Nigel S Scrutton

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 64

Top Topics

Escherichia Coli

Electron Transfer

Molecular Dynamics

Top Venues

The FEBS journal

Chembiochem : a European journal of chemical biology

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Shaowei Zhang, Laura N Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, Kaylee Patel, Linus O Johannissen, Lingyun Zhu, Matthew J Cliff, Cunyu Yan, Giorgio Schirò, Martin Weik, Michiyo Sakuma, Colin W Levy, David Leys, Derren J Heyes, Nigel S Scrutton
Photocobilins integrate B 12 and bilin photochemistry for enzyme control. Nature communications 15 (1) (2024)
Shaowei Zhang, Laura N Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, Kaylee Patel, Linus O Johannissen, Lingyun Zhu, Matthew J Cliff, Cunyu Yan, Giorgio Schirò, Martin Weik, Michiyo Sakuma, Colin W Levy, David Leys, Derren J Heyes, Nigel S Scrutton
Photocobilins integrate B 12 and bilin photochemistry for enzyme control. Nature communications 15 (1) (2024)
Shaowei Zhang, Laura N Jeffreys, Harshwardhan Poddar, Yuqi Yu, Chuanyang Liu, Kaylee Patel, Linus O Johannissen, Lingyun Zhu, Matthew J Cliff, Cunyu Yan, Giorgio Schirò, Martin Weik, Michiyo Sakuma, Colin W Levy, David Leys, Derren J Heyes, Nigel S Scrutton
Photocobilins integrate B 12 and bilin photochemistry for enzyme control. Nature communications 15 (1) (2024)
Jingming Zhao, Ying Zhuo, Daniel E Diaz, Muralidharan Shanmugam, Abbey J Telfer, Peter J Lindley, Daniel Kracher, Takahiro Hayashi, Lisa S Seibt, Florence J Hardy, Oliver Manners, Tobias M Hedison, Katherine A Hollywood, Reynard Spiess, Kathleen M Cain, Sofia Diaz-Moreno, Nigel S Scrutton, Morten Tovborg, Paul H Walton, Derren J Heyes, Anthony P Green
Mapping the Initial Stages of a Protective Pathway that Enhances Catalytic Turnover by a Lytic Polysaccharide Monooxygenase. Journal of the American Chemical Society (2023)
Magnus Speirs, Samantha J O Hardman, Andreea I Iorgu, Linus O Johannissen, Derren J Heyes, Nigel S Scrutton, Igor V Sazanovich, Sam Hay
Photoinduced Electron Transfer from a 1,4,5,6-Tetrahydro Nicotinamide Adenine Dinucleotide (Phosphate) Analogue to Oxidized Flavin in an Ene-Reductase Flavoenzyme. The journal of physical chemistry letters (2023)
Nigel S Scrutton
Unravelling the complexity of enzyme catalysis. The FEBS journal 290 (9) (2023)
Joshua N Whitehead, Nicole G H Leferink, Linus O Johannissen, Sam Hay, Nigel S Scrutton
Decoding Catalysis by Terpene Synthases. ACS catalysis 13 (19) (2023)
Aoife Taylor, Shaowei Zhang, Linus O Johannissen, Michiyo Sakuma, Robert S Phillips, Anthony P Green, Sam Hay, Derren J Heyes, Nigel S Scrutton
Mechanistic implications of the ternary complex structural models for the photoenzyme protochlorophyllide oxidoreductase. The FEBS journal (2023)
Yuqi Yu, Arnau Rué Casamajo, William Finnigan, Christian Schnepel, Rhys Barker, Charlotte Morrill, Rachel S Heath, Leonardo De Maria, Nicholas J Turner, Nigel S Scrutton
Structure-Based Design of Small Imine Reductase Panels for Target Substrates. ACS catalysis 13 (18) (2023)
Harshwardhan Poddar, Ronald Rios-Santacruz, Derren J Heyes, Muralidharan Shanmugam, Adam Brookfield, Linus O Johannissen, Colin W Levy, Laura N Jeffreys, Shaowei Zhang, Michiyo Sakuma, Jacques-Philippe Colletier, Sam Hay, Giorgio Schirò, Martin Weik, Nigel S Scrutton, David Leys
Redox driven B 12 -ligand switch drives CarH photoresponse. Nature communications 14 (1) (2023)
Nigel S Scrutton
Unravelling the complexity of enzyme catalysis. The FEBS journal 290 (9) (2023)
Nicole G H Leferink, Andrés M Escorcia, Bodi R Ouwersloot, Linus O Johanissen, Sam Hay, Marc W van der Kamp, Nigel S Scrutton
Molecular Determinants of Carbocation Cyclisation in Bacterial Monoterpene Synthases. Chembiochem : a European journal of chemical biology 23 (5) (2022)
Matthew Russell, Andrew Currin, William Rowe, George Guo-Qiang Chen, Perdita E Barran, Nigel S Scrutton
Baseline proteomics characterisation of the emerging host biomanufacturing organism Halomonas bluephagenesis. Scientific data 9 (1) (2022)
Joshua N Whitehead, Nicole G H Leferink, Gajendar Komati Reddy, Colin W Levy, Sam Hay, Eriko Takano, Nigel S Scrutton
How a 10- epi -Cubebol Synthase Avoids Premature Reaction Quenching to Form a Tricyclic Product at High Purity. ACS catalysis 12 (19) (2022)
Rhys D Barker, Yuqi Yu, Leonardo De Maria, Linus O Johannissen, Nigel S Scrutton
Mechanism of Action of Flavin-Dependent Halogenases. ACS catalysis 12 (24) (2022)
Tobias M Hedison, Andreea I Iorgu, Donato Calabrese, Derren J Heyes, Muralidharan Shanmugam, Nigel S Scrutton
Solution-State Inter-Copper Distribution of Redox Partner-Linked Copper Nitrite Reductases: A Pulsed Electron-Electron Double Resonance Spectroscopy Study. The journal of physical chemistry letters 13 (30) (2022)
Rhys D Barker, Yuqi Yu, Leonardo De Maria, Linus O Johannissen, Nigel S Scrutton
Mechanism of Action of Flavin-Dependent Halogenases. ACS catalysis 12 (24) (2022)
Andrew M Stewart, Muralidharan Shanmugam, Roger Jan Kutta, Nigel S Scrutton, Janet Eleanor Lovett, Sam Hay
Combined Pulsed Electron Double Resonance EPR and Molecular Dynamics Investigations of Calmodulin Suggest Effects of Crowding Agents on Protein Structures. Biochemistry 61 (17) (2022)
Helen Park, Helen S Toogood, George Guo-Qiang Chen, Nigel S Scrutton
Co-production of biofuel, bioplastics and biochemicals during extended fermentation of Halomonas bluephagenesis. Microbial biotechnology (2022)
Samuel L Rose, Seiki Baba, Hideo Okumura, Svetlana V Antonyuk, Daisuke Sasaki, Tobias M Hedison, Muralidharan Shanmugam, Derren J Heyes, Nigel S Scrutton, Takashi Kumasaka, Takehiko Tosha, Robert R Eady, Masaki Yamamoto, S Samar Hasnain
Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases. Proceedings of the National Academy of Sciences of the United States of America 119 (30) (2022)
Linus O Johannissen, Aoife Taylor, Samantha J O Hardman, Derren J Heyes, Nigel S Scrutton, Sam Hay
How Photoactivation Triggers Protochlorophyllide Reduction: Computational Evidence of a Stepwise Hydride Transfer during Chlorophyll Biosynthesis. ACS catalysis 12 (7) (2022)
Helen S Toogood, Nigel S Scrutton
Flavin oxidation state impacts on nitrofuran antibiotic binding orientation in nitroreductases. The Biochemical journal 478 (18) (2021)
Mauro A Rinaldi, Clara A Ferraz, Nigel S Scrutton
Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli. Natural product reports (2021)
Hanan L Messiha, Karl A P Payne, Nigel S Scrutton, David Leys
A Biological Route to Conjugated Alkenes: Microbial Production of Hepta-1,3,5-triene. ACS synthetic biology 10 (2) (2021)
Alec Banner, Helen S Toogood, Nigel S Scrutton
Consolidated Bioprocessing: Synthetic Biology Routes to Fuels and Fine Chemicals. Microorganisms 9 (5) (2021)
Derren J Heyes, Shaowei Zhang, Aoife Taylor, Linus O Johannissen, Samantha J O Hardman, Sam Hay, Nigel S Scrutton
Photocatalysis as the 'master switch' of photomorphogenesis in early plant development. Nature plants 7 (3) (2021)
Clara A Ferraz, Nicole G H Leferink, Iaroslav Kosov, Nigel S Scrutton
Isopentenol Utilization Pathway for the Production of Linalool in Escherichia coli Using an Improved Bacterial Linalool/Nerolidol Synthase. Chembiochem : a European journal of chemical biology 22 (13) (2021)
Adrian J Jervis, Erik K R Hanko, Mark S Dunstan, Christopher J Robinson, Eriko Takano, Nigel S Scrutton
A plasmid toolset for CRISPR-mediated genome editing and CRISPRi gene regulation in Escherichia coli. Microbial biotechnology 14 (3) (2021)
Tobias M Hedison, Erik Breslmayr, Muralidharan Shanmugam, Kwankao Karnpakdee, Derren J Heyes, Anthony P Green, Roland Ludwig, Nigel S Scrutton, Daniel Kracher
Insights into the H2 O2 -driven catalytic mechanism of fungal lytic polysaccharide monooxygenases. The FEBS journal 288 (13) (2021)
Fraser Andrews, Matthew Faulkner, Helen S Toogood, Nigel S Scrutton
Combinatorial use of environmental stresses and genetic engineering to increase ethanol titres in cyanobacteria. Biotechnology for biofuels 14 (1) (2021)
Nicole G H Leferink, Nigel S Scrutton
Predictive Engineering of Class I Terpene Synthases Using Experimental and Computational Approaches. Chembiochem : a European journal of chemical biology (2021)
Harshwardhan Poddar, Derren J Heyes, Giorgio Schirò, Martin Weik, David Leys, Nigel S Scrutton
A guide to time-resolved structural analysis of light-activated proteins. The FEBS journal (2021)
Shaowei Zhang, Alan R F Godwin, Aoife Taylor, Samantha J O Hardman, Thomas A Jowitt, Linus O Johannissen, Sam Hay, Clair Baldock, Derren J Heyes, Nigel S Scrutton
Dual role of the active site 'lid' regions of protochlorophyllide oxidoreductase in photocatalysis and plant development. The FEBS journal 288 (1) (2020)
Mohamed Amer, Robin Hoeven, Paul Kelly, Matthew Faulkner, Michael H Smith, Helen S Toogood, Nigel S Scrutton
Renewable and tuneable bio-LPG blends derived from amino acids. Biotechnology for biofuels 13 (2020)
Samantha J O Hardman, Andreea I Iorgu, Derren J Heyes, Nigel S Scrutton, Igor V Sazanovich, Sam Hay
Ultrafast Vibrational Energy Transfer between Protein and Cofactor in a Flavoenzyme. The journal of physical chemistry. B 124 (25) (2020)
Paraminder Dhillon, Nigel S Scrutton
In conversation with Nigel Scrutton. The FEBS journal 288 (6) (2020)
Savvas Louka, Sarah M Barry, Derren J Heyes, M Qadri E Mubarak, Hafiz Saqib Ali, Lona M Alkhalaf, Andrew W Munro, Nigel S Scrutton, Gregory L Challis, Sam P De Visser
Catalytic Mechanism of Aromatic Nitration by Cytochrome P450 TxtE: Involvement of a Ferric-Peroxynitrite Intermediate. Journal of the American Chemical Society 142 (37) (2020)
Samantha J O Hardman, Derren J Heyes, Igor V Sazanovich, Nigel S Scrutton
Photocycle of Cyanobacteriochrome TePixJ. Biochemistry 59 (32) (2020)
Jonathan Wilkes, Anthony Scott-Tucker, Mike Wright, Tom Crabbe, Nigel S Scrutton
Exploiting Single Domain Antibodies as Regulatory Parts to Modulate Monoterpenoid Production in E. coli. ACS synthetic biology 9 (10) (2020)
Mohamed Amer, Helen Toogood, Nigel S Scrutton
Engineering nature for gaseous hydrocarbon production. Microbial cell factories 19 (1) (2020)
Tobias M Hedison, Muralidharan Shanmugam, Derren J Heyes, Ruth Edge, Nigel S Scrutton
Active Intermediates in Copper Nitrite Reductase Reactions Probed by a Cryotrapping-Electron Paramagnetic Resonance Approach. Angewandte Chemie (International ed. in English) 59 (33) (2020)
Joanna A Hughes, Samantha J O Hardman, Nigel S Scrutton, Darren M Graham, Jonathan R Woodward, Alex R Jones
Observation of the Δg mechanism resulting from the ultrafast spin dynamics that follow the photolysis of coenzyme B12. The Journal of chemical physics 151 (20) (2019)
Issa S Issa, Helen S Toogood, Linus O Johannissen, James Raftery, Nigel S Scrutton, John M Gardiner
C3 and C6 Modification-Specific OYE Biotransformations of Synthetic Carvones and Sequential BVMO Chemoenzymatic Synthesis of Chiral Caprolactones. Chemistry (Weinheim an der Bergstrasse, Germany) 25 (12) (2019)
Andrew Currin, Neil Swainston, Mark S Dunstan, Adrian J Jervis, Paul Mulherin, Christopher J Robinson, Sandra Taylor, Pablo Carbonell, Katherine A Hollywood, Cunyu Yan, Eriko Takano, Nigel S Scrutton, Rainer Breitling
Highly multiplexed, fast and accurate nanopore sequencing for verification of synthetic DNA constructs and sequence libraries. Synthetic biology (Oxford, England) 4 (1) (2019)
Lewis J Kearsey, Nicole Prandi, Vijaykumar Karuppiah, Cunyu Yan, David Leys, Helen Toogood, Eriko Takano, Nigel S Scrutton
Structure of the Cannabis sativa olivetol-producing enzyme reveals cyclization plasticity in type III polyketide synthases. The FEBS journal 287 (8) (2019)
Adrian J Jervis, Pablo Carbonell, Maria Vinaixa, Mark S Dunstan, Katherine A Hollywood, Christopher J Robinson, Nicholas J W Rattray, Cunyu Yan, Neil Swainston, Andrew Currin, Rehana Sung, Helen S Toogood, Sandra Taylor, Jean-Loup Faulon, Rainer Breitling, Eriko Takano, Nigel S Scrutton
Machine Learning of Designed Translational Control Allows Predictive Pathway Optimization in Escherichia coli. ACS synthetic biology 8 (1) (2019)
Valentina Lukinović, Jonathan R Woodward, Teresa C Marrafa, Muralidharan Shanmugam, Derren J Heyes, Samantha J O Hardman, Nigel S Scrutton, Sam Hay, Alistair J Fielding, Alex R Jones
Photochemical Spin Dynamics of the Vitamin B12 Derivative, Methylcobalamin. The journal of physical chemistry. B 123 (22) (2019)
Aled D Roberts, Paul Kelly, Jennifer Bain, John J Morrison, Ian Wimpenny, Mike Barrow, Robert T Woodward, Matthieu Gresil, Christopher F Blanford, Sam Hay, Jonathan James Blaker, Steve G Yeates, Nigel S Scrutton
Graphene-aramid nanocomposite fibres via superacid co-processing. Chemical communications (Cambridge, England) 55 (78) (2019)
Adrian J Jervis, Pablo Carbonell, Sandra Taylor, Rehana Sung, Mark S Dunstan, Christopher J Robinson, Rainer Breitling, Eriko Takano, Nigel S Scrutton
SelProm: A Queryable and Predictive Expression Vector Selection Tool for Escherichia coli. ACS synthetic biology 8 (7) (2019)
Gabriel A Ascue Avalos, Helen S Toogood, Shirley Tait, Hanan L Messiha, Nigel S Scrutton
From Bugs to Bioplastics: Total (+)-Dihydrocarvide Biosynthesis by Engineered Escherichia coli. Chembiochem : a European journal of chemical biology 20 (6) (2019)
Tobias M Hedison, Derren J Heyes, Muralidharan Shanmugam, Andreea I Iorgu, Nigel S Scrutton
Solvent-slaved protein motions accompany proton coupled electron transfer reactions catalysed by copper nitrite reductase. Chemical communications (Cambridge, England) 55 (42) (2019)
Nicole G H Leferink, Kara E Ranaghan, Jaime Battye, Linus O Johannissen, Sam Hay, Marc W van der Kamp, Adrian J Mulholland, Nigel S Scrutton
Taming the Reactivity of Monoterpene Synthases To Guide Regioselective Product Hydroxylation. Chembiochem : a European journal of chemical biology 21 (7) (2019)
Nataliya Archipowa, Roger Jan Kutta, Derren J Heyes, Nigel S Scrutton
Stepwise Hydride Transfer in a Biological System: Insights into the Reaction Mechanism of the Light-Dependent Protochlorophyllide Oxidoreductase. Angewandte Chemie (International ed. in English) 57 (10) (2018)
Uzma Choudry, Derren J Heyes, Samantha J O Hardman, Michiyo Sakuma, Igor V Sazanovich, Joyce Woodhouse, Eugenio De La Mora, Martin N Pedersen, Michael Wulff, Martin Weik, Giorgio Schirò, Nigel S Scrutton
Photochemical Mechanism of an Atypical Algal Phytochrome. Chembiochem : a European journal of chemical biology 19 (10) (2018)
Tanja Knaus, Vasilis Tseliou, Luke D Humphreys, Nigel S Scrutton, Francesco G Mutti
A biocatalytic method for the chemoselective aerobic oxidation of aldehydes to carboxylic acids. Green chemistry : an international journal and green chemistry resource : GC 20 (17) (2018)
Hanan L Messiha, Syed T Ahmed, Vijaykumar Karuppiah, Reynier Suardíaz, Gabriel A Ascue Avalos, Natalie Fey, Stephen Yeates, Helen S Toogood, Adrian J Mulholland, Nigel S Scrutton
Biocatalytic Routes to Lactone Monomers for Polymer Production. Biochemistry 57 (13) (2018)
Aisling Ní Cheallaigh, David J Mansell, Helen S Toogood, Shirley Tait, Antonios Lygidakis, Nigel S Scrutton, John M Gardiner
Chemoenzymatic Synthesis of the Intermediates in the Peppermint Monoterpenoid Biosynthetic Pathway. Journal of natural products 81 (7) (2018)
Kara E Ranaghan, William G Morris, Laura Masgrau, Senthilkumar Kittusamy, Linus O Johannissen, Nigel S Scrutton, Jeremy N Harvey, Frederick R Manby, Adrian J Mulholland
Ab Initio QM/MM Modeling of the Rate-Limiting Proton Transfer Step in the Deamination of Tryptamine by Aromatic Amine Dehydrogenase. The journal of physical chemistry. B 121 (42) (2017)
Andreea I Iorgu, Nicola J Baxter, Matthew J Cliff, Jonathan P Waltho, Sam Hay, Nigel S Scrutton
1H, 15N and 13C backbone resonance assignments of pentaerythritol tetranitrate reductase from Enterobacter cloacae PB2. Biomolecular NMR assignments 12 (1) (2017)
Carlo N G Giachello, Nigel S Scrutton, Alex R Jones, Richard A Baines
Magnetic Fields Modulate Blue-Light-Dependent Regulation of Neuronal Firing by Cryptochrome. The Journal of neuroscience : the official journal of the Society for Neuroscience 36 (42) (2017)
Neil Swainston, Riza Batista-Navarro, Pablo Carbonell, Paul D Dobson, Mark Dunstan, Adrian J Jervis, Maria Vinaixa, Alan R Williams, Sophia Ananiadou, Jean-Loup Faulon, Robert Müller, Douglas B Kell, Nigel S Scrutton, Rainer Breitling
biochem4j: Integrated and extensible biochemical knowledge through graph databases. PloS one 12 (7) (2017)
Antonios Lygidakis, Vijaykumar Karuppiah, Robin Hoeven, Aisling Ní Cheallaigh, David Leys, John M Gardiner, Helen S Toogood, Nigel S Scrutton
Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases. Angewandte Chemie (International ed. in English) 55 (33) (2016)
Antonios Lygidakis, Vijaykumar Karuppiah, Robin Hoeven, Aisling Ní Cheallaigh, David Leys, John M Gardiner, Helen S Toogood, Nigel S Scrutton
Pinpointing a Mechanistic Switch Between Ketoreduction and "Ene" Reduction in Short-Chain Dehydrogenases/Reductases. Angewandte Chemie (Weinheim an der Bergstrasse, Germany) 128 (33) (2016)
Demet Kekilli, Christine A Petersen, David A Pixton, Dlzar D Ghafoor, Gaylany H Abdullah, Florian S N Dworkowski, Michael T Wilson, Derren J Heyes, Samantha J O Hardman, Loretta M Murphy, Richard W Strange, Nigel S Scrutton, Colin R Andrew, Michael A Hough
Engineering proximal vs. distal heme-NO coordination via dinitrosyl dynamics: implications for NO sensor design. Chemical science 8 (3) (2016)