Shengdar Q Tsai

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 29

Top Topics

Sickle Cell Disease

Genetic Diversity

Top Venues

Nature genetics

bioRxiv : the preprint server for biology

Nature biotechnology

This page only lists publications with an associated author ORCID identifier.

Publications

Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C Wellinger, Ian Kirby, Patrick H van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C Widmer, Shengdar Q Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T Jeker
Selective haematological cancer eradication with preserved haematopoiesis. Nature 630 (8017) (2024)
Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C Wellinger, Ian Kirby, Patrick H van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C Widmer, Shengdar Q Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T Jeker
Selective haematological cancer eradication with preserved haematopoiesis. Nature (2024)
Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C Wellinger, Ian Kirby, Patrick H van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C Widmer, Shengdar Q Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T Jeker
Selective haematological cancer eradication with preserved haematopoiesis. Nature (2024)
Cicera R Lazzarotto, Varun Katta, Yichao Li, Elizabeth Urbina, GaHyun Lee, Shengdar Q Tsai
CHANGE-seq-BE enables simultaneously sensitive and unbiased in vitro profiling of base editor genome-wide activity. bioRxiv : the preprint server for biology (2024)
Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C Wellinger, Ian Kirby, Patrick H van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C Widmer, Shengdar Q Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T Jeker
Selective haematological cancer eradication with preserved haematopoiesis. Nature 630 (8017) (2024)
Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C Wellinger, Ian Kirby, Patrick H van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C Widmer, Shengdar Q Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T Jeker
Selective haematological cancer eradication with preserved haematopoiesis. Nature 630 (8017) (2024)
Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C Wellinger, Ian Kirby, Patrick H van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C Widmer, Shengdar Q Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T Jeker
Selective haematological cancer eradication with preserved haematopoiesis. Nature (2024)
Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C Wellinger, Ian Kirby, Patrick H van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C Widmer, Shengdar Q Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T Jeker
Selective haematological cancer eradication with preserved haematopoiesis. Nature 630 (8017) (2024)
Simon Garaudé, Romina Marone, Rosalba Lepore, Anna Devaux, Astrid Beerlage, Denis Seyres, Alessandro Dell' Aglio, Darius Juskevicius, Jessica Zuin, Thomas Burgold, Sisi Wang, Varun Katta, Garret Manquen, Yichao Li, Clément Larrue, Anna Camus, Izabela Durzynska, Lisa C Wellinger, Ian Kirby, Patrick H van Berkel, Christian Kunz, Jérôme Tamburini, Francesco Bertoni, Corinne C Widmer, Shengdar Q Tsai, Federico Simonetta, Stefanie Urlinger, Lukas T Jeker
Selective haematological cancer eradication with preserved haematopoiesis. Nature 630 (8017) (2024)
Christiano R R Alves, Leillani L Ha, Rebecca A Yaworski, Cicera R Lazzarotto, Kathleen A Christie, Aoife Reilly, Ariane Beauvais, Roman M Doll, Demitri de la Cruz, Casey A Maguire, Kathryn J Swoboda, Shengdar Q Tsai, Rashmi Kothary, Benjamin P Kleinstiver
Base editing as a genetic treatment for spinal muscular atrophy. bioRxiv : the preprint server for biology (2023)
Christiano R R Alves, Leillani L Ha, Rebecca Yaworski, Emma R Sutton, Cicera R Lazzarotto, Kathleen A Christie, Aoife Reilly, Ariane Beauvais, Roman M Doll, Demitri de la Cruz, Casey A Maguire, Kathryn J Swoboda, Shengdar Q Tsai, Rashmi Kothary, Benjamin P Kleinstiver
Optimization of base editors for the functional correction of SMN2 as a treatment for spinal muscular atrophy. Nature biomedical engineering (2023)
Thiyagaraj Mayuranathan, Gregory A Newby, Ruopeng Feng, Yu Yao, Kalin D Mayberry, Cicera R Lazzarotto, Yichao Li, Rachel M Levine, Nikitha Nimmagadda, Erin Dempsey, Guolian Kang, Shaina N Porter, Phillip A Doerfler, Jingjing Zhang, Yoonjeong Jang, Jingjing Chen, Henry William Bell, Merlin Crossley, Senthil Velan Bhoopalan, Akshay Sharma, John F Tisdale, Shondra M Pruett-Miller, Yong Cheng, Shengdar Q Tsai, David R Liu, Mitchell J Weiss, Jonathan S Yen
Potent and uniform fetal hemoglobin induction via base editing. Nature genetics (2023)
Christiano R R Alves, Leillani L Ha, Rebecca A Yaworski, Cicera R Lazzarotto, Kathleen A Christie, Aoife Reilly, Ariane Beauvais, Roman M Doll, Demitri de la Cruz, Casey A Maguire, Kathryn J Swoboda, Shengdar Q Tsai, Rashmi Kothary, Benjamin P Kleinstiver
Base editing as a genetic treatment for spinal muscular atrophy. bioRxiv : the preprint server for biology (2023)
Christiano R R Alves, Leillani L Ha, Rebecca A Yaworski, Cicera R Lazzarotto, Kathleen A Christie, Aoife Reilly, Ariane Beauvais, Roman M Doll, Demitri de la Cruz, Casey A Maguire, Kathryn J Swoboda, Shengdar Q Tsai, Rashmi Kothary, Benjamin P Kleinstiver
Base editing as a genetic treatment for spinal muscular atrophy. bioRxiv : the preprint server for biology (2023)
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q Tsai, Myriam Armant, Scot A Wolfe, Rosalba Giugno, Daniel E Bauer, Luca Pinello
Human genetic diversity alters off-target outcomes of therapeutic gene editing. Nature genetics 55 (1) (2022)
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q Tsai, Myriam Armant, Scot A Wolfe, Rosalba Giugno, Daniel E Bauer, Luca Pinello
Human genetic diversity alters off-target outcomes of therapeutic gene editing. Nature genetics (2022)
Alessio David Nahmad, Cicera R Lazzarotto, Natalie Zelikson, Talia Kustin, Mary Tenuta, Deli Huang, Inbal Reuveni, Daniel Nataf, Yuval Raviv, Miriam Horovitz-Fried, Iris Dotan, Yaron Carmi, Rina Rosin-Arbesfeld, David Nemazee, James E Voss, Adi Stern, Shengdar Q Tsai, Adi Barzel
In vivo engineered B cells secrete high titers of broadly neutralizing anti-HIV antibodies in mice. Nature biotechnology 40 (8) (2022)
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q Tsai, Myriam Armant, Scot A Wolfe, Rosalba Giugno, Daniel E Bauer, Luca Pinello
Human genetic diversity alters off-target outcomes of therapeutic gene editing. Nature genetics 55 (1) (2022)
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q Tsai, Myriam Armant, Scot A Wolfe, Rosalba Giugno, Daniel E Bauer, Luca Pinello
Human genetic diversity alters off-target outcomes of therapeutic gene editing. Nature genetics (2022)
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q Tsai, Myriam Armant, Scot A Wolfe, Rosalba Giugno, Daniel E Bauer, Luca Pinello
Human genetic diversity alters off-target outcomes of therapeutic gene editing. Nature genetics 55 (1) (2022)
Samuele Cancellieri, Jing Zeng, Linda Yingqi Lin, Manuel Tognon, My Anh Nguyen, Jiecong Lin, Nicola Bombieri, Stacy A Maitland, Marioara-Felicia Ciuculescu, Varun Katta, Shengdar Q Tsai, Myriam Armant, Scot A Wolfe, Rosalba Giugno, Daniel E Bauer, Luca Pinello
Human genetic diversity alters off-target outcomes of therapeutic gene editing. Nature genetics 55 (1) (2022)
Krishanu Saha, Erik J Sontheimer, P J Brooks, Melinda R Dwinell, Charles A Gersbach, David R Liu, Stephen A Murray, Shengdar Q Tsai, Ross C Wilson, Daniel G Anderson, Aravind Asokan, Jillian F Banfield, Krystof S Bankiewicz, Gang Bao, Jeff W M Bulte, Nenad Bursac, Jarryd M Campbell, Daniel F Carlson, Elliot L Chaikof, Zheng-Yi Chen, R Holland Cheng, Karl J Clark, David T Curiel, James E Dahlman, Benjamin E Deverman, Mary E Dickinson, Jennifer A Doudna, Stephen C Ekker, Marina E Emborg, Guoping Feng, Benjamin S Freedman, David M Gamm, Guangping Gao, Ionita C Ghiran, Peter M Glazer, Shaoqin Gong, Jason D Heaney, Jon D Hennebold, John T Hinson, Anastasia Khvorova, Samira Kiani, William R Lagor, Kit S Lam, Kam W Leong, Jon E Levine, Jennifer A Lewis, Cathleen M Lutz, Danith H Ly, Samantha Maragh, Paul B McCray, Todd C McDevitt, Oleg Mirochnitchenko, Ryuji Morizane, Niren Murthy, Randall S Prather, John A Ronald, Subhojit Roy, Sushmita Roy, Venkata Sabbisetti, W Mark Saltzman, Philip J Santangelo, David J Segal, Mary Shimoyama, Melissa C Skala, Alice F Tarantal, John C Tilton, George A Truskey, Moriel Vandsburger, Jonathan K Watts, Kevin D Wells, Scot A Wolfe, Qiaobing Xu, Wen Xue, Guohua Yi, Jiangbing Zhou, null null
The NIH Somatic Cell Genome Editing program. Nature 592 (7853) (2021)
Nikolay L Malinin, GaHyun Lee, Cicera R Lazzarotto, Yichao Li, Zongli Zheng, Nhu T Nguyen, Matthew Liebers, Ved V Topkar, A John Iafrate, Long P Le, Martin J Aryee, J Keith Joung, Shengdar Q Tsai
Defining genome-wide CRISPR-Cas genome-editing nuclease activity with GUIDE-seq. Nature protocols 16 (12) (2021)
Gregory A Newby, Jonathan S Yen, Kaitly J Woodard, Thiyagaraj Mayuranathan, Cicera R Lazzarotto, Yichao Li, Heather S Sheppard, Shaina N Porter, Yu Yao, Kalin Mayberry, Kelcee A Everette, Yoonjeong Jang, Christopher J Podracky, Elizabeth Thaman, Christophe Lechauve, Akshay Sharma, Jordana M Henderson, Michelle F Richter, Kevin Tianmeng Zhao, Shannon M Miller, Tina Wang, Luke W Koblan, Anton P McCaffrey, John F Tisdale, Theodosia A Kalfa, Shondra M Pruett-Miller, Shengdar Q Tsai, Mitchell J Weiss, David R Liu
Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature 595 (7866) (2021)
Cicera R Lazzarotto, Nikolay L Malinin, Yichao Li, Ruochi Zhang, Yang Yang, GaHyun Lee, Eleanor Cowley, Yanghua He, Xin Lan, Kasey Jividen, Varun Katta, Natalia G Kolmakova, Christopher T Petersen, Qian Qi, Evgheni Strelcov, Samantha Maragh, Giedre Krenciute, Jian Ma, Yong Cheng, Shengdar Q Tsai
CHANGE-seq reveals genetic and epigenetic effects on CRISPR-Cas9 genome-wide activity. Nature biotechnology 38 (11) (2020)
Killian S Hanlon, Benjamin P Kleinstiver, Sara P Garcia, Mikołaj Piotr Zaborowski, Adrienn Volak, Stefan E Spirig, Alissa Muller, Alexander A Sousa, Shengdar Q Tsai, Niclas E Bengtsson, Camilla Lööv, Martin Ingelsson, Jeffrey S Chamberlain, David P Corey, Martin J Aryee, J Keith Joung, Xandra O Breakefield, Casey A Maguire, Bence György
High levels of AAV vector integration into CRISPR-induced DNA breaks. Nature communications 10 (1) (2019)
Cicera R Lazzarotto, Nhu T Nguyen, Xing Tang, Jose Malagon-Lopez, Jimmy A Guo, Martin J Aryee, J Keith Joung, Shengdar Q Tsai
Defining CRISPR-Cas9 genome-wide nuclease activities with CIRCLE-seq. Nature protocols 13 (11) (2019)
Yong Cheng, Shengdar Q Tsai
Illuminating the genome-wide activity of genome editors for safe and effective therapeutics. Genome biology 19 (1) (2018)
Shengdar Q Tsai
Discovering the Genome-Wide Activity of CRISPR-Cas Nucleases. ACS chemical biology 13 (2) (2017)