David R Liu (David Liu)

Publication Activity (10 Years)

Years Active: 2017-2024
Publications (10 Years): 92

Top Topics

Sickle Cell Disease

Skeletal Muscle

Top Venues

Nature biotechnology

Science (New York, N.Y.)

Nature chemistry

Nature communications

This page only lists publications with an associated author ORCID identifier.

Publications

Shuyi Zhang, Ziyuan Ma, Wenjie Li, Yunhao Shen, Yunxin Xu, Gengjiang Liu, Jiamin Chang, Zeju Li, Hong Qin, Boxue Tian, Haipeng Gong, David R Liu, B Thuronyi, Christopher A Voigt
EvoAI enables extreme compression and reconstruction of the protein sequence space. Research square (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Xinyuan Guo, Dujuan Zhang, Shun Zhang, Changwei Li, Jun Wu, Peyton B Randolph, Alexander A Sousa, Chao Qu, Yifan Zhu, Yuting Guan, Liren Wang, Mingyao Liu, Bo Feng, Gaojie Song, David R Liu, Dali Li
Author Correction: Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos. Nature biotechnology (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Shuyi Zhang, Ziyuan Ma, Wenjie Li, Yunhao Shen, Yunxin Xu, Gengjiang Liu, Jiamin Chang, Zeju Li, Hong Qin, Boxue Tian, Haipeng Gong, David R Liu, B Thuronyi, Christopher A Voigt
EvoAI enables extreme compression and reconstruction of the protein sequence space. Research square (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Meirui An, Aditya Raguram, Samuel W Du, Samagya Banskota, Jessie R Davis, Gregory A Newby, Paul Z Chen, Krzysztof Palczewski, David R Liu
Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo. Nature biotechnology (2024)
Smriti Pandey, Xin D Gao, Nicholas A Krasnow, Amber McElroy, Y Allen Tao, Jordyn E Duby, Benjamin J Steinbeck, Julia McCreary, Sarah E Pierce, Jakub Tolar, Torsten B Meissner, Elliot L Chaikof, Mark J Osborn, David R Liu
Efficient site-specific integration of large genes in mammalian cells via continuously evolved recombinases and prime editing. Nature biomedical engineering (2024)
Samuel I Gould, Alexandra N Wuest, Kexin Dong, Grace A Johnson, Alvin Hsu, Varun K Narendra, Ondine Atwa, Stuart S Levine, David R Liu, Francisco J Sánchez Rivera
High-throughput evaluation of genetic variants with prime editing sensor libraries. Nature biotechnology (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Emily Zhang, Monica E Neugebauer, Nicholas A Krasnow, David R Liu
Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference. Nature communications 15 (1) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Shuyi Zhang, Ziyuan Ma, Wenjie Li, Yunhao Shen, Yunxin Xu, Gengjiang Liu, Jiamin Chang, Zeju Li, Hong Qin, Boxue Tian, Haipeng Gong, David R Liu, B Thuronyi, Christopher A Voigt
EvoAI enables extreme compression and reconstruction of the protein sequence space. Research square (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Emily Zhang, Monica E Neugebauer, Nicholas A Krasnow, David R Liu
Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference. Nature communications 15 (1) (2024)
Alexander A Sousa, Colin Hemez, Lei Lei, Soumba Traore, Katarina Kulhankova, Gregory A Newby, Jordan L Doman, Keyede Oye, Smriti Pandey, Philip H Karp, Paul B McCray, David R Liu
Systematic optimization of prime editing for the efficient functional correction of CFTR F508del in human airway epithelial cells. Nature biomedical engineering (2024)
Rebecca P Kim-Yip, Ryan McNulty, Bradley Joyce, Antonio Mollica, Peter J Chen, Purnima Ravisankar, Benjamin K Law, David R Liu, Jared E Toettcher, Evgueni A Ivakine, Eszter Posfai, Britt Adamson
Efficient prime editing in two-cell mouse embryos using PEmbryo. Nature biotechnology (2024)
Jaron A M Mercer, Stephan J DeCarlo, Shourya S Roy Burman, Vedagopuram Sreekanth, Andrew T Nelson, Moritz Hunkeler, Peter J Chen, Katherine Aleisha Donovan, Praveen Kokkonda, Praveen K Tiwari, Veronika M Shoba, Arghya Deb, Amit Choudhary, Eric S Fischer, David R Liu
Continuous evolution of compact protein degradation tags regulated by selective molecular glues. Science (New York, N.Y.) 383 (6688) (2024)
Emily Zhang, Monica E Neugebauer, Nicholas A Krasnow, David R Liu
Phage-assisted evolution of highly active cytosine base editors with enhanced selectivity and minimal sequence context preference. Nature communications 15 (1) (2024)
Rebecca P Kim-Yip, Ryan McNulty, Bradley Joyce, Antonio Mollica, Peter J Chen, Purnima Ravisankar, Benjamin K Law, David R Liu, Jared E Toettcher, Evgueni A Ivakine, Eszter Posfai, Britt Adamson
Efficient prime editing in two-cell mouse embryos using PEmbryo. Nature biotechnology (2024)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Liang Chen, Mengjia Hong, Changming Luan, Hongyi Gao, Gaomeng Ru, Xinyuan Guo, Dujuan Zhang, Shun Zhang, Changwei Li, Jun Wu, Peyton B Randolph, Alexander A Sousa, Chao Qu, Yifan Zhu, Yuting Guan, Liren Wang, Mingyao Liu, Bo Feng, Gaojie Song, David R Liu, Dali Li
Adenine transversion editors enable precise, efficient A•T-to-C•G base editing in mammalian cells and embryos. Nature biotechnology (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Han Zhang, Karen Kelly, Jonathan Lee, Dimas Echeverria Moreno, David A Cooper, Rebecca Panwala, Zexiang Chen, Nicholas Gaston, Gregory A Newby, Jun Xie, David R Liu, Guangping Gao, Scot A Wolfe, Anastasia Khvorova, Jonathan K Watts, Erik J Sontheimer
Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo . bioRxiv : the preprint server for biology (2023)
Jessie R Davis, Samagya Banskota, Jonathan M Levy, Gregory A Newby, Xiao Wang, Andrew V Anzalone, Andrew T Nelson, Peter J Chen, Andrew D Hennes, Meirui An, Heejin Roh, Peyton B Randolph, Kiran Musunuru, David R Liu
Efficient prime editing in mouse brain, liver and heart with dual AAVs. Nature biotechnology (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Mandana Arbab, Zaneta Matuszek, Kaitlyn M Kray, Ailing Du, Gregory A Newby, Anton J Blatnik, Aditya Raguram, Michelle F Richter, Kevin Tianmeng Zhao, Jonathan M Levy, Max W Shen, William David Arnold, Dan Wang, Jun Xie, Guangping Gao, Arthur H M Burghes, David R Liu
Base editing rescue of spinal muscular atrophy in cells and in mice. Science (New York, N.Y.) (2023)
Thiyagaraj Mayuranathan, Gregory A Newby, Ruopeng Feng, Yu Yao, Kalin D Mayberry, Cicera R Lazzarotto, Yichao Li, Rachel M Levine, Nikitha Nimmagadda, Erin Dempsey, Guolian Kang, Shaina N Porter, Phillip A Doerfler, Jingjing Zhang, Yoonjeong Jang, Jingjing Chen, Henry William Bell, Merlin Crossley, Senthil Velan Bhoopalan, Akshay Sharma, John F Tisdale, Shondra M Pruett-Miller, Yong Cheng, Shengdar Q Tsai, David R Liu, Mitchell J Weiss, Jonathan S Yen
Potent and uniform fetal hemoglobin induction via base editing. Nature genetics (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Kelcee A Everette, Gregory A Newby, Rachel M Levine, Kalin Mayberry, Yoonjeong Jang, Thiyagaraj Mayuranathan, Nikitha Nimmagadda, Erin Dempsey, Yichao Li, Senthil Velan Bhoopalan, Xiong Liu, Jessie R Davis, Andrew T Nelson, Peter J Chen, Alexander A Sousa, Yong Cheng, John F Tisdale, Mitchell J Weiss, Jonathan S Yen, David R Liu
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice. Nature biomedical engineering (2023)
Luke W Koblan, Mandana Arbab, Max W Shen, Jeffrey A Hussmann, Andrew V Anzalone, Jordan L Doman, Gregory A Newby, Dian Yang, Beverly Mok, Joseph M Replogle, Albert Xu, Tyler A Sisley, Jonathan S Weissman, Britt Adamson, David R Liu
Author Correction: Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning. Nature biotechnology (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Zackery A Ely, Nicolas Mathey-Andrews, Santiago Naranjo, Samuel I Gould, Kim L Mercer, Gregory A Newby, Christina M Cabana, William M Rideout, Grissel Cervantes Jaramillo, Jennifer M Khirallah, Katie Holland, Peyton B Randolph, William A Freed-Pastor, Jessie R Davis, Zachary Kulstad, Peter M K Westcott, Lin Lin, Andrew V Anzalone, Brendan L Horton, Nimisha B Pattada, Sean-Luc Shanahan, Zhongfeng Ye, Stefani Spranger, Qiaobing Xu, Francisco J Sánchez Rivera, David R Liu, Tyler Jacks
A prime editor mouse to model a broad spectrum of somatic mutations in vivo. Nature biotechnology (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Haoxin Li, Tiantai Ma, Jarrett R Remsberg, Sang Joon Won, Kristen E DeMeester, Evert Njomen, Daisuke Ogasawara, Kevin Tianmeng Zhao, Tony P Huang, Bingwen Lu, Gabriel M Simon, Bruno Melillo, Stuart L Schreiber, Jens Lykke-Andersen, David R Liu, Benjamin F Cravatt
Assigning functionality to cysteines by base editing of cancer dependency genes. Nature chemical biology (2023)
Alexander A Peterson, David R Liu
Small-molecule discovery through DNA-encoded libraries. Nature reviews. Drug discovery (2023)
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Katherine Aleisha Donovan, Veronika Shoba, Santosh Kumar Chaudhary, Jaron A M Mercer, Sophia Lai, Ananthan Sadagopan, Max Jan, Eric S Fischer, David R Liu, Benjamin L Ebert, Amit Choudhary
Proteolysis-targeting chimeras with reduced off-targets. Nature chemistry 16 (2) (2023)
Elliot H Choi, Susie Suh, Andrzej T Foik, Henri Leinonen, Gregory A Newby, Xin D Gao, Samagya Banskota, Thanh Hoang, Samuel W Du, Zhiqian Dong, Aditya Raguram, Sajeev Kohli, Seth Blackshaw, David C Lyon, David R Liu, Krzysztof Palczewski
In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration. Nature communications 13 (1) (2022)
Jessie R Davis, Xiao Wang, Isaac P Witte, Tony P Huang, Jonathan M Levy, Aditya Raguram, Samagya Banskota, Nabil G Seidah, Kiran Musunuru, David R Liu
Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors. Nature biomedical engineering 6 (11) (2022)
Alexander A Peterson, Aziz M Rangwala, Manish K Thakur, Patrick S Ward, Christie Hung, Ian R Outhwaite, Alix I Chan, Dmitry L Usanov, Vamsi K Mootha, Markus A Seeliger, David R Liu
Discovery and molecular basis of subtype-selective cyclophilin inhibitors. Nature chemical biology 18 (11) (2022)
Tony P Huang, Zachary J Heins, Shannon M Miller, Brandon G Wong, Pallavi A Balivada, Tina Wang, Ahmad S Khalil, David R Liu
High-throughput continuous evolution of compact Cas9 variants targeting single-nucleotide-pyrimidine PAMs. Nature biotechnology (2022)
Jonathan C Chen, Jonathan P Chen, Max W Shen, Michael Wornow, Minwoo Bae, Wei-Hsi Yeh, Alvin Hsu, David R Liu
Generating experimentally unrelated target molecule-binding highly functionalized nucleic-acid polymers using machine learning. Nature communications 13 (1) (2022)
Kousuke Mouri, Michael H Guo, Carl G de Boer, Michelle M Lissner, Ingrid A Harten, Gregory A Newby, Hannah A DeBerg, Winona F Platt, Matteo Gentili, David R Liu, Daniel J Campbell, Nir Hacohen, Ryan Tewhey, John P Ray
Prioritization of autoimmune disease-associated genetic variants that perturb regulatory element activity in T cells. Nature genetics 54 (5) (2022)
Jordan L Doman, Alexander A Sousa, Peyton B Randolph, Peter J Chen, David R Liu
Designing and executing prime editing experiments in mammalian cells. Nature protocols 17 (11) (2022)
Julian C W Willis, Pedro Silva-Pinheiro, Lily Widdup, Michal Minczuk, David R Liu
Compact zinc finger base editors that edit mitochondrial or nuclear DNA in vitro and in vivo. Nature communications 13 (1) (2022)
Monica E Neugebauer, Alvin Hsu, Mandana Arbab, Nicholas A Krasnow, Amber N McElroy, Smriti Pandey, Jordan L Doman, Tony P Huang, Aditya Raguram, Samagya Banskota, Gregory A Newby, Jakub Tolar, Mark J Osborn, David R Liu
Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity. Nature biotechnology (2022)
Beverly Y Mok, Anna V Kotrys, Aditya Raguram, Tony P Huang, Vamsi K Mootha, David R Liu
CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA. Nature biotechnology 40 (9) (2022)
Travis R Blum, Hao Liu, Michael S Packer, Xiaozhe Xiong, Pyung-Gang Lee, Sicai Zhang, Michelle F Richter, George Minasov, Karla J F Satchell, Min Dong, David R Liu
Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity. Science (New York, N.Y.) 371 (6531) (2021)
Krishanu Saha, Erik J Sontheimer, P J Brooks, Melinda R Dwinell, Charles A Gersbach, David R Liu, Stephen A Murray, Shengdar Q Tsai, Ross C Wilson, Daniel G Anderson, Aravind Asokan, Jillian F Banfield, Krystof S Bankiewicz, Gang Bao, Jeff W M Bulte, Nenad Bursac, Jarryd M Campbell, Daniel F Carlson, Elliot L Chaikof, Zheng-Yi Chen, R Holland Cheng, Karl J Clark, David T Curiel, James E Dahlman, Benjamin E Deverman, Mary E Dickinson, Jennifer A Doudna, Stephen C Ekker, Marina E Emborg, Guoping Feng, Benjamin S Freedman, David M Gamm, Guangping Gao, Ionita C Ghiran, Peter M Glazer, Shaoqin Gong, Jason D Heaney, Jon D Hennebold, John T Hinson, Anastasia Khvorova, Samira Kiani, William R Lagor, Kit S Lam, Kam W Leong, Jon E Levine, Jennifer A Lewis, Cathleen M Lutz, Danith H Ly, Samantha Maragh, Paul B McCray, Todd C McDevitt, Oleg Mirochnitchenko, Ryuji Morizane, Niren Murthy, Randall S Prather, John A Ronald, Subhojit Roy, Sushmita Roy, Venkata Sabbisetti, W Mark Saltzman, Philip J Santangelo, David J Segal, Mary Shimoyama, Melissa C Skala, Alice F Tarantal, John C Tilton, George A Truskey, Moriel Vandsburger, Jonathan K Watts, Kevin D Wells, Scot A Wolfe, Qiaobing Xu, Wen Xue, Guohua Yi, Jiangbing Zhou, null null
The NIH Somatic Cell Genome Editing program. Nature 592 (7853) (2021)
Christopher J Podracky, Chihui An, Alexandra DeSousa, Brent M Dorr, Dominic M Walsh, David R Liu
Laboratory evolution of a sortase enzyme that modifies amyloid-β protein. Nature chemical biology 17 (3) (2021)
Wei-Hsi Yeh, Olga Shubina-Oleinik, Jonathan M Levy, Bifeng Pan, Gregory A Newby, Michael Wornow, Rachel Burt, Jonathan C Chen, Jeffrey R Holt, David R Liu
In vivo base editing restores sensory transduction and transiently improves auditory function in a mouse model of recessive deafness. Science translational medicine 12 (546) (2021)
Luke W Koblan, Michael R Erdos, Leslie B Gordon, Francis S Collins, Jonathan D Brown, David R Liu
Base editor treats progeria in mice. Nature (2021)
Gregory A Newby, Jonathan S Yen, Kaitly J Woodard, Thiyagaraj Mayuranathan, Cicera R Lazzarotto, Yichao Li, Heather S Sheppard, Shaina N Porter, Yu Yao, Kalin Mayberry, Kelcee A Everette, Yoonjeong Jang, Christopher J Podracky, Elizabeth Thaman, Christophe Lechauve, Akshay Sharma, Jordana M Henderson, Michelle F Richter, Kevin Tianmeng Zhao, Shannon M Miller, Tina Wang, Luke W Koblan, Anton P McCaffrey, John F Tisdale, Theodosia A Kalfa, Shondra M Pruett-Miller, Shengdar Q Tsai, Mitchell J Weiss, David R Liu
Base editing of haematopoietic stem cells rescues sickle cell disease in mice. Nature 595 (7866) (2021)
Luke W Koblan, Mandana Arbab, Max W Shen, Jeffrey A Hussmann, Andrew V Anzalone, Jordan L Doman, Gregory A Newby, Dian Yang, Beverly Mok, Joseph M Replogle, Albert Xu, Tyler A Sisley, Jonathan S Weissman, Britt Adamson, David R Liu
Efficient C•G-to-G•C base editors developed using CRISPRi screens, target-library analysis, and machine learning. Nature biotechnology 39 (11) (2021)
Luke W Koblan, Michael R Erdos, Christopher Wilson, Wayne A Cabral, Jonathan M Levy, Zheng-Mei Xiong, Urraca L Tavarez, Lindsay M Davison, Yantenew G Gete, Xiaojing Mao, Gregory A Newby, Sean P Doherty, Narisu Narisu, Quanhu Sheng, Chad Krilow, Charles Y Lin, Leslie B Gordon, Kan Cao, Francis S Collins, Jonathan D Brown, David R Liu
In vivo base editing rescues Hutchinson-Gilford progeria syndrome in mice. Nature 589 (7843) (2021)
Tony P Huang, Gregory A Newby, David R Liu
Precision genome editing using cytosine and adenine base editors in mammalian cells. Nature protocols 16 (2) (2021)
Beverly Y Mok, Marcos H de Moraes, Jun Zeng, Matthew M Yeh, Anna V Kotrys, Aditya Raguram, FoSheng Hsu, Matthew C Radey, S Brook Peterson, Vamsi K Mootha, Joseph D Mougous, David R Liu
A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing. Nature 583 (7817) (2020)
Christopher Wilson, Peter J Chen, Zhuang Miao, David R Liu
Programmable m6A modification of cellular RNAs with a Cas13-directed methyltransferase. Nature biotechnology 38 (12) (2020)
Audrone Lapinaite, Gavin J Knott, Cody M Palumbo, Enrique Lin-Shiao, Michelle F Richter, Kevin Tianmeng Zhao, Peter A Beal, David R Liu, Jennifer A Doudna
DNA capture by a CRISPR-Cas9-guided adenine base editor. Science (New York, N.Y.) 369 (6503) (2020)
Shannon M Miller, Tina Wang, David R Liu
Phage-assisted continuous and non-continuous evolution. Nature protocols 15 (12) (2020)
Jonathan M Levy, Wei-Hsi Yeh, Nachiket Pendse, Jessie R Davis, Erin Hennessey, Rossano Butcher, Luke W Koblan, Jason Comander, Qin Liu, David R Liu
Cytosine and adenine base editing of the brain, liver, retina, heart and skeletal muscle of mice via adeno-associated viruses. Nature biomedical engineering 4 (1) (2020)
Andrew V Anzalone, Luke W Koblan, David R Liu
Genome editing with CRISPR-Cas nucleases, base editors, transposases and prime editors. Nature biotechnology 38 (7) (2020)
Jordan L Doman, Aditya Raguram, Gregory A Newby, David R Liu
Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors. Nature biotechnology 38 (5) (2020)
Michelle F Richter, Kevin Tianmeng Zhao, Elliot O Eton, Audrone Lapinaite, Gregory A Newby, Benjamin W Thuronyi, Christopher Wilson, Luke W Koblan, Jing Zeng, Daniel E Bauer, Jennifer A Doudna, David R Liu
Phage-assisted evolution of an adenine base editor with improved Cas domain compatibility and activity. Nature biotechnology 38 (7) (2020)
Shannon M Miller, Tina Wang, Peyton B Randolph, Mandana Arbab, Max W Shen, Tony P Huang, Zaneta Matuszek, Gregory A Newby, Holly A Rees, David R Liu
Continuous evolution of SpCas9 variants compatible with non-G PAMs. Nature biotechnology 38 (4) (2020)
Qiupeng Lin, Yuan Zong, Chenxiao Xue, Shengxing Wang, Shuai Jin, Zixu Zhu, Yanpeng Wang, Andrew V Anzalone, Aditya Raguram, Jordan L Doman, David R Liu, Caixia Gao
Prime genome editing in rice and wheat. Nature biotechnology 38 (5) (2020)
Hui Kwon Kim, Sungtae Lee, Younggwang Kim, Jinman Park, Seonwoo Min, Jae Woo Choi, Tony P Huang, Sungroh Yoon, David R Liu, Hyongbum Henry Kim
High-throughput analysis of the activities of xCas9, SpCas9-NG and SpCas9 at matched and mismatched target sequences in human cells. Nature biomedical engineering 4 (1) (2020)
Mary S Morrison, Christopher J Podracky, David R Liu
The developing toolkit of continuous directed evolution. Nature chemical biology 16 (6) (2020)
Susie Suh, Elliot H Choi, Henri Leinonen, Andrzej T Foik, Gregory A Newby, Wei-Hsi Yeh, Zhiqian Dong, Philip D Kiser, David C Lyon, David R Liu, Krzysztof Palczewski
Restoration of visual function in adult mice with an inherited retinal disease via adenine base editing. Nature biomedical engineering 5 (2) (2020)
Timothy B Roth, Benjamin M Woolston, Gregory Stephanopoulos, David R Liu
Phage-Assisted Evolution of Bacillus methanolicus Methanol Dehydrogenase 2. ACS synthetic biology 8 (4) (2019)
Phillip A Lichtor, Zhen Chen, Nadine H Elowe, Jonathan C Chen, David R Liu
Side chain determinants of biopolymer function during selection and replication. Nature chemical biology 15 (4) (2019)
Holly A Rees, Christopher Wilson, Jordan L Doman, David R Liu
Analysis and minimization of cellular RNA editing by DNA adenine base editors. Science advances 5 (5) (2019)
Benjamin W Thuronyi, Luke W Koblan, Jonathan M Levy, Wei-Hsi Yeh, Christine Zheng, Gregory A Newby, Christopher Wilson, Mantu Bhaumik, Olga Shubina-Oleinik, Jeffrey R Holt, David R Liu
Continuous evolution of base editors with expanded target compatibility and improved activity. Nature biotechnology 37 (9) (2019)
Juan Pablo Maianti, Grace A Tan, Amedeo Vetere, Amie J Welsh, Bridget K Wagner, Markus A Seeliger, David R Liu
Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme. Nature chemical biology 15 (6) (2019)
Jeffrey L Bessen, Lena K Afeyan, Vlado Dančík, Luke W Koblan, David B Thompson, Chas Leichner, Paul A Clemons, David R Liu
High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nature communications 10 (1) (2019)
Chun-Qing Song, Tingting Jiang, Michelle Richter, Luke H Rhym, Luke W Koblan, Maria Paz Zafra, Emma M Schatoff, Jordan L Doman, Yueying Cao, Lukas E Dow, Julie Lihua Zhu, Daniel G Anderson, David R Liu, Hao Yin, Wen Xue
Adenine base editing in an adult mouse model of tyrosinaemia. Nature biomedical engineering 4 (1) (2019)
Holly A Rees, Wei-Hsi Yeh, David R Liu
Development of hRad51-Cas9 nickase fusions that mediate HDR without double-stranded breaks. Nature communications 10 (1) (2019)
Jeffrey L Bessen, Lena K Afeyan, Vlado Dančík, Luke W Koblan, David B Thompson, Chas Leichner, Paul A Clemons, David R Liu
Addendum: High-resolution specificity profiling and off-target prediction for site-specific DNA recombinases. Nature communications 10 (1) (2019)
Tony P Huang, Kevin Tianmeng Zhao, Shannon M Miller, Nicole M Gaudelli, Benjamin L Oakes, Christof Fellmann, David F Savage, David R Liu
Circularly permuted and PAM-modified Cas9 variants broaden the targeting scope of base editors. Nature biotechnology 37 (6) (2019)
Y Bill Kim, Kevin T Zhao, David B Thompson, David R Liu
An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells. Nature communications 10 (1) (2019)
Weixin Tang, David R Liu
Rewritable multi-event analog recording in bacterial and mammalian cells. Science (New York, N.Y.) 360 (6385) (2018)
Alexis C Komor, Ahmed H Badran, David R Liu
Editing the Genome Without Double-Stranded DNA Breaks. ACS chemical biology 13 (2) (2017)
Alix I Chan, Lynn M McGregor, Tara Jain, David R Liu
Discovery of a Covalent Kinase Inhibitor from a DNA-Encoded Small-Molecule Library × Protein Library Selection. Journal of the American Chemical Society 139 (30) (2017)
Alexis C Komor, Kevin T Zhao, Michael S Packer, Nicole M Gaudelli, Amanda L Waterbury, Luke W Koblan, Y Bill Kim, Ahmed H Badran, David R Liu
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity. Science advances 3 (8) (2017)