewart, Joffrey Mianné, Silvia Corrochano, Warren Emmett, Gemma Codner, Michael Groves, Ryutaro Fukumura, Yoichi Gondo, Mark Lythgoe, Erwin Pauws, Emma Peskett, Philip Stanier, Lydia Teboul, Martina Hallegger, Andrea Calvo, Adriano Chiò, Adrian M Isaacs, Nicolas L Fawzi, Eric Wang, David E Housman, Francisco Baralle, Linda Greensmith, Emanuele Buratti, Vincent Plagnol, Elizabeth Mc Fisher, Abraham Acevedo-Arozena
Mice with endogenous TDP-43 mutations exhibit gain of splicing function and characteristics of amyotrophic lateral sclerosis. The EMBO journal 37 (11) (2018)
Zachary Monahan, Veronica H Ryan, Abigail M Janke, Kathleen A Burke, Shannon N Rhoads, Gül H Zerze, Robert O'Meally, Gregory L Dignon, Alexander E Conicella, Wenwei Zheng, Robert B Best, Robert N Cole, Jeetain Mittal, Frank Shewmaker, Nicolas L Fawzi
Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity. The EMBO journal 36 (20) (2017)
Abigail M Janke, Da Hee Seo, Vahid Rahmanian, Alexander E Conicella, Kaylee L Mathews, Kathleen A Burke, Jeetain Mittal, Nicolas L Fawzi
Lysines in the RNA Polymerase II C-Terminal Domain Contribute to TAF15 Fibril Recruitment. Biochemistry 57 (17) (2017)