Philip J Santangelo (P J Santangelo)

ORCID

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 43

Top Venues

Nano letters

PLoS pathogens

Nature biomedical engineering

Science advances

Georgia Institute of Technology

This page only lists publications with an associated author ORCID identifier.

Affiliation History

Georgia Institute of Technology Jan 07 2007

United States

Professor :: Biomedical Engineering

Publications

Mausumi Basu, Chiara Zurla, Tabassum Tasnim Auroni, Daryll Vanover, Lorena C S Chaves, Heena Sadhwani, Heather Pathak, Rahul Basu, Jared P Beyersdorf, Oluwatomi O Amuda, Amany Elsharkawy, Varun Mosur, Robert A Arthur, Henry Claussen, Loren E Sasser, Jay A Wroe, Hannah E Peck, Mukesh Kumar, Margo A Brinton, Philip J Santangelo
mRNA-encoded Cas13 can be used to treat dengue infections in mice. Nature microbiology 9 (8) (2024)
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA. PLoS pathogens 20 (7) (2024)
Mausumi Basu, Chiara Zurla, Tabassum Tasnim Auroni, Daryll Vanover, Lorena C S Chaves, Heena Sadhwani, Heather Pathak, Rahul Basu, Jared P Beyersdorf, Oluwatomi O Amuda, Amany Elsharkawy, Varun Mosur, Robert A Arthur, Henry Claussen, Loren E Sasser, Jay A Wroe, Hannah E Peck, Mukesh Kumar, Margo A Brinton, Philip J Santangelo
mRNA-encoded Cas13 can be used to treat dengue infections in mice. Nature microbiology (2024)
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA. PLoS pathogens 20 (7) (2024)
David W Wolfson, Nam-Kyun Kim, Ki Hong Lee, Jared P Beyersdorf, Jonathan J Langberg, Natasha Fernandez, Dahim Choi, Nadine Zureick, Tae Yun Kim, Seongho Bae, Jin-Mo Gu, Jonathan L Kirschman, Jinqi Fan, Christina Y Sheng, Danielle Gottlieb Sen, Bret Mettler, Jung Hoon Sung, Young-Sup Yoon, Sung-Jin Park, Philip J Santangelo, Hee Cheol Cho
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18. Nature biomedical engineering (2024)
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA. PLoS pathogens 20 (7) (2024)
Mausumi Basu, Chiara Zurla, Tabassum Tasnim Auroni, Daryll Vanover, Lorena C S Chaves, Heena Sadhwani, Heather Pathak, Rahul Basu, Jared P Beyersdorf, Oluwatomi O Amuda, Amany Elsharkawy, Varun Mosur, Robert A Arthur, Henry Claussen, Loren E Sasser, Jay A Wroe, Hannah E Peck, Mukesh Kumar, Margo A Brinton, Philip J Santangelo
mRNA-encoded Cas13 can be used to treat dengue infections in mice. Nature microbiology 9 (8) (2024)
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA. PLoS pathogens 20 (7) (2024)
Lorena C S Chaves, Nichole Orr-Burks, Daryll Vanover, Varun V Mosur, Sarah R Hosking, Pramod Kumar E K, Hyeyoon Jeong, Younghun Jung, José A F Assumpção, Hannah E Peck, Sarah L Nelson, Kaitlyn N Burke, McKinzie A Garrison, Robert A Arthur, Henry Claussen, Nicholas S Heaton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
mRNA-encoded Cas13 treatment of Influenza via site-specific degradation of genomic RNA. PLoS pathogens 20 (7) (2024)
David W Wolfson, Nam-Kyun Kim, Ki Hong Lee, Jared P Beyersdorf, Jonathan J Langberg, Natasha Fernandez, Dahim Choi, Nadine Zureick, Tae Yun Kim, Seongho Bae, Jin-Mo Gu, Jonathan L Kirschman, Jinqi Fan, Christina Y Sheng, Danielle Gottlieb Sen, Bret Mettler, Jung Hoon Sung, Young-Sup Yoon, Sung-Jin Park, Philip J Santangelo, Hee Cheol Cho
Transient pacing in pigs with complete heart block via myocardial injection of mRNA coding for the T-box transcription factor 18. Nature biomedical engineering (2024)
Afsane Radmand, Melissa P Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G Huayamares, Marine Z C Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J Santangelo, James E Dahlman
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo . Nano letters 23 (3) (2023)
Afsane Radmand, Melissa P Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G Huayamares, Marine Z C Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J Santangelo, James E Dahlman
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo . Nano letters 23 (3) (2023)
Afsane Radmand, Melissa P Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G Huayamares, Marine Z C Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J Santangelo, James E Dahlman
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo . Nano letters (2023)
Afsane Radmand, Melissa P Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G Huayamares, Marine Z C Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J Santangelo, James E Dahlman
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo . Nano letters 23 (3) (2023)
Afsane Radmand, Melissa P Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G Huayamares, Marine Z C Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J Santangelo, James E Dahlman
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo . Nano letters 23 (3) (2023)
Afsane Radmand, Melissa P Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G Huayamares, Marine Z C Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J Santangelo, James E Dahlman
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo . Nano letters 23 (3) (2023)
Afsane Radmand, Melissa P Lokugamage, Hyejin Kim, Curtis Dobrowolski, Ryan Zenhausern, David Loughrey, Sebastian G Huayamares, Marine Z C Hatit, Huanzhen Ni, Ada Del Cid, Alejandro J Da Silva Sanchez, Kalina Paunovska, Elisa Schrader Echeverri, Aram Shajii, Hannah Peck, Philip J Santangelo, James E Dahlman
The Transcriptional Response to Lung-Targeting Lipid Nanoparticles in Vivo . Nano letters 23 (3) (2023)
Laura Rotolo, Daryll Vanover, Nicholas C Bruno, Hannah E Peck, Chiara Zurla, Jackelyn Murray, Richard K Noel, Laura O'Farrell, Mariluz Araínga, Nichole Orr-Burks, Jae Yeon Joo, Lorena C S Chaves, Younghun Jung, Jared P Beyersdorf, Sanjeev Gumber, Ricardo Guerrero-Ferreira, Santiago Cornejo, Merrilee Thoresen, Alicia K Olivier, Katie M Kuo, James C Gumbart, Amelia R Woolums, François J Villinger, Eric R Lafontaine, Robert J Hogan, Neal K Devaraj, Philip J Santangelo
Species-agnostic polymeric formulations for inhalable messenger RNA delivery to the lung. Nature materials (2022)
Fang-Yi Su, Qingyang Henry Zhao, Shreyas N Dahotre, Lena Gamboa, Swapnil Subhash Bawage, Aaron D Silva Trenkle, Ali Zamat, Hathaichanok Phuengkham, Rajesh M Valanparambil, Philip J Santangelo, Gabriel A Kwong
In vivo mRNA delivery to virus-specific T cells by light-induced ligand exchange of MHC class I antigen-presenting nanoparticles. Science advances 8 (8) (2022)
Marine Z C Hatit, Melissa P Lokugamage, Curtis N Dobrowolski, Kalina Paunovska, Huanzhen Ni, Kun Zhao, Daryll Vanover, Jared P Beyersdorf, Hannah E Peck, David Loughrey, Manaka Sato, Ana Cristian, Philip J Santangelo, James E Dahlman
Species-dependent in vivo mRNA delivery and cellular responses to nanoparticles. Nature nanotechnology 17 (3) (2022)
Kalina Paunovska, Alejandro J Da Silva Sanchez, Melissa P Lokugamage, David Loughrey, Elisa Schrader Echeverri, Ana Cristian, Marine Z C Hatit, Philip J Santangelo, Kun Zhao, James E Dahlman
The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure. Nano letters 22 (24) (2022)
Curtis N Dobrowolski, Kalina Paunovska, Elisa Schrader Echeverri, David Loughrey, Alejandro J Da Silva Sanchez, Huanzhen Ni, Marine Z C Hatit, Melissa P Lokugamage, Yanina Kuzminich, Hannah E Peck, Philip J Santangelo, James E Dahlman
Nanoparticle single-cell multiomic readouts reveal that cell heterogeneity influences lipid nanoparticle-mediated messenger RNA delivery. Nature nanotechnology 17 (8) (2022)
Kalina Paunovska, Alejandro J Da Silva Sanchez, Melissa P Lokugamage, David Loughrey, Elisa Schrader Echeverri, Ana Cristian, Marine Z C Hatit, Philip J Santangelo, Kun Zhao, James E Dahlman
The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure. Nano letters (2022)
Cory D Sago, Melissa P Lokugamage, David Loughrey, Kevin E Lindsay, Robert Hincapie, Brandon R Krupczak, Sujay Kalathoor, Manaka Sato, Elisa Schrader Echeverri, Jordan P Fitzgerald, Zubao Gan, Lena Gamboa, Kalina Paunovska, Carlos A Sanhueza, Marine Z C Hatit, Neal K Devaraj, Philip J Santangelo, James E Dahlman
Augmented lipid-nanoparticle-mediated in vivo genome editing in the lungs and spleen by disrupting Cas9 activity in the liver. Nature biomedical engineering 6 (2) (2022)
Kalina Paunovska, Alejandro J Da Silva Sanchez, Melissa P Lokugamage, David Loughrey, Elisa Schrader Echeverri, Ana Cristian, Marine Z C Hatit, Philip J Santangelo, Kun Zhao, James E Dahlman
The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure. Nano letters 22 (24) (2022)
Daryll Vanover, Chiara Zurla, Hannah E Peck, Nichole Orr-Burks, Jae Yeon Joo, Jackelyn Murray, Nathan Holladay, Ryan A Hobbs, Younghun Jung, Lorena C S Chaves, Laura Rotolo, Aaron W Lifland, Alicia K Olivier, Dapeng Li, Kevin O Saunders, Gregory D Sempowski, James E Crowe, Barton F Haynes, Eric R Lafontaine, Robert J Hogan, Philip J Santangelo
Nebulized mRNA-Encoded Antibodies Protect Hamsters from SARS-CoV-2 Infection. Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2022)
Huanzhen Ni, Marine Z C Hatit, Kun Zhao, David Loughrey, Melissa P Lokugamage, Hannah E Peck, Ada Del Cid, Abinaya Muralidharan, YongTae Kim, Philip J Santangelo, James E Dahlman
Piperazine-derived lipid nanoparticles deliver mRNA to immune cells in vivo. Nature communications 13 (1) (2022)
Jared P Beyersdorf, Swapnil Bawage, Nahid Iglesias, Hannah E Peck, Ryan A Hobbs, Jay A Wroe, Chiara Zurla, Charles A Gersbach, Philip J Santangelo
Robust, Durable Gene Activation In Vivo via mRNA-Encoded Activators. ACS nano 16 (4) (2022)
Kalina Paunovska, Alejandro J Da Silva Sanchez, Melissa P Lokugamage, David Loughrey, Elisa Schrader Echeverri, Ana Cristian, Marine Z C Hatit, Philip J Santangelo, Kun Zhao, James E Dahlman
The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure. Nano letters 22 (24) (2022)
Kalina Paunovska, Alejandro J Da Silva Sanchez, Melissa P Lokugamage, David Loughrey, Elisa Schrader Echeverri, Ana Cristian, Marine Z C Hatit, Philip J Santangelo, Kun Zhao, James E Dahlman
The Extent to Which Lipid Nanoparticles Require Apolipoprotein E and Low-Density Lipoprotein Receptor for Delivery Changes with Ionizable Lipid Structure. Nano letters 22 (24) (2022)
P Pradhan, Randall Toy, Navdeep Jhita, Alexandra Atalis, Bhawana Pandey, A Beach, E L Blanchard, Samuel G Moore, David A Gaul, Philip J Santangelo, Dmitry M Shayakhmetov, Krishnendu Roy
TRAF6-IRF5 kinetics, TRIF, and biophysical factors drive synergistic innate responses to particle-mediated MPLA-CpG co-presentation. Science advances 7 (3) (2021)
Krishanu Saha, Erik J Sontheimer, P J Brooks, Melinda R Dwinell, Charles A Gersbach, David R Liu, Stephen A Murray, Shengdar Q Tsai, Ross C Wilson, Daniel G Anderson, Aravind Asokan, Jillian F Banfield, Krystof S Bankiewicz, Gang Bao, Jeff W M Bulte, Nenad Bursac, Jarryd M Campbell, Daniel F Carlson, Elliot L Chaikof, Zheng-Yi Chen, R Holland Cheng, Karl J Clark, David T Curiel, James E Dahlman, Benjamin E Deverman, Mary E Dickinson, Jennifer A Doudna, Stephen C Ekker, Marina E Emborg, Guoping Feng, Benjamin S Freedman, David M Gamm, Guangping Gao, Ionita C Ghiran, Peter M Glazer, Shaoqin Gong, Jason D Heaney, Jon D Hennebold, John T Hinson, Anastasia Khvorova, Samira Kiani, William R Lagor, Kit S Lam, Kam W Leong, Jon E Levine, Jennifer A Lewis, Cathleen M Lutz, Danith H Ly, Samantha Maragh, Paul B McCray, Todd C McDevitt, Oleg Mirochnitchenko, Ryuji Morizane, Niren Murthy, Randall S Prather, John A Ronald, Subhojit Roy, Sushmita Roy, Venkata Sabbisetti, W Mark Saltzman, Philip J Santangelo, David J Segal, Mary Shimoyama, Melissa C Skala, Alice F Tarantal, John C Tilton, George A Truskey, Moriel Vandsburger, Jonathan K Watts, Kevin D Wells, Scot A Wolfe, Qiaobing Xu, Wen Xue, Guohua Yi, Jiangbing Zhou, null null
The NIH Somatic Cell Genome Editing program. Nature 592 (7853) (2021)
Melissa P Lokugamage, Daryll Vanover, Jared Beyersdorf, Marine Z C Hatit, Laura Rotolo, Elisa Schrader Echeverri, Hannah E Peck, Huanzhen Ni, Jeong-Kee Yoon, YongTae Kim, Philip J Santangelo, James E Dahlman
Optimization of lipid nanoparticles for the delivery of nebulized therapeutic mRNA to the lungs. Nature biomedical engineering 5 (9) (2021)
Emmeline L Blanchard, Daryll Vanover, Swapnil Subhash Bawage, Pooja Munnilal Tiwari, Laura Rotolo, Jared P Beyersdorf, Hannah E Peck, Nicholas C Bruno, Robert Hincapie, Frank Michel, Jackelyn Murray, Heena Sadhwani, Bob Vanderheyden, Neal K Devaraj, Margo A Brinton, Eric R Lafontaine, Robert J Hogan, Chiara Zurla, Philip J Santangelo
Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents. Nature biotechnology 39 (6) (2021)
Molly R Braun, Sarah L Noton, Emmeline L Blanchard, Afzaal M Shareef, Philip J Santangelo, William Evan Johnson, Rachel Fearns
Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcripts. PLoS pathogens 17 (5) (2021)
Kalina Paunovska, Alejandro Da Silva Sanchez, Matthew T Foster, David Loughrey, Emmeline L Blanchard, Fatima Z Islam, Zubao Gan, Athanasios Mantalaris, Philip J Santangelo, James E Dahlman
Increased PIP3 activity blocks nanoparticle mRNA delivery. Science advances 6 (30) (2020)
Emmeline L Blanchard, Justin D Lawrence, Jeffery A Noble, Minghao Xu, Taekyu Joo, Nga Lee Ng, Britney E Schmidt, Philip J Santangelo, Neal K Devaraj
Enveloped Virus Inactivation on Personal Protective Equipment by Exposure to Ozone. medRxiv : the preprint server for health sciences (2020)
Emmeline L Blanchard, Molly R Braun, Aaron W Lifland, Barbara Ludeke, Sarah L Noton, Daryll A Vanover, Chiara Zurla, Rachel Fearns, Philip J Santangelo
Polymerase-tagged respiratory syncytial virus reveals a dynamic rearrangement of the ribonucleocapsid complex during infection. PLoS pathogens 16 (10) (2020)
Emmeline L Blanchard, Danae Argyropoulou, Chiara Zurla, Sushma M Bhosle, Daryll Vanover, Philip J Santangelo
Quantification and Localization of Protein-RNA Interactions in Patient-Derived Archival Tumor Tissue. Cancer research 79 (20) (2019)
Kevin E Lindsay, Sushma M Bhosle, Chiara Zurla, Jared P Beyersdorf, Kenneth A Rogers, Daryll Vanover, Peng Xiao, Mariluz Araínga, Lisa M Shirreff, Bruno Pitard, Patrick Baumhof, Francois Villinger, Philip J Santangelo
Visualization of early events in mRNA vaccine delivery in non-human primates via PET-CT and near-infrared imaging. Nature biomedical engineering 3 (5) (2019)
Sakaorat Lertjuthaporn, Claudia Cicala, Donald Van Ryk, Matthew Liu, Jason Yolitz, Danlan Wei, Fatima Nawaz, Allison Doyle, Brooke Horowitch, Chung Park, Shan Lu, Yang Lou, Shixia Wang, Ruimin Pan, Xunqing Jiang, Francois Villinger, Siddappa N Byrareddy, Philip J Santangelo, Lynn Morris, Constantinos Kurt Wibmer, Kristin Biris, Rosemarie D Mason, Jason Gorman, Joseph Hiatt, Elena Martinelli, Mario Roederer, Dai Fujikawa, Giacomo Gorini, Genoveffa Franchini, Anush Arakelyan, Aftab A Ansari, Kovit Pattanapanyasat, Xiang-Peng Kong, Anthony S Fauci, James Arthos
Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7. PLoS pathogens 14 (8) (2018)
Kristin H Loomis, Kevin E Lindsay, Chiara Zurla, Sushma M Bhosle, Daryll A Vanover, Emmeline L Blanchard, Jonathan L Kirschman, Ravi V Bellamkonda, Philip J Santangelo
In Vitro Transcribed mRNA Vaccines with Programmable Stimulation of Innate Immunity. Bioconjugate chemistry 29 (9) (2018)
Dwight M Chambers, Leandro Moretti, Jennifer J Zhang, Spencer W Cooper, Davis M Chambers, Philip J Santangelo, Thomas H Barker
LEM domain-containing protein 3 antagonizes TGFβ-SMAD2/3 signaling in a stiffness-dependent manner in both the nucleus and cytosol. The Journal of biological chemistry 293 (41) (2018)

Philip J Santangelo.css-eqlu8i{font-size:small;padding-left:4px;} (P J Santangelo)

Publication Activity (10 Years)

Top Topics

Top Venues

Philip J Santangelo (P J Santangelo)