Josef M Penninger (Josef Penninger)

ResearcherID ORCID

Publication Activity (10 Years)

Years Active: 2016-2024
Publications (10 Years): 92

Top Topics

Respiratory Syndrome Coronavirus

Neuropathic Pain

Regulatory T Cells

Candida Albicans

Top Venues

Nature communications

EMBO molecular medicine

Nature microbiology

This page only lists publications with an associated author ORCID identifier.

Publications

Johannes Stadlmann, Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M Markovitz, Josef M Penninger, Friedrich Altmann
Non-targeted isomer-sensitive N-glycome analysis reveals new layers of organ-specific diversity in mice. Research square (2024)
Teemu Kilpiö, Sini Skarp, Ábel Perjés, Julia Swan, Leena Kaikkonen, Samu Saarimäki, István Szokodi, Josef M Penninger, Zoltán Szabó, Johanna Magga, Risto Kerkelä
Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model. American journal of physiology. Cell physiology 326 (5) (2024)
Johannes Stadlmann, Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M Markovitz, Josef M Penninger, Friedrich Altmann
Non-targeted isomer-sensitive N-glycome analysis reveals new layers of organ-specific diversity in mice. Research square (2024)
Teemu Kilpiö, Sini Skarp, Ábel Perjés, Julia Swan, Leena Kaikkonen, Samu Saarimäki, István Szokodi, Josef M Penninger, Zoltán Szabó, Johanna Magga, Risto Kerkelä
Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model. American journal of physiology. Cell physiology 326 (5) (2024)
Vanessa M Monteil, Shane C Wright, Matheus Dyczynski, Max J Kellner, Sofia K Appelberg, Sebastian Wolfgang Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stéphanie Devignot, Elizabeth G Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker Martin Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Montserrat, David W Hawman, Heinrich Feldmann, Moritz Horn, Josef M Penninger, Ali Mirazimi
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells. Nature microbiology 9 (6) (2024)
Clément Quintard, Emily Tubbs, Gustav Jonsson, Jie Jiao, Jun Wang, Nicolas Werschler, Camille Laporte, Amandine Pitaval, Thierno-Sidy Bah, Gideon Pomeranz, Caroline Bissardon, Joris Kaal, Alexandra Leopoldi, David A Long, Pierre Blandin, Jean-Luc Achard, Christophe Battail, Astrid Hagelkruys, Fabrice Navarro, Yves Fouillet, Josef M Penninger, Xavier Gidrol
A microfluidic platform integrating functional vascularized organoids-on-chip. Nature communications 15 (1) (2024)
Vanessa M Monteil, Shane C Wright, Matheus Dyczynski, Max J Kellner, Sofia K Appelberg, Sebastian Wolfgang Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stéphanie Devignot, Elizabeth G Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker Martin Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Montserrat, David W Hawman, Heinrich Feldmann, Moritz Horn, Josef M Penninger, Ali Mirazimi
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells. Nature microbiology (2024)
Teemu Kilpiö, Sini Skarp, Ábel Perjés, Julia Swan, Leena Kaikkonen, Samu Saarimäki, István Szokodi, Josef M Penninger, Zoltán Szabó, Johanna Magga, Risto Kerkelä
Apelin regulates skeletal muscle adaptation to exercise in a high-intensity interval training model. American journal of physiology. Cell physiology 326 (5) (2024)
Domagoj Cikes, Michael Leutner, Shane J F Cronin, Maria Novatchkova, Lorenz Pfleger, Radka Klepochová, Benjamin Lair, Marlène Lac, Camille Bergoglio, Nathalie Viguerie, Gerhard Dürnberger, Elisabeth Roitinger, Mihaela Grivej, Tommy R Lundberg, Thomas Gustafsson, Astrid Hagelkruys, Geneviève Tavernier, Virginie Bourlier, Claude Knauf, Michael Krebs, Alexandra Kautzky-Willer, Cedric Moro, Martin Krssak, Michael Orthofer, Josef M Penninger
Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nature aging (2024)
Domagoj Cikes, Michael Leutner, Shane J F Cronin, Maria Novatchkova, Lorenz Pfleger, Radka Klepochová, Benjamin Lair, Marlène Lac, Camille Bergoglio, Nathalie Viguerie, Gerhard Dürnberger, Elisabeth Roitinger, Mihaela Grivej, Tommy R Lundberg, Thomas Gustafsson, Astrid Hagelkruys, Geneviève Tavernier, Virginie Bourlier, Claude Knauf, Michael Krebs, Alexandra Kautzky-Willer, Cedric Moro, Martin Krssak, Michael Orthofer, Josef M Penninger
Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nature aging 4 (1) (2024)
Ayami Ota, Takahiro Iguchi, Sachiko Nitta, Ryunosuke Muro, Nanami Mino, Masayuki Tsukasaki, Josef M Penninger, Takeshi Nitta, Hiroshi Takayanagi
Synchronized development of thymic eosinophils and thymocytes. International immunology (2024)
Vanessa M Monteil, Shane C Wright, Matheus Dyczynski, Max J Kellner, Sofia K Appelberg, Sebastian Wolfgang Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stéphanie Devignot, Elizabeth G Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker Martin Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Montserrat, David W Hawman, Heinrich Feldmann, Moritz Horn, Josef M Penninger, Ali Mirazimi
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells. Nature microbiology 9 (6) (2024)
Domagoj Cikes, Michael Leutner, Shane J F Cronin, Maria Novatchkova, Lorenz Pfleger, Radka Klepochová, Benjamin Lair, Marlène Lac, Camille Bergoglio, Nathalie Viguerie, Gerhard Dürnberger, Elisabeth Roitinger, Mihaela Grivej, Tommy R Lundberg, Thomas Gustafsson, Astrid Hagelkruys, Geneviève Tavernier, Virginie Bourlier, Claude Knauf, Michael Krebs, Alexandra Kautzky-Willer, Cedric Moro, Martin Krssak, Michael Orthofer, Josef M Penninger
Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nature aging 4 (1) (2024)
Clément Quintard, Emily Tubbs, Gustav Jonsson, Jie Jiao, Jun Wang, Nicolas Werschler, Camille Laporte, Amandine Pitaval, Thierno-Sidy Bah, Gideon Pomeranz, Caroline Bissardon, Joris Kaal, Alexandra Leopoldi, David A Long, Pierre Blandin, Jean-Luc Achard, Christophe Battail, Astrid Hagelkruys, Fabrice Navarro, Yves Fouillet, Josef M Penninger, Xavier Gidrol
A microfluidic platform integrating functional vascularized organoids-on-chip. Nature communications 15 (1) (2024)
Johannes Stadlmann, Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M Markovitz, Josef M Penninger, Friedrich Altmann
Non-targeted isomer-sensitive N-glycome analysis reveals new layers of organ-specific diversity in mice. Research square (2024)
Vanessa M Monteil, Shane C Wright, Matheus Dyczynski, Max J Kellner, Sofia K Appelberg, Sebastian Wolfgang Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stéphanie Devignot, Elizabeth G Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker Martin Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Montserrat, David W Hawman, Heinrich Feldmann, Moritz Horn, Josef M Penninger, Ali Mirazimi
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells. Nature microbiology 9 (6) (2024)
Johannes Stadlmann, Johannes Helm, Stefan Mereiter, Tiago Oliveira, Anna Gattinger, David M Markovitz, Josef M Penninger, Friedrich Altmann
Non-targeted isomer-sensitive N-glycome analysis reveals new layers of organ-specific diversity in mice. Research square (2024)
Domagoj Cikes, Michael Leutner, Shane J F Cronin, Maria Novatchkova, Lorenz Pfleger, Radka Klepochová, Benjamin Lair, Marlène Lac, Camille Bergoglio, Nathalie Viguerie, Gerhard Dürnberger, Elisabeth Roitinger, Mihaela Grivej, Tommy R Lundberg, Thomas Gustafsson, Astrid Hagelkruys, Geneviève Tavernier, Virginie Bourlier, Claude Knauf, Michael Krebs, Alexandra Kautzky-Willer, Cedric Moro, Martin Krssak, Michael Orthofer, Josef M Penninger
Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nature aging 4 (1) (2024)
Clément Quintard, Emily Tubbs, Gustav Jonsson, Jie Jiao, Jun Wang, Nicolas Werschler, Camille Laporte, Amandine Pitaval, Thierno-Sidy Bah, Gideon Pomeranz, Caroline Bissardon, Joris Kaal, Alexandra Leopoldi, David A Long, Pierre Blandin, Jean-Luc Achard, Christophe Battail, Astrid Hagelkruys, Fabrice Navarro, Yves Fouillet, Josef M Penninger, Xavier Gidrol
A microfluidic platform integrating functional vascularized organoids-on-chip. Nature communications 15 (1) (2024)
Philipp Starkl, Gustav Jonsson, Tyler Artner, Bruna Lenfers Turnes, Laura-Marie Gail, Tiago Oliveira, Aakanksha Jain, Nadine Serhan, Karel Stejskal, Karin Lakovits, Anastasiya Hladik, Meilin An, Keith M Channon, Hail Kim, Thomas Köcher, Wolfgang Weninger, Georg Stary, Sylvia Knapp, Victoria Klang, Nicolas Gaudenzio, Clifford J Woolf, Shweta Tikoo, Rohit Jain, Josef M Penninger, Shane J F Cronin
Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain. Science immunology 9 (98) (2024)
Clément Quintard, Emily Tubbs, Gustav Jonsson, Jie Jiao, Jun Wang, Nicolas Werschler, Camille Laporte, Amandine Pitaval, Thierno-Sidy Bah, Gideon Pomeranz, Caroline Bissardon, Joris Kaal, Alexandra Leopoldi, David A Long, Pierre Blandin, Jean-Luc Achard, Christophe Battail, Astrid Hagelkruys, Fabrice Navarro, Yves Fouillet, Josef M Penninger, Xavier Gidrol
A microfluidic platform integrating functional vascularized organoids-on-chip. Nature communications 15 (1) (2024)
Domagoj Cikes, Michael Leutner, Shane J F Cronin, Maria Novatchkova, Lorenz Pfleger, Radka Klepochová, Benjamin Lair, Marlène Lac, Camille Bergoglio, Nathalie Viguerie, Gerhard Dürnberger, Elisabeth Roitinger, Mihaela Grivej, Tommy R Lundberg, Thomas Gustafsson, Astrid Hagelkruys, Geneviève Tavernier, Virginie Bourlier, Claude Knauf, Michael Krebs, Alexandra Kautzky-Willer, Cedric Moro, Martin Krssak, Michael Orthofer, Josef M Penninger
Gpcpd1-GPC metabolic pathway is dysfunctional in aging and its deficiency severely perturbs glucose metabolism. Nature aging 4 (1) (2024)
Philipp Starkl, Gustav Jonsson, Tyler Artner, Bruna Lenfers Turnes, Laura-Marie Gail, Tiago Oliveira, Aakanksha Jain, Nadine Serhan, Karel Stejskal, Karin Lakovits, Anastasiya Hladik, Meilin An, Keith M Channon, Hail Kim, Thomas Köcher, Wolfgang Weninger, Georg Stary, Sylvia Knapp, Victoria Klang, Nicolas Gaudenzio, Clifford J Woolf, Shweta Tikoo, Rohit Jain, Josef M Penninger, Shane J F Cronin
Mast cell-derived BH4 and serotonin are critical mediators of postoperative pain. Science immunology 9 (98) (2024)
Vanessa M Monteil, Shane C Wright, Matheus Dyczynski, Max J Kellner, Sofia K Appelberg, Sebastian Wolfgang Platzer, Ahmed Ibrahim, Hyesoo Kwon, Ioannis Pittarokoilis, Mattia Mirandola, Georg Michlits, Stéphanie Devignot, Elizabeth G Elder, Samir Abdurahman, Sándor Bereczky, Binnur Bagci, Sonia Youhanna, Teodor Aastrup, Volker Martin Lauschke, Cristiano Salata, Nazif Elaldi, Friedemann Weber, Nuria Montserrat, David W Hawman, Heinrich Feldmann, Moritz Horn, Josef M Penninger, Ali Mirazimi
Crimean-Congo haemorrhagic fever virus uses LDLR to bind and enter host cells. Nature microbiology 9 (6) (2024)
Kirill Salewskij, Josef M Penninger
Blood Vessel Organoids for Development and Disease. Circulation research 132 (4) (2023)
Jasmin Taubenschmid-Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rózsová, Christian Studer, Daniela Lötsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl-Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Jürgen Arthur Knoblich, Ulrich Elling, Moritz Horn, Josef M Penninger
A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO molecular medicine 15 (3) (2023)
Kirill Salewskij, Josef M Penninger
Blood Vessel Organoids for Development and Disease. Circulation research 132 (4) (2023)
Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J F Cronin, Maria Novatchkova, Anoop M Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Tommy R Lundberg, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S Chamberlain, Marica Bakovic, Siddharth Banka, Josef M Penninger
PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nature metabolism (2023)
Barizah Malik, Iva Vokic, Thomas Mohr, Marle Poppelaars, Martin Holcmann, Philipp Novoszel, Gerald Timelthaler, Thomas Lendl, Dana Krauß, Ulrich Elling, Michael Mildner, Josef M Penninger, Peter Petzelbauer, Maria Sibilia, Agnes Csiszar
FAM3C/ILEI protein is elevated in psoriatic lesions and triggers psoriasiform hyperproliferation in mice. EMBO molecular medicine (2023)
Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J F Cronin, Maria Novatchkova, Anoop M Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Tommy R Lundberg, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S Chamberlain, Marica Bakovic, Siddharth Banka, Josef M Penninger
Author Correction: PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nature metabolism (2023)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Author Correction: Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 14 (1) (2023)
Kirill Salewskij, Josef M Penninger
Blood Vessel Organoids for Development and Disease. Circulation research 132 (4) (2023)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Author Correction: Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 14 (1) (2023)
Stéphanie Devignot, Tim Wai Sha, Thomas Rainer Burkard, Patrick Schmerer, Astrid Hagelkruys, Ali Mirazimi, Ulrich Elling, Josef M Penninger, Friedemann Weber
Low-density lipoprotein receptor-related protein 1 (LRP1) as an auxiliary host factor for RNA viruses. Life science alliance 6 (7) (2023)
Vanessa M Monteil, Hyesoo Kwon, Lijo John, Cristiano Salata, Gustav Jonsson, Sabine U Vorrink, Sofia K Appelberg, Sonia Youhanna, Matheus Dyczynski, Alexandra Leopoldi, Nicole Leeb, Jennifer Volz, Astrid Hagelkruys, Max J Kellner, Stéphanie Devignot, Georg Michlits, Michelle Foong-Sobis, Friedemann Weber, Volker Martin Lauschke, Moritz Horn, Heinrich Feldmann, Ulrich Elling, Josef M Penninger, Ali Mirazimi
Identification of CCZ1 as an essential lysosomal trafficking regulator in Marburg and Ebola virus infections. Nature communications 14 (1) (2023)
Busra Turgu, Amal El-Naggar, Melanie Kogler, Luigi Tortola, Hai-Feng Zhang, Mariam Hassan, Michael M Lizardo, Sonia H Y Kung, Wan Lam, Josef M Penninger, Poul H Sorensen
The HACE1 E3 ligase mediates RAC1-dependent control of mTOR signaling complexes. EMBO reports (2023)
Kirill Salewskij, Josef M Penninger
Blood Vessel Organoids for Development and Disease. Circulation research 132 (4) (2023)
Nagesha Guthalu Kondegowda, Joanna Filipowska, Jeong-Su Do, Nancy Leon-Rivera, Rosemary Li, Rollie Hampton, Selassie Ogyaadu, Camilla Levister, Josef M Penninger, Helena Reijonen, Carol J Levy, Rupangi C Vasavada
RANKL/RANK is required for cytokine-induced beta cell death; osteoprotegerin, a RANKL inhibitor, reverses rodent type 1 diabetes. Science advances 9 (44) (2023)
Jasmin Taubenschmid-Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rózsová, Christian Studer, Daniela Lötsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl-Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Jürgen Arthur Knoblich, Ulrich Elling, Moritz Horn, Josef M Penninger
A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO molecular medicine 15 (3) (2023)
Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J F Cronin, Maria Novatchkova, Anoop M Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Tommy R Lundberg, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S Chamberlain, Marica Bakovic, Siddharth Banka, Josef M Penninger
PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nature metabolism (2023)
Domagoj Cikes, Kareem Elsayad, Erdinc Sezgin, Erika Koitai, Ferenc Torma, Michael Orthofer, Rebecca Yarwood, Leonhard X Heinz, Vitaly Sedlyarov, Nasser Darwish Miranda, Adrian Taylor, Sophie Grapentine, Fathiya Al-Murshedi, Anne Abot, Adelheid Weidinger, Candice Kutchukian, Colline Sanchez, Shane J F Cronin, Maria Novatchkova, Anoop M Kavirayani, Thomas Schuetz, Bernhard Haubner, Lisa Haas, Astrid Hagelkruys, Suzanne Jackowski, Andrey V Kozlov, Vincent Jacquemond, Claude Knauf, Giulio Superti-Furga, Tommy R Lundberg, Thomas Gustafsson, John McDermot, Martin Lowe, Zsolt Radak, Jeffrey S Chamberlain, Marica Bakovic, Siddharth Banka, Josef M Penninger
PCYT2-regulated lipid biosynthesis is critical to muscle health and ageing. Nature metabolism (2023)
Jasmin Taubenschmid-Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rózsová, Christian Studer, Daniela Lötsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl-Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Jürgen Arthur Knoblich, Ulrich Elling, Moritz Horn, Josef M Penninger
A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO molecular medicine (2023)
Jasmin Taubenschmid-Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rózsová, Christian Studer, Daniela Lötsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl-Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Jürgen Arthur Knoblich, Ulrich Elling, Moritz Horn, Josef M Penninger
A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO molecular medicine 15 (3) (2023)
Jasmin Taubenschmid-Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rózsová, Christian Studer, Daniela Lötsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl-Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Jürgen Arthur Knoblich, Ulrich Elling, Moritz Horn, Josef M Penninger
A whole-genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors. EMBO molecular medicine 15 (3) (2023)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Vanessa M Monteil, Brett Eaton, Elena Postnikova, Michael Murphy, Benedict Braunsfeld, Ian Crozier, Franz Kricek, Janine Niederhöfer, Alice Schwarzböck, Helene Breid, Stéphanie Devignot, Jonas Klingström, Charlotte Thålin, Max J Kellner, Wanda Christ, Sebastian Havervall, Stefan Mereiter, Sylvia Knapp, Anna Sanchez Jimenez, Agnes Bugajska-Schretter, Alexander Dohnal, Christine Ruf, Romana Gugenberger, Astrid Hagelkruys, Nuria Montserrat, Ivona Kozieradzki, Omar Hasan Ali, Johannes Stadlmann, Michael R Holbrook, Connie Schmaljohn, Chris Oostenbrink, Robert H Shoemaker, Ali Mirazimi, Gerald Wirnsberger, Josef M Penninger
Clinical grade ACE2 as a universal agent to block SARS-CoV-2 variants. EMBO molecular medicine 14 (8) (2022)
Ke Song, Xinyan Yang, Geng An, Xinyu Xia, Jiexiang Zhao, Xiaoheng Xu, Cong Wan, Tianyuan Liu, Yi Zheng, Shaofang Ren, Mei Wang, Gang Chang, Shane J F Cronin, Josef M Penninger, Tao Jing, Xianghong Ou, Shuan Rao, Zhaoting Liu, Xiao-Yang Zhao
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models. Nature communications 13 (1) (2022)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Astrid Hagelkruys, Marion Horrer, Jasmin Taubenschmid-Stowers, Anoop M Kavirayani, Maria Novatchkova, Michael Orthofer, Tsung-Pin Pai, Domagoj Cikes, Sergei Zhuk, Meritxell Balmaña, Christopher Esk, Rubina Koglgruber, Paul Moeseneder, Jelena Lazovic, Lydia M Zopf, Shane J F Cronin, Ulrich Elling, Jürgen Arthur Knoblich, Josef M Penninger
The HUSH complex controls brain architecture and protocadherin fidelity. Science advances 8 (44) (2022)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Shane J F Cronin, Shuan Rao, Miguel Á Tejada, Bruna Lenfers Turnes, Simon Licht-Mayer, Takao Omura, Christian Brenneis, Emily Jacobs, Lee Barrett, Alban Latremoliere, Nick Andrews, Keith M Channon, Alexandra Latini, Anthony C Arvanites, Lance S Davidow, Michael Costigan, Lee L Rubin, Josef M Penninger, Clifford J Woolf
Phenotypic drug screen uncovers the metabolic GCH1/BH4 pathway as key regulator of EGFR/KRAS-mediated neuropathic pain and lung cancer. Science translational medicine 14 (660) (2022)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Christopher W Fell, Astrid Hagelkruys, Ana Cicvaric, Marion Horrer, Lucy Liu, Joshua Shing Shun Li, Johannes Stadlmann, Anton A Polyansky, Stefan Mereiter, Miguel Angel Tejada, Tomislav Kokotović, Venkat Swaroop Achuta, Angelica Scaramuzza, Kimberly A Twyman, Michelle M Morrow, Jane Juusola, Huifang Yan, Jingmin Wang, Margit Burmeister, Biswa Choudhury, Thomas Levin Andersen, Gerald Wirnsberger, Uffe Holmskov, Norbert Perrimon, Bojan Žagrović, Francisco J Monje, Jesper Bonnet Moeller, Josef M Penninger, Vanja Nagy
FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder. EMBO molecular medicine 14 (9) (2022)
Rong Zhu, Daniel Canena, Mateusz Sikora, Miriam Klausberger, Hannah Seferovic, Ahmad Reza Mehdipour, Lisa Hain, Elisabeth Laurent, Vanessa M Monteil, Gerald Wirnsberger, Ralph Wieneke, Robert Tampé, Nikolaus F Kienzl, Lukas Mach, Ali Mirazimi, Yoo Jin Oh, Josef M Penninger, Gerhard Hummer, Peter Hinterdorfer
Force-tuned avidity of spike variant-ACE2 interactions viewed on the single-molecule level. Nature communications 13 (1) (2022)
Patrick O Humbert, Tamara Zoranovic Pryjda, Blanka Pranjic, Andrew Farrell, Kohei Fujikura, Ricardo de Matos Simoes, Rezaul Karim, Ivona Kozieradzki, Shane J F Cronin, G Gregory Neely, Thomas F Meyer, Astrid Hagelkruys, Helena E Richardson, Josef M Penninger
TSPAN6 is a suppressor of Ras-driven cancer. Oncogene 41 (14) (2022)
Theresa Dolejsi, Murilo Delgobo, Thomas Schuetz, Luigi Tortola, Katrin G Heinze, Ulrich Hofmann, Stefan Frantz, Axel Bauer, Frank Ruschitzka, Josef M Penninger, Gustavo Campos Ramos, Bernhard J Haubner
Adult T-cells impair neonatal cardiac regeneration. European heart journal 43 (28) (2022)
Masahiro Onji, Nicolas Werschler, Josef M Penninger
A critical relationship between bone and fat: the role of bone marrow adipose-derived RANKL in bone metabolism. EMBO reports 22 (7) (2021)
Tomokazu Yamaguchi, Midori Hoshizaki, Takafumi Minato, Satoru Nirasawa, Masamitsu N Asaka, Mayumi Niiyama, Masaki Imai, Akihiko Uda, Jasper Fuk-Woo Chan, Saori Takahashi, Jianbo An, Akari Saku, Ryota Nukiwa, Daichi Utsumi, Maki Kiso, Atsuhiro Yasuhara, Vincent Kwok-Man Poon, Chris Chung-Sing Chan, Yuji Fujino, Satoru Motoyama, Satoshi Nagata, Josef M Penninger, Haruhiko Kamada, Kwok-Yung Yuen, Wataru Kamitani, Ken Maeda, Yoshihiro Kawaoka, Yasuhiro Yasutomi, Yumiko Imai, Keiji Kuba
ACE2-like carboxypeptidase B38-CAP protects from SARS-CoV-2-induced lung injury. Nature communications 12 (1) (2021)
David Hoffmann, Stefan Mereiter, Yoo Jin Oh, Vanessa M Monteil, Elizabeth G Elder, Rong Zhu, Daniel Canena, Lisa Hain, Elisabeth Lobner, Clemens Grünwald-Gruber, Miriam Klausberger, Gustav Jonsson, Max J Kellner, Maria Novatchkova, Melita Ticevic, Antoine Chabloz, Gerald Wirnsberger, Astrid Hagelkruys, Friedrich Altmann, Lukas Mach, Johannes Stadlmann, Chris Oostenbrink, Ali Mirazimi, Peter Hinterdorfer, Josef M Penninger
Identification of lectin receptors for conserved SARS-CoV-2 glycosylation sites. The EMBO journal 40 (19) (2021)
Tümay Capraz, Nikolaus F Kienzl, Elisabeth Lobner, Jan Walther Perthold, Esther Föderl-Höbenreich, Clemens Grünwald-Gruber, Daniel Maresch, Vanessa M Monteil, Janine Niederhöfer, Gerald Wirnsberger, Ali Mirazimi, Kurt Zatloukal, Lukas Mach, Josef M Penninger, Chris Oostenbrink, Johannes Stadlmann
Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor. eLife 10 (2021)
Busra Turgu, Fan Zhang, Amal El-Naggar, Gian Luca Negri, Melanie Kogler, Luigi Tortola, Fraser Johnson, Tony Ng, Amy Li, Donald Yapp, William Lockwood, Daniel Martinez, John M Maris, Mads Daugaard, Josef M Penninger, Christopher S Hughes, Poul H Sorensen
HACE1 blocks HIF1α accumulation under hypoxia in a RAC1 dependent manner. Oncogene 40 (11) (2021)
Justin Stebbing, Ginés Sánchez Nievas, Marco Falcone, Sonia Youhanna, Peter Richardson, Silvia Ottaviani, Joanne X Shen, Christian Sommerauer, Giusy Tiseo, Lorenzo Ghiadoni, Agostino Virdis, Fabio Monzani, Luis Romero Rizos, Francesco Forfori, Almudena Avendaño Céspedes, Salvatore De Marco, Laura Carrozzi, Fabio Lena, Pedro Manuel Sánchez-Jurado, Leonardo Gianluca Lacerenza, Nencioni Cesira, David Caldevilla Bernardo, Antonio Perrella, Laura Niccoli, Lourdes Sáez Méndez, Daniela Matarrese, Delia Goletti, Yee Joo Tan, Vanessa M Monteil, George Dranitsaris, Fabrizio Cantini, Alessio Farcomeni, Shuchismita Dutta, Stephen K Burley, Mirjana Jerkic, Mauro Pistello, William Li, Marta Mas Romero, Fernando Andrés Pretel, Rafaela Sánchez Simón-Talero, Rafael García-Molina, Claudia Kutter, James H Felce, Zehra F Nizami, Andras G Miklosi, Josef M Penninger, Francesco Menichetti, Ali Mirazimi, Pedro Abizanda Soler, Volker Martin Lauschke
JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality. Science advances 7 (1) (2021)
Rebeca Kawahara, Anastasia Chernykh, Kathirvel Alagesan, Marshall Bern, Wei-Qian Cao, Robert J Chalkley, Kai Cheng, Matthew S F Choo, Nathan Edwards, Radoslav Goldman, Marcus Hoffmann, Yingwei Hu, Yifan Huang, Jin Young Kim, Doron Kletter, Benoit Liquet, Mingqi Liu, Yehia Mechref, Bo Meng, Sriram Neelamegham, Terry Nguyen-Khuong, Jonas Nilsson, Adam Pap, Gun Wook Park, Benjamin L Parker, Cassandra L Pegg, Josef M Penninger, Toan K Phung, Markus Pioch, Erdmann Rapp, Enes Sakalli, Miloslav Sanda, Benjamin L Schulz, Nichollas E Scott, Georgy Sofronov, Johannes Stadlmann, Sergey Y Vakhrushev, Christina M Woo, Hung-Yi Wu, Peng-Yuan Yang, Wantao Ying, Hui Zhang, Yong Zhang, Jingfu Zhao, Joseph Zaia, Stuart M Haslam, Giuseppe Palmisano, Jong Shin Yoo, Göran Larson, Kai-Hooi Khoo, Katalin F Medzihradszky, Daniel Kolarich, Nicolle H Packer, Morten Thaysen-Andersen
Author Correction: Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nature methods (2021)
Rebeca Kawahara, Anastasia Chernykh, Kathirvel Alagesan, Marshall Bern, Wei-Qian Cao, Robert J Chalkley, Kai Cheng, Matthew S F Choo, Nathan Edwards, Radoslav Goldman, Marcus Hoffmann, Yingwei Hu, Yifan Huang, Jin Young Kim, Doron Kletter, Benoit Liquet, Mingqi Liu, Yehia Mechref, Bo Meng, Sriram Neelamegham, Terry Nguyen-Khuong, Jonas Nilsson, Adam Pap, Gun Wook Park, Benjamin L Parker, Cassandra L Pegg, Josef M Penninger, Toan K Phung, Markus Pioch, Erdmann Rapp, Enes Sakalli, Miloslav Sanda, Benjamin L Schulz, Nichollas E Scott, Georgy Sofronov, Johannes Stadlmann, Sergey Y Vakhrushev, Christina M Woo, Hung-Yi Wu, Peng-Yuan Yang, Wantao Ying, Hui Zhang, Yong Zhang, Jingfu Zhao, Joseph Zaia, Stuart M Haslam, Giuseppe Palmisano, Jong Shin Yoo, Göran Larson, Kai-Hooi Khoo, Katalin F Medzihradszky, Daniel Kolarich, Nicolle H Packer, Morten Thaysen-Andersen
Community evaluation of glycoproteomics informatics solutions reveals high-performance search strategies for serum glycopeptide analysis. Nature methods 18 (11) (2021)
Vanessa M Monteil, Matheus Dyczynski, Volker Martin Lauschke, Hyesoo Kwon, Gerald Wirnsberger, Sonia Youhanna, Mirjana Jerkic, Arthur S Slutsky, Carmen Hurtado Del Pozo, Moritz Horn, Nuria Montserrat, Josef M Penninger, Ali Mirazimi
Human soluble ACE2 improves the effect of remdesivir in SARS-CoV-2 infection. EMBO molecular medicine 13 (1) (2020)
Takafumi Minato, Satoru Nirasawa, Teruki Sato, Tomokazu Yamaguchi, Midori Hoshizaki, Tadakatsu Inagaki, Kazuhiko Nakahara, Tadashi Yoshihashi, Ryo Ozawa, Saki Yokota, Miyuki Natsui, Souichi Koyota, Taku Yoshiya, Kumiko Yoshizawa-Kumagaye, Satoru Motoyama, Takeshi Gotoh, Yoshikazu Nakaoka, Josef M Penninger, Hiroyuki Watanabe, Yumiko Imai, Saori Takahashi, Keiji Kuba
B38-CAP is a bacteria-derived ACE2-like enzyme that suppresses hypertension and cardiac dysfunction. Nature communications 11 (1) (2020)
Marius Wunderle, Matthias Ruebner, Lothar Häberle, Eva Schwenke, Carolin C Hack, Christian M Bayer, Martin C Koch, Judith Schwitulla, Ruediger Schulz-Wendtland, Ivona Kozieradzki, Michael P Lux, Matthias W Beckmann, Sebastian M Jud, Josef M Penninger, Michael O Schneider, Peter Andreas Fasching
RANKL and OPG and their influence on breast volume changes during pregnancy in healthy women. Scientific reports 10 (1) (2020)
Antoine Chabloz, Jonas V Schaefer, Ivona Kozieradzki, Shane J F Cronin, Daniel Strebinger, Francesca Macaluso, Jiri Wald, Terence Howard Rabbitts, Andreas Plückthun, Thomas C Marlovits, Josef M Penninger
Salmonella-based platform for efficient delivery of functional binding proteins to the cytosol. Communications biology 3 (1) (2020)
Lilian M Fennell, Carlos Gomez-Diaz, Luiza Deszcz, Anoop Kavirayani, David Hoffmann, Kota Yanagitani, Alexander Schleiffer, Karl Mechtler, Astrid Hagelkruys, Josef M Penninger, Fumiyo Ikeda
Site-specific ubiquitination of the E3 ligase HOIP regulates apoptosis and immune signaling. The EMBO journal 39 (24) (2020)
Magdalena Paolino, Rubina Koglgruber, Shane J F Cronin, Iris Uribesalgo, Esther Rauscher, Juergen Harreiter, Michael K Schuster, Dagmar Bancher-Todesca, Blanka Pranjic, Maria Novatchkova, Juan P Fededa, Andrea J White, Verena Sigl, Sabine Dekan, Thomas Penz, Christoph Bock, Lukas Kenner, Georg A Hollander, Graham Anderson, Alexandra Kautzky-Willer, Josef M Penninger
RANK links thymic regulatory T cells to fetal loss and gestational diabetes in pregnancy. Nature 589 (7842) (2020)
Takeshi Nitta, Masanori Tsutsumi, Sachiko Nitta, Ryunosuke Muro, Emma C Suzuki, Kenta Nakano, Yoshihiko Tomofuji, Shinichiro Sawa, Tadashi Okamura, Josef M Penninger, Hiroshi Takayanagi
Fibroblasts as a source of self-antigens for central immune tolerance. Nature immunology 21 (10) (2020)
Vanja Nagy, Ronja Hollstein, Tsung-Pin Pai, Michel K Herde, Pisanu Buphamalai, Paul Moeseneder, Ewelina Lenartowicz, Anoop Kavirayani, Georg Christoph Korenke, Ivona Kozieradzki, Roberto Nitsch, Ana Cicvaric, Francisco J Monje Quiroga, Matthew A Deardorff, Emma C Bedoukian, Yun Li, Gökhan Yigit, J Formula See Text Rg Menche, E Ferda Perçin, Bernd Wollnik, Christian Henneberger, Frank J Kaiser, Josef M Penninger
HACE1 deficiency leads to structural and functional neurodevelopmental defects. Neurology. Genetics 5 (3) (2019)
Shuan Rao, Laura Mondragón, Blanka Pranjic, Toshikatsu Hanada, Gautier Stoll, Thomas Köcher, Peng Zhang, Alexander Jais, Alexander Lercher, Andreas Bergthaler, Daniel Schramek, Katharina Haigh, Valentina Sica, Marion Leduc, Nazanine Modjtahedi, Tsung-Pin Pai, Masahiro Onji, Iris Uribesalgo, Reiko Hanada, Ivona Kozieradzki, Rubina Koglgruber, Shane J Cronin, Zhigang She, Franz Quehenberger, Helmut H Popper, Lukas Kenner, Jody J Haigh, Oliver Kepp, Malgorzata Rak, Kaican Cai, Guido Kroemer, Josef M Penninger
AIF-regulated oxidative phosphorylation supports lung cancer development. Cell research 29 (7) (2019)
Iris Uribesalgo, David Hoffmann, Yin Zhang, Anoop Kavirayani, Jelena Lazovic, Judit Berta, Maria Novatchkova, Tsung-Pin Pai, Reiner A Wimmer, Viktória László, Daniel Schramek, Rezaul Karim, Luigi Tortola, Sumit Deswal, Lisa Haas, Johannes Zuber, Miklós Szűcs, Keiji Kuba, Balazs Dome, Yihai Cao, Bernhard J Haubner, Josef M Penninger
Apelin inhibition prevents resistance and metastasis associated with anti-angiogenic therapy. EMBO molecular medicine 11 (8) (2019)
Cheen Euong Ang, Qing Ma, Orly L Wapinski, ShengHua Fan, Ryan A Flynn, Qian Yi Lee, Bradley Coe, Masahiro Onoguchi, Victor Hipolito Olmos, Brian T Do, Lynn Dukes-Rimsky, Jin Xu, Koji Tanabe, LiangJiang Wang, Ulrich Elling, Josef M Penninger, Yang Zhao, Kun Qu, Evan E Eichler, Anand Srivastava, Marius Wernig, Howard Y Chang
The novel lncRNA lnc-NR2F1 is pro-neurogenic and mutated in human neurodevelopmental disorders. eLife 8 (2019)
Giorgia Mastrella, Mengzhuo Hou, Min Li, Veit M Stoecklein, Nina Zdouc, Marie N M Volmar, Hrvoje Miletic, Sören Reinhard, Christel C Herold-Mende, Susanne Kleber, Katharina Eisenhut, Ciro Gargiulo Isacco, Michael Synowitz, Angelo L Vescovi, Patrick N Harter, Josef M Penninger, Ernst Wagner, Michel Mittelbronn, Rolf Bjerkvig, Dolores Hambardzumyan, Ulrich Schüller, Jörg-Christian Tonn, Josefine Radke, Rainer Glass, Roland E Kälin
Targeting APLN/APLNR Improves Antiangiogenic Efficiency and Blunts Proinvasive Side Effects of VEGFA/VEGFR2 Blockade in Glioblastoma. Cancer research 79 (9) (2019)
Daniel Andergassen, Markus Muckenhuber, Philipp C Bammer, Tomasz M Kulinski, Hans-Christian Theussl, Takahiko Shimizu, Josef M Penninger, Florian M Pauler, Quanah James Hudson
The Airn lncRNA does not require any DNA elements within its locus to silence distant imprinted genes. PLoS genetics 15 (7) (2019)
Herwig P Moll, Klemens Pranz, Monica Musteanu, Beatrice Grabner, Natascha Hruschka, Julian Mohrherr, Petra Aigner, Patricia Stiedl, Luka Brcic, Viktoria Laszlo, Daniel Schramek, Richard H Moriggl, Robert Eferl, Judit Moldvay, Katalin Dezso, Pedro P López-Casas, Dagmar Stoiber, Manuel Hidalgo, Josef M Penninger, Maria Sibilia, Balázs Győrffy, Mariano Barbacid, Balázs Dome, Helmut H Popper, Emilio Casanova
Afatinib restrains K-RAS-driven lung tumorigenesis. Science translational medicine 10 (446) (2019)
Daniel Szappanos, Roland Tschismarov, Thomas Perlot, Sandra Westermayer, Katrin Fischer, Ekaterini Platanitis, Fabian Kallinger, Maria Novatchkova, Caroline Lassnig, Mathias Müller, Veronika Sexl, Keiryn L Bennett, Michelle Foong-Sobis, Josef M Penninger, Thomas Decker
The RNA helicase DDX3X is an essential mediator of innate antimicrobial immunity. PLoS pathogens 14 (11) (2018)
Tomokazu Yamaguchi, Takashi Suzuki, Teruki Sato, Akinori Takahashi, Hiroyuki Watanabe, Ayumi Kadowaki, Miyuki Natsui, Hideaki Inagaki, Satoko Arakawa, Shinji Nakaoka, Yukio Koizumi, Shinsuke Seki, Shungo Adachi, Akira Fukao, Toshinobu Fujiwara, Tohru Natsume, Akinori Kimura, Masaaki Komatsu, Shigeomi Shimizu, Hiroshi Ito, Yutaka Suzuki, Josef M Penninger, Tadashi Yamamoto, Yumiko Imai, Keiji Kuba
The CCR4-NOT deadenylase complex controls Atg7-dependent cell death and heart function. Science signaling 11 (516) (2018)
Shuan Rao, Verena Sigl, Reiner Alois Wimmer, Maria Novatchkova, Alexander Jais, Gabriel Wagner, Stephan Handschuh, Iris Uribesalgo, Astrid Hagelkruys, Ivona Kozieradzki, Luigi Tortola, Roberto Nitsch, Shane J Cronin, Michael Orthofer, Daniel Branstetter, Jude Canon, John Rossi, Manolo D'Arcangelo, Johan Botling, Patrick Micke, Linnea La Fleur, Karolina Edlund, Michael Bergqvist, Simon Ekman, Thomas Lendl, Helmut Popper, Hiroshi Takayanagi, Lukas Kenner, Fred R Hirsch, William Dougall, Josef M Penninger
RANK rewires energy homeostasis in lung cancer cells and drives primary lung cancer. Genes & development 31 (20) (2017)
Daniel Andergassen, Christoph P Dotter, Daniel Wenzel, Verena Sigl, Philipp C Bammer, Markus Muckenhuber, Daniela Mayer, Tomasz M Kulinski, Hans-Christian Theussl, Josef M Penninger, Christoph Bock, Denise P Barlow, Florian M Pauler, Quanah James Hudson
Mapping the mouse Allelome reveals tissue-specific regulation of allelic expression. eLife 6 (2017)
Charles W Tran, Samuel D Saibil, Thierry Le Bihan, Sara R Hamilton, Karl S Lang, Han You, Samuel D Saibil, Kristine M Garza, Alisha R Elford, Kelly Tai, Michael E Parsons, Kip Wigmore, Mitchell G Vainberg, Josef M Penninger, James R Woodgett, Tak W Mak, Pamela S Ohashi
Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation. Journal of immunology (Baltimore, Md. : 1950) 199 (12) (2017)
Kazuki Nagashima, Shinichiro Sawa, Takeshi Nitta, Masanori Tsutsumi, Tadashi Okamura, Josef M Penninger, Tomoki Nakashima, Hiroshi Takayanagi
Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nature immunology 18 (6) (2017)
Tokiwa Yamasaki, Norie Deki-Arima, Asahito Kaneko, Norio Miyamura, Mamiko Iwatsuki, Masato Matsuoka, Noriko Fujimori-Tonou, Yoshimi Okamoto-Uchida, Jun Hirayama, Jamey D Marth, Yuji Yamanashi, Hiroshi Kawasaki, Koji Yamanaka, Josef M Penninger, Shigenobu Shibata, Hiroshi Nishina
Age-dependent motor dysfunction due to neuron-specific disruption of stress-activated protein kinase MKK7. Scientific reports 7 (1) (2017)
Jian Luo, Zhengfeng Yang, Yu Ma, Zhiying Yue, Hongyu Lin, Guojun Qu, Jinping Huang, Wentao Dai, Chenghai Li, Chunbing Zheng, Leqin Xu, Huaqing Chen, Jiqiu Wang, Dali Li, Stefan Siwko, Josef M Penninger, Guang Ning, Jianru Xiao, Mingyao Liu
LGR4 is a receptor for RANKL and negatively regulates osteoclast differentiation and bone resorption. Nature medicine 22 (5) (2016)
Gerald Wirnsberger, Florian Zwolanek, Tomoko Asaoka, Ivona Kozieradzki, Luigi Tortola, Reiner A Wimmer, Anoop Kavirayani, Friedrich Fresser, Gottfried Baier, Wallace Y Langdon, Fumiyo Ikeda, Karl Kuchler, Josef M Penninger
Inhibition of CBLB protects from lethal Candida albicans sepsis. Nature medicine 22 (8) (2016)
Nobuko Akiyama, Nobukazu Takizawa, Maki Miyauchi, Hiromi Yanai, Ryosuke Tateishi, Miho Shinzawa, Riko Yoshinaga, Masaaki Kurihara, Yosuke Demizu, Hisataka Yasuda, Shintaro Yagi, Guoying Wu, Mitsuru Matsumoto, Reiko Sakamoto, Nobuaki Yoshida, Josef M Penninger, Yasuhiro Kobayashi, Jun-Ichiro Inoue, Taishin Akiyama
Identification of embryonic precursor cells that differentiate into thymic epithelial cells expressing autoimmune regulator. The Journal of experimental medicine 213 (8) (2016)