James Shorter

Loop profile ORCID

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 37

Top Topics

Binding Protein

Amyotrophic Lateral Sclerosis

Endoplasmic Reticulum

Top Venues

bioRxiv : the preprint server for biology

The Journal of biological chemistry

This page only lists publications with an associated author ORCID identifier.

Publications

Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W Cleveland, James Shorter, Sandrine Da Cruz
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS. bioRxiv : the preprint server for biology (2024)
Katelyn M Sweeney, Sapanna Chantarawong, Edward M Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS genetics 20 (2) (2024)
Katelyn M Sweeney, Sapanna Chantarawong, Edward M Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS genetics 20 (2) (2024)
Sonia Vazquez-Sanchez, Britt Tilkin, Fatima Gasset-Rosa, Sitao Zhang, Diana Piol, Melissa McAlonis-Downes, Jonathan Artates, Noe Govea-Perez, Yana Verresen, Lin Guo, Don W Cleveland, James Shorter, Sandrine Da Cruz
Frontotemporal dementia-like disease progression elicited by seeded aggregation and spread of FUS. bioRxiv : the preprint server for biology (2024)
Katelyn M Sweeney, Sapanna Chantarawong, Edward M Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS genetics 20 (2) (2024)
JiaBei Lin, Peter J Carman, Craig W Gambogi, Nathan M Kendsersky, Edward Chuang, Stephanie N Gates, Adam L Yokom, Alexandrea N Rizo, Daniel R Southworth, James Shorter
Design principles to tailor Hsp104 therapeutics. bioRxiv : the preprint server for biology (2024)
JiaBei Lin, Peter J Carman, Craig W Gambogi, Nathan M Kendsersky, Edward Chuang, Stephanie N Gates, Adam L Yokom, Alexandrea N Rizo, Daniel R Southworth, James Shorter
Design principles to tailor Hsp104 therapeutics. bioRxiv : the preprint server for biology (2024)
Katelyn M Sweeney, Sapanna Chantarawong, Edward M Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS genetics 20 (2) (2024)
Katelyn M Sweeney, Sapanna Chantarawong, Edward M Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS genetics 20 (2) (2024)
JiaBei Lin, Peter J Carman, Craig W Gambogi, Nathan M Kendsersky, Edward Chuang, Stephanie N Gates, Adam L Yokom, Alexandrea N Rizo, Daniel R Southworth, James Shorter
Design principles to tailor Hsp104 therapeutics. bioRxiv : the preprint server for biology (2024)
Katelyn M Sweeney, Sapanna Chantarawong, Edward M Barbieri, Greg Cajka, Matthew Liu, Lynn Spruce, Hossein Fazelinia, Bede Portz, Katie Copley, Tomer Lapidot, Lauren Duhamel, Phoebe Greenwald, Naseeb Saida, Reut Shalgi, James Shorter, Ophir Shalem
CRISPR screen for protein inclusion formation uncovers a role for SRRD in the regulation of intermediate filament dynamics and aggresome assembly. PLoS genetics 20 (2) (2024)
Rubika Balendra, Ruiz De Los Mozos Igor, Hana M Odeh, Idoia Glaria, Carmelo Milioto, Katherine M Wilson, Agnieszka M Ule, Martina Hallegger, Laura Masino, Stephen Martin, Rickie Patani, James Shorter, Jernej Ule, Adrian M Isaacs
Transcriptome-wide RNA binding analysis of C9orf72 poly(PR) dipeptides. Life science alliance 6 (9) (2023)
Kevin Rhine, Hana M Odeh, James Shorter, Sua Myong
Regulation of Biomolecular Condensates by Poly(ADP-ribose). Chemical reviews (2023)
Lin Guo, Jacob R Mann, Jocelyn C Mauna, Katie E Copley, Hejia Wang, Jack D Rubien, Hana M Odeh, JiaBei Lin, Bo Lim Lee, Laura Ganser, Emma Robinson, Kevin M Kim, Anastasia C Murthy, Tapas Paul, Bede Portz, Amanda M Gleixner, Zamia Diaz, Jenny L Carey, Ashleigh Smirnov, George Padilla, Ellen Lavorando, Carolann Espy, Yulei Shang, Eric J Huang, Alessandra Chesi, Nicolas L Fawzi, Sua Myong, Christopher J Donnelly, James Shorter
Defining RNA oligonucleotides that reverse deleterious phase transitions of RNA-binding proteins with prion-like domains. bioRxiv : the preprint server for biology (2023)
Kevin Rhine, Hana M Odeh, James Shorter, Sua Myong
Regulation of Biomolecular Condensates by Poly(ADP-ribose). Chemical reviews (2023)
JiaBei Lin, James Shorter, Aaron L Lucius
AAA+ proteins: one motor, multiple ways to work. Biochemical Society transactions 50 (2) (2022)
Juan R Peinado, Kriti Chaplot, Timothy S Jarvela, Edward M Barbieri, James Shorter, Iris Lindberg
Sequestration of TDP-43 216-414 Aggregates by Cytoplasmic Expression of the proSAAS Chaperone. ACS chemical neuroscience 13 (11) (2022)
Tatjana Weil, Abbna Kirupakaran, My-Hue Le, Philipp Rebmann, Joel Mieres-Perez, Leila Issmail, Carina Conzelmann, Janis A Müller, Lena Rauch, Andrea Gilg, Lukas Wettstein, Ruediger Gross, Clarissa Read, Tim Bergner, Sandra Axberg Pålsson, Nadja Uhlig, Valentina Eberlein, Heike Wöll, Frank-Gerrit Klärner, Steffen Stenger, Beate M Kümmerer, Hendrik Streeck, Giorgio Fois, Manfred Frick, Peter Braubach, Anna-Lena Spetz, Thomas Grunwald, James Shorter, Elsa Sanchez-Garcia, Thomas Schrader, Jan Münch
Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2 (9) (2022)
Julia T Warren, Ryan R Cupo, Peeradol Wattanasirakul, David H Spencer, Adam E Locke, Vahagn Makaryan, Audrey Anna Bolyard, Meredith L Kelley, Natalie L Kingston, James Shorter, Christine Bellanné-Chantelot, Jean Donadieu, David C Dale, Daniel C Link
Heterozygous Variants of CLPB are a Cause of Severe Congenital Neutropenia. Blood (2021)
Charlotte M Fare, James Shorter
(Dis)Solving the problem of aberrant protein states. Disease models & mechanisms 14 (5) (2021)
Casey N Cook, Yanwei Wu, Hana M Odeh, Tania F Gendron, Karen R Jansen-West, Giulia Del Rosso, Mei Yue, Peizhou Jiang, Edward Gomes, Jimei Tong, Lillian M Daughrity, Nicole M Avendano, Monica Castanedes Casey, Wei Shao, Björn E Oskarsson, Giulio S Tomassy, Alexander McCampbell, Frank Rigo, Gourisankar Ghosh, James Shorter, Yong-Jie Zhang, Leonard Petrucelli
C9orf72 poly(GR) aggregation induces TDP-43 proteinopathy. Science translational medicine 12 (559) (2021)
Tatjana Weil, Rüdiger Groß, Annika Röcker, Kenny Bravo-Rodriguez, Christian Heid, Andrea Sowislok, My-Hue Le, Nelli Erwin, Mridula Dwivedi, Stephen M Bart, Paul Bates, Lukas Wettstein, Janis A Müller, Mirja Harms, Konstantin Sparrer, Yasser B Ruiz-Blanco, Christina M Stürzel, Jens von Einem, Sina Lippold, Clarissa Read, Paul Walther, Marco Hebel, Florian Kreppel, Frank-Gerrit Klärner, Gal Bitan, Michael Ehrmann, Tanja Weil, Roland Hermann Alfons Winter, Thomas Schrader, James Shorter, Elsa Sanchez-Garcia, Jan Münch
Supramolecular Mechanism of Viral Envelope Disruption by Molecular Tweezers. Journal of the American Chemical Society 142 (40) (2020)
Ryan R Cupo, James Shorter
Skd3 (human ClpB) is a potent mitochondrial protein disaggregase that is inactivated by 3-methylglutaconic aciduria-linked mutations. eLife 9 (2020)
Heike J Wobst, Korrie L Mack, Dean G Brown, Nicholas J Brandon, James Shorter
The clinical trial landscape in amyotrophic lateral sclerosis-Past, present, and future. Medicinal research reviews 40 (4) (2020)
Zachary M March, Katelyn Sweeney, Hanna Kim, Xiaohui Yan, Laura M Castellano, Meredith E Jackrel, JiaBei Lin, Edward Chuang, Edward Gomes, Corey W Willicott, Karolina Michalska, Robert P Jedrzejczak, Andrzej Joachimiak, Kim A Caldwell, Guy A Caldwell, Ophir Shalem, James Shorter
Therapeutic genetic variation revealed in diverse Hsp104 homologs. eLife 9 (2020)
Xiang Ye, JiaBei Lin, Leland Mayne, James Shorter, S Walter Englander
Structural and kinetic basis for the regulation and potentiation of Hsp104 function. Proceedings of the National Academy of Sciences of the United States of America 117 (17) (2020)
James Shorter
Phase separation of RNA-binding proteins in physiology and disease: An introduction to the JBC Reviews thematic series. The Journal of biological chemistry 294 (18) (2019)
Edward M Barbieri, James Shorter
TDP-43 shapeshifts to encipher FTD severity. Nature neuroscience 22 (1) (2019)
Jeremy J Ryan, Macy L Sprunger, Kayla Holthaus, James Shorter, Meredith E Jackrel
Engineered protein disaggregases mitigate toxicity of aberrant prion-like fusion proteins underlying sarcoma. The Journal of biological chemistry 294 (29) (2019)
Yong-Jie Zhang, Lin Guo, Patrick K Gonzales, Tania F Gendron, Yanwei Wu, Karen Jansen-West, Aliesha D O'Raw, Sarah R Pickles, Mercedes Prudencio, Yari Carlomagno, Mariam A Gachechiladze, Connor Ludwig, Ruilin Tian, Jeannie Chew, Michael A DeTure, Wen-Lang Lin, Jimei Tong, Lillian M Daughrity, Mei Yue, Yuping Song, Jonathan W Andersen, Monica Castanedes Casey, Aishe Kurti, Abhishek Datta, Giovanna Antognetti, Alexander McCampbell, Rosa Rademakers, Björn E Oskarsson, Gourisankar Ghosh, Martin Edward Kampmann, Michael Emmerson Ward, John D Fryer, Christopher D Link, James Shorter, Leonard Petrucelli
Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity. Science (New York, N.Y.) 363 (6428) (2019)
Edward Gomes, James Shorter
The molecular language of membraneless organelles. The Journal of biological chemistry 294 (18) (2018)
Leeanne McGurk, Edward Gomes, Lin Guo, James Shorter, Nancy M Bonini
Poly(ADP-ribose) Engages the TDP-43 Nuclear-Localization Sequence to Regulate Granulo-Filamentous Aggregation. Biochemistry 57 (51) (2018)
Edward Chuang, Acacia M Hori, Christina D Hesketh, James Shorter
Amyloid assembly and disassembly. Journal of cell science 131 (8) (2018)
Aaron D Gitler, Paraminder Dhillon, James Shorter
Neurodegenerative disease: models, mechanisms, and a new hope. Disease models & mechanisms 10 (5) (2018)
Kyota Yasuda, Sarah F Clatterbuck-Soper, Meredith E Jackrel, James Shorter, Stavroula Mili
FUS inclusions disrupt RNA localization by sequestering kinesin-1 and inhibiting microtubule detyrosination. The Journal of cell biology 216 (4) (2017)
Stephanie N Gates, Adam L Yokom, JiaBei Lin, Meredith E Jackrel, Alexandrea N Rizo, Nathan M Kendsersky, Courtney E Buell, Elizabeth A Sweeny, Korrie L Mack, Edward Chuang, Mariana P Torrente, Min Su, James Shorter, Daniel R Southworth
Ratchet-like polypeptide translocation mechanism of the AAA+ disaggregase Hsp104. Science (New York, N.Y.) 357 (6348) (2017)
James Shorter
Liquidizing FUS via prion-like domain phosphorylation. The EMBO journal 36 (20) (2017)